ライフサイエンスコーパス: adaptor molecule

1 on myeloid cells and associates with a novel adaptor molecule.

2 C maturation requires TLR2 and MyD88, a TLR2 adaptor molecule.

3 ptive immunity without the need for this TLR adaptor molecule.

4 yrosine kinases: Btk, Lyn, Syk, and the Blnk adaptor molecule.

5 as substantially dependent on this TLR/IL-1R adaptor molecule.

6 transmits an activating signal via the DAP10 adaptor molecule.

7 tion and suggest the involvement of multiple adaptor molecules.

8 crotubule motors as well as actin-associated adaptor molecules.

9 ation, and the relative abundance of certain adaptor molecules.

10 ly required for the recruitment of signaling adaptor molecules.

11 function previously assigned exclusively to adaptor molecules.

12 substrate receptor proteins through specific adaptor molecules.

13 rocytic markers, and ionized calcium-binding adaptor molecule 1 (IBA1) as a constitutive microglial m

14 ry markers including ionized calcium-binding adaptor molecule 1 (Iba1), glial fibrillary acidic prote

15 w that the beta-arrestin1.signal-transducing adaptor molecule 1 (STAM1) complex, initially identified

16 In mammals, Toll-IL-1R-containing adaptor molecule 1 (TICAM1)-dependent TLR pathways induc

17 ike receptor 3 (TLR3) and Toll-like receptor adaptor molecule 1 (TRIF).

18 ription factor 3 and ionized calcium binding adaptor molecule 1 for neurons and glia, respectively, a

19 -4(-/-), TLR-2/4(-/-), MyD88(-/-), MyD88/TLR adaptor molecule 1(-/-), interleukin-1 receptor [IL-1R1]

20 its adaptor protein TRIF (Toll-like receptor adaptor molecule 1) but does not require the MyD88 (myel

21 in), and microglial (ionized calcium binding adaptor molecule 1) markers was performed.

22 ta (4G8), microglia (ionized calcium binding adaptor molecule 1), astrocytes (glial fibrillary acidic

23 munostained with the ionized calcium-binding adaptor molecule 1; Iba-1) and the interaction of microg

24 ron (TRIF, also called TIR-domain-containing adaptor molecule-1 (TICAM-1)) is a signaling adaptor mol

25 adaptor protein Toll/IL-1R domain-containing adaptor molecule-1 (TRIF) did not develop larger brain d

26 tion and duration of ionized calcium-binding adaptor molecule-1-positive microglial reactivity in the

27 ntaining 2A (SH2D2A), and signal transducing adaptor molecule 2 (STAM2) as novel candidate adaptors t

28 that Rin1 interacts with signal-transducing adaptor molecule 2 (STAM2), a protein that associates wi

29 did not require TLRs 2, 4, or 9 or MyD88/TLR adaptor molecule 2 but did require MyD88, indicating a r

30 We previously identified the adaptor molecule Act1 as a negative regulator of BAFF-me

31 d of IL-17RA and IL-17RB, which recruits the adaptor molecule Act1 for downstream signaling.

32 a biallelic missense mutation (T536I) in the adaptor molecule ACT1 in two siblings with CMC.

33 The use of His-tagged protein A as adaptor molecule allows Affinity Grids to be used for th

34 litated by duplication of the genes encoding adaptor molecules and charging enzymes.

35 n which ICP0 promotes the degradation of TLR adaptor molecules and inhibition of the inflammatory res

36 it may perform this function by trafficking adaptor molecules and kinases to the pericentrosomal and

37 ifying the host sensors that detect WNV, the adaptor molecules and signaling pathways that regulate t

38 h the SH3 domain of STAM (signal transducing adaptor molecule)) and UBPY (ubiquitin isopeptidase Y) h

39 ntain the insulin receptor substrate (IRS) 1 adaptor molecule, and their formation requires the bindi

40 ng CD64 and FcepsilonR1alpha, with signaling adaptor molecules, and we confirm experimentally that eq

41 ium sensor protein hippocalcin, the clathrin adaptor molecule AP2, the postsynaptic density enriched

42 Adaptor molecules are essential in organizing signaling

43 We identify the MyD88 adaptor molecule as responsible for the majority of cyto

44 er PYHIN family members) associates with the adaptor molecule ASC (apoptosis-associated speck-like pr

45 ient in either caspase-1 or the inflammasome adaptor molecule ASC after rVSV immunization was not sig

46 NALP3, with the adaptor molecule ASC, has been proposed to form a caspas

47 by crossing with IL-1 receptor-deficient or adaptor molecule ASC-deficient mice, but not NLRP3-defic

48 shment and the up-regulation of adhesion and adaptor molecules at the plasma membrane.

49 und that ROMK bound directly to the clathrin adaptor molecule autosomal recessive hypercholesterolemi

50 ays of NF-kappaB activation and utilizes the adaptor molecule BCL10 (B-cell leukemia/lymphoma 10).

51 composed of the scaffold protein CARMA1, the adaptor molecule BCL10, and the paracaspase MALT1.

52 KG2C, NKp44, and NKp46, which associate with adaptor molecules bearing immunoreceptor tyrosine-based

53 Adaptor molecules bearing immunoreceptor tyrosine-based

54 Furthermore, Shc, an adaptor molecule between antigen receptors and the Ras/E

55 erts its therapeutic effect by serving as an adaptor molecule between FKBP12 and the cell proliferati

56 Fibulin-5 thus serves as an adaptor molecule between monomeric elastin and the matri

57 actin cytoskeleton and because they serve as adaptor molecules between PSGL-1 and Syk, we examined th

58 ated substrate) and STAM (signal transducing adaptor molecule), both of which harbor multiple ubiquit

59 We previously demonstrated that the adaptor molecule breast cancer antiestrogen resistance 3

60 s indicate that PGC1alpha represents a novel adaptor molecule capable of recruiting the necessary tra

61 nd c-Kit are generally deemed as independent adaptor molecules capable of transducing cytokine-specif

62 High expression of the adaptor molecule Cas has been linked to resistance to th

63 ed mice, we found that signaling through the adaptor molecule caspase activation and recruitment doma

64 nction of IPS-1, an essential RIG-I and MDA5 adaptor molecule, completely disabled the innate antivir

65 t these limitations by the use of a chimeric adaptor molecule comprising the extracellular domains of

66 Bcl10 is an essential adaptor molecule connecting antigen receptor signaling c

67 TLRs and downstream adaptor molecules contain a conserved cytoplasmic TIR do

68 complexed with the IgG-specific CD64-IgE Fc adaptor molecule could provide a substitute for human re

69 cyte phosphoprotein of 76 kDa (SLP-76) is an adaptor molecule critical for immunoreceptor and integri

70 ic 'YEEP' motif that was able to recruit the adaptor molecule Crk-L and phosphatidylinositol-3-OH kin

71 d zebrafish genome to identify six different adaptor molecules: Dap10, Dap12, Cd3zeta, Cd3zeta-like,

72 with human TLRs and macrophages from TLR and adaptor molecule-deficient mice and evaluated macrophage

73 Here, we demonstrate that the endocytic adaptor molecule Disabled-2 (Dab2), which we have previo

74 of full-length, unmutated Bcl10, a signaling adaptor molecule encoded by a gene found to translocate

75 ule (TRADD), the Fas-associated death domain adaptor molecule (FADD), caspase-8, TNFR-associated fact

76 e peptidoglycan recognition proteins and the adaptor molecules Fas-associated protein with a death do

77 cleotides that also serves a dual role as an adaptor molecule for a number of intracellular DNA recep

78 CCR5, and CXCR3, in which CCR5 can act as an adaptor molecule for CD4 signaling.

79 nitiated by liver-resident cells through the adaptor molecule for cytosolic RNA sensors, Mavs, and th

80 DNAX-activating protein of 12 kDa is an adaptor molecule for different myeloid expressed recepto

81 ary response gene 88 (MyD88) is an essential adaptor molecule for IL-1 as well as most Toll-like rece

82 esults indicate that TAX1BP1 functions as an adaptor molecule for Itch to target MAVS during RNA viru

83 lthough myeloid differentiation factor 88 an adaptor molecule for most TLRs, is important for protect

84 ndings for animals lacking MAVS, the central adaptor molecule for RLR signaling.

85 with SRY and hypothesized to function as an adaptor molecule for SRY by tethering the KAP1-NuRD-SETD

86 Fas-associated death domain (FADD) is an adaptor molecule for the death receptor subfamily of the

87 We propose that dEHBP1 functions as an adaptor molecule for the exocytosis and recycling of Del

88 ivator 1alpha (PGC1alpha) serves as a unique adaptor molecule for the recruitment of additional coact

89 alphaSNAP, the adaptor molecule for the SNARE-priming enzyme N-ethylmal

90 MyD88 is the main adaptor molecule for TLR and IL-1R family members.

91 Mice deficient in MyD88, an adaptor molecule for TLR9 and IL-1R signaling, also had

92 ignaling, since MyD88 and TRIF are the major adaptor molecules for all bacterial TLRs.

93 MyD88 is a common Toll-like receptor (TLR) adaptor molecule found to be essential for induction of

94 F2-induced ERK activation through binding to adaptor molecule GRB2 to interfere with its association

95 atory responses, and an involvement of other adaptor molecules has not been suggested in TLR5-depende

96 rn recognition receptors and their signaling adaptor molecules has recently emerged as an essential c

97 ts (TOG and RNA) are modulated by a bivalent adaptor molecule (hnRNP A2).

98 ds on NF-kappaB activation, partially on the adaptor molecule IFN-promoter stimulator-1 and the novel

99 o mycobacteria, the possible function of the adaptor molecule IL-1R-associated kinase (IRAK)-4 agains

100 ssociated factor (TRAF)1 is an intracellular adaptor molecule important for signaling by TNFR.

101 ining a caspase-recruitment domain (ASC), an adaptor molecule important for TLR-mediated caspase-1 ac

102 TRIF is an adaptor molecule important in transducing signals from i

103 MyD88 is a key adaptor molecule in inflammatory pathways involved in in

104 TRAF6, a crucial adaptor molecule in innate and adaptive immunity, contai

105 s with insulin receptor and Nck/Dock SH2/SH3-adaptor molecule in photoreceptor path-finding.

106 ion have focused primarily on its role as an adaptor molecule in signaling pathways in the cytoplasm,

107 RhoH serves as adaptor molecule in T cell receptor signaling and RhoH e

108 nt domain-containing protein 9 (CARD9) is an adaptor molecule in the cytosol of myeloid cells, requir

109 ntified full-length presenilin as a critical adaptor molecule in the dephosphorylation of VEGFR1.

110 ACT1 is an essential adaptor molecule in the IL-17 signaling pathway.

111 cess is primarily through its function as an adaptor molecule in the IL-1R signaling pathway.

112 ng recruiting domain (ASC)/PYCARD, a central adaptor molecule in the Nod-like receptor (NLR) pathway,

113 Here, we show that expression of MAVS, a key adaptor molecule in the RIG-I-like receptor RNA-sensing

114 inker for activation of T cells (Lat), a key adaptor molecule in the TCR signaling pathway, in T cell

115 Second, iOPN played a role as an adaptor molecule in TLR2 and dectin-1 signaling pathways

116 s strongly suggest that Rip2 functions as an adaptor molecule in transducing signals from immune rece

117 ibution of pattern recognition receptors and adaptor molecules in immunity to malaria remains poorly

118 s (PI(3)Ks) are activated through associated adaptor molecules in response to G protein-coupled and t

119 does not associate with any known signaling adaptor molecule, including DAP10, DAP12, or the FcRgamm

120 omponents, these TLRs associate with several adaptor molecules, including myeloid differentiation fac

121 ith increased surface expression of critical adaptor molecules, including the growth factor receptor

122 e immune signaling pathway that includes the adaptor molecule interferon promoter stimulator 1 (IPS-1

123 As such, stimulator of IFN genes (STING), an adaptor molecule involved in cytosolic DNA sensing, is r

124 otein, CD2-associated protein (CD2AP), is an adaptor molecule involved in podocyte homeostasis that c

125 X-activation protein 12 (DAP12), a signaling adaptor molecule involved in signal transduction of acti

126 tance of the LPS receptor TLR4 and MyD88, an adaptor molecule involved in the activation of the major

127 Paxillin is an adaptor molecule involved in the assembly of focal adhes

128 CD2AP, an adaptor molecule involved in the internalization of ubiq

129 mRNA expression of MyD88, the adaptor molecule involved in TLR4 signaling, was signifi

130 r herpesviruses, occurs independently of the adaptor molecule IPS-1.

131 The p14 adaptor molecule is part of the late endosomal/LAMTOR (l

132 nition responses, that controlling levels of adaptor molecules is a recurring strategy in regulating

133 shown to interact with a number of cytosolic adaptor molecules, it is possible that the interaction o

134 in-protein interactions of the receptor with adaptor molecules, kinases, and G proteins.

135 These results suggest that TLR adaptor molecules knockdown, such as MyD88 or TRAM, can

136 Mutations in the adaptor molecule LAT can lead to autoimmunity.

137 ing immunoreceptors associate with signaling adaptor molecules like FcepsilonR1gamma or CD247.

138 n-radixin-moesin (ERM) proteins, a family of adaptor molecules linking the cortical actin cytoskeleto

139 Here we identify Mlf1-adaptor molecule (Madm), a novel tumour suppressor that

140 ells and that signaling through the helicase adaptor molecule MAVS (mitochondrial antiviral signaling

141 h recognize viral RNA and signal through the adaptor molecule MAVS (mitochondrial antiviral signaling

142 he present study, we found that MDA5 and its adaptor molecule MAVS are critical for type I interferon

143 The mitochondrial adaptor molecule MAVS plays critical roles in coordinati

144 ORF-9b targets the mitochondrial-associated adaptor molecule MAVS signalosome by usurping PCBP2 and

145 ensing pathway mediated by the mitochondrial adaptor molecule MAVS, the TLR3 adaptor TRIF, or the tra

146 re, we show that the mitochondria-associated adaptor molecule, MAVS, is required for optimal NLRP3 in

147 eptors, RIG-I and MDA5, and their downstream adaptor molecule, MAVS.

148 hways by promoting filament formation of the adaptor molecule, MAVS.

149 naling pathways by affecting the function of adaptor molecules may provide new strategies to countera

150 adaptor-inducing interferon-beta (TRIF), an adaptor molecule mediating TLR3 signaling and MyD88-inde

151 eceptors transduce their signals through the adaptor molecule MyD88 and members of the IL-1R-associat

152 Indeed, we demonstrate that the adaptor molecule MyD88 associates with TLR5 and silencin

153 ugh TLR2 and requires the recruitment of the adaptor molecule MyD88 but not CD14.

154 vestigated the involvement of the common TLR adaptor molecule MyD88 in host responses to C. pneumonia

155 naling by Toll-like receptors and the common adaptor molecule MyD88 in intestinal epithelial homeosta

156 aling by toll-like receptor 4 and the common adaptor molecule MyD88 in the pathogenesis of atheroscle

157 In this study, we show that the adaptor molecule MyD88 is critical for the magnitude of

158 scription factors XBP1 and CHOP nor the TLR4 adaptor molecule MyD88 is necessary for caspase-8 activa

159 The adaptor molecule MyD88 is necessary for responses to all

160 engagement, colocalization of Opn-i and the adaptor molecule MyD88 was associated with induction of

161 In macrophages, TLR4 and the adaptor molecule MyD88, but not TLR2 or TLR5, are requir

162 retch-induced EMT requires the innate immune adaptor molecule MyD88.

163 through Toll-like receptor 7 (TLR7) and its adaptor molecule MyD88.

164 cells is greatly reduced in mice lacking the adaptor molecule MyD88.

165 HSCs from mice deficient in TLR9 or the TLR adaptor molecule MyD88.

166 that does not require the Toll-like receptor adaptor molecule MyD88.

167 stem depends on TLRs that signal through the adaptor molecule MyD88.

168 t governed by the IL-1R family/TLR signaling adaptor molecule MyD88.

169 n TLR2-TLR6 interactions and are mediated by adaptor molecules MyD88 and TIRAP/Mal.

170 vates two signaling pathways mediated by the adaptor molecules MyD88 and Toll/IL-IR domain-containing

171 ng TLR-7, type I IFN receptor, and CCR2, the adaptor molecules MyD88, IL-1R-associated kinase (IRAK)-

172 Toll-like receptors (TLRs) associate with adaptor molecules (MyD88, Mal/TIRAP, TRAM, and TRIF) to

173 LRs, the IL-1R, and the IL-18R, use a common adaptor molecule, MyD88, for transducing activation sign

174 through Toll-like receptor 7 (TLR7) and its adaptor molecule, MyD88.

175 ling is dependent on the presence of another adaptor molecule, MyD88.

176 s severely impaired in mice deficient in the adaptor molecule myeloid differentiation antigen 88 (MyD

177 Toll-like receptor 3 (TLR3), signal via the adaptor molecule myeloid differentiation factor 88 (MyD8

178 role of TLR2, TLR4, and TLR9 and the common adaptor molecule myeloid differentiation factor 88 (MyD8

179 l blood through a mechanism dependent on the adaptor molecule myeloid differentiation primary respons

180 ciated molecular patterns and signal through adaptor molecules, myeloid differentiation factor 88 (My

181 he purified, recombinant SH3.1 domain of the adaptor molecule noncatalytic region of tyrosine kinase

182 cking for protein kinases, phosphatases, and adaptor molecules obligate for resensitization and recyc

183 ffold for protein kinases, phosphatases, and adaptor molecules obligate for resensitization and recyc

184 B-lymphocyte adaptor molecule of 32 kDa (Bam32) is a known mediator o

185 that Cdc42-mediated migration relies on the adaptor molecule p130(Cas).

186 established binding partners of BCAR3 is the adaptor molecule, p130(Cas).

187 between protein kinase C (PKC) iota and the adaptor molecule Par6.

188 containing adaptor-inducing IFN-beta-related adaptor molecule produced equivalent cytokines as wild-t

189 downstream signaling pathways and/or shared adaptor molecules, rather than through direct extracellu

190 rs NOD1 and NOD2 and their common downstream adaptor molecule, receptor interacting protein 2 (RIP2;

191 of the TLR-4 signaling adaptor TRIF-related adaptor molecule reduced nuclear factor-kappaB activity

192 MyD88 is an adaptor molecule required for activation of proinflammat

193 MyD88, a key adaptor molecule required for many innate immunity recep

194 al caspase recruitment domain (ASC) is a key adaptor molecule required for the inflammatory processes

195 bachia bacteria demonstrated similar TLR and adaptor molecule requirements.

196 daptor family that includes Rap1-interacting adaptor molecule (RIAM) and lamellipodin, proteins invol

197 ntially associated with Rap1-GTP-interacting adaptor molecule (RIAM) both in vitro and in vivo, which

198 e of Rap1-guanosine triphosphate-interacting adaptor molecule (RIAM) for talin-1 recruitment and thus

199 Rap1-interacting adaptor molecule (RIAM) is a Rap1 effector that mediates

200 llipodin (MRL) protein (Rap1-GTP-interacting adaptor molecule (RIAM) or lamellipodin), talin and acti

201 l GTPases interact with Rap1-GTP-interacting adaptor molecule (RIAM), a member of the MRL (Mig-10/RIA

202 n of Rap1-guanosine triphosphate-interacting adaptor molecule (RIAM), a Rap1 effector, blocks this re

203 dent integrin regulator Rap1-GTP-interacting adaptor molecule (RIAM), the recruitment of talin into T

204 eractions--vinculin and Rap1-GTP-interacting adaptor molecule (RIAM)--in the formation and maturation

205 (Q204L) did not reverse Rap1-GTP-interacting adaptor molecule (RIAM)-dependent increases in cell adhe

206 red in mice lacking the Rap1-GTP-interacting adaptor molecule (RIAM).

207 egulate integrins, RapL and Rap1 interacting adaptor molecule (RIAM).

208 ges by selective conditional deletion of the adaptor molecule Rictor inhibits the generation of M2 ma

209 receptor complex that includes the essential adaptor molecule RIP.

210 ked upregulation of FAS, FAS ligand, and the adaptor molecules RIPK1 and CFLAR.

211 The adaptor molecule SAP (signaling lymphocytic activation m

212 Finally, although mice that lack the adaptor molecule SAP (SLAM-associated protein) resemble

213 The adaptor molecule SAP is expressed in T lymphocytes and n

214 ceptors have been shown to interact with the adaptor molecule SAP; however, subsequent intracellular

215 Instead, apoptosis required the TLR adaptor molecule SARM1, which localized to the mitochond

216 We found that the adaptor molecule SH2 domain-containing leukocyte protein

217 ion of the key T cell receptor (TCR)-coupled adaptor molecule SH2-domain-containing phosphoprotein of

218 One such protein is the adaptor molecule Shc, a protein that complexes with Grb2

219 elocytic leukemia zinc finger (PLZF) and the adaptor molecule signaling lymphocyte activation molecul

220 The adaptor molecule signaling lymphocytic activation molecu

221 ative (XLP) disease due to deficiency in the adaptor molecule signaling lymphocytic activation molecu

222 hus, SARM appears to be unique among the TIR adaptor molecules, since it functions to restrict viral

223 SH2D1A encodes the adaptor molecule SLAM-associated protein (SAP), which is

224 M costimulation requires the presence of the adaptor molecule SLAM-associated protein.

225 our studies demonstrate a novel role for the adaptor molecule SLP-76 in regulating HIV-1 infection in

226 proximal signaling complex nucleated by the adaptor molecules SLP-76 and LAT1 is required for activa

227 mechanism, we investigated the role of a key adaptor molecule SQSTM1/p62.

228 We used timed deletion of the TCR-signaling adaptor molecule Src homology 2 domain-containing phosph

229 We demonstrate that signal transduction adaptor molecule STAM-1A interacts with C. elegans LOV-1

230 e with the SH3 domain of signal transduction adaptor molecule (STAM) (AMSH) is a conserved metallopro

231 Signal-transducing adaptor molecule (STAM)-1, but not related STAM-2, inter

232 Src homology 3 domain of signal transducing adaptor molecule (STAM)] was fused to the carboxyl termi

233 ors IFI16 and cGAS as well as the signalling adaptor molecule STING.

234 ates whether knocking down two important TLR adaptor molecules, such as myeloid differentiation prote

235 minal caspase recruitment domain (ASC) is an adaptor molecule that has recently been implicated in th

236 adaptor molecule-1 (TICAM-1)) is a signaling adaptor molecule that is critically involved in the Toll

237 s-induced signaling adaptor (VISA), a unique adaptor molecule that is essential for retinoic acid ind

238 receptor-associated factor (TRAF)2 is a key adaptor molecule that is known to mediate proinflammator

239 CIKS/ACT1 is an adaptor molecule that is necessary for signaling by memb

240 PDLIM2 is an adaptor molecule that links different components of the

241 The LAT gene encodes an adaptor molecule that links receptor engagement to criti

242 Grb2 is an adaptor molecule that mediates Ras-MAPK activation induc

243 previously unknown requirement for MyD88, an adaptor molecule that mediates signals at most TLRs, for

244 -associated factor 6 (TRAF6) is an important adaptor molecule that mediates the TNFR family and inter

245 ptosis or "anoikis." TMS1/ASC is a bipartite adaptor molecule that participates in inflammatory and a

246 vation molecule-associated protein (SAP), an adaptor molecule that recruits Fyn to the signaling lymp

247 target cell through expression of ezrin, an adaptor molecule that tethers proteins to the actin cyto

248 aptor protein 12 (DAP12) is a trans-membrane adaptor molecule that transduces activating signals in N

249 alpha and TIR-containing motif 1 (SARM1), an adaptor molecule that we found to be directly involved i

250 g is negatively regulated by beta-arrestins, adaptor molecules that also activate different intracell

251 ic intracellular compartment is conducted by adaptor molecules that bind to target motifs within the

252 ociated factor (TRAF) 2 and TRAF6, which are adaptor molecules that couple TNF and interleukin-1 rece

253 Transcription factors are adaptor molecules that detect regulatory sequences in th

254 tor substrate (IRS) proteins are cytoplasmic adaptor molecules that function as signaling intermediat

255 The Dok proteins are a family of adaptor molecules that have a well defined role in regul

256 CAP/Ponsin belongs to the SoHo family of adaptor molecules that includes ArgBP2 and Vinexin.

257 llection of regulatory RNA-binding proteins, adaptor molecules that link Brk to signaling pathways ge

258 A genes is essential for generating the tRNA adaptor molecules that link genetic sequence and protein

259 ells, as well as on the set of intracellular adaptor molecules that link NT signalling to distinct bi

260 activation and proliferation dependent upon adaptor molecules that mediate formation of the immunolo

261 human TLR that associates directly with the adaptor molecule TIR domain-containing adaptor inducing

262 iation primary response 88- and TRIF-related adaptor molecule/TIR domain-containing adapter-inducing

263 4 TLR genes (TLR1, TLR2, TLR4, TLR6) and the adaptor molecule TIRAP between 205 African American wome

264 level of similarity between TcpB and the TLR adaptor molecule TIRAP.

265 nd 6; NOD-like receptor 2; and the signaling adaptor molecule TIRAP.

266 n 4 TLR genes (TLR1, TLR2, TLR4, TLR6) and 2 adaptor molecules (TIRAP, MyD88) were associated with C.

267 In contrast, other TIR adaptor molecules, TIRAP/Mal, TRIF, and TRAM, are not re

268 We demonstrate that CRKL serves as an adaptor molecule to facilitate focal adhesion formation,

269 ochips that can be decorated with switchable adaptor molecules to select for target proteins of inter

270 Src and Syk families, which activate several adaptor molecules to trigger Ca(2+) release and, in turn

271 Similarly, TLR signaling through the adaptor molecule Toll/IL-1R domain-containing adapter in

272 was determined using siRNA against the TLR3 adaptor molecule Toll/IL-1R homologous region-domain-con

273 proinflammatory pathway is dependent on the adaptor molecules Toll/IL-1 receptor domain-containing a

274 imilarly, macrophages from mice deficient in adaptor molecules Toll/IL-1R domain-containing adaptor-i

275 The TLR adaptor molecule, Toll/IL-1R domain-containing adaptor i

276 TNF-alpha, the TNFR-associated death domain adaptor molecule (TRADD), the Fas-associated death domai

277 MEKK1 was recruited to CD40 and adaptor molecule TRAF2 after CD40 ligation, and Map3k1(d

278 R) family member, forms a complex containing adaptor molecules TRAF2 and TRAF3, ubiquitin-conjugating

279 ese findings show an unexpected role for the adaptor molecule TRAF6 in Smad-mediated TGF-beta signali

280 TRIF-related adaptor molecule (TRAM) is the fourth Toll/IL-1 resistan

281 ing interferon-beta (TRIF), and TRIF-related adaptor molecule (TRAM) to activate transcription factor

282 ntiation protein 88 (MyD88) and TRIF-related adaptor molecule (TRAM), could affect mRNA expression of

283 erentiation protein (MyD88) and TRIF-related adaptor molecule (TRAM), using small interfering RNA abo

284 that TF4 binds to TLR4 but not TRIF-related adaptor molecule (TRAM), whereas TF5 binds to TRAM stron

285 ing adapter-inducing IFN-beta (TRIF)-related adaptor molecule (TRAM), which recruits TRIF.

286 ducing interferon-beta (TRIF)-, TRIF-related adaptor molecule (TRAM)-, and STING-deficient mice.

287 ng IFN-beta (TRIF) requires the TRIF-related adaptor molecule (TRAM).

288 This stimulation leads to recruitment of the adaptor molecule TRIF (Toll/IL-1 resistance (TIR) domain

289 absence of caspase-8 activity, required the adaptor molecule TRIF, and proceeded in a cell autonomou

290 NA helicases DDX1, DDX21, and DHX36, and the adaptor molecule TRIF, by isolation and sequencing of po

291 sive effect was not dependent on TLR3 or its adaptor molecule Trif.

292 signaling events, which are mediated by the adaptor molecule TRIF.

293 pter-inducing interferon-beta (TRIF)-related adaptor molecule), TRIF, and MyD88, whereas A52 binds to

294 iating TLR3- or TLR4-induced signaling as an adaptor molecule, TRIF can participate in proteolytic mo

295 association of TLR4 with MD-2 and downstream adaptor molecules, TRIF and MyD88, into lipid rafts lead

296 A prominent difference was at the level of adaptor molecules; TRIF, MyD88, MAVS, and STING.

297 Phosphorylation of the LAT adaptor molecule was observed in 4 s, and diacylglycerol

298 Here, we introduce the concept of His-tagged adaptor molecules, which eliminate the need for the targ

299 domain protein 2 (Fhl2) is an intracellular adaptor molecule with a high protein-protein interaction

300 Eukaryotic cell adaptor molecules, without any intrinsic enzymatic activ