ライフサイエンスコーパス: adaptive immunity

1 s neuronal circuits that regulate innate and adaptive immunity.

2 pansion during the initial step of bacterial adaptive immunity.

3 earliest critical junctures in evolution of adaptive immunity.

4 ls, chemokines, and cytokines, of innate and adaptive immunity.

5 thways that lead to activation of innate and adaptive immunity.

6 eotide content of invading viruses to confer adaptive immunity.

7 erance by suppressing aberrant activation of adaptive immunity.

8 llowing activation is required for efficient adaptive immunity.

9 temporal bridge until the reconstruction of adaptive immunity.

10 S5, suggesting that it promotes avoidance of adaptive immunity.

11 tes and is essential for T cell function and adaptive immunity.

12 driven chronic inflammation independently of adaptive immunity.

13 d RARs and their complex roles in innate and adaptive immunity.

14 per' T cells, the principal orchestrators of adaptive immunity.

15 nctioning as a self-sufficient first line of adaptive immunity.

16 One action of 1,25(OH)2D3 is to upregulate adaptive immunity.

17 p mild symptoms associated with long-lasting adaptive immunity.

18 d for further research into the evolution of adaptive immunity.

19 hich enables disease to progress unabated by adaptive immunity.

20 nd cytokine responses, which results in weak adaptive immunity.

21 s, suggesting a role for ILC2s in regulating adaptive immunity.

22 of these critical controllers of innate and adaptive immunity.

23 s and recombination, which are essential for adaptive immunity.

24 Macrophages are important in innate and adaptive immunity.

25 n-presenting cells, is a cardinal feature of adaptive immunity.

26 n as immune adherence, with consequences for adaptive immunity.

27 ortant link between Lactobacillales and host adaptive immunity.

28 serve as a key interface between innate and adaptive immunity.

29 in Down syndrome, suggesting abnormality of adaptive immunity.

30 latory system governing the establishment of adaptive immunity.

31 hat drives cancer escape by disabling T cell adaptive immunity.

32 nodes (LN) to drive peripheral tolerance and adaptive immunity.

33 abling the induction of protective antiviral adaptive immunity.

34 ins) exhibit diverse functions in innate and adaptive immunity.

35 powerful mechanism coupling inflammation to adaptive immunity.

36 h intratumoral activation of both innate and adaptive immunity.

37 uding dedifferentiation, innate immunity and adaptive immunity.

38 y predate its more recent role in innate and adaptive immunity.

39 m, while still allowing for the induction of adaptive immunity.

40 lowing nonprofessional cells to benefit from adaptive immunity.

41 ietic cells initiate and maintain innate and adaptive immunity.

42 estral RAG2, allowing for the development of adaptive immunity.

43 blood cells play diverse roles in innate and adaptive immunity.

44 nd that Nlrp2 was dispensable for innate and adaptive immunity.

45 diverse repertoire of T cells essential for adaptive immunity.

46 f RELMalpha were abrogated in the absence of adaptive immunity.

47 s an arsenal of defenses, such as CRISPR-Cas adaptive immunity.

48 er sterile inflammation and, in vertebrates, adaptive immunity.

49 ndings demonstrate the importance of TfR1 in adaptive immunity.

50 ment and bridging the gap between innate and adaptive immunity.

51 sponses may be exploited to enhance neonatal adaptive immunity.

52 that have characteristics of both innate and adaptive immunity.

53 tes possessing Ig superfamily receptor-based adaptive immunity.

54 so a DAMP in invertebrates that lack DCs and adaptive immunity.

55 bound to MHC molecules lies at the center of adaptive immunity.

56 proteins that occupies a central position in adaptive immunity.

57 g cell injury that precedes the evolution of adaptive immunity.

58 ith diverse modulatory effects in innate and adaptive immunity.

59 ths, and is indispensable in both innate and adaptive immunity.

60 that this is likely a general phenomenon in adaptive immunity.

61 n IL-1 receptor 1 (IL-1R1) signaling but not adaptive immunity.

62 ly shown to have regulatory activity only in adaptive immunity.

63 idence of antagonism between the two arms of adaptive immunity.

64 l event in the evolution of jawed vertebrate adaptive immunity.

65 s treat cancer by mobilizing both innate and adaptive immunity.

66 , i.e., postnatal cortical tissue that lacks adaptive immunity.

67 r germinal center (GC) formation and humoral adaptive immunity.

68 pecificities via DNA recombination underpins adaptive immunity.

69 h) cells, which are important for protective adaptive immunity.

70 acknowledged vital bridge between innate and adaptive immunity.

71 T cells play a central role in orchestrating adaptive immunity.

72 tant for rapid linkage of innate immunity to adaptive immunity.

73 -lambda receptor, Ifnlr1, and independent of adaptive immunity.

74 centre (GC) response is a pivotal process in adaptive immunity.

75 s as a central regulator of inflammation and adaptive immunity.

76 city and the release of cytokines that prime adaptive immunity.

77 presentation of antigens to lymphocytes for adaptive immunity.

78 eration and direction by bridging innate and adaptive immunity.

79 rior to the establishment of fully competent adaptive immunity.

80 d plays an important role in both innate and adaptive immunity.

81 ts operating reflexively regulate innate and adaptive immunity.

82 nce of myeloid malignancies and a decline in adaptive immunity.

83 lls that activate T cells, linking innate to adaptive immunity.

84 Toll-like receptor signaling, which initiate adaptive immunity.

85 hese cells with potent aptitude to stimulate adaptive immunity.

86 nd dendritic cells all bridge the innate and adaptive immunity.

87 oles for IL-6 in innate immune responses and adaptive immunity.

88 e and context-specific effects on innate and adaptive immunity.

89 een antigen-specific CTLs and APC to amplify adaptive immunity.

90 flammatory interventions and potentiation of adaptive immunity.

91 es that affect several aspects of innate and adaptive immunity.

92 ogram required for Th17 cell development and adaptive immunity.

93 I interferon (IFN) production and antitumor adaptive immunity.

94 expression of CPS5 only in mice with intact adaptive immunity.

95 Vitamin A is a potent regulator of adaptive immunity.

96 sion, and new types of CRISPR-Cas systems of adaptive immunity.

97 te immune system, and how this may influence adaptive immunity.

98 sistent MNV, apart from a role in modulating adaptive immunity.

99 L1 and induces these effectors of innate and adaptive immunity.

100 etics, environmental factors, and innate and adaptive immunity.

101 have focused predominantly on stimulation of adaptive immunity.

102 via CXCL5 and produce IL-10, which inhibits adaptive immunity.

103 oid progenitors and suppress both innate and adaptive immunity.

104 with its receptor AdipoR1 and by modulating adaptive immunity.

105 unction, compromising effective antimalarial adaptive immunity.

106 Adaptive immunity, addressed here, integrates the activi

107 indromic repeat (CRISPR)-Cas systems provide adaptive immunity against foreign elements.

108 Bacteria and archaea employ adaptive immunity against foreign genetic elements using

109 ts-CRISPR associated) systems, which provide adaptive immunity against foreign nucleic acids.

110 receptors play critical roles in innate and adaptive immunity against intracellular pathogens.

111 n in the GI tract and for establishing local adaptive immunity against pathogens.

112 ecific CD4 TRM cells play a critical role in adaptive immunity against reinfection and memory induced

113 Mincle deficiency enhanced adaptive immunity against the parasite, correlating with

114 in immunoregulation by connecting innate and adaptive immunity and are emerging therapeutic targets.

115 Ns are crucial mediators of human innate and adaptive immunity and are massively produced from plasma

116 munologic roles of autophagy span innate and adaptive immunity and are often manifested in inflammato

117 ling TAM signaling may promote engagement of adaptive immunity and complement T-cell checkpoint block

118 ns completely inhibited T-helper 1-dependent adaptive immunity and compromised the function of natura

119 combination is the distinguishing feature of adaptive immunity and enables effective immune responses

120 2 innate lymphoid cells (ILC2s) can regulate adaptive immunity and eosinophil and alternatively activ

121 ic and led to establishment of HAdV-specific adaptive immunity and expression of early viral genes ex

122 Bacterial adaptive immunity and genome engineering involving the C

123 es, based on a 100-gene signature reflecting adaptive immunity and glucocorticoid receptor signaling.

124 The subclass-defining genes correspond to adaptive immunity and glucocorticoid receptor signaling.

125 flagellar motility; but, its contribution to adaptive immunity and immune system development is compl

126 RP-1) is a scavenger receptor that regulates adaptive immunity and inflammation.

127 ging manifests with a combination of failing adaptive immunity and insufficiently restrained inflamma

128 cell egress from the thymus is essential for adaptive immunity and involves chemotaxis along a sphing

129 y, skin inflammation occurs independently of adaptive immunity and is associated with cutaneous expan

130 NF-kappaB is a key regulator of innate and adaptive immunity and is implicated in the pathogenesis

131 Given this role in adaptive immunity and its highly monomorphic nature in t

132 rate that IRAK-4 is essential for innate and adaptive immunity and necessary for efficient control of

133 Full efficacy required Il-12, Ifn-gamma, adaptive immunity and neutrophils.

134 munotherapy platform to stimulate innate and adaptive immunity and promote a universal antitumour res

135 as an immune checkpoint molecule to regulate adaptive immunity and promote immune tolerance.

136 rostatus influences NK cell contributions to adaptive immunity and raises important questions regardi

137 tion of lymphocytes by antigen is central to adaptive immunity and self-tolerance, yet how this is de

138 mine lymphocyte activation's relationship to adaptive immunity and significance in the context of isc

139 This could reflect early impaired adaptive immunity and suggests potential therapeutic tar

140 ng questions related to interactions between adaptive immunity and the CNS and considers the possible

141 antigen presentation, chemotaxis, innate and adaptive immunity and their regulation.

142 stablishment of chronicity is independent of adaptive immunity and therefore different from the mecha

143 interactions between the bacterium and host adaptive immunity and to inform rational vaccine design,

144 Dendritic cells (DCs) link innate and adaptive immunity and use a host of innate immune and in

145 idermal barrier, dysregulation of innate and adaptive immunity, and a high susceptibility to bacteria

146 including cell-to-cell communication, innate/adaptive immunity, and cell proliferation.

147 to accumulated cellular damage, decreases in adaptive immunity, and chronic inflammation.

148 ls was dependent upon intestinal microbiota, adaptive immunity, and common-gamma chain-dependent sign

149 rganisms educates the immune system, induces adaptive immunity, and initiates memory B and T cells th

150 ntiinflammatory pathway regulates innate and adaptive immunity, and modulation of this reflex by vagu

151 tiviral type I IFN, proinflammatory factors, adaptive immunity, and pathology is pathogen dependent.

152 ctin-3 (Gal-3) modulates the host innate and adaptive immunity, and plays significant roles during mi

153 duced neuroinvasiveness, induction of strong adaptive immunity, and protection of mice from wild-type

154 egarding the regulatory functions of ILCs in adaptive immunity, and suggest that lung ILC2s promote B

155 In particular, little is known about bat adaptive immunity, and the presence of functional MHC mo

156 , contribute to vascular homeostasis, innate/adaptive immunity, and wound healing.

157 tinct strategies, including innate immunity; adaptive immunity; and dormancy induction, or programmed

158 lammation) and 274 (52%) were downregulated [adaptive immunity (antigen presentation, T-cell function

159 Both innate and adaptive immunities are involved.

160 Innate and adaptive immunity are activated by both infections and t

161 usly undefined mechanism in which innate and adaptive immunity are linked by TIR domain-containing ad

162 fundamental principles of innate control of adaptive immunity are well established, it is not fully

163 In organisms lacking adaptive immunity, as well as in mammals, the innate imm

164 ceptor (AgR) genes is not only essential for adaptive immunity, but also a risk for autoimmunity and

165 L)-18 is an important effector of innate and adaptive immunity, but its expression must also be tight

166 ory and have an important role in innate and adaptive immunity, but the role of IL-36 signaling in re

167 rtant roles in regulation of both innate and adaptive immunity, but whether and how mTOR modulates hu

168 t patients, global suppression of innate and adaptive immunities by immunosuppressive agents limits i

169 nce of chronic infection involves evasion of adaptive immunity by antigenic variation(7).

170 HIV-associated dysregulation of adaptive immunity by depletion of CD4 Th cells most like

171 CRISPR-Cas systems provide microbes with adaptive immunity by employing short DNA sequences, term

172 hanism by which trastuzumab links innate and adaptive immunity by facilitating activation of antigen-

173 xic functions or depend on the tuning of Th1 adaptive immunity by IFN-gamma.

174 have versatile functions in contributing to adaptive immunity by internalizing and transporting anti

175 erial factor in the modulation of innate and adaptive immunity by M. tuberculosis, suggesting strateg

176 ombinase (RAG1/2) plays an essential role in adaptive immunity by mediating V(D)J recombination in de

177 Dying cells initiate adaptive immunity by providing both antigens and inflamm

178 Antigen receptor diversity underpins adaptive immunity by providing the ground for clonal sel

179 Our results suggest that induction of adaptive immunity by RANTES and eotaxin could hold the k

180 The general view that only adaptive immunity can build immunological memory has rec

181 he coordinated activation of both innate and adaptive immunity can effectively reduce the risk of tum

182 Playing a central role in both innate and adaptive immunity, CD4(+) T cells are a key target for g

183 ed four gene clusters involved in innate and adaptive immunity, chemotaxis, cell-adhesion and transcr

184 It is not clear how tissue stress and adaptive immunity contribute to the activation of intrae

185 recent advances in our understanding of how adaptive immunity contributes to the pathogenesis of ACS

186 Adaptive immunity depends on mature thymocytes leaving t

187 quires the sequential activity of innate and adaptive immunity effectors.

188 ofTyro3 Thus, a PROS1-mediated feedback from adaptive immunity engages a rheostat, TYRO3, on innate i

189 modulatory effects involving both innate and adaptive immunity, even in heavily pretreated multiple m

190 associated with TILs fraction, tumor purity, adaptive immunity gene expression signatures and improve

191 on of innate immunity and underexpression of adaptive immunity genes, whereas negligible changes were

192 Adaptive immunity had been long thought of as an exclusi

193 d development where a component of bacterial adaptive immunity has been harnessed to address importan

194 The influence of cell death on adaptive immunity has been studied for decades.

195 NA recombination, the hallmark of vertebrate adaptive immunity, has the potential to generate a vast

196 Whereas innate and adaptive immunity have established roles in cardiovascul

197 Consequently, proteins mediating adaptive immunity (IFNG, STAT1, TLR1) are deficient, whe

198 In adaptive immunity, IL-33 interacts with dendritic cells,

199 irculating T cells, implies that traditional adaptive immunity imparts incomplete protection.

200 In contrast, the role of adaptive immunity in AD remains largely unknown.

201 d with young HSCs, contributing to decreased adaptive immunity in aged individuals.

202 Cas systems has established a novel means of adaptive immunity in bacteria and archaea and deepened o

203 rgence of the CRISPR/Cas system of antiviral adaptive immunity in bacteria as a facile system for gen

204 Adaptive immunity in bacteria involves RNA-guided survei

205 ovide a foundation to understand the role of adaptive immunity in bat antiviral responses.

206 CRISPR systems mediate adaptive immunity in diverse prokaryotes.

207 This study highlights the importance of adaptive immunity in driving persistent and progressive

208 The role of adaptive immunity in early cancer development is controv

209 Adaptive immunity in jawless fishes is based on antigen

210 nses are critical determinants of subsequent adaptive immunity in leishmaniasis, yet few studies addr

211 To examine the significance of cDC-initiated adaptive immunity in maintaining homeostasis, independen

212 lays a causal role in maintaining innate and adaptive immunity in obesity.

213 icance and highlights the role of innate and adaptive immunity in the etiology of periodontitis.

214 (HDM) effectively activates both innate and adaptive immunity in the lung mucosa.

215 (-/-) mice, suggesting similar initiation of adaptive immunity in the two strains.

216 ofacitinib effectively suppressed innate and adaptive immunity in the vessel wall.

217 egulatory mechanisms restraining energy-avid adaptive immunity in times of starvation and exerting a

218 This signaling is pivotal for activating adaptive immunity in vertebrates, suggesting a close evo

219 Radiotherapy induces and promotes innate and adaptive immunity in which host STING plays an important

220 s/autophagy, in addition to known innate and adaptive immunity, in the pathogenesis of leprosy, highl

221 venger receptors, keeping them available for adaptive immunity induction by splenic CD8alpha(+) dendr

222 are versatile cells that regulate innate and adaptive immunity, influence metabolism and tissue repai

223 To test the hypothesis that adaptive immunity influences AD pathogenesis, we generat

224 vely, these findings provide a mechanism for adaptive immunity involvement in the kidney defect in so

225 The connection between innate and adaptive immunity is best exemplified by antigen present

226 Adaptive immunity is driven by the expansion, somatic hy

227 y control blood-stage parasite numbers while adaptive immunity is gradually established.

228 e immune responses, their role in regulating adaptive immunity is just starting to be appreciated.

229 Our findings demonstrate that antitumor adaptive immunity is not adversely impaired by autophagy

230 How bacterial pathogens evade adaptive immunity is not well understood.

231 Even though adaptive immunity is present in teleost fish, these spec

232 However, the role of STING in adaptive immunity is still unknown.

233 ysiologic role of these factors in innate or adaptive immunity is unclear, although IL-33 might funct

234 immunity in mice and humans, yet its role in adaptive immunity is unclear.

235 al transition of host defense from innate to adaptive immunity is unexpectedly mirrored at the cellul

236 ntrol of HMPV replication, pathogenesis, and adaptive immunity is unknown.

237 Induction of adaptive immunity leads to the establishment of immunolo

238 Due to their key role in adaptive immunity, many viruses, including Kaposi's sarc

239 ction, suggesting that NK cells, but not HCV adaptive immunity, may contribute to HCV viral control f

240 re, thanks to a peculiar form of prokaryotic adaptive immunity mediated by clustered regularly inters

241 hways limit pathogen invasion of the CNS and adaptive immunity mediates control of many neural infect

242 cellular protozoa (IL-8) or bridge innate to adaptive immunity (MIP-3alpha and RANTES (regulated on a

243 T cells are integral to adaptive immunity; mouse studies indicate that tissue lo

244 cant role in suppressing both the innate and adaptive immunities of the host.

245 owever, delayed reconstitution of innate and adaptive immunity often causes fatal complications.

246 Using our experimental model, impact of adaptive immunity on S. aureus colonisation could be ass

247 hat loss of BabA expression is not driven by adaptive immunity or toll-like receptor signaling, and t

248 ons involved in complex diseases, innate and adaptive immunity, or food preferences, 32 loci were ide

249 is is known to produce antigenic peptides in adaptive immunity, our findings demonstrate its new role

250 candidates for adjuvants to boost innate and adaptive immunity, our understanding of the effect of Cp

251 CRISPR adaptive immunity pathways protect prokaryotic cells aga

252 the absence of either maternal or offspring adaptive immunity permitted efficient vertical transmiss

253 on in thymic regeneration and restoration of adaptive immunity posttransplant.

254 on is an important bridge between innate and adaptive immunity primarily because B-1 cells produce na

255 of B cell activation, as it links innate and adaptive immunity, promoting potent B cell responses.

256 provide a natural bridge between innate and adaptive immunity, rapidly and potently respond to patho

257 activation may extend beyond gestation while adaptive immunity recovers.

258 ng enzymes, and a wide variety of innate and adaptive immunity-related proteins.

259 precise origin of a long-term suppression of adaptive immunity remains doubtful.

260 nnate immunity initiating dermatitis and the adaptive immunity required for subsequent development of

261 kinase (BTK) are protagonists in innate and adaptive immunity, respectively.

262 Recent advances in understanding adaptive immunity should facilitate vaccine development

263 Inducing tumour-specific adaptive immunity, such as cytotoxic T lymphocyte (CTL)

264 role of cell-extrinsic effects on innate and adaptive immunity, suggesting that the transmission of E

265 PR-associated) operon establish an RNA-based adaptive immunity system in prokaryotes.

266 and the adaptation module of the prokaryotic adaptive immunity systems.

267 ariety of biological functions in innate and adaptive immunity that are instrumental in the maintenan

268 mplexities involved in the innate control of adaptive immunity that extend beyond TCR engagement, cos

269 sentation in lymph nodes plays a key role in adaptive immunity, the cellular mechanisms that regulate

270 and how Nod1 and Nod2 proteins contribute to adaptive immunity, this study investigated their role in

271 eptors (FcgammaRs) for IgG couple innate and adaptive immunity through activation of effector cells b

272 anslational relevance to rapidly orchestrate adaptive immunity through DC maturation.

273 iral RNAi spreading that parallels mammalian adaptive immunity through reverse-transcribed vDNA circl

274 Adjuvants promote adaptive immunity through the triggering of innate signa

275 Although adaptive immunity to B. burgdorferi has been extensively

276 e importance of LCs and DCs in orchestrating adaptive immunity to HIV-1.

277 SHP1 in CD11c(+) cells phenocopies enhanced adaptive immunity to Leishmania.

278 We studied the induction of adaptive immunity to neonatal infection with a murine re

279 cur more frequently in humans lacking robust adaptive immunity to Plasmodium falciparum Nevertheless,

280 However, assessing the contribution of adaptive immunity to protection against S. epidermidis c

281 clearance and prevents development of potent adaptive immunity to reinfection.

282 the regulatory functions of CD47 in inducing adaptive immunity to vaccination.

283 Imbalance in innate and adaptive immunity together with environmental factors is

284 ine and human VL and plays a role in shaping adaptive immunity toward a Th1 profile.

285 age for the lymphoid subsets responsible for adaptive immunity, unlike cells from other hematopoietic

286 to how hosts can be equipped with innate and adaptive immunity via heat-killed DK128 treatment to pro

287 of intestinal epithelial cells, escape from adaptive immunity, virus persistence, and shedding.

288 er female reproductive tract may also affect adaptive immunity, we modeled CD8 T cell responses using

289 bacteria to activate the potentially lethal adaptive immunity when they need it most: in high-densit

290 ation is profoundly influenced by innate and adaptive immunity, which can be regulated locally within

291 immune system, particularly the emergence of adaptive immunity, which has likely been a major evoluti

292 ibute to the understanding of the priming of adaptive immunity, which is known to be altered during t

293 human cancers shows evidence for spontaneous adaptive immunity, which is reflected by the presence of

294 t the combined activation of both innate and adaptive immunity will result in better antitumor effica

295 's established and novel roles in innate and adaptive immunity with a focus on the functional differe

296 eficiencies (CIDs) are diseases of defective adaptive immunity with diverse clinical phenotypes.

297 ulates the innate immune system and enhances adaptive immunity with reduced toxicity.

298 with immunogenic reprogramming of innate and adaptive immunity within the TME.

299 present a novel and improved model for human adaptive immunity without relying on complex surgery to

300 ve a reduced innate immune response and lack adaptive immunity, would be susceptible to the infection