ライフサイエンスコーパス: addition reaction

1 utive formation of two C-C bonds in a single addition reaction.

2 the high temperatures needed to promote the addition reaction.

3 ng tetrasubstituted ones, in a "C(2) + N(1)" addition reaction.

4 enantiofacial selectivity in the dialkylzinc addition reaction.

5 ntal to the enantioselectivity of asymmetric addition reaction.

6 quaternary stereogenic centers via the aldol addition reaction.

7 ) rapidly react with GSH and Cys via Michael addition reaction.

8 the sense of stereoinduction observed in the addition reaction.

9 RNA, with efficiency comparable to the G(-1) addition reaction.

10 tions and also regulate the de novo telomere addition reaction.

11 e 2 (TUTase 2; RET2) catalyzes the uridylate addition reaction.

12 cation sites by the beta-elimination/Michael addition reaction.

13 type coupling as well as an enantioselective addition reaction.

14 -Pr)(3)](2), is not active in the asymmetric addition reaction.

15 at the methylene carbon during the oxidative-addition reaction.

16 cetonitrile hexafluorophosphate catalyze the addition reaction.

17 this may be a previously unsuspected generic addition reaction.

18 and ATP) also apply to the o-xylene-fumarate addition reaction.

19 nstead of the commonly proposed nucleophilic addition reaction.

20 cysteine-316 in alpha-tubulin via a Michael addition reaction.

21 Pd-catalyzed hydrogenation or thiol-mediated addition reaction.

22 involved a 6-exo-trig free-radical conjugate addition reaction.

23 's catalytic Cys115 residue by a Michael 1,4-addition reaction.

24 anhydride) chain via a one-step nucleophilic addition reaction.

25 AP) is the enzyme that catalyzes the poly(A) addition reaction.

26 uminate the molecular basis for the fumarate addition reaction.

27 m N-acyliminium ion cyclization-nucleophilic addition reactions.

28 ts noncanonical participation in bimolecular addition reactions.

29 o elusive tetrahedral intermediates of amide addition reactions.

30 s or can be used in stereoselective carbonyl addition reactions.

31 roxides, or that promote nucleophilic halide addition reactions.

32 erved that appear to be the result of oxygen addition reactions.

33 vity of chiral lithium amide-induced enolate addition reactions.

34 a variety of nucleophilic and electrophilic addition reactions.

35 ation reaction, and hydrogen abstraction and addition reactions.

36 ant methods to execute robust carbonyl anion addition reactions.

37 nd expanding the generality of these Michael addition reactions.

38 used to guarantee good results in conjugate addition reactions.

39 hoxyphenyl (PMP) in the Lewis acid-catalyzed addition reactions.

40 r to enals, enones, and enoates in conjugate addition reactions.

41 ndergoes tandem electrophile/nucleophile 1,4-addition reactions.

42 ng Julia olefination and methyl ketone aldol addition reactions.

43 s previously shown to catalyze both of these addition reactions.

44 terminal alkynyl substituent produced in the addition reactions.

45 s USE enhances both the cleavage and poly(A) addition reactions.

46 the scope of potential donors for conjugate addition reactions.

47 ydrogen atom transfer to alkenes and Minisci addition reactions.

48 Xaa-NH2-type peptidic catalysts in conjugate addition reactions.

49 ficient and enantioselective boryl and silyl addition reactions.

50 enantioselective nickel-catalyzed conjugate addition reactions.

51 ymmetric quimioselective aldol and conjugate addition reactions.

52 ies in copper-catalyzed asymmetric conjugate addition reactions.

53 nt from that used previously for other boron addition reactions.

54 moieties in organic matter via nucleophilic addition reactions.

55 e classical reactivity pattern for conjugate addition reactions.

56 he development of Lewis base catalyzed aldol addition reactions.

57 xample of Bronsted acid catalysis in radical addition reactions.

58 -CF3 and C-C or C-heteroatom bonds by formal addition reactions across pi-systems, as such difunction

59 nd even carbon nucleophiles, can be used for addition reactions after tethering them to enol ethers.

60 nchona alkaloid-urea catalyzed sulfa-Michael addition reactions, also applies to the catalytic system

61 An intermolecular Michael addition reaction and an intramolecular condensation wer

62 r was found to be activated by the ubiquitin-addition reaction and blocked by the ubiquitin-removal r

63 tereoselective heteroatom-directed conjugate addition reaction and cyclopentanone ring cyclization as

64 (CN(-)) based on a Michael-type nucleophilic addition reaction and intramolecular charge transfer (IC

65 rophosphate release completes the nucleotide addition reaction and is associated with extensive confo

66 t a good understanding of the hetero-Michael addition reaction and the relative reactivities of biolo

67 on equivalents in Lewis base catalysed aldol addition reactions and allow for the preparation of cros

68 ining a cis-enone are susceptible to Michael addition reactions and are potent inhibitors of several

69 e Pd(CNAr(Dipp2))(2) is active for oxidative addition reactions and readily reacts with benzyl chlori

70 ons likely feature silyl radicals undergoing addition reactions and SH 2 reactions.

71 ted aldehydes) with lysine residues (Michael addition reactions) and also by interactions with alkoxy

72 issions followed by hydrogenation, gas phase addition reaction, and/or partial oxidation.

73 sequential inter/intramolecular substitution-addition reactions, and in some cases, ring rearrangemen

74 anchoring chemical functions via the Michael addition reaction; and (iii) PDOPA was used as a reactiv

75 Copper-catalyzed asymmetric conjugate addition reactions are a very powerful and widely applie

76 rogen abstraction reactions and the hydrogen addition reactions are calculated.

77 the catalytic and stoichiometric asymmetric addition reactions are different, indicating that the pr

78 function as a dipole in a 1,3 dipolar cyclo-addition reaction as the initial step in a novel type of

79 reaction and an intermolecular nucleophilic addition reaction as the key steps.

80 vorable conditions for PAHs by the gas-phase addition reaction at a relatively low temperature compar

81 azide complex 10 undergoes a Zr(+)/P FLP N,N-addition reaction at the terminal azide nitrogen atom to

82 introduced; these boryl and silyl conjugate addition reactions (BCA and SCA, respectively), which pr

83 roduct of this stereoselective rearrangement-addition reaction, beta-oxyalkenylbenziodoxole, represen

84 The bimolecular rate constants of the addition reaction between hydroxyl radical (*OH) and nit

85 s-cinchona catalyst 3b activates the Michael addition reaction between malononitrile derivatives 2 an

86 ands are built using a one-step nucleophilic addition reaction between poly(isobutylene-alt-maleic an

87 A reversible Michael addition reaction between thiol nucleophiles and cyanoen

88 unsaturated carboxylic acid derivatives: The addition reactions between achiral Ni(II)-complex of the

89 In this work, cross silyl benzoin addition reactions between acylsilanes (1) and aldehydes

90 ng the stereochemical outcome of the Michael addition reactions between nucleophilic glycine equivale

91 This paper describes a systematic study of addition reactions between the chiral Ni(II) complex of

92 ereoselectivity in the corresponding Michael addition reactions between the Ni(II) complex of glycine

93 his understanding, such as kinetics of thiol addition reactions, bioactivities, as well as steric and

94 also found to be useful in the dimethylzinc addition reaction, both catalyzing the addition to benza

95 ed in the titanium-mediated asymmetric aldol addition reaction by treatment with titanium tetrachlori

96 be activated toward highly enantioselective addition reactions by (salen)metal catalysts to an impor

97 hanism of the enantioselective sulfa-Michael addition reaction catalyzed by a cinchona alkaloid-squar

98 y in eukarya via an unusual 3'-5' nucleotide addition reaction catalyzed by the tRNA(His) guanylyltra

99 The guanine nucleotide addition reaction catalyzed by Thg1 extends the polynucl

100 The fumarate addition reaction, catalyzed by the enzyme benzylsuccina

101 relevance to reductive elimination/oxidation addition reaction chemistry of transition metal catalyst

102 Nucleophilic addition reactions compete with two electron reduction o

103 In addition, reaction conditions that facilitate catalyst r

104 These addition reactions create up to two stereogenic centers,

105 This regioselective alkyl radical addition reaction does not require metals, ligands or ad

106 broad functional group compatibility of this addition reaction enable substitution patterns that are

107 e artifactually from spontaneous elimination/addition reactions following initial metabolism at the t

108 The initial addition reaction follows a stepwise diradical pathway t

109 e have compared the mechanism of the alcohol addition reaction for the enyne with that of the enyne w

110 The net electrophilic addition reactions formally require 2e(-) oxidation of t

111 Study of the intramolecular aza-Michael addition reaction from an aminofluorovinylsulfone opens

112 catalyzed asymmetric guanidine aza-conjugate addition reaction has been developed.

113 The beta-elimination/Michael addition reaction has been employed for the modification

114 The initial addition reaction has to overcome an energy barrier of a

115 eral activator of organotrimethylsilanes for addition reactions has been established.

116 mediated, enantioselective vinylogous aldol addition reactions has been investigated.

117 oundations of the Lewis base catalyzed aldol addition reactions have been investigated.

118 rved characteristics of the toluene-fumarate addition reaction (i.e., retention of a methyl H atom an

119 ark publications of the first directed aldol addition reaction in 1973, the site, diastereo-, and ena

120 one can be efficiently combined to a Michael addition reaction in a new two-step domino reaction, all

121 cyclohexane-1,2-diamine]Br(2), catalyzed the addition reaction in the presence of water.

122 Ligand 3f was found to catalyze this addition reaction in up to 76% ee.

123 t more widespread roles for 3'-5' nucleotide addition reactions in biology than previously expected.

124 ion chemistry stemming from condensation and addition reactions in OA formed by photooxidation of iso

125 both green mechanochromism and load-induced addition reactions in solution and solid.

126 )](2-) are excellent participants in Michael addition reactions in the presence of a strong acid.

127 different branching ratios for the OH and Cl addition reactions in the presence of NOx.

128 dergo base-mediated intramolecular conjugate addition reactions in which a carbamate and a urea, resp

129 esultant enynals participate in a variety of addition reactions including aldol condensations and rea

130 uced indirect trapping of the retroconjugate addition reaction intermediate involved in the epimeriza

131 rate-determining step in this novel fumarate addition reaction involves breaking a C-H bond.

132 amma ligand binding domain through a Michael addition reaction involving a protein cysteine residue a

133 ergo a highly regio- and stereoselective 1,2-addition reaction involving protonation of an ortho carb

134 tereoselectivity observed in the diethylzinc addition reaction involving regioisomeric, pseudo-enanti

135 The activation enthalpy of the reverse addition reaction is also subject to structural variatio

136 The quinone addition reaction is characterized by excellent chemosel

137 ta confirm that the disiloxanediol-catalyzed addition reaction is first order in catalyst over all co

138 These correlations revealed the thiol addition reaction is primarily sensitive to the electron

139 mechanism detailing the observed cyclization/addition reaction is proposed.

140 NMR experiments indicate that the addition reaction is reversible under acidic conditions.

141 ditions) on catalytic enantioselective silyl addition reactions is analyzed.

142 The oxidative addition reaction mechanism was studied using density fu

143 This Article demonstrates how nucleophilic addition reactions mediated by photoredox catalysis can

144 both intra- and intermolecular nucleophilic addition reactions mediated by strong Lewis acids, such

145 oelectronic effect that controls the type of addition reaction observed.

146 The subsequent addition reaction of 2 with the appropriate isocyanate p

147 elective [1 + 2] cycloaddition or a carbonyl addition reaction of a thermally generated pi-delocalize

148 has been developed via a tandem thio-Michael addition reaction of an in situ generated alpha,beta-uns

149 Five-component sequential Ugi/nucleophilic addition reaction of aromatic aldehydes, primary amines,

150 tudy the energetics and the mechanism of the addition reaction of borylenes to unsaturated CC bonds,

151 An efficient Michael addition reaction of differently substituted enones with

152 ine sodium salt (N35A) was synthesized by an addition reaction of glycidyl methacrylate with the sodi

153 oro-2,4-dinitrobenzene, for the nucleophilic addition reaction of GSH to ethacrynic acid, the H107S s

154 f 1 was confirmed by thiol-selective Michael addition reaction of immunoprecipitated CD43-myc/FLAG.

155 mmobilized anion-pi catalysts to explore the addition reaction of malonic acid half thioesters to eno

156 rnatively, 2 can be prepared by an oxidative-addition reaction of Mes(2)Si(H)OTf (Tf = CF(3)SO(3)) wi

157 A novel Horner-Emmons olefination conjugate addition reaction of N-acetylamides to form 1,5-disubsti

158 The first example of a catalytic Michael addition reaction of non-activated aliphatic nitriles to

159 An intramolecular FeCl3-catalyzed Michael addition reaction of styrene, a poor nucleophile, onto a

160 The electrophilic addition reaction of sulfur monochloride and sulfur dich

161 r the unreported, enantioselective conjugate addition reaction of the barbituric acid pharmacaphore t

162 zed Leu66 side chain, suggesting a conjugate addition reaction of the imidazole nitrogen to the highl

163 ccinyl)cysteine (2SC) is formed by a Michael addition reaction of the Krebs cycle intermediate, fumar

164 Addition reactions of (TSPP)Rh-OH to unactivated termina

165 adings as low as 0.1 mol%, for the conjugate addition reactions of 1,3-dicarbonyl compounds to beta-n

166 ith the faster reactions of 2 in THF and the addition reactions of 2 to carbonyl compounds.

167 ate the first irreversible step in oxidative addition reactions of a zerovalent nickel catalyst to a

168 The deborylative 1,2-addition reactions of alkyl 1,1-diborons proceed in the

169 eadily prepared from sequential 1,4- and 1,2-addition reactions of allyl and 3-substituted allylsilan

170 orthoplatinated triaryl phosphite-catalyzed addition reactions of arylboronic acids with aldehydes f

171 CuCl/bipyridine-catalyzed addition reactions of arylboroxines with aldehydes and a

172 microwave energy, CuCl/bipyridine-catalyzed addition reactions of arylboroxines with aldimines were

173 The addition reactions of borylenes to multiple C-C bonds ar

174 The title compound (1) undergoes 1,2-addition reactions of both electrophilic and nucleophili

175 Catalyst-controlled divergent addition reactions of enoldiazoacetamides with nitrones

176 relief of pyramidalization strain, as in the addition reactions of fullerenes, presumably contributes

177 s of the regioisomers and thermodynamics for addition reactions of olefins with Rh-H and Rh-OH units

178 ion of developments for asymmetric conjugate addition reactions of organocopper reagents with nonrace

179 III) intermediate that has been proposed for addition reactions of organocopper(I) reagents and alpha

180 Oxa-Michael reactions, i.e. addition reactions of oxygen nucleophiles to conjugated

181 Addition reactions of perfluoroalkyl radicals to ordinar

182 es and palladium-catalyzed isomerization and addition reactions of propargylic acetates.

183 retical study is presented of several ligand addition reactions of the triplet fragments (3)Fe(CO)(4)

184 Alkylation and conjugate addition reactions of trivalent phosphorus (P(III)) spec

185 In addition, reaction of (N4)Pd(II)Me(2) with cumene hydrop

186 In addition, reaction of 1 with (t)BuMe2SiCl results in the

187 In addition, reaction of plant RG lyase digestion products

188 In addition, reaction of tripyrrane 11 with acenaphthopyrro

189 In addition, reactions of NO(3) with biogenic hydrocarbons

190 Examples of addition reactions on the metal centre, B-H activation,

191 fined almost exclusively to substitution and addition reactions on the perimeters of the compounds ("

192 and beta-functionalization of carbonyls, and addition reactions onto double and triple bonds.

193 o not generally follow the rules that govern addition reactions or the making of pristine fullerenes.

194 studies have established that the oxidative addition reactions proceed by a dissociative mechanism.

195 In the latter method, the formal oxidative addition reaction produced ((iPr)PDI)FeBr (1-Br), along

196 both the desired glycoside (e.g., 9) and the addition-reaction product (e.g., the anomeric mixed acet

197 d (b) catalyzing the transformation from the addition-reaction product to the desired glycoside (e.g.

198 ols were racemic, most likely due to a rapid addition reaction promoted by LiX (X = Br and Cl).

199 d in highly enantioselective Diels-Alder and addition reactions, providing functionalized bicyclo[2.2

200 s, where they function in the critical G(-1) addition reaction required for tRNA(His) maturation.

201 ric compounds react with GT through a simple addition reaction resulting in formation of the carbinol

202 The first addition reaction results in the formation of a predomin

203 ones, sulfoxides, and esters in Michael-type addition reactions reveals, for the first time, that the

204 y initiating the cleavage reaction by Pb(2+) addition, reaction samples were automatically injected d

205 Finally, mechanistically related addition reactions such as ketone additions to imines (M

206 lso reacts more efficiently in electrophilic addition reactions such as those with sulfides.

207 ments were linked by a challenging conjugate addition reaction that also generated the C11 quaternary

208 d rate enhancement of the disfavored enolate addition reaction that coincides with an increase in sel

209 NA residues suggest an unfinished nucleotide-addition reaction that is likely at equilibrium between

210 ssential to this strategy is a novel radical addition reaction that permits the attachment of a fully

211 (*+) adduct may represent a general class of addition reactions that can form complex heterocyclic sp

212 t only electrostatically but also by Michael addition reaction to cysteine, lysine, or arginine funct

213 tal, and Horner-Emmons olefination-conjugate addition reaction to form 1-[(phenylthio)methyl]-5-[(eth

214 that will undergo an intramolecular Michael addition reaction to form two new stereogenic centers.

215 roxy intermediate can perform a nucleophilic addition reaction to the substrate, NOHA.

216 oes a second reductive elimination/oxidative addition reaction to yield isotopically labeled methane

217 by photolysis of CH4-rich ice or by hydrogen-addition reactions to acetylene condensed from the gas p

218 e or exceptionally highly regioselective 1,4-addition reactions to alpha,beta-gamma,delta-unsaturated

219 on mode is analogous to that of most thermal addition reactions to C70.

220 a method to expand the scope of nucleophilic addition reactions to carbon-carbon multiple bonds.

221 The Zr(+)/P pair 10 undergoes selective 1,4-addition reactions to conjugated enones and to a conjuga

222 Conjugate addition reactions to enones can now be done in water at

223 f reduction, cycloaddition, and nucleophilic addition reactions to form highly substituted azetidines

224 r toward heterocumulenes, undergoing Zr(+)/P addition reactions to the carbonyl groups of an alkyl is

225 pha-disubstituted-beta-aminonitriles through addition reactions to the corresponding N-tert-butanesul

226 application of two methyl ketone boron aldol addition reactions to the latent C(7)-C(11) dialdehyde s

227 nd undergoes typical regioselective 1,2-Zr/B addition reactions to yield the metallaheterocyclic prod

228 The conjugate addition reactions used both acrylate and maleimide Mich

229 e application of an Evans Cu-catalyzed aldol addition reaction using a strained cyclopropyl ketenethi

230 attached at the 6-position via an oxidative addition reaction using I2.

231 ded to the 5-position of 17 via an oxidative addition reaction using iodine, ethanol, and water under

232 attached at the 5-position via an oxidative addition reaction using iodine.

233 stitution has on thermally forbidden [2 + 2] addition reactions using high-level density functional t

234 ] 2 via alkyl halide alkylations and Michael addition reactions was systematically studied as a gener

235 alytic performance in representative Michael addition reactions was used in an effort to compare the

236 rrhenius activation parameters for the aldol addition reaction were determined.

237 lues for pyruvate and aldehydes in the aldol addition reactions were affected </=10-fold in the doubl

238 The corresponding Michael addition reactions were found to proceed at room tempera

239 This addition reaction which proceeds in mild and moderate di

240 cal enzyme family and catalyzes the fumarate addition reaction, which enables microorganisms to utili

241 These sulfite addition reactions, which are slowly reversible and are

242 uinonediimine participated in a Michael-type addition reaction with 2-SH-benzazoles and after intramo

243 ed p-quinone imine participates in a Michael addition reaction with 2-SH-benzazoles leading to the di

244 hown to undergo a new type of tandem radical addition reaction with alkynes that affords five-membere

245 d ketimines have been applied for asymmetric addition reaction with allylmagnesium bromide.

246 ted quinone diimine undergoes a Michael-type addition reaction with arylsulfinic acids to yield the r

247 ion surrogate in the DBU-catalyzed conjugate addition reaction with enones and enals for the synthesi

248 t presents the least steric obstacles to the addition reaction with methane yields the greatest energ

249 g of GSH in a GSH and GSSG mixture via a 1,4-addition reaction with p-benzoquinone (BQ), followed by

250 A 1,4-addition reaction with propynal coupled with Schiff base

251 e) undergoes tandem electrophile/nucleophile addition reactions with a high degree of regiocontrol de

252 , in most cases, diastereoselectivity of the addition reactions with a Ni(II) complex of the chiral S

253 carbamates and CuCN.2LiCl participate in 1,4-addition reactions with alpha, beta-unsaturated esters,

254 These reagents also undergo conjugate addition reactions with alpha,beta-alkynyl esters, sulfo

255 rignard reagents examined gave exclusive 1,4-addition reactions with alpha,beta-gamma,delta-unsaturat

256 Thus, AA is subject to typical olefin-addition reactions with bromine, sulfuryl chloride, m-ch

257 systematic studies of arylcuprate conjugate addition reactions with cis and trans gamma-alkoxy-alpha

258 the nitro group, thus competent for Michael addition reactions with cysteine and histidine.

259 silylene species undergoes facile oxidative addition reactions with dihydrogen (at sub-ambient tempe

260 s as a very reactive nucleophilic carbene in addition reactions with five simple alkenes.

261 e resulting 2,3-dihydropyridones undergo 1,4-addition reactions with Grignard reagents in the presenc

262 iomeric ratios are obtained in the conjugate addition reactions with methyl vinyl ketone while low en

263 ed spiropyrrolidines were synthesized by 1,4-addition reactions with nitroalkanes, followed by reduct

264 a,beta-Unsaturated ketones generally undergo addition reactions with nucleophiles with a preference f

265 N-carbamoyl-4-pyridones undergo conjugate addition reactions with organocuprates and organozincate

266 Catalytic asymmetric conjugate addition reactions with organometallic reagents are powe

267 ndergo intra- or intermolecular nucleophilic addition reactions with stabilized enolates, silyl keten

268 ch reactive aldehydes are subject to Michael addition reactions with the side chains of lysine, histi

269 structures studied rapidly underwent Michael addition reactions with the test nucleophile glutathione

270 her, HNO is predicted to principally undergo addition reactions with thiols and ferric proteins.

271 A host of sequential 1,2-addition reactions with various alkyl halides was discov

272 f Se-alkylselenocysteine followed by Michael addition reactions with various thiol nucleophiles gener

273 The second addition reaction, with enones, does not occur under our