ライフサイエンスコーパス: additively

1 tively when TF is limiting but otherwise act additively.

2 c lineage, they appear to act separately and additively.

3 or multiplicatively but contributes to costs additively.

4 creased until inhibitor combinations behaved additively.

5 s often been assumed that mutant alleles act additively.

6 ting that they can function independently or additively.

7 ibit G(1)-phase progression individually and additively.

8 of TNF alpha independently of each other and additively.

9 are assumed to be diallelic and to interact additively.

10 and Sp3 can trans-activate the mor promoter additively.

11 n to enhance oriS function significantly and additively.

12 ulted in increased CD36 expression alone and additively.

13 ique pharmacological attributes that can act additively.

14 phine (2.5 mg/kg) enhanced anti-hyperalgesia additively (10 Hz EA) or synergistically (100 Hz EA) com

15 e spectrum of drug sensitivity other than to additively accelerate cell death.

16 D28 costimulation coupled to TCL1 expression additively accelerates dose-dependent T cell growth.

17 ase and cytolysin did not increase virulence additively, accounting for 50.6% of the pathogenicity an

18 In particular, many non-additively accumulated proteins (61-62%) in the F(1) and

19 These phosphorylation events additively activate CPEB4 in M-phase by maintaining it i

20 ancisella infection and that these cytokines additively activate host cells to control LVS intracellu

21 In contrast, FOXA1 and NKX2.1 additively activate transcription from Ccsp, which inclu

22 tion, overexpression of both IRF-8 and IRF-1 additively activated IL-27 p28 promoter.

23 et1-3) that vary in responsiveness to TH and additively affect metamorphic timing.

24 al N291G and P294K substitutions in human RR additively affect substrate specificity.

25 hosphatase 1 docking at the KNL-1 N terminus additively affected checkpoint silencing, indicating tha

26 Mutations additively affected the affinity of the NELF-E-binding a

27 ssociated with withdrawal, independently and additively alter distinct brain circuits.

28 Many of these genes were additively altered in a coinfection with PMV+SPMV and co

29 Ectopic STM and WUS functions interacted non-additively and activated a subset of meristem functions,

30 f leaf complexity and that SGL1 and FCL1 act additively and are required for petiole development.

31 ons were tested where genotypes were modeled additively and dominantly.

32 Signals from cones are combined both additively and in opposition to create the perception of

33 Mutations in p7 and NS2 acted additively and increased the specific infectivity of vH-

34 del where the binding of each GABAergic drug additively and independently reduces the free energy of

35 mutants showed that each domain contributed additively and independently to binding affinity; in con

36 iants and (iii) specific dyes, appear to act additively and independently to increase terminator inco

37 erization process and that the NTDs function additively and independently.

38 point mutations that account for resistance additively and independently; one is in fabZ, a dehydrat

39 modulates the activity of the SC cells both additively and multiplicatively and changes the preferre

40 ividuals with mild cognitive impairment both additively and multiplicatively.

41 CP-1 inhibition was post-transcriptional and additively and synergistically enhanced by fluticasone a

42 upplementation, whereas Xrn2 depletion acted additively and thus independently of miR-122.

43 ch both electrical and gene therapies can be additively applied to treat diabetic wound healing.

44 QTL affecting sexual isolation act additively, are largely different in males and females,

45 Thus, WRKY38 and WRKY62 function additively as negative regulators of plant basal defense

46 presenting different vRNAs were not packaged additively, as would be expected under specific packagin

47 sity factors found in previous studies to be additively associated with child psychopathology; family

48 Seropositivity to more herpesviruses was additively associated with greater LTL attrition (3 herp

49 us (t = 2.74; p<.008) were independently and additively associated with increased DAT binding in the

50 The 5-HTTLPR short allele appeared to be additively associated with increasing gray matter volume

51 sites (all P<0.05) and, when combined, were additively associated with long-term survival (P=0.0001)

52 al volume index) were each independently and additively associated with risk of incident HF hospitali

53 oundary lubrication, either independently or additively, at an articular cartilage-cartilage interfac

54 PGE2 in a manner that was synergistically or additively augmented by cytokines.

55 Each gene additively augments embryonic lethality in crosses betwe

56 suspicion be high, and any partial solutions additively be implemented.

57 Mutations in both of these AU elements additively block recognition of the downstream 3' splice

58 of Src, MEK activation, and c-myc expression additively blocks CSF-1-induced D2 expression.

59 are essential throughout development and act additively but are dispensable at adulthood.

60 ing that the three binding sites do not work additively, but rather function as a unit.

61 efore, the wound-healing process is impaired additively by aging and ischemia.

62 were not substantially changed when adjusted additively by baseline GRACE risk score (HR, 0.975 [95%

63 paradigm that extends the laser tuning range additively by employing multiple monolithically grown ga

64 , as evaluated by lesion size, was increased additively by in vivo iron availability, and cysteine mo

65 is rapid open channel block was reduced (non-additively) by interventions that slow C-type inactivati

66 Data from multiple rotations can be additively combined, generating a chemical image of the

67 e results suggest that MCPIP1 and MCPIP4 may additively contribute to control IL-6 production in vivo

68 We conclude that TNFalpha and IGF-I may additively contribute to fibrosis during intestinal infl

69 y and do not have independent functions that additively contribute to HCMV latency.

70 rminal predicted alpha-helical/Motif 6 site, additively contribute to repression.

71 C-reactive protein and CAD independently and additively contributed to the risk prediction: low CRP a

72 helix-loop-helix transcription factors that additively control jasmonate-related defense responses,

73 elix transcription factors that are known to additively control jasmonate-related defense responses,

74 We show that the three arginines additively control the subcellular localization of SF2/A

75 both TNFRSF4 and TNFRSF25 independently and additively costimulate vaccine-induced CD8(+) T cell pro

76 We identify a series of mutations that additively decouple the Pincer motif from the ATPase cor

77 Similarly, these interventions additively decrease cell viability.

78 TNF-Tg and GC treatment additively decreased mechanical strength and stiffness i

79 systolic dysfunction, with each minor allele additively decreasing the odds for LV ejection fraction

80 co-regulate target genes synergistically or additively, depending on the target transcriptional enha

81 oretical expectation for a correlated set of additively determined traits, the average G matrix of th

82 additively while strong enhancers behave sub-additively due to competition with the target promoter.

83 h hy5 and cop1 revealed that BBX25 and BBX24 additively enhance COP1 and suppress HY5 functions.

84 nhibitors of these respective pathways super-additively enhance CPT's cytotoxicity, suggesting their

85 ctivators of gamma-globin gene expression to additively enhance HbF.

86 a2+ ionophore and phorbol ester strongly and additively enhance this Rap1A activation.

87 Eotaxin inhibition was transcriptional and additively enhanced by the glucocorticoid fluticasone an

88 nd Hsp40 (HDJ-1 and HDJ-2) independently and additively enhanced E1 binding to the origin.

89 low concentrations, ANP and beta-AR agonists additively enhanced expression of brown fat and mitochon

90 Topical H1/2r antagonists additively enhanced permeability barrier homeostasis in

91 mbination of these lipids synergistically or additively enhanced TH2 responses and, strikingly, induc

92 itant activation of the PKA and PKC cascades additively enhanced the amplitude of flow-induced [Ca(2+

93 normal T cells with fludarabine or rituximab additively enhanced the direct cytotoxic effect of these

94 expression of beta-defensin 2 and S100A9 and additively enhanced the expression of S100A7 and S100A8.

95 y increased when parasites were administered additively, even when the presence of the most pathogeni

96 These traits contributed additively, explaining 17.5% of the variation in total c

97 evel in the F1 hybrid, implying that the non-additively expressed siRNA clusters resulted in lower ac

98 The tag is additively fabricated on flexible plastic foil and compr

99 gly, reporter gene expression also increased additively following each of seven doses of FIV delivere

100 l events that act either multiplicatively or additively found support in 8% and none of the trees, re

101 r dramatically: in V. harveyi, the sRNAs act additively; however, in V. cholerae, the sRNAs act redun

102 eetiolation responses, either redundantly or additively; however, phyB acted as a modulator of cotyle

103 proportion to Gag, the S domain was packaged additively, implying that the Alu and S domains are pack

104 e and RYGB surgery-induced weight loss would additively improve S(I) and other cardiometabolic factor

105 Neuronal Sxl acts additively in 2 neuronal subpopulations, one of which co

106 ntrast, the hunchback enhancers function sub-additively in anterior regions containing saturating lev

107 /ICE family of proteases, inhibit cell death additively in C. elegans.

108 The CI and CII proteins behave strictly additively in client protection.

109 Although these pathways act additively in culture, they act synergistically in vivo

110 Their alleles act nearly additively in heterozygotes.

111 nd IL-1 beta in combination appeared to work additively in promoting IgG2.

112 stered together, the two MAbs acted at least additively in providing protection against challenge wit

113 phyA and phyB act additively in red light input to the clock, whereas cry1

114 levels of the Bicoid activator, but function additively in regions where there are diminishing levels

115 and feature cue information were represented additively in shared frontal, parietal, and cingulate re

116 he nicotine biosynthetic pathway and may act additively in the activation of JA responses.

117 FcgammaRIIIa confer risk for SLE and may act additively in the pathogenesis of disease, whereas the h

118 lso that the receptor uses multiple proteins additively in vivo.

119 e with plasma levels of VWF, individually or additively, in a large cohort of healthy subjects.

120 oexpress five FAD mutations (5XFAD mice) and additively increase Abeta42 production.

121 ing pathways were found to independently and additively increase alpha1(I) collagen gene expression b

122 suppress KLF1 and BCL11 gene expression and additively increase fetal hemoglobin in primary human er

123 suppress KLF1 and BCL11 gene expression and additively increase fetal hemoglobin in primary human er

124 h CBmp and IQmp are agonist ligands that non-additively increase L-type Ca2+ channel opening probabil

125 bodies that target a non-overlapping site to additively increase parasite inhibition.

126 with SMN2 splice-switching oligonucleotides additively increase SMN expression and improve survival

127 GTP and isoleucine, which independently and additively increase the affinity of CodY for its target

128 h C(6)-Cer and each of these same inhibitors additively increased ABCA12 expression, indicating that

129 ation in cells with active Akt/PKB, LY294002 additively increased apoptosis and inhibited clonogenic

130 t MASH1 overexpression and FGF-2 deprivation additively increased beta-III-tubulin and decreased cycl

131 a a Brca2/Rad51-dependent mechanism and were additively increased by deletion of the Blm helicase.

132 t1 mRNA levels under normoxic conditions and additively increased glut1 mRNA levels in concert with h

133 Rac1 activity was additively increased in CECs treated with CCL11 and VEGF

134 nd-expressing cells, TIGIT and PD-1 blockade additively increased proliferation, cytokine production,

135 ndently by different pathways, although each additively increased the level of p21WAF1 cell cycle inh

136 However, the combination of EMD+PDGF-BB additively increased wound fill for both ALK PHOS (+) an

137 photoreceptors other than phytochrome A and additively increases ABA insensitivity conferred by the

138 taneous knockdown of supervillin and anillin additively increases cell division failure.

139 the association persisted with each C-allele additively increasing the FVIII:C level by 14.3 IU dL(-1

140 the val/val phenotype but instead interacts additively, indicating that these genes affect distinct

141 ence within the nucleosome entry-exit region additively influence nucleosomal DNA accessibility by in

142 Finally, NPHP4 and Jade-1 additively inhibit canonical Wnt signaling, and this gen

143 must express H2-E MHC class II molecules to additively inhibit IDDM in NOD mice.

144 In vitro, apoE and LRP1 additively inhibit macrophage apoptosis.

145 response using chemical inhibitors or siRNA additively inhibited HCV replication and induced viral c

146 359) peptide that inhibits G(q/11) signaling additively inhibited IGF-stimulated ERK1/2 activation, i

147 IL-10 plus corticosteroids additively inhibited IL-1beta secretion in human PBMNCs

148 Rapamycin combined with IDEC-131 additively inhibited MLRs.

149 Sirt1 and Sirt2 inhibitors additively inhibited the constitutive AKT activity in th

150 Interruption of both signaling cascades additively inhibited the wound-healing process.

151 d alpha 1B-AR antisense ODNs and antagonists additively inhibits PHE-induced delta pHi by 90%.

152 ed knockdown of both PLCepsilon and PLCbeta3 additively inhibits PI hydrolysis, suggesting independen

153 Depletion of Trimmer and Papi/Tdrkh additively inhibits trimming, causing accumulation of ap

154 ple linear model, which assumes that neurons additively integrate sound levels in each frequency band

155 be served by the intraparietal sulcus, which additively integrated a spatially specific activation ga

156 he unstructured tail of its Hec1 subunit are additively integrated to elicit gradual tuning of NDC80-

157 NPC1L1 and HMGCR polymorphisms had 5.8 mg/dl additively lower LDL-C and a 10.8% log-linearly additive

158 ore than 5,500 alloys in use today cannot be additively manufactured because the melting and solidifi

159 re we report the first example of a class of additively manufactured carbon fiber reinforced composit

160 fatigue life of electron beam melting (EBM) additively manufactured parts is currently dominated by

161 d to the distribution of applied stresses in additively manufactured parts to maximise the fatigue li

162 s understanding the nature of variability in additively manufactured parts.

163 pore architecture is a critical variable in additively manufactured scaffold design for functional t

164 report that austenitic 316L stainless steels additively manufactured via a laser powder-bed-fusion te

165 h greater population activity, while that of additively modulated neurons decreased.

166 from biological and adoptive relatives acted additively on adoptee AUD liability.

167 nd showed that the three variants each acted additively on gene expression.

168 MSX and rapamycin act additively on Gln3-Myc13 phosphorylation, but MSX clearl

169 however, were of little consequence, either additively or in interaction with combat.

170 TA-p63, repress endogenous AFP transcription additively or independently.

171 trait-based mortality to be modelled either additively or multiplicatively, and individual variabili

172 Seed infertility QTL act additively or recessively, consistent with findings in o

173 able in number, and seed-infertility QTL act additively or recessively.

174 can control whether the sRNAs appear to act additively or redundantly.

175 MEK inhibitor and/or BRAF inhibitor additively or synergistically combined with digitoxin to

176 n cells is affected at several levels, which additively or synergistically result in the appearance o

177 ed that glucocorticoids and beta(2)-agonists additively or synergistically suppress tumor necrosis fa

178 We discuss how Dorsal and Twist work either additively or synergistically to activate different targ

179 Several compounds also acted either additively or synergistically to inhibit enzyme activity

180 they are copackaged and whether they can act additively or synergistically to inhibit HIV-1 replicati

181 These may interact additively or synergistically, increasing the likelihood

182 ith inputs from other network nodes that act additively or synergistically.

183 or overexpression of eIF4E individually and additively partially rescues the rapamycin-induced decre

184 n combination with C. sordellii lethal toxin additively prevented glucocorticoid suppression of TNF-a

185 ingly, deficiency of both IL-1beta and IL-18 additively prevented LPS-induced mortality.

186 ternative exons, with multiple motifs acting additively rather than cooperatively.

187 norhizobium meliloti nodL and nodF mutations additively reduce infection of Medicago truncatula.

188 used in combination with MEK inhibitors, can additively reduce the transformation induced by p110beta

189 The combination of cells additively reduced the infarct size and promoted vascula

190 owever, combining eserine with methoctramine additively reduced the ISF Abeta further in both animals

191 Food fortification with iron and EDTA additively reduces BPb concentrations.

192 t manners, exemplifying that different MCTPs additively regulate a specific plant developmental proce

193 38 MAPK and Smad signaling independently and additively regulate alpha1(I) collagen gene expression b

194 ene, indicating that anaerobic expression is additively repressed by FadR and ArcA-ArcB.

195 Coexpression of p65 and E1A additively represses the transient MMTV but restores the

196 ned before BMT KGF + PFT-beta administration additively restored numbers of cortical and medullary TE

197 se, and well-spaced pulses of ligand combine additively, resulting in greater pathway output than wit

198 in TP53/PTEN double knockout GBM mouse model additively shortens the latency of glioma onset and surv

199 bsence of soluble IL-1R (with which it acted additively) significantly attenuated the spontaneous/aut

200 ediate variable to which all loci contribute additively, so that new alleles can accumulate in any or

201 RT-PCR confirmed that NO* and SB could additively stabilize certain mRNA transcripts, an effect

202 -2 and mGluR learning phenotypes behaved non-additively, suggesting that Drep 2 might be involved in

203 bitors (CNIs) in combination with prednisone additively suppressed IFNgamma production and degranulat

204 The rga and gai null mutations additively suppressed the recessive sly1 mutant phenotyp

205 s indicates that PAX-6 isoforms can interact additively, synergistically, or antagonistically, depend

206 ated HGF promoter activity independently and additively through binding to the Sp1 binding site in th

207 und, suggesting that these RPP genes operate additively through EDS1, NDR1 and as-yet-undefined signa

208 CLA and OCS act non-additively to activate atNHE1, indicating convergent, ph

209 sesses two regions that appear to contribute additively to chaperone binding.

210 ariation between families and was decomposed additively to characterize the correlation structure wit

211 ntitative disease resistance loci, which act additively to confer disease resistance.

212 inhibitors we show that Rap1b and VEGFR2 act additively to control angiogenesis in vivo.

213 at three common SNPs in the DBH promoter act additively to control phenotypic variation in DBH levels

214 antly, in V. harveyi, the Qrr sRNAs function additively to control quorum sensing.

215 ALD1 and PAD4 can act additively to control SA, PATHOGENESIS RELATED GENE1 (PR

216 code induction, although val does contribute additively to defects in subsequent patterning of the ot

217 how that multiple, unlinked loci act largely additively to determine position along the major niche a

218 It is concluded that these regions act additively to direct phloem-specific gene expression.

219 of these genes contributes independently and additively to E2-mediated silencing, indicating that E2

220 resources also responded dynamically and non-additively to eCO2 and warming, shaping the plant respon

221 The components of the combined adjuvant work additively to enable both antigen and adjuvant dose spar

222 tremes show that each amino acid contributes additively to enzyme function, with epistatic contributi

223 -propionic acid hydrobromide (AMPA) interact additively to evoke [3H]ACh release, and synergistically

224 uggest that multiple sscat-binding sites act additively to fine-tune signaling via cytoplasmic retent

225 These NB-LRR proteins then act additively to generate a full disease resistance respons

226 Wnt and Fgf function additively to generate dHb progenitors.

227 independently associated with and contribute additively to hippocampal cortical thinning.

228 most BVM resistance and PIR mutations acted additively to impair viral replication, particularly in

229 pathway, we hypothesized that they could act additively to improve infectivity and reduce toxicity to

230 cose supplementation acted independently and additively to increase N-linked glycan branching.

231 GTP and the BCAAs were shown to act additively to increase the affinity of CodY for DNA; inc

232 at multiple diet components can interact non-additively to influence gut microbial diversity.

233 ncer contains three subelements contributing additively to its activity, and functionally important r

234 isolate HIV-1(89.6); many anti-HIV-1 Abs act additively to mediate this biological function.

235 We found that these two pathways contribute additively to nutrient limitation-induced haploid invasi

236 Each pair contributed additively to overall affinity, with 61% from Lys-270/Ly

237 kk3 and low expression levels of sFRP1/5 act additively to potentiate the Wnt/JNK signaling pathway g

238 within the transcription activator Ets-1 act additively to produce graded DNA binding affinity.

239 de new evidence that portion size and ED act additively to promote energy intake at meals among presc

240 th arginine and leucine act individually and additively to propagate signals that are dependent on th

241 Proline-directed phosphorylation acted additively to regulate multiple aspects of ATF4 degradat

242 letion studies, functioned independently and additively to regulate the exit of tumor cells from quie

243 We find that polygenic variation contributes additively to risk in ASD cases who carry a strongly act

244 Moreover, SGT1b and RAR1 contribute additively to RPP5-mediated pathogen recognition.

245 omes 2, 7, and 1, respectively, and interact additively to suppress mammary carcinoma development in

246 activity, with the 5-aryl group contributing additively to the allosteric enhancer activity.

247 r effect; (2) multiple HMG boxes contributed additively to the hUBF-adduct interaction, providing a p

248 a model in which upstream motifs contribute additively to the log-expression level of a gene, this m

249 ing mutations contributing independently and additively to the outcome.

250 form independently and appear to contribute additively to the overall expression from the locus.

251 anaphase resolution) and Src64B contributed additively to this form of cell death.

252 ally focus on detecting loci that contribute additively to trait variation.

253 e Gal11 activator-binding domains contribute additively to transcription activation and Mediator recr

254 ype (similar to N-type channels) contributed additively to transmitter release from the hair cell.

255 s recombination and loss of Srs2 contributed additively to UV sensitivity.

256 have found that these proteins cooperate to additively transactivate p21 and suppress cell prolifera

257 nce (based on a low-pH survival assay) supra-additively up to 8500-fold during active cell growth, an

258 ect each trait in the same direction and act additively, we also found evidence for epistasis between

259 hibit no cross-resistance with Rif, function additively when co-administered with Rif, and suppress r

260 in isolation and contributed to the response additively when combined with other features.

261 B2 receptor, independently but also largely additively when combined, enhance senescence-associated

262 NRF-1 and NRF-2 act additively while NRF-2 synergizes with CREB/ATF at FMR1'

263 ggests that weakly active enhancers function additively while strong enhancers behave sub-additively

264 Lyn inhibited Akt/PKB additively with an okadaic acid-sensitive endogenous pho

265 First, we ask whether Taxol will combine additively with another stabilizer or whether one stabil

266 t the inhibition of RAD52-ssDNA binding acts additively with BRCA2 or MUS81 depletion in cell killing

267 w that the chiral counterion can be combined additively with chiral ligands to enable an asymmetric t

268 These PxxP motif mutations affect signaling additively with CRIB domain mutations, indicating that B

269 Furthermore, xenon works additively with cyclosporin A to preserve post-transplan

270 Moreover, GSNO acted additively with decreased temperature, which promoted mu

271 e test the hypothesis that such peptides act additively with detergents when applied in parallel.

272 competitive manner but instead was packaged additively with endogenous 7SL.

273 hil-active chemoattractant that can function additively with eotaxin and a dual CCR3/5-HT2A receptor

274 y as an eosinophil chemoattractant that acts additively with eotaxin.

275 s factor-alpha (TNF) and IL-1beta functioned additively with Et-1 in increasing IL-8 production.

276 alysis indicates that ETR1 and EIN4 function additively with ETR2 to control this trait.

277 that addition of ceramide analogs alone and additively with fatty acids decreased SRE expression and

278 In conclusion, FGF21 acts additively with GLP-1 to prevent insulinopenic diabetes

279 The porcine cathelicidin peptide PR-39 acted additively with human cathelicidin LL-37 to kill group A

280 onstrated that insulin acts independently or additively with human chorionic gonadotropin to enhance

281 the synthesis of cell wall polymers and act additively with inhibitors or mutations disrupting cellu

282 caCaMKKalpha could stimulate glucose uptake additively with insulin in insulin-sensitive muscle, in

283 that caCaMKKalpha stimulates glucose uptake additively with insulin, and in insulin-resistant muscle

284 on to shock caused by B. anthracis and works additively with LeTx.

285 dcs1 interacted epistatically or contributed additively with loci on other chromosomes.

286 l lines; and (d) PKCzeta inhibitors function additively with other inhibitors that target similar or

287 loss is, functionally, a stress that can act additively with other stresses to arrest cells in G1 in

288 de, a VR1 agonist in acidic conditions, acts additively with PDBu and remains effective after chronic

289 B(-/-) mice revealed that rosiglitazone acts additively with PTP1B deletion.

290 Genetic analysis indicates that WIN3 acts additively with several known SA regulators, including P

291 oid cells, simvastatin induced HbF alone and additively with tBHQ, but it did not increase KLF2 mRNA

292 ied a secondary interval on Chr 2 that works additively with the Chr 1 locus to increase lateral sept

293 ellin-deficient mutation dwarf1 and interact additively with the dominant gain-of-function mutations

294 signal 1 inhibitor cyclosporine A (CsA) and additively with the signal 3 inhibitor rapamycin to bloc

295 ntly of Rp-cAMPS, Trk-IgGs, and LY294002 and additively with them.

296 1P3, regulates epithelial integrity and acts additively with TNF in compromising respiratory barrier

297 nd that the proteases DegS and DegP function additively with VesC and a novel protease, TapA, to degr

298 that ABA synthesized in the embyro interacts additively with Vp1 to prevent precocious induction of a

299 The two signaling pathways are combined additively, without interactions, and epistasis only ari

300 al SUMO modifications may act redundantly or additively, yet they may mediate dedicated functions as