ライフサイエンスコーパス: addition of @1 to

1 The reaction involves the oxidative addition of B2pin2 to 1 to give RhCl(Bpin)2{xant(P(i)Pr2

2 )2} (7) have also been obtained by oxidative addition of HBR2 to 1.

3 Addition of MeOTf to 1 results in elimination of benzene

4 The first addition of thiol to 1 proceeds at a much greater rate t

5 The tetramer is stabilized by the addition of up to 1 equiv of a cation but is fully disas

6 The oxidative addition of HCl to 2 selectively yields the cis-hydride-

7 Repeated addition of 1 to 4 followed by cyclization resulted in t

8 when added at up to 6 wt%, while the further addition of MMT (to 8 wt%) reduced the reinforcement eff

9 -crystal to single-crystal transformation by addition of H2 to a precursor 1,3-pentadiene complex.

10 ating boryl ancillary ligands, the oxidative addition of H2 to a single site Sn(II) system has been a

11 dase could be increased by 2.66-fold via the addition of ISL to a beta-glucuronidase solution that co

12 The addition of ixazomib to a regimen of lenalidomide and de

13 Computed energies of oxidative addition of methane to a series of three- and four-coord

14 and meta-analysis, we found no evidence that addition of oats to a GFD affects symptoms, histology, i

15 ions of the cis-gDFC at the 1300 pN plateau: addition of oxygen to a ring-opened diradicaloid interme

16 The addition of potassium to a high-sodium meal attenuates t

17 .Ribosomes assemble through the hierarchical addition of proteins to a ribosomal RNA scaffold.

18 imaging platform using base-catalyzed double addition of thiols to a strained internal alkyne such as

19 It was hypothesized that the addition of tolvaptan to a background diuretic improved

20 lized with AHF, dyspnea, and congestion, the addition of tolvaptan to a standardized furosemide regim

21 Addition of trimethylphosphine to a bis(phenolate)benzyl

22 The addition of ubiquitin to a target protein has long been

23 Using organocatalyzed stereospecific additions of thiols to activated alkynes, high-molar-mas

24 This anticipated the addition of PGA1 to active site Cys298 and the potential

25 Conversely, the addition of IGF1 to acute olfactory bulb slices elicited

26 INTERPRETATION: Addition of bevacizumab to adjuvant chemotherapy did not

27 We aimed to evaluate the addition of bevacizumab to adjuvant chemotherapy in earl

28 underlying cardiac disease at baseline, the addition of trastuzumab to adjuvant anthracycline and ta

29 vival outcomes has been established with the addition of trastuzumab to adjuvant chemotherapy for hum

30 h and electron poor enones underwent Michael addition of nitrophosphonates to afford the quaternary a

31 nd Double capsules were comparable to Micro, addition of PEG to ALG in MicroMix capsules improved eng

32 is protocol has two steps: an aminocatalyzed addition of ketones to alkylidene isoxazol-5-ones, follo

33 ia-ene reaction, known as the intramolecular addition of enols to alkynes or alkenes, has experienced

34 ducting an open-to-air, copper(II)-catalyzed addition of pinBBdan to alkynoates and alkynamides.

35 In this work, the Bingel-Hirsch addition of diethylbromomalonate to all non-equivalent b

36 antioselective isothiourea-catalyzed Michael addition of nitroalkanes to alpha,beta-unsaturated p-nit

37 Addition of BCID to an established ASP shortened the tim

38 ipoprotein signal sequence and catalyzes the addition of diacylglycerol to an invariant cysteine.

39 INTERPRETATION: The addition of gemcitabine to anthracycline and taxane-base

40 The addition of methylprednisolone to antibody therapy corre

41 Recommendation Key updates include the addition of olanzapine to antiemetic regimens for adults

42 studies have shown convincing evidence that addition of CMVIG to antiviral prophylaxis lowers CMV en

43 lacking but retrospective data suggest that addition of CMVIG to antiviral prophylaxis may reduce ra

44 Moreover, the addition of CHK1i to AraC does not generate de novo muta

45 I lyase-like family catalyze the asymmetric addition of ammonia to arylacrylates, yielding high valu

46 Thus, addition of rivaroxaban to aspirin has the potential to

47 atients with stable coronary artery disease, addition of rivaroxaban to aspirin lowered major vascula

48 The enantioselective addition of anilines to azoalkenes was accomplished thro

49 Conclusion The addition of sonoelastography to B-mode US provided stati

50 Addition of hREG3A to bacterial cultures reduced levels

51 vidence of further clinical benefit with the addition of onartuzumab to bevacizumab compared with bev

52 Addition of myosin to blood augmented the thrombotic res

53 astration-resistant prostate cancer with the addition of custirsen to cabazitaxel and prednisone trea

54 The addition of bevacizumab to capecitabine in the adjuvant

55 The unprecedented actinide-catalyzed addition of alcohols to carbodiimides is presented.

56 Purpose To evaluate the efficacy of the addition of palifosfamide to carboplatin and etoposide i

57 It is hypothesised that the addition of iron to caseins in the presence of orthophos

58 Conclusion The addition of palifosfamide to CE failed to improve surviv

59 Similarly, addition of NTZ to cells pretreated with MPP(+) could re

60 65 years of age with newly diagnosed AF, the addition of ethnicity to CHA2DS2-VASc score significantl

61 Based on IDI and NRI, addition of vWF to CHA2DS2-VASc statistically improved i

62 We evaluated whether addition of amlodipine to chelation strategies would red

63 Conclusion Although the addition of cetuximab to chemoradiation for SCCAC was as

64 ely randomized phase III trial evaluated the addition of pertuzumab to chemotherapy in patients with

65 of patients with OA-MCL might be improved by addition of rituximab to chemotherapy treatment.

66 The addition of trastuzumab to chemotherapy extends survival

67 The addition of antioxidants to chitosan-fish gelatin matrix

68 Results At a median follow-up of 7.4 years, addition of rituximab to chlorambucil led to significant

69 Conclusion The addition of bevacizumab to cisplatin and etoposide in th

70 vivo studies have confirmed that the direct addition of LXA4 to CLP neutrophils increased phagocytic

71 Addition of FA to color fundus photography resulted in a

72 ly), nor did the change in %L from 6 to 9 mo.Addition of cowpea to complementary feeding in Malawian

73 The addition of cetuximab to concurrent chemoradiation did n

74 Conclusion The addition of DBT to conventional 2D screening mammography

75 of expression [Q1]) had no benefit with the addition of GO to conventional chemotherapy (relapse ris

76 comes regardless of GO exposure, whereas the addition of GO to conventional chemotherapy resulted in

77 Here, we report that the addition of IMS to conventional glycoproteomics platform

78 The addition of IMS to conventional LC-MS-based metabolomics

79 For patients with LAPC (stage III), the addition of IRE to conventional chemotherapy and radiati

80 Overall, the addition of rituximab to corticosteroid and CsA appeared

81 ulticenter trial to test the efficacy of the addition of rituximab to corticosteroids (CSs) and cyclo

82 Integrated "-Omics" analyses showed that addition of galactose to culture medium improves total o

83 ) mice had decreased decorin expression, and addition of TIP39 to cultured fibroblasts induced decori

84 offer a preclinical proof of concept for the addition of NAC to current therapeutic T-cell expansion

85 The addition of XL888 to current regimens may serve an addit

86 on involves the reversible posttranslational addition of palmitate to cysteines and promotes membrane

87 INTERPRETATION: The addition of sorafenib to DEB-TACE does not improve progr

88 Compared with diagnostic CT alone, addition of PET to diagnostic CT significantly increased

89 howed a 15.7-month survival benefit with the addition of pertuzumab to docetaxel and trastuzumab (THP

90 The addition of ramucirumab to docetaxel met the prespecifie

91 nced KRAS-mutant non-small cell lung cancer, addition of selumetinib to docetaxel did not improve pro

92 INTERPRETATION: The addition of evofosfamide to doxorubicin as first-line th

93 Addition of C5a to electrically paced CMs caused prolong

94 In patients with chronic heart failure, the addition of aliskiren to enalapril led to more adverse e

95 tification of patients most suitable for the addition of palbociclib to endocrine therapy after tumou

96 Addition of palbociclib to endocrine therapy improves pr

97 at facilitate the catalytic enantioselective additions of nucleophiles to enoates.

98 na thioureas catalyze the asymmetric Michael addition of nitroalkanes to enones.

99 Michael addition of thiourea to enones with subsequent intramole

100 Bottom Line: Addition of iron to ESAs improves hematopoietic response

101 The addition of bevacizumab to ET in first-line treatment fa

102 The addition of hypoalbuminemia to Euro score enhanced net r

103 ived a similar PFS benefit as wild type from addition of everolimus to exemestane.

104 We aimed to establish whether addition of cannabidiol to existing anti-epileptic regim

105 The addition of thrombolytic to extracorporeal cardiopulmona

106 The addition of enalapril to fenoldopam restored the natriur

107 INTERPRETATION: Addition of custirsen to first-line docetaxel and predni

108 INTERPRETATION: Addition of SIRT to first-line FOLFOX chemotherapy for p

109 These analyses support the addition of oxaliplatin to fluoropyrimidine-based adjuva

110 he phase III CRYSTAL study demonstrated that addition of cetuximab to fluorouracil, leucovorin, and i

111 ted efficacy benefits were observed upon the addition of cetuximab to FOLFIRI in CRYSTAL, and compara

112 umors derived a significant benefit from the addition of cetuximab to FOLFIRI; patients with RAS tumo

113 The addition of SIRT to FOLFOX-based first-line chemotherapy

114 The trend for oxidative addition of methane to four-coordinate Ir(I) was closely

115 H (pHT) increased with chain length with the addition of up to four nucleotides, after which the stab

116 The aim of this study is to establish if addition of pictilisib to fulvestrant can improve progre

117 Although addition of pictilisib to fulvestrant did not significan

118 the glycyl radical enzyme that catalyzes the addition of toluene to fumarate, benzylsuccinate synthas

119 The addition of bevacizumab to gemcitabine-docetaxel for fir

120 Our findings show that the addition of necitumumab to gemcitabine and cisplatin che

121 INTERPRETATION: The addition of vandetanib to gemcitabine monotherapy did no

122 The addition of selenium to GLS glass generally results in a

123 Notably, the addition of cholesterol to GM1-containing NDs did not ha

124 unds increasing in peak area response by the addition of MeOH to H2O, 5%, is outweighed by the fracti

125 ally yet still ignored observations that the addition of nucleophiles to halo nitroarenes resulting i

126 irium in the setting of advanced cancer, the addition of lorazepam to haloperidol compared with halop

127 y applicable methods for efficient catalytic additions of easy-to-handle allyl-B(pin) (pin=pinacolato

128 For major bleeding, the addition of vWF to HAS-BLED improved the c-index but not

129 The addition of CTR to HP medium was able to recover Klotho

130 Conversely, addition of sialidases to human peripheral blood mononuc

131 that consists of the palladium(II)-catalyzed addition of arylboroxines to imines derived from trifluo

132 The first enantioselective addition of nitroalkanes to imines (nitro-Mannich reacti

133 nvolved in chiral phosphoric acids catalyzed addition of nucleophiles to imines.

134 er-catalyzed intermolecular enantioselective addition of styrenes to imines has been achieved under m

135 The addition of eltrombopag to immunosuppressive therapy was

136 dosing unit enabled the directed postcolumn addition of reagents to individual droplet fractions.

137 and Drug Administration (FDA) regulates the addition of iodine to infant formulas, the iodization of

138 Further oxidative addition of pinacolborane to intermediate 2 leading to t

139 In contrast, addition of pinacolborane to [(IPr**)AgOPh] at -40 degre

140 Addition of triphenylsilane to [(iPr2) TpCu]2 (mu-OH)2 i

141 udy from the PICCOLO trial, which tested the addition of panitumumab to irinotecan therapy in patient

142 Selective addition of radicals to isonitriles can be harnessed for

143 The addition of Y4 to KCNK9-expressing carcinoma cells reduc

144 efficiently catalyze asymmetric nucleophilic addition of nitromethane to ketimines derived from alpha

145 n patients with newly diagnosed myeloma, the addition of bortezomib to lenalidomide and dexamethasone

146 n patients with newly diagnosed myeloma, the addition of bortezomib to lenalidomide and dexamethasone

147 We aimed to study whether the addition of bortezomib to lenalidomide and dexamethasone

148 The addition of bevacizumab to letrozole improved PFS in hor

149 The addition of palbociclib to letrozole in this phase 2 stu

150 , with expression in E coli resulting in the addition of phosphoethanolamine to lipid A.

151 Further addition of H2 to LnFe-CH2OSiMe3 releases CH3OSiMe3, dem

152 The addition of bevacizumab to lomustine affected neither he

153 Data from a phase 2 trial suggested that the addition of bevacizumab to lomustine might improve overa

154 Addition of EV to macrophages also promoted transcriptio

155 These reactions are believed to proceed via addition of water to metal vinylidene intermediates (4).

156 n folate extraction techniques involving the addition of enzymes to milk.

157 We sought to examine whether the addition of omalizumab to milk OIT reduces treatment-rel

158 hromatin remodeler PICKLE (PKL) promotes the addition of H3K27me3 to MIR156A/MIR156C but is not respo

159 The addition of phytase to MNP and MNP+RUTF significantly in

160 Also, the addition of prebiotics to MNPs is a promising approach t

161 The addition of OxA to MSA-MA mixtures yields a modest NPF e

162 yields a modest NPF enhancement, whereas the addition of OxA to MSA-MA-H2O has no effect.

163 Unlike other reducing agents, addition of SO2 to must/wine upon heating cleaves intrap

164 tion of ketimines, while in the nucleophilic addition of acetylacetone to N-Boc protected aldimines T

165 The addition of aspirin to n-3 fatty acids did not alter any

166 Interestingly, addition of pN15 to NaCl-washed PSII membranes decreased

167 e early markers of rituximab effect and that addition of rituximab to NIAT does not affect safety.

168 The sequenced addition of RLi to nitriles, trapping with isopropylform

169 amino acids and catalyze asymmetric Michael additions of ketones to nitroalkenes.

170 ynamic conditions, we find evidence that the addition of nitrogen to nitrogen-limited cells results i

171 This technique is based on the high rates of addition of radicals to nitrones or nitroso compounds (s

172 ary Michael-type reactions: enamine-mediated addition of acetone to nitrostyrenes, and nitroalkane ad

173 Herein, we demonstrate that addition of hepsin to OA cartilage in explant culture in

174 Class II furcation defects treated with the addition of PC to OFD heal with a significant improvemen

175 The addition of PCs to OFD revealed a small improvement in t

176 In our recent clinical trial, the addition of omalizumab to oral immunotherapy (OIT) for m

177 ivery) plus carboplatin every 3 weeks or the addition of bevacizumab to paclitaxel and carboplatin ad

178 We assessed whether the addition of buparlisib to paclitaxel improves clinical o

179 The LOTUS trial investigated the addition of ipatasertib to paclitaxel as first-line ther

180 Conclusion The addition of seribantumab to paclitaxel did not result in

181 The addition of Si to paddy soil can decrease As uptake by r

182 We show that the addition of tin to palladium catalysts coupled with an a

183 sitive transient currents were recorded upon addition of Na(+) to PaNhaP proteoliposomes, indicating

184 ments demonstrate the viability of oxidative addition of I2 to Pd(II).

185 Conclusion Addition of nintedanib to pemetrexed plus cisplatin resu

186 receptive molecules that were negated by the addition of peptide to peptide-receptive MHC molecules.

187 The addition of HBpin to phosphorous triamide 1 results in c

188 indings from the PANORAMA study suggest that addition of acetylcysteine to pirfenidone does not subst

189 in FVC indicated that clinical benefit from addition of acetylcysteine to pirfenidone is unlikely, w

190 Addition of FXIa to plasma was able to reverse the abili

191 We assessed whether the addition of pembrolizumab to platinum-doublet chemothera

192 The addition of electrolytes to polyethylene glycol does not

193 The clinical utility of the addition of electrolytes to polyethylene glycol for the

194 d that the decrease in light scattering upon addition of ATP to polymerized unphosphorylated NM2s cor

195 Addition of salt to preformed Fbeta* accelerates transit

196 In detail, we show that addition of water to prilocaine, an active pharmaceutica

197 of this conjugation method to enable precise addition of payloads to proteins, synthesis of antibody-

198 investigation that probes the chemoselective addition of Ag to Pt-Fe3O4 heterodimer seeds to form Ag-

199 Addition of lamotrigine to quetiapine treatment improved

200 Multivariate analysis revealed that the addition of chemotherapy to radiation therapy, whether s

201 nt with HNSCC significantly benefit from the addition of cetuximab to radiotherapy and cisplatin, and

202 We found that the addition of chemotherapy to radiotherapy significantly i

203 In this population, addition of PTF to RAS inhibitors resulted in a smaller

204 0.4-1.6 MPa pressure for 1-72 h through the addition of water (to reach to 13, 15 and 17% wet basis,

205 Purpose To evaluate the impact of the addition of bortezomib to rituximab, cyclophosphamide, d

206 Addition of pyridine to RuCl2(H2IMes)(PCy3)( horizontal

207 We recommend the addition of PRE to SCJC for the enhancement of anthocyan

208 The addition of salt to screen the charged nanostructures in

209 by PGE-M suppression would benefit from the addition of apricoxib to second-line docetaxel or pemetr

210 derate risk demonstrated no benefit with the addition of ezetimibe to simvastatin (Pint =0.034).

211 We investigated the efficacy of the addition of ezetimibe to simvastatin for the prevention

212 The addition of ezetimibe to simvastatin in patients stabili

213 m pentamer to octamer), built by incremental addition of peptides to smaller oligomers, revealed subs

214 The addition of iron to sodium caseinate solution containing

215 Here we show that the addition of sulfur to soil results in an initial surge i

216 The addition of azithromycin to standard regimens for antibi

217 INTERPRETATION: The addition of bevacizumab to standard chemotherapy, follow

218 Evaluations in vivo demonstrated that the addition of CRLX101 to standard chemoradiotherapy signif

219 ventilation in the intensive care unit, the addition of dexmedetomidine to standard care compared wi

220 93%] of 3206 men randomised) showed that the addition of docetaxel to standard of care improved survi

221 The addition of docetaxel to standard of care should be cons

222 Addition of evolocumab to standard background therapy in

223 At its current list price of $14523, the addition of evolocumab to standard background therapy in

224 The addition of levosimendan to standard treatment in adults

225 ous-cell carcinoma of the head and neck, the addition of panitumumab to standard fractionation radiot

226 study, we aimed to assess whether or not the addition of rindopepimut to standard chemotherapy is abl

227 d clinical trials have demonstrated that the addition of rituximab to standard chemotherapy induction

228 g media upon cardiac gene expression and the addition of selenium to standard culture media recapitul

229 In a randomized controlled trial, addition of simvastatin to standard therapy did not redu

230 Addition of glucose to starved Saccharomyces cerevisiae

231 atients who derive greatest benefit from the addition of ezetimibe to statin therapy for secondary pr

232 Addition of ezetimibe to statin therapy in patients with

233 demonstration of clinical benefits from the addition of ezetimibe to statin therapy in subjects with

234 the greatest potential for benefit from the addition of ezetimibe to statin therapy.

235 At current prices, the addition of PCSK9i to statin therapy is estimated to pro

236 content amount gradually increased with the addition of OF to tarhana, but decidedly higher total ph

237 The addition of ADAM17 to the culture supernatant of stimula

238 In all steps (such as nitrogen extrusion, addition of amine to the dirhodium carbenoid, and the en

239 Addition of ammonia to the dibenzyl complex results in m

240 nching of mCherry occurs both via the direct addition of betaME to the chromophore and through betaME

241 ion state and enables the C-C bond oxidative addition of biphenylene to the corresponding cationic go

242 c protein that forms stable homotetramers on addition of BLA to the protein.

243 The addition of BSGI to the annual breast screen of asymptom

244 Functionally, the addition of calcium to the motility assays ablated the i

245 The addition of CDs to the extractant agent had a selective

246 n darkness and in presence of light, and the addition of chitosan to the gelling bath.

247 om (S)-acetoxysuccinimide via an unusual syn-addition of cuprate to the alpha,beta-unsaturated lactam

248 Initial addition of DABCO to the porphyrin macrocycle in chlorof

249 The addition of EMILINs to the ligand repertoire of fibrilli

250 The addition of ferroelectricity to the 2D family opens up p

251 Addition of fludarabine to the lymphodepletion regimen i

252 Compared to nonfluorinated methane, the addition of fluorine to the substrate assists the reacti

253 inal pathology of Fx-/- mice was reversed by addition of fucose to the diet, which restored fucosylat

254 Stoichiometric addition of HCl to the Co(I)-(N2) cleanly affords the Co

255 Addition of hVISA to the model resulted in 76% hVISA ide

256 -H bond breaking does not occur prior to the addition of I2 to the reaction mixture.

257 The addition of I3C to the diet of AHR null mice had less of

258 e, and the portal insulin:glucagon ratio.The addition of lactisole to the OGTT caused increases in th

259 lue, limiting possible sources for this late addition of mass to the Earth-Moon system.

260 transfer from Nbeta to Ir prior to oxidative addition of MeI to the iridium center.

261 etical examples, and in the real-data study, addition of men to the analysis yielded the same odds ra

262 d to the eneimide 57 in 80% yield by the 1,2-addition of methyllithium to the nitrile function, cycli

263 The addition of modifiers to the ESI process is demonstrated

264 In a cascade event, initial Michael addition of NaNO2 to the MBH acetate furnishes the allyl

265 For all proteins, the addition of NIS to the protein-SDS samples resulted in e

266 DSC and XRD studies indicated that the addition of oil to the lipid phase could disturb the cry

267 ntoxide (N2O5) formed quickly, following the addition of ozone to the smoke aerosol, and ClNO2(g) pro

268 The addition of P5P to the solution of 1 results in a hydrog

269 The addition of PEG to the antibody-functionalized BD-UNCD s

270 Higher specificity was achieved with the addition of PEG to the antibody-functionalized bead surf

271 e singlet diradical in each case, or (b) via addition of PhCCl to the diazo analogues of noradamantyl

272 ne type of lipid A modification involves the addition of phosphoethanolamine to the 1 and 4' headgrou

273 indings to a child with refractory NS by the addition of pioglitazone to the treatment correlated wit

274 Our findings strongly support the addition of PrEP to the standard of prevention for men w

275 Addition of proline to the matrix increased consumption

276 nts of the library with known affinity, upon addition of PT to the solution.

277 The addition of rbRosa26 to the tool box of transgenic resea

278 ethod does not require sample preparation or addition of reagents to the protein solution before or d

279 Addition of RVSP to the STS score significantly reclassi

280 y charged surface (more efficiently with the addition of salt to the solution), display less in-plane

281 Contrasting this, the addition of salts to the non-charged phase, has minimal

282 Addition of sorbitol to the germination medium also part

283 Addition of substituents to the phenyl ring has only mod

284 Addition of suPAR to the 3-BRS significantly improved th

285 an effective TSS as tTA can be repressed by addition of tetracycline to the diet at larval and/or ad

286 f the vinyl radicals 1. and 2. from 1 by 1,7-addition of thiols to the diazofluorenes.

287 Because addition of toluene to the oil increased reduction of ni

288 al, motility is dramatically inhibited after addition of tropomyosin to the mutant actin.

289 EAD) and quadricyclane and reported that the addition of water to the neat reagents caused an acceler

290 Addition of water to the reaction showed a remarkable im

291 The addition of water to the system leads to a drastic chang

292 ligible for bendamustine plus rituximab, the addition of ibrutinib to this regimen results in signifi

293 ry ligand energetic effects to the oxidative addition of ammonia to three-coordinate Ir(I) complexes

294 The addition of CAC to traditional risk factors improved the

295 , and type 2 diabetes mellitus, but that the addition of CRF to traditional risk factors significantl

296 thiourea catalysts using the Friedel Crafts addition of indole to trans-beta-nitrostyrene.

297 nalysis indicates that the thermodynamics of addition of methane to trans-(PH3)2IrX are generally str

298 results can be interpreted by assuming that addition of methanol to water produces a different varia

299 ae abundances were strongly inhibited by the addition of QSI to WBD-infected corals, whereas putative

300 Additions of TG to wheat protein and flour based doughs