ライフサイエンスコーパス: addiction

1 pendence on FGF13 for survival ("nononcogene addiction").

2 ins (e.g., chronic pain, depression relapse, addiction).

3 target for the treatment of methamphetamine addiction.

4 tion-deficit hyperactivity disorder and drug addiction.

5 tigating the neurobiological basis of opioid addiction.

6 cleus accumbens core considered hallmarks of addiction.

7 dulating the signaling components of cystine addiction.

8 ions are therefore critical for treatment of addiction.

9 ral processes related to motivation and drug addiction.

10 n system, which is involved in both pain and addiction.

11 low normalization of prefrontal circuitry in addiction.

12 t promote the development and persistence of addiction.

13 ical function that promote the transition to addiction.

14 outcome notification of monetary rewards in addiction.

15 ide promising therapeutic approaches in drug addiction.

16 disease, schizophrenia, mood disorders, and addiction.

17 adverse effects such as sedation, apnoea, or addiction.

18 cape likely underlies chronic drug abuse and addiction.

19 ll learning, or maladaptively in the case of addiction.

20 potential pathophysiological role in cocaine addiction.

21 ositively correlated with one's level of SNS addiction.

22 several neurological disorders and nicotine addiction.

23 tial therapy for anxiety, schizophrenia, and addiction.

24 development of relapse treatment of cocaine addiction.

25 lf-administration and reinstatement model of addiction.

26 disorder, posttraumatic stress disorder, and addiction.

27 sociation between mood disorders and tobacco addiction.

28 te to precision pharmacotherapy for pain and addiction.

29 targets for the treatment of psychostimulant addiction.

30 FS may have on relapse in humans with heroin addiction.

31 behaviors spanning anxiety behavior and drug addiction.

32 ism as a potential treatment option for drug addiction.

33 potential as treatments for psychostimulant addiction.

34 disrupting mitochondrial fission in cocaine addiction.

35 potential new therapeutic target for alcohol addiction.

36 oid-induced immune signaling, tolerance, and addiction.

37 critically associated to stroke and alcohol addiction.

38 expanded by targeting MYC-induced oncogenic addiction.

39 licating the insula as a key brain region in addiction.

40 d anxiety disorders and provide insight into addiction.

41 oral and pharmacological treatments for drug addiction.

42 es may be efficacious treatments for cocaine addiction.

43 an agonist therapy for treatment of cocaine addiction.

44 o assess motivation for drugs in humans with addiction.

45 survival, a phenomenon described as oncogene addiction.

46 stinence is a defining feature of human drug addiction.

47 th issues of opioid diversion, overdose, and addiction.

48 o the likely receptor that mediates nicotine addiction.

49 rapeutic target for the treatment of cocaine addiction.

50 mpaired impulse control associated with drug addiction.

51 ventions could be effective in treating drug addiction.

52 -emotional functional alterations in cocaine addiction.

53 lex psychiatric phenomena such as stress and addiction.

54 translational potential for treating cocaine addiction.

55 the subthalamic nucleus (STN HFS) for heroin addiction.

56 and nicotine addiction, but not for cocaine addiction.

57 ad to new therapeutic approaches to treating addiction.

58 critical for smoking initiation and nicotine addiction.

59 pproach to the beneficial treatment for METH addiction.

60 sturbance may underpin drug-biased choice in addiction.

61 eed to understand the neurobiology of opiate addiction.

62 a personalized treatment approach to cocaine addiction.

63 rpinnings for compulsive overeating and drug addiction.

64 mportant for executive control of reward and addiction.

65 ations that are highly vulnerable to tobacco addiction.

66 a pharmacotherapy for methamphetamine (meth) addiction.

67 substantial adverse consequences for cocaine addiction.

68 her been demonstrated among individuals with addictions.

69 nology addictions and substance and gambling addictions.

70 control disorders also known as behavioural addictions.

71 erest are associated with technology-related addictions.

72 treating neuropsychiatric diseases and drug addictions.

73 individual amino acids to identify possible addictions across a panel of breast cancer cells.

74 ive effects is a cardinal symptom of cocaine addiction and a DSM-V criterion for substance abuse diso

75 l role for G9a in promoting comorbid cocaine addiction and anxiety and suggest that increased epigene

76 ne neurons and their targets are involved in addiction and cue-induced relapse.

77 quantities and repeated overuse can lead to addiction and deleterious effects on health.

78 ticity of dual-system components that govern addiction and excessive behavior and suggests that alter

79 type-specific mechanisms underlying alcohol addiction and identify targets for the development of ne

80 the heterogeneity underlying the subtypes of addiction and indicate differential mechanisms in the ex

81 Psychiatric disorders such as addiction and mania are marked by persistent reward seek

82 present an important target relevant to drug addiction and other mental health disorders.

83 ward understanding the circuit bases of drug addiction and other psychiatric disorders.

84 fects (analgesia) and their adverse effects (addiction and overdose).

85 in the spotlight as a novel target for both addiction and Parkinson's disease (PD), as well as other

86 ic and neurological diseases, including drug addiction and Parkinson's disease.

87 ed by dysfunctional decision-making, such as addiction and pathological gambling.

88 ortray an anatomical morphology model of SNS addiction and point to brain morphology similarities and

89 ms of reward and inhibitory control maintain addiction and provoke relapse during abstinence.

90 to identify factors responsible for glucose addiction and recovered the two subunits of the xCT anti

91 are a key node in the circuitry that drives addiction and relapse, yet cocaine apparently has no eff

92 isk identified the enrichment terms morphine addiction and retrograde endocannabinoid signaling, wher

93 n (Orx) system plays a critical role in drug addiction and reward-related behaviors.

94 Several neuropsychiatric conditions, such as addiction and schizophrenia, may arise in part from dysr

95 ecrease in G9a activity actually exacerbates addiction and sensitivity to relapse under stressful sit

96 ing-state functional connectivity in cocaine addiction and tested whether resting-state functional co

97 suggest that PPU may represent a behavioral addiction and that interventions helpful in targeting be

98 Heroin addiction and the rs1137070 variant interactively altere

99 nce to relate compulsive eating behavior and addiction and to characterize their underlying neurobiol

100 rted among individuals with alcohol and drug addictions and contribute to the acquisition and mainten

101 Analyses were performed across all addictions and for substance and gambling addictions sep

102 ilarities and differences between technology addictions and substance and gambling addictions.

103 al types of addiction (most notably nicotine addiction) and other compulsive behaviors.

104 ically examine the concept of so-called food addiction, and despite growing evidence, we argue that t

105 anxiety, stress, reward, mnestic functions, addiction, and epilepsy.

106 ence for Hb involvement in major depression, addiction, and schizophrenia, as well as in pain and ana

107 urtship, sleep, learning and memory, stress, addiction, and social interactions.

108 tor (KOR) has been implicated in depression, addictions, and other central nervous system disorders a

109 reward region, is capable of increasing both addiction- and anxiety-like behaviors in rats.

110 rtex-to-central amygdala projection as a new addiction- and motivation-related projection and a poten

111 This has supported the notion of addiction as a "drug habit," and has led to considerable

112 retation of the Warburg effect and glutamine addiction as features of a growth state that provides re

113 Swiprosin-1) plays in the control of alcohol addiction-associated behaviours.

114 upted DA signaling in humans associated with addiction, attention-deficit/ hyperactivity disorder, sc

115 nforcing effects of cocaine that can lead to addiction, atypical DAT inhibitors have been developed t

116 tergic transcriptional changes that underlie addiction behavior and identify JQ1 as a promising candi

117 addiction; however, LS afferents that drive addiction behaviors are unknown.

118 erged as regulators of learning, memory, and addiction behaviors.

119 ons in synaptic plasticity that may underlie addiction behaviors.

120 ly used for treatment of opiate and nicotine addiction, but not for cocaine addiction.

121 Drug addiction can be conceptualized at a basic level as mala

122 , our results show how blunting MYC oncogene addiction can leverage cancer cell sensitivity to PARPi,

123 havior, a defining characteristic of cocaine addiction, can be precipitated by contextual cues, yet t

124 as contributed to upsurges in opioid-related addiction cases and overdose deaths.

125 While it is commonly believed that addiction causes pervasive impairment in cognitive funct

126 This process is 'hijacked' by drug addiction, causing cue-induced cravings and relapse.

127 high-risk migrant communities, prisons, and addiction centres.

128 ) individuals were recruited from outpatient addiction clinics and detoxification units and assessed

129 ized clinical trial was conducted at 5 urban addiction clinics in Norway between November 1, 2012, an

130 (DMS), a brain region critically involved in addiction, contains medium spiny neurons (MSNs) expressi

131 However, data from animal models of addiction demonstrate that a variety of drug-induced mol

132 sticity underlying normal skill learning and addiction, endogenous and exogenous opiates also modulat

133 Driven by oncogenic signaling, glutamine addiction exhibited by cancer cells often leads to sever

134 e addicted to cocaine, females transition to addiction faster and experience greater difficulties rem

135 ay prime for changing oncogene senescence to addiction for a single key oncogene involved in lung can

136 ed for effective antiaddiction therapies and addiction-free painkillers.

137 e is evidence for sex differences in cocaine addiction from both clinical and preclinical studies.

138 Genetics of Alcoholism (COGA); the Study of Addiction, Genetics, and Environment (SAGE); the Yale-Pe

139 Drug addiction has been associated with lack of insight into

140 However, its involvement in drug addiction has been minimally explored.

141 Opiate abuse and addiction have become a worldwide epidemic with great so

142 contribute to drug-biased decision-making in addiction, here showing a role for the orbitofrontal cor

143 observations echo two core features of drug addiction: high motivation to seek addictive substances,

144 rged as an important structure in reward and addiction; however, LS afferents that drive addiction be

145 tergic system has been implicated in alcohol addiction; however, the molecular underpinnings of this

146 NRG3) and ErbB4 have been linked to nicotine addiction; however, the neuronal mechanisms and behavior

147 broad spectrum of psychiatric disorders and addiction in adulthood.

148 TAp73 as a crucial factor causing glutamine addiction in aggressive medulloblastomas.

149 table mechanism of escape from NRAS oncogene addiction in AML.

150 y increased glycolytic flux leads to glucose addiction in cancer cells and a corresponding increase i

151 ting a potential target for the treatment of addiction in chronic users.

152 y be a promising treatment approach for meth addiction in humans.

153 s that are necessary to reach a diagnosis of addiction in humans.

154 on model proposes that obesity overlaps with addiction in terms of neurobiological alterations in the

155 avioural symptoms in Parkinson's disease and addictions in the general population.

156 We also show that in contrast to other addictions in which the anterior-/ mid- cingulate cortex

157 of mGluR2/3 in different aspects of nicotine addiction, including acquisition and maintenance of nico

158 Opioid addiction, including addiction to heroin, has markedly i

159 nt to anxiety/stressor disorders and alcohol addiction, including anxiogenesis, deficits in fear exti

160 The cost and pervasiveness of heroin addiction, including resistance to recovery from addicti

161 ct may be blunted across drug and behavioral addictions independent of acute or chronic drug effects.

162 that single target.SIGNIFICANCE STATEMENT In addiction, intense incentive motivation often becomes na

163 ion among drug-naive youth with a behavioral addiction-Internet gaming disorder (IGD).

164 Cocaine addiction is a disease characterized by chronic relapse

165 Drug addiction is a long-lasting disease characterized by com

166 Addiction is a maladaptive pattern of behavior following

167 s on behavior.SIGNIFICANCE STATEMENT Cocaine addiction is a neuropsychiatric disorder that is detrime

168 Opioid tolerance and the potential for addiction is a significant burden associated with pain m

169 g degrees of SNS addiction, we show that SNS addiction is associated with a presumably more efficient

170 Together, our data reveal that cystine-addiction is associated with EMT in breast cancer during

171 Addiction is characterized by abnormalities in prefronta

172 Addiction is characterized by high relapse susceptibilit

173 Cocaine addiction is characterized by patterns of compulsive dru

174 The difficulty in treating drug addiction is compounded by the high comorbidity with oth

175 Cigarette addiction is driven partly by the physiological effects

176 Methamphetamine addiction is mimicked in rats that self-administer the d

177 Addiction is often characterized by intense motivation f

178 Addiction is supposedly characterized by a shift from go

179 As a hallmark of drug addiction is the inability to limit drug use despite neg

180 ions of the mesocorticolimbic system in drug addiction is unknown.

181 Neurotransmitter function in behavioral addictions is poorly understood, but has important impli

182 ence would nevertheless produce "symptoms of addiction." It did, including escalation of intake, sens

183 The addiction liability of these drugs has led to the curren

184 not necessary for the development of cocaine addiction-like behavior in rats.SIGNIFICANCE STATEMENT S

185 eking isn't necessary for the development of addiction-like behavior, and that our procedure doesn't

186 approach and contact pavlovian cues, and for addiction-like behavior.

187 Patients with BED display an addiction-like symptomatology and the dopamine system mi

188 at a subpopulation of CD-1 mice demonstrate "addiction-like" aggressive behavior, suggesting an evolu

189 rns of individual differences in compulsive "addiction-like" aggressive behavior.

190 etermine whether they would be sensitive to "addiction-like" features of aggression in CD-1 mice.

191 n the striatum of individuals with substance addiction may be explained using learning-deficit theory

192 Discovery of novel mechanisms underlying addiction may present a solution.

193 tergic neurons and receptors, suggested that addiction might be treatable by medications that inhibit

194 t learning and thus compatible with the food addiction model of obesity.

195 The food addiction model proposes that obesity overlaps with addi

196 novel approach to the study of smoking, and addiction more generally.

197 s are relevant for tackling several types of addiction (most notably nicotine addiction) and other co

198 Inhalants, including toluene, target the addiction neurocircuitry and are often one of the first

199 e of glutamatergic neurotransmission in drug addiction, novel medication development strategies seek

200 ity disorder, binge eating disorder, cocaine addiction, obesity, and type 2 diabetes.

201 Leveraging the addiction of ALL to folic acid, we conjugated folate to

202 We show that reproductive addiction of Rm to endobacteria extends to mating, and i

203 nciple, rational strategy to target the MYB "addiction" of Ph(+) ALL.Significance: MYB blockade can s

204 interactive effects of rs1137070 and heroin addiction on gray matter volume (GMV) based on 78 heroin

205 r these alterations are a general feature of addictions or are a result of prolonged exposure to drug

206 icated in several brain disorders, including addiction, Parkinson's disease, Alzheimer's disease and

207 tegy for the treatment of intractable heroin addiction, particularly in individuals who are resistant

208 n of this pathway may contribute to nicotine addiction, particularly in individuals with genetic vari

209 s, childbirth, and lactation, is a promising addiction pharmacotherapy.

210 nt breast cancer cells conferred the cystine-addiction phenotype by modulating the signaling componen

211 The cystine addiction phenotype is associated with a higher level of

212 observable behaviours that characterize the addiction phenotype, such as compulsive drug consumption

213 the mesostriatal reward system, resulting in addiction phenotypes.

214 ations, resulting in drinking escalation and addiction phenotypes.

215 and dopamine function between two behavioral addiction phenotypes: pathological gambling (PG) and bin

216 Negative reinforcement theories of drug addiction posit that addicts use drugs to alleviate nega

217 ine content of cigarettes may decrease their addiction potential in populations that are highly vulne

218 tine content of cigarettes to lower nicotine addiction potential in the United States.

219 Addiction potential of the cigarettes was assessed using

220 n and thereby enhances expression of certain addiction-promoting genes.

221 of drug seeking, especially in a subset of "addiction-prone" rats.

222 ction, including resistance to recovery from addiction, provide a compelling basis for developing nov

223 risks associated with cannabis use, such as addiction, psychosis, and cognitive impairment) than can

224 Varenicline, a pharmacotherapy for tobacco addiction, reduces alcohol consumption in humans and rod

225 nificantly enriched in the Knowledgebase for Addiction Related Genes (ARG) database.

226 suggesting that miR-495 selectively affects addiction-related behaviors.

227 : The nucleus accumbens (nAc) is involved in addiction-related behaviour caused by several drugs of a

228 addition to serving as a therapy for cocaine addiction-related diseases, enhanced bioscavenging again

229 demonstrated that DNA methylation changes in addiction-related genes could be potential biomarkers fo

230 levels of 384 CpGs in promoter regions of 82 addiction-related genes in 256 African Americans (AAs) (

231 Altered DNA methylation in addiction-related genes may modify the susceptibility to

232 Recent research on addiction-related memory processes suggests that protrac

233 m is implicated in the regulation of several addiction-related phenomena, such as drug intake, withdr

234 sociated with impulsivity, hyperactivity and addiction-related phenotypes.

235 exogenous opiates also modulate learning and addiction-related striatal plasticity.

236 marks, suggesting its role as an enhancer in addiction-relevant brain regions, such as the dorsolater

237 nisms that shape risk or resilience for drug addiction remain unclear.

238 anges in neurons, the role of glia in opiate addiction remains largely unstudied.

239 the association between rs1137070 and heroin addiction remains unclear.

240 The identification of addiction resilience factors is a potential strategy to

241 sorders and other vulnerabilities to tobacco addiction respond to cigarettes with reduced nicotine co

242 h, including sleep/wake regulation, feeding, addiction, reward and motivation, anxiety and depression

243 tic strength in VTA DA neurons and increased addiction risk after PE.SIGNIFICANCE STATEMENT Prenatal

244 tal ethanol exposure (PE) leads to increased addiction risk which could be mediated by enhanced excit

245 neurons is a critical cellular mechanism for addiction risk.

246 developmental factors known to increase drug addiction risk.

247 n turn contributes to PE-induced increase in addiction risk.

248 ll addictions and for substance and gambling addictions separately.

249 ponent of the neural systems responsible for addiction, serving as a key component of the plasticity

250 ted to the brain over the course of nicotine addiction-shapes brain circuits that, among other functi

251 Although behavioral addictions share many clinical features with drug addict

252 striatum, whereas individuals with gambling addiction showed decreased activation in the dorsal stri

253 g reward outcome, individuals with substance addiction showed increased activation in the ventral str

254 ion, individuals with substance and gambling addictions showed decreased striatal activation compared

255 g resistance to therapies targeting oncogene-addiction.Significance: These important findings identif

256 er key feature of the persistence of alcohol addiction since it leads to relapse and for which there

257 (depression, posttraumatic stress disorder, addiction, social anxiety disorder, bipolar disorder, sc

258 O, MEDLINE, PubMed, and the Cochrane Tobacco Addiction Specialized Register were searched for randomi

259 g our understanding of mechanisms underlying addiction susceptibility.

260 eurobiological mechanisms of psychostimulant addiction, the only effective treatment for many addicts

261 annel in the brain and a target for nicotine addiction therapy, and the 19-residue conotoxin alpha-GI

262 iatric disorders including schizophrenia and addiction, there has been relatively little investigatio

263 ications by drugs of abuse are often tied to addiction, these data suggest a possible mechanism for t

264 tions share many clinical features with drug addictions, they show strikingly large variation in thei

265 ent ranging from levels below a hypothesized addiction threshold to those representative of commercia

266 With no effective treatment for AMPH addiction to date, there is urgent need for the identifi

267 re we used established rodent models of drug addiction to determine whether they would be sensitive t

268 hese neurons is implicated in Schizophrenia, addiction to drugs, and Parkinson's disease.

269 This actionable molecular addiction to functional PARP1 signaling was preserved in

270 Opioid addiction, including addiction to heroin, has markedly increased in the past

271 exposure to legal drugs promotes subsequent addiction to illicit drugs.

272 Addiction to nicotine and the inability to quit smoking

273 Oncogenic addiction to the Fms-like tyrosine kinase 3 (FLT3) is a

274 we identify a unique subpopulation based on addiction to the high-affinity glucose transporter, Glut

275 We discuss a model in which an "epigenetic addiction" to the HJURP chaperone represents an Achilles

276 nscriptome-based drug discovery to target an addiction trait.

277 loxone distribution combined with linkage to addiction treatment (cost saving), and naloxone distribu

278 stribution combined with PrEP and linkage to addiction treatment (ICER $95 337 per QALY) at a willing

279 P, and naloxone distribution plus linkage to addiction treatment and PrEP.

280 anagement for EtG-negative urine samples and addiction treatment attendance, or reinforcement only fo

281 ion alone, but when combined with linkage to addiction treatment is cost saving compared with no addi

282 bining naloxone distribution with linkage to addiction treatment or pre-exposure prophylaxis (PrEP) f

283 naloxone distribution, PrEP, and linkage to addiction treatment results in greater health benefits i

284 Y, and naloxone distribution plus linkage to addiction treatment was cost saving compared with no add

285 tion of naloxone distribution and linkage to addiction treatment was the optimal strategy in 34% of i

286 naloxone distribution, PrEP, and linkage to addiction treatment was the optimal strategy in 37% of i

287 ution, naloxone distribution plus linkage to addiction treatment, naloxone distribution plus PrEP, an

288 ese complexes may have potential for cocaine addiction treatment.SIGNIFICANCE STATEMENT Tolerance to

289 Drug self-administration models of addiction typically require animals to make the same res

290 tion of monetary rewards in individuals with addiction using image-based meta-analyses of fMRI studie

291 s with schizophrenia, depression, or cocaine addiction, using functional magnetic resonance imaging (

292 Group differences (individuals with addiction vs control individuals) in reward-related brai

293 ct of sleep and circadian rhythms changes on addiction vulnerability in adolescence and suggest areas

294 ule out the alternative hypothesis of shared addiction vulnerability to legal and illegal drugs.

295 gic state within the NAC as a mediator of MA addiction vulnerability.

296 of the aSI model as a valid model of alcohol addiction vulnerability.

297 elpful in targeting behavioral and substance addictions warrant consideration for adaptation and use

298 site (SNS) users with varying degrees of SNS addiction, we show that SNS addiction is associated with

299 Using procedures established to model drug addiction, we showed that a subpopulation of CD-1 mice d

300 to further explore the role of NOP system in addiction, we used NOP (-/-) rats to study the motivatio