ライフサイエンスコーパス: additive effect

1 loci at least one of which has a significant additive effect.

2 Beyond this concentration, TAA showed an additive effect.

3 served stalk HA and M2e that seem to have an additive effect.

4 while mixtures of two sizes primarily had an additive effect.

5 es in Solidago mass loss caused negative non-additive effect.

6 beyond what would be predicted for a simple additive effect.

7 optotic death to a degree well exceeding the additive effect.

8 ; CL95 -0.007-0.044), suggesting at least an additive effect.

9 considered jointly with smoking, has a supra-additive effect.

10 later levels of processing, attention had an additive effect.

11 and BMP4 in the presence of DKK1 produced an additive effect.

12 lance (p < .05), but insulin did not have an additive effect.

13 x, and coexpression of the constructs had an additive effect.

14 ter when combined with hypoxia suggesting an additive effect.

15 s in which the two cytokines had at least an additive effect.

16 019; CL95 0.001-0.036), denoting a more-than-additive effect.

17 ing a more complex interaction than a simple additive effect.

18 The use of a water-based HS did not have an additive effect.

19 rogression and in combination showed a clear additive effect.

20 in a toxic unit of 1.85 indicating less than additive effects.

21 rom multiple pollen-pistil interactions with additive effects.

22 the power to detect additive and additive-by-additive effects.

23 -additive lethality is as common as strictly additive effects.

24 on in combination is twice as large as their additive effects.

25 phenotypic variance explained by genome-wide additive effects.

26 e cyclins and cdks might have synergistic or additive effects.

27 lternative, as it is more apt to capture non-additive effects.

28 can interact with one another to produce non-additive effects.

29 scenarios, including possible synergistic or additive effects.

30 of ahFAD2, and both loci showed significant additive effects.

31 inib and chemotherapeutic agents resulted in additive effects.

32 e with bevacizumab, sunitinib or EMAP had no additive effects.

33 bine with bevacizumab, sunitinib or EMAP had additive effects.

34 ors were not substitutable but had more than additive effects.

35 gnition and that surface polymorphisms exert additive effects.

36 o the accumulation of numerous loci of small additive effects.

37 , we observed that the substitutions had non-additive effects.

38 results were heterogeneous and suggested non-additive effects.

39 dherence to single interventions, indicating additive effects.

40 ic accumulation by many genes with small and additive effects.

41 n, amount of food and begging effort exerted additive effects.

42 ens, and combinations of the antibodies have additive effects.

43 hanges to mechanical properties arising from additive effects.

44 accounting primarily for the contribution of additive effects.

45 ltin with juvenoids resulted in greater than additive effects.

46 evere GN, whereas combination therapy had no additive effects.

47 ombined targeting of FLT3-ITD and BTK showed additive effects.

48 nant effect for MPH was partly identified as additive effect; 2) the ranking of factors affecting het

49 omosome 4 at 48 weeks of age had the largest additive effect (550.4 +/- 68.0 g, 11.5% of the phenotyp

50 icantly body weight (BW) and adiposity, with additive effects after sequential exposure.

51 hus the dominant biotic interaction, but non-additive effects also impact the outcome of competition

52 g a transfusion and developing sepsis has an additive effect and is associated with even worse surviv

53 from ACD response for solution suggested an additive effect and moderate synergism for NPS-OA.

54 Each copy of the T risk allele has an additive effect and was associated with thinner global a

55 ons of these genes can be used to achieve an additive effect and whether this leads to enhanced yield

56 ce is regulated by many genes with small and additive effects and is correlated with the susceptibili

57 s, the limit number of effects is 2q - 1 for additive effects and is the number of heterozygous genot

58 ction efficiency, together with the study of additive effects and mechanistic probes, is consistent w

59 he high-permeability water channel AQP1 have additive effects and together increase the water permeab

60 Combination of sCAR-Fc and shRdRp2.4 exerted additive effects and was significantly more effective th

61 ween the additive model matrix and the h - 1 additive effects, and dominance values are factorized as

62 a function of the haplotype model matrix for additive effects, and genomic dominance relationship mat

63 and the potentiator ivacaftor, it showed an additive effect, as measured by the increase in the chlo

64 For example, MBNL1 is influenced by an additive effect at rs13069559, which itself is masked by

65 Despite apparent additive effects at largely distinct loci in the two pop

66 e accumulated to accurately define the Ag(+) additive effect, based on its role displayed in various

67 FICI values showed an additive effect between FK506 and PHMB, AMB, or VCZ.

68 Haplotype analysis also revealed an additive effect between HLA-C, HLA-B, and MICA variants.

69 Analysis of double mutants showed no additive effects between mutations in ncs-1 and trp-1 or

70 n avoided neuronal excitotoxicity and had an additive effect both on hemodynamic variables and for pr

71 u-Talalay offers quantitative definition for additive effect (CI = 1), synergism (CI < 1), and antago

72 Most of the known organic additives effect coupling of iodoarenes, but not bromoar

73 een the vGWAS signals independent of the MHC additive effects, each with a weak effect but jointly ex

74 r-promoting mutations have relatively small, additive effects, either through the well-established ca

75 pairs of alleles that mediate 'co-operative additive' effects, either to improve disease suppression

76 These additive effects elucidate one of the potential pathways

77 rrelations, we detected a total of 19 and 21 additive-effect floral QTL in the field and the greenhou

78 e antagonistic, mixtures of juvenoids showed additive effects following a concentration addition mode

79 alyses were used to determine the predicted, additive effect for each dose pair within each drug mixt

80 TEMI to have a multiplicative rather than an additive effect for resource utilization since these mea

81 The sum of the significant and suggestive additive effects for bodyweight at specific ages account

82 Main components are additive and additive-by-additive effects for GCA and dominance-related effects f

83 Additive effects for past-year suicide ideation (AOR, 2.

84 (P < 0.001 and P < 0.0001), with no apparent additive effects for the combined treatment.

85 - and interspecific competition can have non-additive effects has rarely been tested.

86 igations into the origins of this unexpected additive effect have demonstrated that the carbon-carbon

87 the parasite growth independently but had an additive effect if combined together indicating involvem

88 t but from 12 weeks of age they exceeded the additive effect in a few cases.

89 m in dsRNA combinations (CI=0.4-0.82) vs. an additive effect in carboplatin/paclitaxel treatment (CI=

90 These results show a significant additive effect in cell killing and they provide initial

91 ct of C4 on I507-ATC DeltaF508 CFTR, but its additive effect in combination with VX-809, implies that

92 he presence of human complement, and have an additive effect in combination.

93 n displayed increased DNA synthesis, with an additive effect in hepatocytes harboring both SV1 overex

94 HLA class I alleles that have a co-operative additive effect in mediating HIV disease control and fou

95 n to various degrees, but it did not have an additive effect in restoring activity.

96 ylation increased TGF-beta1 release, with no additive effect in WASp(-/-) platelets, signifying that

97 T revealed that Notch and mecom did not have additive effects in blocking MCC formation, suggesting t

98 h heterogeneous systems, but antagonistic or additive effects in bulk oil.

99 d 79, 58, 80 and 29 percent inhibition, with additive effects in combination as well.

100 s in vitro, and that CM and fibroblasts have additive effects in enhancing islet function and reducin

101 iological and transcriptional end points but additive effects in heart rate and pepck1 upregulation,

102 Additive effects in human glioblastoma cells were also d

103 hibitor suberoylanilide hydroxamic acid show additive effects in inducing p21, GADD45, and PUMA expre

104 sing factor (PDF)-immunoreactive neurons has additive effects in LD, resulting in an evening peak pha

105 udy was designed to investigate the possible additive effects in liver of an acute dose of grape seed

106 Additionally, the mixtures displayed additive effects in most but not all parameters in adult

107 vestigation on urine samples to evaluate the additive effects in negative ion mode.

108 phage migration inhibitory factor (MIF) have additive effects in neutrophil recruitment.

109 artment-specific IFN-gammaR signaling exerts additive effects in orchestrating intracerebral inflamma

110 both H1R and H4R in the challenge phase had additive effects in preventing the intestinal consequenc

111 FbaA and PAM (i.e., the M53 protein) had additive effects in promoting GAS survival in whole bloo

112 dual inhibition of DDT and MIF demonstrated additive effects in vitro, DDT plays a dominant role in

113 ompete with one another (ie, exert less-than-additive effects) in human laboratory studies of craving

114 These additive effects indicate that both GAPs collaborate in

115 are low in Swiss rivers, the possibility of additive effects may be of concern.

116 tions and could be responsible for the small additive effects, missing heritability and the lack of r

117 lization breadth was closely predicted by an additive-effect model and explained by complementary neu

118 ly, we discuss their relationship with other additive-effects models and their advantages in inferenc

119 t depends on the type of starvation, with an additive effect observed when multiple nutrients are dep

120 t was equal to that of dark rearing, with no additive effect observed.

121 tions showed superior response rates without additive effects observed for carboplatin.

122 n of phenotypic variance attributable to the additive effect of all variants interrogated in these GW

123 s only partially reduced by Rac1 mKO with no additive effect of alpha2KD.

124 heart failure (HF) mortality, as well as the additive effect of an increasing number of cardiovascula

125 The additive effect of biotic (As-oxidizing bacteria) and ab

126 ypoxia and subsequent enrichment there is an additive effect of both conditions on hippocampal neurog

127 We also detected an additive effect of both polymorphisms in the multivariat

128 pgACC activation in relatives, indicating an additive effect of CACNA1C variation on familial risk.

129 Although any additive effect of cholesterol-enriched diet to ABL was

130 No additive effect of clofazimine was observed after the fi

131 To evaluate the potential synergistic or additive effect of combining these chimeric antigens, we

132 ects of chronic fluoxetine, but there was no additive effect of CR in fluoxetine-treated mice.

133 r and nonvascular cell types; therefore, the additive effect of DDAH1 expression in multiple organ sy

134 The ACCORD Lipid trial studied the additive effect of fenofibrate therapy along with low-do

135 of GLP-1 and PYY 3-36 (P = 0.03) next to the additive effect of GLP-1 (P = 0.006) on the composite ap

136 An additive effect of high-fat and high-sucrose diet on the

137 Surprisingly, this additive effect of nuclear tGIV/cytoplasmic pYGIV was ob

138 The supra-additive effect of overexpressing the three sRNAs result

139 ther systems; however, our results showed no additive effect of p53 and Arf coinactivation in promoti

140 ion, we demonstrate in both species that the additive effect of prestimulus activity on evoked activi

141 There was no additive effect of PRGF when used along with GTR in the

142 ol overall is likely to be influenced by the additive effect of some or all of the other HLA alleles

143 lines (p = .0001), which indicates a strong additive effect of subcutaneous glucose and lactate/pyru

144 gistic stimulatory activity compared with an additive effect of the 3 individual bacteria.

145 as in human pancreatic cell lines showed an additive effect of the GEMCAP combination however, it in

146 The additive effect of the mixed cell- delta-MnO(2) system w

147 llowed by a summation of evidence showing an additive effect of the regulators.

148 Additive effects of 20:4-PC and LY294002 were not observ

149 Further, we found that the additive effects of [warming x N deposition] and [warmin

150 The observations of the additive effects of advanced and delayed precipitation p

151 The predictive model integrated the additive effects of all 11 single-nucleotide polymorphis

152 Additive effects of an antibody against VEGFR-2 in conju

153 To investigate the potential additive effects of blood transfusion and sepsis on colo

154 ights, Sigmaw(i) = 1.00 for models including additive effects of BRA and year].

155 ew studies have examined the independent and additive effects of breastfeeding (BF) and sugar-sweeten

156 forced contingencies that may be a result of additive effects of cocaine and cannabis use.

157 both GCTA and GWA are limited to the overall additive effects of common DNA variants, whereas twin st

158 GWA analysis, which, like GCTA, only detects additive effects of common DNA variants.

159 It has a potential to explain the additive effects of concomitant diseases or preexisting

160 c effects of histone acetylase inhibitors or additive effects of doxorubicin and dexamethasone, raisi

161 producing greater antitumor effects than the additive effects of each form of therapy.

162 ation, which impairs SA synthesis, exhibited additive effects of enhanced susceptibility from both el

163 Thus, the additive effects of future, more frequent droughts may i

164 ion that supports a threshold hypothesis for additive effects of genetic modifiers in the sensitized

165 SWB that can be explained by the cumulative additive effects of genetic polymorphisms that are commo

166 used a resampling procedure to simulate the additive effects of genetic variation on overall food-we

167 -type (Wt) and single knockout mice revealed additive effects of Gsta4(-/-) and Ppara(-/-) silencing

168 h low levels of horizontal transmission, the additive effects of host and symbiont loci will determin

169 ic outcomes so far, we did not see more than additive effects of HPV types on the risk of HSIL in wom

170 orylation of both STAT1 and p65 mediated the additive effects of IFNgamma and TNFalpha on LCN2 expres

171 ew that specificity does not derive from the additive effects of individual interactions but rather f

172 regions either reflect stimulus intensity or additive effects of intensity and expectations, respecti

173 Non-additive effects of intra- and interspecific competition

174 n-activated protein kinase signaling and the additive effects of MEK and BRAF mutations are counterpr

175 mediated by heterodimer formation or by the additive effects of mixed chemokines on their respective

176 provide a quantitative basis for integrating additive effects of multiple global change drivers into

177 effects on calcium influx correlate with the additive effects of mutations in nodF and nodL on legume

178 Also, the additive effects of our detected mouse loci more closely

179 These results demonstrate additive effects of p38 and JNK MAPK inhibition by MKP-1

180 out-breeding-to-selfing transition based on additive effects of segregating alleles.

181 elated intrinsic resistance results from the additive effects of several ND10 components and that the

182 ion in cortical surface area is explained by additive effects of SNPs dispersed throughout the genome

183 tract (CSE) exposure as well as the possible additive effects of the combination therapy with a phosp

184 ability could be explained by the collective additive effects of the genotyped SNP from the discovery

185 es that differed from those expected for the additive effects of the individual chemicals.

186 -linking, we observed small but reproducible additive effects of the lack of A20 and CYLD.

187 ause and is at least partly explained by the additive effects of the same polygenic variants.

188 t temperature-sensitive mutations due to the additive effects of the Tmp(-) phenotype.

189 The additive effects of these antagonistic circuit elements

190 drug users could show additive (or more-than-additive) effects of stress and cues on craving, using e

191 that dual targeting of these factors has an additive effect on ablating UPEC virulence.

192 respectively) suggests susceptibility and an additive effect on AMD risk.

193 mbined MeJA with Ethephon or H(2)O(2) had an additive effect on betacyanin accumulation in dark-grown

194 Niacin showed a selected additive effect on chemoattractant-induced activation of

195 ined addition of lipids and oxygen showed an additive effect on concentration of higher alcohols wher

196 LKB1 and transduction of HPV16 E6/E7 had an additive effect on constraining cell senescence while pr

197 se results reveal that TLR8 and TLR9 have an additive effect on controlling TLR7 function and TLR7-me

198 us and the 3'-UTR polymorphism status had an additive effect on DAT binding.

199 Flow has an additive effect on efficiency through 50 mL/min, when va

200 y 13 member A (FAM13A) were shown to have an additive effect on FEV1/FVC levels in the genetic risk s

201 tion alleles of MYB and bHLH proteins had an additive effect on GSL levels, as demonstrated by the an

202 s and ants--had a substantially greater-than-additive effect on herbivory.

203 of hCRM1 and hSRp40 resulted in a more-than-additive effect on HIV-1 release.

204 l and triglycerides genetic risk load has an additive effect on IHD risk.

205 oduction, concurrent blockade has a marginal additive effect on IL-2 production, IL-13 secretion, and

206 of Orai1 and PLA2g6 produced similar and non-additive effect on migration, whereas knockdown of STIM1

207 l starvation alarmone (p)ppGpp, polyP has an additive effect on nucleoid dynamics and organization du

208 m for compensation, harvest began to have an additive effect on overall mortality (rho = 0.60; 90% BC

209 In adults, harvest had an additive effect on overall mortality throughout the 42-y

210 3 in hepatocytes achieves a nearly complete, additive effect on prevention of core-induced spontaneou

211 omoter-reporter assays, p300 and PCAF had an additive effect on PTH stimulation of MMP-13 promoter ac

212 that of allosteric modulators, which show an additive effect on R628E receptors.

213 binations of multiple mutations displayed an additive effect on reducing NS2-induced ubiquitination.

214 25 at postnatal day 5 (PND5) demonstrated an additive effect on survival.

215 un and Ets2 co-immunoprecipitated and had an additive effect on Syk expression.

216 on through both CD28 and CD81 resulted in an additive effect on T-cell activation.

217 ion of MsFkh with Relish-RHD did not have an additive effect on the activity of moricin promoter, sug

218 tory of previous malignancy does not have an additive effect on the cancer-specific and overall survi

219 on of the two truncated proteins produces an additive effect on the inhibition of FtsA(+) polymerizat

220 mber of NOD2 and ATG16L1 risk alleles had an additive effect on the proportion of abnormal Paneth cel

221 arriers and length of stay seemed to have an additive effect on the risk of contracting C difficile.

222 ivates both signaling pathways, producing an additive effect on viability and enhancing both prolifer

223 In addition, cyaY and yggX mutations have additive effects on 6-phosphogluconate dehydratase-depen

224 ody deficiency and anti-CD4 depletion has no additive effects on aortic root atherosclerosis.

225 roallergen sensitization and RV wheezing had additive effects on asthma risk at adolescence.

226 on of DLK protein expression and the lack of additive effects on axon growth upon co-manipulation sug

227 the di-leucine motif (BACE1LLAA/KR) produces additive effects on BACE1 stabilization and defective in

228 rogenesis and to assess their individual and additive effects on behavioral performance on a perceptu

229 These additive effects on calcium influx correlate with the ad

230 tion with MSN2 and MSN4 deletion resulted in additive effects on CCC1 transcription, suggesting that

231 rwise silencing of ZAP70, SYK, or LCK showed additive effects on cell growth inhibition, providing a

232 Combined knockdown of Cten and ILK had no additive effects on cell motility compared with knockdow

233 Deletions of rga4 and scd1 had additive effects on cell width, and the proteins localiz

234 The mutations exerted independent, additive effects on circadian period, biased toward shor

235 Stress and cues have additive or more-than-additive effects on drug seeking in laboratory animals,

236 vities results in synergistic, epistatic, or additive effects on energy balance control.

237 a PYK2 inhibitor and Na2S did not result in additive effects on infarct size.

238 When used in combination, TAC and SRL had additive effects on inhibition of IFN-gamma- and IL-17-p

239 otreatment of MPA with IFN-alpha resulted in additive effects on ISG expression and enhanced IFN-indu

240 concentrations, and their expression had no additive effects on LGP2-mediated negative regulation.

241 ic and environmental factors not only exerts additive effects on locomotor hyperactivity and sensorim

242 and PI3K inhibition, respectively, produced additive effects on p-Akt and cell growth, consistent wi

243 ombination of hypoxia and low glucose showed additive effects on POX expression.

244 egment in the Class I MHC demonstrated clear additive effects on schizophrenia risk, demonstrating th

245 ealed multiple loss-of-function alleles with additive effects on serum levels of the oxysterol, 24S-h

246 ation of SOCS-3 and PTP-1B in brain revealed additive effects on several parameters, including partia

247 trait loci (QTLs) with predominantly small, additive effects on SLB resistance.

248 ombination, predation and parasitism had non-additive effects on the abundance of the intermediate co

249 d chloroplast function combined did not show additive effects on the circadian period, which suggests

250 Active movement and DBS had largely additive effects on the firing rate of most neurons, ind

251 ockdown of Lxralpha produced equivalent, non-additive effects on the lipogenic genes.

252 nhibition of adult neurogenesis did not have additive effects on the magnitude of volume loss but did

253 n types of substituents exert consistent and additive effects on the regioselectivity of substitution

254 esent together, PCSK9 and HMGCR variants had additive effects on the risk of both cardiovascular even

255 y weight, whereas at the same time exhibited additive effects on top of MC4R deficiency on lipid and

256 tion factors and the chromatin template with additive effects on transcription.

257 Synergistic or additive effects or both on cardiometabolic risk may be

258 The observed additive effect reinforces the central role of AC6 and c

259 C7 with significant additive, imprinting and additive effects, respectively.

260 T delivery and Activin A treatment showed an additive effect, resulting in on average 60% of the ESCs

261 with 2 single nucleotide polymorphisms with additive effects, rs2957692 (P=1.54x10(-13)) and rs29577

262 This additive effect should be considered to identify individ

263 everal mycotoxins, and therefore synergic or additive effects, should be taken into account when dete

264 power and resolution, and observed primarily additive effects, similar to what is seen for complex tr

265 ndothelial permeability and that VEGF has no additive effect, suggesting a common pathway.

266 However, intrathecal PACAP did not show additive effects, suggesting that the agonist effect was

267 pplication of 3,4-DAP plus GV-58 had a supra-additive effect that completely reversed the deficit in

268 rvive to warming, highlighting the potential additive effects that herbivory will have on ultimately

269 Antibiotic combinations typically have an additive effect: the efficacy of the combination matches

270 significant independent inhibitory effect or additive effect to BAK efficacy on acanthamoebal surviva

271 Auxiliary subunits exert an additive effect to heteromerization, and thus relief of

272 n of HDAC6 and HDAC9 together resulted in an additive effect to increase cell movement but did not al

273 HDAC6 and -9 had additive effects to promote cell survival via modulating

274 hand, marijuana and alcohol might follow an additive effect trend.

275 ession compared to control cells; whereas no additive effect was observed by co-depletion of both pro

276 sion and in the pure bulk oil, while only an additive effect was observed in a liposome system.

277 But a slightly additive effect was observed when AAPH system was used.

278 nd one of the earliest examples of the metal additive effect was observed with silver ions (Ag(+)).

279 To compensate for these additive effects, we have developed an empirical method

280 However, no additive effects were noted when black currant and rowan

281 Additive effects were seen for CDKN2A (hazard ratio, 2.3

282 Although individual additive effects were small, the fixation for alternativ

283 Furthermore, we did not detect an additive effect when combined with V600EBRAF, nor could

284 in vitro glycan shielding capacity, with an additive effect when these sites were reintroduced into

285 ter neurotoxic potential than cocaine and an additive effect when they are combined.

286 pheres to a similar extent, and there was no additive effect when they were coexpressed.

287 ations of these BRCT(2) domain residues have additive effects when combined in a single allele.

288 d by both OA and copper individually, but no additive effects when exposed as combined stressors were

289 duced DOX cardiotoxicity but did not produce additive effects when used together with 2-DG.

290 ve value is expressed as a function of h - 1 additive effects, where h = number of alleles or haploty

291 oinositide 3-kinase (PI3K) inhibitors had an additive effect, whereas Erk1/2 (extracellular signal ac

292 REI was identified on SSC8 with significant additive effect, which overlapped with QTL for nitrogen

293 Through these studies, an unusual additive effect with DMAP has been uncovered that allows

294 Finally, insulin stimulation produced an additive effect with SOCS3 overexpression, further induc

295 ificant F508del-CFTR rescue and displayed an additive effect with the investigational drug VX-809.

296 Additional analyses suggested an additive effect with those who both received a blood tra

297 Experimental studies show that statins exert additive effects with agents, such as cisplatin, to impa

298 For both wax and cutin, cer9 showed mostly additive effects with cer6, long-chain acyl-CoA syntheta

299 on in vitro and in vivo, iguratimod also has additive effects with glucocorticoids.

300 uced all PDE4 isotypes expression and showed additive effects with rolipram enhancing cAMP levels.