ライフサイエンスコーパス: adaptor protein complex

1 1b but not other CD1 isoforms bound the AP-3 adaptor protein complex.

2 plex with AP-2, the plasma membrane clathrin adaptor protein complex.

3 for communicating conformational changes to adaptor protein complexes.

4 through E3-mediated ubiquitination of Smad4/adaptor protein complexes.

5 unctional homologies with the beta-chains of adaptor protein complexes.

6 Although adaptor protein complex 1 (AP-1) and Golgi-localized, ga

7 Adaptor protein complex 1 (AP-1) is an evolutionary cons

8 Disruption of the clathrin adaptor protein complex 1 (AP-1) restores Chs3p transpor

9 Disruption of the clathrin adaptor protein complex 1 (AP-1) restores Fus1p localiza

10 Association of the Golgi-specific adaptor protein complex 1 (AP-1) with the membrane is a

11 ay rapid movement, colocalize with clathrin, adaptor protein complex 1 (AP-1), and TGN46, but not the

12 toward the subendothelial matrix, using the adaptor protein complex 1 (AP-1), where it may provide t

13 plasmic domains and the core of the clathrin adaptor protein complex 1 (AP1).

14 thrin, and the gamma appendage domain of the adaptor protein complex 1 (AP1).

15 ea, whereas the localization of the clathrin adaptor protein complex 1 in the trans-Golgi network rem

16 identified an essential requirement for both adaptor protein complexes 1 and 3 in this process by emp

17 Thus, adaptor protein complexes 1 and 3 play an essential dual

18 strain background (lacking a dynamin and an adaptor-protein complex 1 subunit).

19 Here, we find that the adaptor protein complex-1 (AP-1) mediates trafficking of

20 The adaptor protein complex-1 (AP-1) sorts and packages memb

21 autoinhibition and increased binding to the adaptor protein complex-1 gamma-appendage.

22 ail via their VHS domains, as well as to the adaptor protein complex-1 via their hinge domains.

23 internalization is mediated by the clathrin adaptor protein complex 2 (AP-2) and epsin-1, rather tha

24 LR9 requires UNC93B1-mediated recruitment of adaptor protein complex 2 (AP-2) for delivery to endolys

25 m HIV-1 and to the medium chain (mu2) of the adaptor protein complex 2 (AP-2) in vitro and in vivo.

26 oding Picalm, clathrin, or components of the adaptor protein complex 2 (AP2) have been previously des

27 eract with agonist-occupied 7TMRs as well as adaptor protein complex 2 and clathrin.

28 ha), a kinase devoid of a clathrin-dependent adaptor protein complex 2 binding site, caused a delay i

29 via clathrin-coated pits, where clathrin and adaptor protein complex 2 nucleate and polymerize upon e

30 the plasma membrane preceding recruitment of adaptor protein complex 2, clathrin, and dynamin-related

31 nds on the capacity of CD63 to interact with adaptor protein complexes 2 and 3.

32 lar loop of PAR4 and found that the clathrin adaptor protein complex-2 (AP-2) is important for intern

33 In mammals, the heterotetrameric adaptor protein complex-2 (AP-2) is required for the for

34 unactivated PAR1 is mediated by the clathrin adaptor protein complex-2 (AP-2), where the mu2-adaptin

35 stitutive internalization is mediated by the adaptor protein complex-2 (AP-2), whereas AP-2 and epsin

36 unactivated PAR1 is mediated by the clathrin adaptor protein complex-2 (AP-2), which binds to a dista

37 The clathrin adaptor AP2 (adaptor protein complex-2) is critical for constitutive

38 lysosomal membrane proteins coexist with the adaptor protein complex 3 (AP-3) in neuronal cells.

39 Adaptor protein complex 3 (AP-3) is a heterotetramer tha

40 Here we show that the adaptor protein complex 3 (AP-3) is required for the eff

41 complex 1 (BLOC-1), which interacts with the adaptor protein complex 3 (AP-3), mediating a common end

42 zygous mutation of the gene encoding the dog adaptor protein complex 3 (AP3) beta-subunit, directing

43 E-) found in its cytoplasmic tail to recruit adaptor protein complex 3 for export from the trans-Golg

44 The yeast AP-3 (Adaptor Protein Complex 3) coat and the class C Vps/HOPS

45 Examples of common components are the adaptor protein complex-3 (AP-3) and biogenesis of lysos

46 We now report that the adaptor protein complex-3 (AP-3) regulates PAR1 ubiquiti

47 es mutated in the Hermansky-Pudlak syndrome, adaptor protein complex-3 and biogenesis of lysosome-rel

48 P4S1 gene, encoding the sigma subunit of the adaptor protein complex 4 (AP-4).

49 one mutation in each of three genes encoding adaptor protein complex 4 (AP4) subunits: a nonsense mut

50 teract both with the mu2 subunit of the AP-2 adaptor protein complex and with ALG-2-interacting prote

51 res both a functional AP-3 (heterotetrameric adaptor protein complex) and HOPS (homotypic fusion and

52 The endosomal clathrin adaptor protein complex AP-1 is a key cellular cofactor

53 We identified multiple subunits of the adaptor protein complex AP-2 (CLAP), an essential compon

54 ions between the mu2 subunit of the clathrin adaptor protein complex AP-2 and tyrosine-based internal

55 with beta-adaptin, a subunit of the clathrin adaptor protein complex AP-2.

56 llular partner of the GYxxtheta motif is the adaptor protein complex AP-2.

57 The heterotetrameric adaptor protein complex AP-3 has been shown to function

58 medium subunit mu4 of the recently described adaptor protein complex AP-4.

59 s, whose sorting is mediated by the clathrin adaptor protein complex (AP) AP-1B.

60 oblasts from mocha mice that lack functional adaptor protein complex (AP)-3, small interfering RNA-me

61 Clathrin and the adaptor protein complex (AP-2) constitute the major coat

62 own to be important for the interaction with adaptor protein complexes (AP) that mediate the endosoma

63 tive association with the endocytic clathrin adaptor protein complex, AP-2, strongly suggest that Eps

64 cytoplasmic domains by the heterotetrameric adaptor protein complex, AP-2.

65 onjugate and a fluorescently tagged clathrin adaptor protein complex, AP-2.

66 Stonin 2 also interacts indirectly with the adaptor protein complex, AP-2.

67 Here we show that the adaptor protein complex, AP-3, directly interacts with m

68 One of the adaptor protein complexes, AP-3, is present in two forms

69 Adaptor protein complexes (AP1-4) are ubiquitously expre

70 Specifically, the adaptor protein complex AP2 binds phosphatidylinositol-4

71 Thus, as with the classical endocytic adaptor protein complex AP2, beta-arrestin1 functions as

72 chain of the clathrin-associated coated pit adaptor protein complex AP2.

73 Adaptor protein complexes (APs) are evolutionarily conse

74 ct interactions with the clathrin-associated adaptor protein complexes (APs) in C. elegans.

75 rganelles, the coat components, clathrin and adaptor protein complexes (APs), must be released.

76 These findings show that 14-3-3 adaptor protein complexes are druggable targets and iden

77 Heterotetrameric adaptor protein complexes are important mediators of car

78 ng clathrin and the beta-subunit of the AP-2 adaptor protein complex, at discrete locations that are

79 R-mediated signals modulate a multimolecular adaptor protein complex containing Grb2, Shc, SHIP, CrkL

80 adaptin protein that constitutes part of the adaptor protein complex found at the cytoplasmic face of

81 re of three leukemia transformation-relevant adaptor protein complexes (Grb2/Gab2/Shc1 complex, CrkI

82 IDTS and did not impede interaction with the adaptor protein complex IcmS/IcmW, which is thought to f

83 A new study reveals a key role for the AP4 adaptor protein complex in the Golgi-to-endosome traffic

84 we explore the role of AP-2, a key endocytic adaptor protein complex, in the development of rat hippo

85 Pase domain, was shown to bind both clathrin adaptor protein complexes, indicating a role in membrane

86 ntegration at the postreceptor level through adaptor protein complexes, influencing cellular dependen

87 he major coat constituents, clathrin and the adaptor protein complexes, interact with each other, wit

88 report that both the AP-3 (heterotetrameric adaptor protein complex) interaction domain and clathrin

89 t endocytic processing through disruption of adaptor protein complexes is likely to result from the A

90 stematically examined the effect of ablating adaptor protein complexes on the localization of this pr

91 pp120 co-localized with alpha-adaptin in the adaptor protein complex that anchors endocytosed protein

92 ef to adaptor protein-2 (AP-2), which is the adaptor protein complex that is required for the interna

93 sorting domains with downstream assembly of adaptor protein complexes that constitute the endosomal

94 , results in the recruitment and assembly of adaptor protein complexes that function to transduce sig

95 otif that is similar to motifs recognized by adaptor protein complexes that sort transmembrane protei

96 g., coat protein complex I, II, and clathrin/adaptor protein complex), the exomer does not form buds

97 tifs that are known to interact with various adaptor protein complexes; the other is the sequence ESS

98 ocks recruitment of BIG1 and BIG2, Arfs, and adaptor protein complexes to the endosome.

99 encodes sigma3A, a small subunit of the AP-3 adaptor protein complex, was demonstrated to bind IRS-1

100 migration through regulation of Crk and CAS adaptor protein complexes, which are necessary for cell