ライフサイエンスコーパス: adaptor complex

1 -facing in the open form of the AP2 clathrin adaptor complex.

2 ived endosome marker (caveolin) and the AP-2 adaptor complex.

3 eceptor 1 or its associated intracytoplasmic adaptor complex.

4 first brain-specific function for a neuronal adaptor complex.

5 rylation-dependent interaction with the AP-1 adaptor complex.

6 1 encodes a mu1 subunit of the AP-1 clathrin adaptor complex.

7 trafficking, but significantly not the AP-2 adaptor complex.

8 -binding sites for the heterotetrameric AP-1 adaptor complex.

9 identified as the beta3A subunit of the AP-3 adaptor complex.

10 affinity membrane-binding sites for the AP-1 adaptor complex.

11 ing further evidence that AP-1 is a clathrin adaptor complex.

12 TGN (trans-Golgi network)-specific clathrin adaptor complex.

13 the existence of a physiologically relevant adaptor complex.

14 yeast GCN5 (yGCN5), components of a putative adaptor complex.

15 he AMPAR GluR2 subunit with the AP2 clathrin adaptor complex.

16 related endogenous beta1 subunit of the AP-1 adaptor complex.

17 ytic sites on the plasma membrane by the AP2 adaptor complex.

18 system, suggesting they form a novel type IV adaptor complex.

19 PDCD10, non-homologous proteins that form an adaptor complex.

20 n shown previously to interact with the AP-3 adaptor complex.

21 by the cytoskeleton, across ligand-integrin-adaptor complexes.

22 t epithelial cells contain two AP-1 clathrin adaptor complexes.

23 n protein degradation by utilizing differing adaptor complexes.

24 tides containing the YDSI motif and purified adaptor complexes.

25 interaction of PACS-1 with heterotetrameric adaptor complexes.

26 cluster motifs on cargo proteins but not to adaptor complexes.

27 ersify the functional repertoire of clathrin adaptor complexes.

28 regulation and for interaction with clathrin adaptor complexes.

29 xes are bona fide native Ada-transcriptional adaptor complexes.

30 s, sigma1 and sigma2, of clathrin-associated adaptor complexes.

31 d pits in vivo, probably via plasma membrane adaptor complexes.

32 n their interaction with clathrin-associated adaptor complexes.

33 cessory proteins that interact with clathrin adaptor complexes.

34 lathrin and the assembly polypeptide 2 (AP2) adaptor complexes.

35 The heterotetrameric adaptor complex 1 (AP-1) and the monomeric Golgi-localiz

36 TP-binding protein, Arfrp1, and the clathrin adaptor complex 1 (AP-1) are required for Vangl2 transpo

37 pairs the dynamics of intracellular clathrin/adaptor complex 1 (AP-1)- or GGA (Golgi-localized, gamma

38 In cells deficient for both the clathrin adaptor complex 1 and Chs6p, where Chs3p is transported

39 We ruled out the involvement of adaptor complex 1B (AP1B) in the basolateral trafficking

40 s depleted of clathrin or its major clathrin adaptor complex 2 (AP-2), a phenotype mimicked by applic

41 The adaptor complex 3 (AP-3) targets membrane proteins from

42 -2) have mutations in the beta 3A subunit of adaptor complex-3 (AP-3) and functional deficiency of th

43 chanistic insight into how an NPC-associated adaptor complex accesses the core transcription machiner

44 and BLOC-2, together with the AP-3 clathrin adaptor complex, act at early endosomes to sort componen

45 ubdomains (1-40 and 40-83) require the yeast adaptor complex ADA2/ADA3/GCN5 for transcriptional activ

46 The AP2 adaptor complex (alpha, beta2, sigma2, and mu2 subunits)

47 proteins interact with clathrin and the AP2 adaptor complex and also bind to the phosphoinositide-co

48 We describe the AP-1 adaptor complex and Arf1 as major regulators of PCP prot

49 ISG, which may be mediated by the AP-1 type adaptor complex and clathrin-coated vesicles, occurs dur

50 between the mu2 subunit of the AP-2 clathrin adaptor complex and ITIM tyrosine residues in the cytopl

51 show that BRAG2 binds clathrin and the AP-2 adaptor complex and that both BRAG2 and Arf5 localize to

52 atypical binding motif for the clathrin AP2 adaptor complex and the major PKA phosphorylation sites

53 he vacuole requires the function of the AP-3 adaptor complex and Vps41p.

54 Cytosolic coat proteins such as clathrin and adaptor complexes and coat protein complex I (COPI) and

55 Heterotetrameric adaptor complexes and SNAREs play key roles in the speci

56 a are necessary for in vitro binding to both adaptor complexes and that Tyr72 has an important role i

57 partners, such as the AP-1 and AP-2 sorting adaptor complexes and the nonvisual arrestins.

58 sis, cooperates with the Ufd1-Npl4 ubiquitin-adaptor complex, and specifically targets Ku80 that is m

59 olgi network and endosomes, linking clathrin adaptor complex AP-1 and the Rab GTPase Ypt31p.

60 tudy, we demonstrate binding of the clathrin adaptor complex AP-1 with the GVYVKM motif of the cytopl

61 Ap1b1 is a subunit of the adaptor complex AP-1, which has been implicated in the t

62 ind AP-2 but did not bind the Golgi-specific adaptor complex AP-1.

63 ) and endosomes that depends on the clathrin adaptor complex AP-1.

64 The epithelial cell-specific clathrin adaptor complex AP-1B facilitates the sorting of various

65 The epithelial cell-specific adaptor complex AP-1B is crucial for correct delivery of

66 he epithelial cell-specific heterotetrameric adaptor complex AP-1B is required for the polarized dist

67 findings of Eps15 association with clathrin adaptor complex AP-2 and its localization in clathrin-co

68 e-based signals with the clathrin-associated adaptor complex AP-2 at the plasma membrane, whereas lys

69 The mu 2 chain of the clathrin-associated adaptor complex AP-2 is a member of the adaptor medium c

70 The adaptor complex AP-2 is the major clathrin-associated ad

71 The adaptor complex AP-2 plays an important role in cargo se

72 ent-protein-tagged beta2 subunit of clathrin adaptor complex AP-2 revealed that EGFR mutants lacking

73 ion signal that interacts with the endocytic adaptor complex AP-2 to facilitate efficient entry of CF

74 phorylation of the beta2 subunit of clathrin adaptor complex AP-2 was detected in three types of cell

75 of the receptor kinase domain, the clathrin adaptor complex AP-2, the Grb2 adaptor protein, and thre

76 ed endocytosis signals are recognized by the adaptor complex AP-2.

77 that full-length CFTR binds to the endocytic adaptor complex AP-2.

78 n, two of the four subunits of the endocytic adaptor complex AP-2.

79 ssociation with the plasma membrane clathrin adaptor complex AP-2.

80 icles is mediated by the clathrin-associated adaptor complex AP-2.

81 ce co-receptor CD4 by hijacking the clathrin adaptor complex AP-2.

82 ocytic machinery, including clathrin and the adaptor complex AP-2.

83 tween intermediate filament proteins and the adaptor complex AP-3.

84 adaptor positioning and in regulation of the adaptor complex AP-3.

85 n at least 4 distinct protein complexes: the adaptor complex AP-3; biogenesis of lysosome-related org

86 f at least 3 distinct protein complexes: the adaptor complex AP-3; the HPS1/HPS4 complex; and BLOC-1

87 -adaptin subunits of the clathrin-associated adaptor complexes AP-1 and AP-2, respectively.

88 to the beta-adaptin subunit of the clathrin adaptor complexes AP-1 and AP-2, which are responsible f

89 Nef, which mediates binding to the clathrin adaptor complexes AP-1, AP-2, and AP-3.

90 which interacts with the endocytic clathrin adaptor complex, AP-2, and is required for its efficient

91 and as a membrane receptor for the clathrin adaptor complex, AP-2, during endocytosis.

92 ractions between CD4, Nef, and the endocytic adaptor complex, AP-2, have been reported.

93 hrin assembled into cages with the endocytic adaptor complex, AP-2.

94 e mu-subunits of plant or mammalian clathrin adaptor complex AP1 and plant AP4 but not that of plant

95 , the involvement of the clathrin-associated adaptor complex AP2 and the identity of the AP2 subunit

96 The clathrin adaptor complex AP2 is thought to be an obligate heterot

97 results suggest that AP50 and the coated pit adaptor complex AP2 may play an important role in regula

98 5 and intersectin, which in turn engaged the adaptor complex AP2.

99 endosomes that requires the heterotetrameric adaptor complex AP3.

100 e show that in the absence of AP-2, the AP-1 adaptor complex appears to functionally substitute for A

101 ciple coat components, clathrin and the AP-2 adaptor complex, assemble a polyhedral lattice at plasma

102 ndosomes requires the phosphorylation of the adaptor complex at a step during or after AP-3 recruitme

103 ule to co-localize the Nef protein with AP-2 adaptor complexes at the cell margin.

104 Accordingly, the heterotetrameric AP-2 adaptor complex binds not only to clathrin and select ca

105 nese through a mechanism involving the Rsp5p adaptor complex Bsd2p/Tre1p/Tre2p.

106 CHC22 associates with the AP1 and AP3 adaptor complexes but not with AP2.

107 W domain, binds to the heterotetrameric AP-2 adaptor complex by associating directly with the globula

108 An exosome adaptor complex called NEXT (nuclear exosome targeting)

109 In the absence of a heterooligomeric adaptor complex composed of FCHO, Eps15, and intersectin

110 ion of FcalphaR results in the modulation of adaptor complexes containing tyrosine-phosphorylated Cbl

111 pgp-2(+) functions in parallel with the AP-3 adaptor complex during gut granule formation.

112 ubunit, incorporated into both AP-2 and AP-1 adaptor complexes, exhibits both types of behavior.

113 ly on a single Y-171 site for the binding to adaptor complex GRB-2-SKAP1.

114 The AP-1 adaptor complex has been cast as the major player in cla

115 A transcriptional adaptor complex has been discovered to house histone ace

116 A heterotetrameric AP-3 adaptor complex has been implicated in the formation of

117 The adaptor protein (AP) 3 adaptor complex has been implicated in the transport of

118 and the medium chain and endocytic clathrin adaptor complexes have been shown by protein-protein int

119 Here we show that AP2, a clathrin adaptor complex important for endocytosis, associates wi

120 Retromer, an adaptor complex in the endosome-to-Golgi retrieval pathw

121 1 has some functions independent of the AP-3 adaptor complex in trafficking to gut granules.

122 n, expression of the mu2 subunit of the AP-2 adaptor complex in virus producer cells was essential fo

123 The adaptor complex includes CpdR, a single-domain response

124 lation in a panel of RTK and their signaling adaptor complexes, including EGFR, MET/GAB1, and IGF1R/I

125 ne acetyltransferase within the Ada and SAGA adaptor complexes indicates the importance of histone ac

126 ts defective in the beta-subunit of the AP-3 adaptor complex, INT1 is correctly localized to the tono

127 The ssrA tag in the covalent adaptor complex interacted with ClpX.ATPgammaS but not C

128 The p97 adaptor complex involved in this function is the Ufd1-Np

129 GA histone acetyltransferase/transcriptional adaptor complex is composed of multiple transcriptional

130 These studies establish that a kinesin motor-adaptor complex is critical for the anterograde axonal t

131 The heterotetrameric AP-1 adaptor complex is involved in the assembly of clathrin-

132 The AP-1B clathrin adaptor complex is responsible for the polarized transpo

133 The AP-2 adaptor complex is widely viewed as a linchpin molecule

134 f the abundance and activity of these ligase-adaptor complexes is critical for main-tenance of optima

135 , gamma-, delta-, zeta-COP subcomplex and AP adaptor complexes is related.

136 TPC), which is proposed to function as a CME adaptor complex, is only conserved in plants and a few o

137 fruit flies, is facilitated by a multimeric adaptor complex known as the apoptosome.

138 HIV-1's Rev protein forms a homo-oligomeric adaptor complex linking viral RNAs to the cellular CRM1/

139 The AP2 clathrin adaptor complex links protein cargo to the endocytic mac

140 We assess the role of clathrin, adaptor complexes, lipid rafts, and Rab22a in an attempt

141 In order to identify components of the adaptor-complex machinery, this study reports the clonin

142 diated by activated Arf GTPases, and the Arf-adaptor complexes mark sites of carrier formation.

143 ssibility that preference for one or another adaptor complex may result in selective mast cell respon

144 ficient for the micro 1B subunit of the AP1B adaptor complex, missort a large proportion of ERBB2 to

145 Like mutations in the AP-1 adaptor complex, mutations in INP53 exhibit synthetic gr

146 e (RNAi)-mediated gene silencing of the AP-2 adaptor complex only disrupts internalization of a subse

147 component, Apm1p, a subunit of the clathrin adaptor complex or For3p, an actin-polymerizing protein,

148 as universal recognition sites for the AP-2 adaptor complex or other clathrin-associated sorting pro

149 The AP-2 clathrin adaptor complex oversees endocytic cargo selection in tw

150 l sorting may not be related to the clathrin-adaptor complex pathway, as is the case for many basolat

151 The AP-1B clathrin adaptor complex plays a key role in the recognition and

152 AR via interaction with the CASK-mLIN7-MINT1 adaptor complex, presynaptic maturation promoted by FGF2

153 The CARMA1-Bcl10-Malt1 adaptor complex regulates NFkappaB activation by antigen

154 ysical interaction between M(5) and the AP-3 adaptor complex regulator AGAP1.

155 Exomer is an adaptor complex required for the direct transport of a s

156 unction and the beta(3)A subunit of the AP-3 adaptor complex, respectively.

157 (TLR4) through the TIRAP-MyD88 and TRAM-TRIF adaptor complexes, respectively, but it is unclear how t

158 s initiated when Sar1-GTP recruits the cargo adaptor complex, Sec23/Sec24, by binding to its GTPase-a

159 ein interactions that form the basis of AP-2 adaptor complex stabilization, key to initiating CCS for

160 The AP2 adaptor complex (subunits alpha, beta2, mu2 and sigma2)

161 ular endosome-to-TGN sorting, is mediated by adaptor complexes, such as retromer and Golgi-localized

162 ndent and cyclic diguanylate (cdG)-dependent adaptor complex that accelerates CtrA degradation in vit

163 lates Miro, a component of the primary motor/adaptor complex that anchors kinesin to the mitochondria

164 identified a novel form of the AP-1 clathrin adaptor complex that contains as one of its subunits mu1

165 Yeast GCN5 is one component of a putative adaptor complex that includes ADA2 and ADA3 and function

166 X-RICS, GABARAP and 14-3-3zeta/theta form an adaptor complex that interconnects GABAAR and dynein/dyn

167 beta-catenin is a central component of the adaptor complex that links cadherins to the actin cytosk

168 stigations showed that DVL3 is present in an adaptor complex that links IGFIR to RAS, which includes

169 CCMs arise from the loss of an adaptor complex that negatively regulates MEKK3-KLF2/4 s

170 pose that Kar9p is a component of a cortical adaptor complex that orients cytoplasmic microtubules.

171 AP-1 is a clathrin adaptor complex that sorts cargo between the trans-Golgi

172 peculate that Mgr3p and Mgr1p function in an adaptor complex that targets substrates to the i-AAA pro

173 lude that ARABIDOPSIS encodes HAT-containing adaptor complexes that are related to the Ada and SAGA c

174 ic reaction, the phosphorylation of the AP-3 adaptor complex, that is linked with synaptic vesicle co

175 orms of the mu1 subunit of the AP-1 clathrin adaptor complex: the ubiquitous mu1A and the epithelial-

176 coexpress two almost identical AP-1 clathrin adaptor complexes: the ubiquitously expressed AP-1A and

177 ecognition site for interaction with the AP1 adaptor complex, thereby marking Kir2.1 for incorporatio

178 nd the recruitment of the beta2-adaptin, AP2 adaptor complex to clathrin as well as transferrin inter

179 also required with coatomer-related clathrin adaptor complexes to bud vesicles from the trans-Golgi n

180 ecognition of an N-end motif by the protease-adaptor complex uses both the identity of the N-terminal

181 Heterotetrameric adaptor complexes vesiculate donor membranes.

182 we show that SIV Nef interacts with the AP-2 adaptor complex via two elements located in the N-termin

183 c inhibitor of cargo recognition by the AP-2 adaptor complex via tyrosine motif-based endocytosis sig

184 ive in promoting the recruitment of the AP-1 adaptor complex, whereas yeast ARF2 was the least active

185 mutations in the beta3A subunit of the AP-3 adaptor complex, which exhibited increased routing of th

186 aenorhabditis elegans, the prototypical AP-2 adaptor complex, which is activated by the accessory fac

187 a-adaptin, one of the components of the AP-2 adaptor complex, which is involved in clathrin-mediated

188 The beta3A subunit of the AP-3 adaptor complex, which likely regulates protein traffick

189 site is via the micro 2 subunit of the AP-2 adaptor complex, which recognizes tyrosine-based interna

190 gene encodes the beta3A subunit of the AP-3 adaptor complex, which regulates vesicular trafficking.

191 e recognized by a family of heterotetrameric adaptor complexes, which then recruit clathrin.

192 ognition by Sla1p, part of an endocytic coat/adaptor complex with clathrin, Pan1p, Sla2p/End4p, and E

193 ermini and that these interact with clathrin adaptor complexes with differing affinities.