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1 capturing beta-catenin via the Legless/BCL9 adaptor.
2 complex formation with dynactin and a cargo adaptor.
3 together with MOB1 as an important signaling adaptor.
4 mic domain for binding to actin cytoskeleton adaptors.
5 n-ligase, recruited by alpha-arrestin-family adaptors.
6 that the surround contours are all potential adaptors.
7 the SLAM-associated protein (SAP) family of adaptors.
8 activation molecule-associated protein (SAP) adaptors.
9 demonstrate that Rif1 is a high-affinity PP1 adaptor, able to out-compete the well-established PP1-in
10 ivation results in the interaction of IL-17R adaptor Act1 with NICD1, followed by the translocation o
11 n and cargo binding that ensures that robust adaptor activity is maintained when high amounts of subs
12 er between BORC and late endosomal/lysosomal adaptor and mitogen activated protein kinase and mechani
13 y conserved network of scaffolding proteins, adaptors and enzymes that form and stabilize cortical as
15 of oligos avoids the necessity of preparing adaptors and the problems associated with inter-adaptor
16 The isolated oligonucleotides are ligated to adaptors, and after damage-specific immunoprecipitation,
20 tant lacking binding sites for the endocytic adaptor AP-2 proteins fails to rescue endocytosis, indic
21 we show that PICK1 binding to the endocytic adaptor AP2 is enhanced by OGD in hippocampal, but not c
24 d relies on the arrestin-related trafficking adaptor (ART)-Rsp5 ubiquitin ligase adaptor network in y
26 ction properties of the p24 and ERV-29 cargo adaptors, as well as their role in cellulase enzyme traf
27 sensors trigger assembly of the inflammasome adaptor ASC into specks, large signaling platforms consi
29 ng muscle atrophy, as the cullin-1 substrate adaptor atrogin-1 is among the most well-characterized m
30 of the viral late gene mRNAs by acting as an adaptor between the viral mRNAs and the cellular mRNA nu
31 s late viral gene expression by acting as an adaptor between viral mRNAs and the cellular nuclear exp
35 fferences in interactions with intracellular adaptors but do not predict cellular adhesiveness for im
37 unts of substrate must be delivered and that adaptors can be eliminated when their tasks have been co
43 HIV-1's Rev protein forms a homo-oligomeric adaptor complex linking viral RNAs to the cellular CRM1/
46 f the abundance and activity of these ligase-adaptor complexes is critical for main-tenance of optima
48 eeds and temporal phases between the central adaptor contour and the surround texture and measured fo
49 Shape aftereffects are suppressed when the adaptor contour is surrounded by a texture of similarly-
50 in which the SCCRO, substrate, and substrate adaptors cooperatively provide tight control of neddylat
51 petitive interruption of dynein-Snapin motor-adaptor coupling, thus immobilizing them in distal axons
52 P2 regulates its interaction with the Reelin adaptor Dab1 and this association is required for CLASP2
55 strate that tango7, not the canonical Apaf-1-adaptor dark, regulates dronc activity at the cortex; in
56 r work points to an optimization of inherent adaptor degradation and cargo binding that ensures that
58 e association of receptor with the signaling adaptor depends on a network of polar and aromatic resid
59 no acid positions in receptors, kinases, and adaptors determine their pathway specificity, assigning
61 vivo Gata6 stimulates EDA-receptor signaling adaptor Edaradd level and NF-kappaB pathway activation,
63 tidylinositol 3-kinase (BCAP) is a signaling adaptor expressed in mature hematopoietic cells, includi
64 ric-a-brac) protein, is a substrate-specific adaptor for Cullin3-RING ubiquitin ligase complex (CRL3(
65 ila In addition, the CLAMP (chromatin-linked adaptor for male-specific lethal [MSL] proteins) zinc fi
68 8 (MyD88), which is the only known signaling adaptor for TLR7, suggesting that a noncanonical mechani
69 primary response gene 88 (MyD88), the common adaptor for toll-like receptor (TLR) and Interleukin-1 r
71 late protein stability as substrate-specific adaptors for ubiquitination, have been implicated in sar
72 se it logjams the ubiquitin ligase substrate adaptor function of KEAP1 by virtue of the fact that it
74 t roles in recruitment of two major clathrin adaptors, Gga (Golgi-localized, gamma-adaptin ear homolo
77 ion of Stimulator of interferon genes, a key adaptor in double-stranded DNA-sensing pathway, followed
78 le for this viral Sm-class RNA as a microRNA adaptor in the regulation of gene expression that follow
79 his shows that BOP proteins act as substrate adaptors in a CUL3(BOP1/BOP2) E3 ubiquitin ligase comple
80 uniscins are a conserved family of endocytic adaptors, including Syp1 in budding yeast and its mammal
83 icated that the Toll/IL-1R domain-containing adaptor inducing IFN-beta/ TNFR-associated factor 3 path
84 ase receptor (PKR), or TIR domain-containing adaptor inducing interferon beta (TRIF) signaling or an
85 In this model, the TIR-domain-containing adaptor-inducing interferon-beta (TRIF) was a central me
86 88, and Toll-IL-1 receptor domain-containing adaptor-inducing interferon-gamma (TRIF), factors critic
89 d that the ability of a cargo to protect its adaptor is adaptor substrate-specific, as adaptors with
91 iates homodimerization and recruits cellular adaptors, is dispensable during ER-to-cytosol transport
93 ter damage-specific immunoprecipitation, the adaptor-ligated oligonucleotides are converted to dsDNA
96 h the Fab fragment of an antibody acts as an adaptor, linking a human protein insert with antigen-bin
100 Moreover, nanopores with internal protein adaptors might find further practical applications in mu
101 f the three Hippo kinases with the signaling adaptor MOB1 and show how they differently affect develo
104 (Q204L) did not reverse Rap1-GTP-interacting adaptor molecule (RIAM)-dependent increases in cell adhe
105 ta (4G8), microglia (ionized calcium binding adaptor molecule 1), astrocytes (glial fibrillary acidic
106 s indicate that PGC1alpha represents a novel adaptor molecule capable of recruiting the necessary tra
107 esults indicate that TAX1BP1 functions as an adaptor molecule for Itch to target MAVS during RNA viru
108 ivator 1alpha (PGC1alpha) serves as a unique adaptor molecule for the recruitment of additional coact
112 ges by selective conditional deletion of the adaptor molecule Rictor inhibits the generation of M2 ma
114 This stimulation leads to recruitment of the adaptor molecule TRIF (Toll/IL-1 resistance (TIR) domain
115 domain protein 2 (Fhl2) is an intracellular adaptor molecule with a high protein-protein interaction
116 e peptidoglycan recognition proteins and the adaptor molecules Fas-associated protein with a death do
118 g is negatively regulated by beta-arrestins, adaptor molecules that also activate different intracell
119 ng CD64 and FcepsilonR1alpha, with signaling adaptor molecules, and we confirm experimentally that eq
121 thway that is dependent on the TLR signaling adaptor MyD88 and its downstream kinase IL-1R-associated
124 proteasome, the ubiquitin-binding autophagy adaptor NBR1, the autophagy protein LC3, and the lysosom
126 plasmic PDZ-protease Prc and the lipoprotein adaptor NlpI contributes to PG enlargement by regulating
127 d that this activity is dependent on the p97 adaptor NPLOC4-UFD1L, ATP hydrolysis, and substrate ubiq
128 yl-3,4-dihydroxylase Ofd1 and nuclear import adaptor Nro1 regulate the hypoxic response in fission ye
129 en previously shown to require the transport adaptor ODA16, as well as the intraflagellar transport (
130 ram's tumour-suppressing effects as NPL4, an adaptor of p97 (also known as VCP) segregase, which is e
131 uted system and in vivo studies to show that adaptors of the ClpXP protease are readily degraded but
134 so serves as the interaction surface for the adaptor p62/Sequestosome-1, which is required for IL-1 s
135 g establishing a deficiency in the signaling adaptor p66Shc in CLL cells, we undertook to identify un
136 ycle barcoding PCR step followed directly by adaptor PCR to generate the library and then bead purifi
137 AP-4 is a member of the heterotetrameric adaptor protein (AP) complex family involved in protein
138 TLRs interact with the TIR domain-containing adaptor protein (TIRAP), triggering a signaling cascade
139 ical for interaction with the mu1 subunit of adaptor protein 1 and the major histocompatibility compl
140 tions create potential binding sites for the adaptor protein 14-3-3 that links Rap1 to the scaffold p
142 pid down-regulation of CD4 via the endocytic adaptor protein 2 (AP-2) complex, a process linked to en
145 sequestosome-1 (SQSTM1) is a multifunctional adaptor protein and autophagic substrate that accumulate
146 transporter that collaborates with the MacA adaptor protein and TolC exit duct to drive efflux of an
148 rotein 3 (NLRP3) inflammasome to recruit the adaptor protein apoptosis-associated speck-like protein
150 ulation of caspase-1 activation requires the adaptor protein ASC (apoptosis-associated speck-like pro
151 ces for binding other regulators, either the adaptor protein Bicaudal-D2 (BicD2) or the multifunction
152 Second, fusion kinase inhibition shifted adaptor protein binding from the fusion oncoprotein to E
153 ing through these receptors converged on the adaptor protein CARD9, a component of the CARD9-Bcl10-MA
155 iated with phosphorylation of the checkpoint adaptor protein Claspin and activation of the Chk1 effec
156 we explore the role of AP-2, a key endocytic adaptor protein complex, in the development of rat hippo
160 this network in Drosophila We find that the adaptor protein Disabled stimulates Abl kinase activity.
164 rial antiviral-signaling protein (MAVS), the adaptor protein for RIG-I like receptor in regulating ho
165 rial antiviral signaling protein (MAVS), the adaptor protein for RIG-I-like receptor in regulating ho
167 pproach identified the SH2 domain-containing adaptor protein GADS as the dominant interaction partner
168 ains a sorting motif that interacts with the adaptor protein GIPC1 to facilitate transport to recycli
170 nce that Drk, the Drosophila ortholog of the adaptor protein Grb2, is essential for ARM within adult
172 CABIT domain of Themis and indirectly to the adaptor protein Grb2, with the latter interaction enabli
173 h factor receptor (EGFR) and the cytoplasmic adaptor protein growth factor receptor-bound protein 2 (
175 PGRP-LE, which through interaction with the adaptor protein Imd leads to activation of the NF-kappaB
176 s, including CRKLCRKL encodes a src-homology adaptor protein implicated in mediating tyrosine kinase
177 ide insight into the mechanistic role of the adaptor protein in mediating the sequential assembly of
178 r cysteine (C151) of the E3 ligase substrate adaptor protein Kelch-like ECH-associated protein 1 (KEA
179 nterfering with a putative synaptic tag, the adaptor protein KIBRA, which protects the atypical PKM f
181 erate intracellular signals, the immune cell adaptor protein linker for the activation of T cells (LA
183 Here, we present the structure of the PilZ adaptor protein MapZ cocrystallized in complex with c-di
184 ly promotes Drp1 binding to the MOM resident adaptor protein mitochondrial fission factor (Mff).
186 the regulatory dominance of the melanophilin adaptor protein over its associated motor and offer an u
188 tigated whether epigenetic regulation of the adaptor protein p66(Shc), a key driver of mitochondrial
189 ouse, hypomorphic mutations in the ubiquitin adaptor protein PLAA cause an infantile-lethal neurodysf
190 ranches of the pathway, in that mTORC1 (with adaptor protein Raptor) is the main complex mediating th
191 Spata2 (spermatogenesis-associated 2) is an adaptor protein recruited into the TNF-RSC to modulate t
193 and function of islets, whereas mTORC2 (with adaptor protein Rictor) impacts islet mass and architect
196 l the molecular basis for how dynein and its adaptor protein Spindly are recruited to the ROD-Zw10-Zw
198 econd messenger that binds and activates the adaptor protein STING to induce type I interferons (IFNs
201 of multiple proteins, among which is a tail adaptor protein that connects the portal protein to the
203 n receptor accessory protein 2 (MRAP2) is an adaptor protein that contributes to melanocortin-4 recep
205 f wild-type two-pronged binding of the UBXD1 adaptor protein that is impaired in disease; this underl
206 ation primary response gene 88 (MyD88) is an adaptor protein that mediates Toll-like receptors and in
207 iated factor 2 (TRAF2) is a second messenger adaptor protein that plays an essential role in propagat
211 Moreover, the toll-like receptor signaling adaptor protein TRIF (TIR-domain-containing adapter-indu
212 screenings, we report that the mitochondrial adaptor protein tripartite motif (TRIM)14 provides a doc
213 -like protein necroptotic signaling with the adaptor protein tumor necrosis factor receptor-associate
214 ion and phagocytosis through coupling to the adaptor protein TYRO protein-tyrosine kinase-binding pro
216 riasis susceptibility gene encoding Act1, an adaptor protein with ubiquitin ligase activity that coup
218 ssays showed that suppression of AP2M1 (AP-2 adaptor protein), RAB5A, VPS35 (vacuolar protein sorting
219 oll-interleukin 1 receptor domain containing adaptor protein)-MyD88-IRAK (interleukin-1 receptor-asso
220 is negatively regulated by an actin-binding adaptor protein, i.e., CD2AP, to allow a balanced and sp
222 ), a 4.1R-ezrin-radixin-moesin (FERM) domain adaptor protein, mediates numerous cellular responses, i
223 via its receptor roundabout4 (Robo4) and the adaptor protein, Paxillin were involved in reducing BBB
225 requires palmitoylation for interacting with adaptor protein-2 (AP-2) and AP-3, respectively, for tra
226 al cord slices and that it is carried out by adaptor protein-2 (AP-2) via clathrin-mediated endocytos
235 AAK1 and GAK, kinase regulators of the host adaptor proteins AP1 and AP2, are essential for hepatiti
237 es and forms inflammasome complexes with the adaptor proteins Asc and caspase-1 to promote the matura
239 Here the authors show that unique caspase adaptor proteins can regulate caspase activity within mu
240 owed by recruitment of SH2 domain-containing adaptor proteins constitutes a central mechanism of intr
241 receptors, specific signaling pathways, and adaptor proteins governs mast cell responsiveness to sti
245 llular proteins are dimeric, multifunctional adaptor proteins that bind to and regulate the activitie
246 ytoplasmic dynein-1 binds dynactin and cargo adaptor proteins to form a transport machine capable of
248 ce of an association of native neuronal AP-2 adaptor proteins with Slack channels, facilitated by a d
249 ification of IAP antagonists, unique caspase adaptor proteins, and mutually exclusive subcellular dom
251 riers by interaction of sorting signals with adaptor proteins, but proteins in the other domain exit
252 n of T cells (LAT) leading to recruitment of adaptor proteins, including Grb2, is one prototypical ex
253 nals in the cytosolic tails of the cargos by adaptor proteins, leading to cargo packaging into coated
254 aryotic cells which involves clathrin and/or adaptor proteins, lipid kinases, phosphatases and the ac
255 Upon ligand binding, TLRs and IL-1Rs recruit adaptor proteins, such as myeloid differentiation primar
259 mplexes consisting of a class VII myosin and adaptor proteins: Myo7a/SANS/Harmonin in stereocilia and
260 with implications for the binding of certain adaptors, providing insight into how disease mutations l
264 aptors must bind their cognate protease, all adaptors run the risk of being recognized by the proteas
267 in and extra-terminal domain (BET) chromatin adaptors serve as immunomodulators by directly regulatin
268 hat represent the NB-ARC (nucleotide-binding adaptor shared by APAF-1, certain R gene products and CE
269 However, in contrast to the conventional Shc adaptors, ShcD suppresses distal phosphorylation of the
270 tivation of T cells (LAT) is a transmembrane adaptor signaling molecule that is part of the TCR compl
273 ng the E3 ubiquitin ligase substrate-binding adaptor speckle-type POZ protein (SPOP) is the most freq
274 used by the Rod-Zw10-Zwilch complex and the adaptor Spindly to recruit dynein to kinetochores in Cae
276 we show that depletion of the nuclear export adaptor SRSF1 prevents neurodegeneration and locomotor d
280 cient in cyclic GMP-AMP synthase (cGAS), its adaptor STING, IRF3, or the type I IFN receptor IFNAR ex
282 ability of a cargo to protect its adaptor is adaptor substrate-specific, as adaptors with artificial
284 d that this principle extends across several adaptor systems, including the hierarchical adaptors tha
285 ulfite (BS) conversion, preamplification and adaptor tagging, library amplification, sequencing and,
286 serve as a mitosis-specific minus-end cargo adaptor, targeting dynein activity to minus-ends to clus
288 2p/LEM2 is a conserved nuclear site-specific adaptor that recruits Cmp7p/CHMP7 and downstream ESCRT f
289 is an E3 ubiquitin ligase and a molecule of adaptor that we have shown is important for non-small-ce
290 zed myosin-binding proteins, putative myosin adaptors that belong to two unrelated families, with fou
291 adaptor systems, including the hierarchical adaptors that drive the Caulobacter bacterial cell cycle
292 hly controlled process involving proteolytic adaptors that regulate protein degradation during cell c
293 oly(rC)-binding proteins are multifunctional adaptors that serve as iron ion chaperones in the cytoso
294 o interact with the Toll-like receptor (TLR) adaptors TIRAP and MyD88, as well as the ubiquitin-assoc
296 y and a SOCS-box containing ubiquitin ligase adaptor to target GFP-tagged proteins for degradation.
297 We examine whether binding of cytoskeletal adaptors to integrin cytoplasmic domains is sufficient f
298 ts adaptor is adaptor substrate-specific, as adaptors with artificial degradation tags were not prote
300 ide motifs found in organelle-specific cargo adaptors, yet activates kinesin-1's function of controll
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