ライフサイエンスコーパス: additivity

1 mbinations in the absence of drug synergy or additivity.

2 ases we observed significant deviations from additivity.

3 l explanation for the observed recovery time additivity.

4 t are not statistically distinguishable from additivity.

5 imental MPs of the mixtures to evaluate dose-additivity.

6 s expected in both arms, with no significant additivity.

7 y Gaussian curvature and display nonpairwise additivity.

8 orrelation with intensity as rationalized by additivity.

9 d a statistically significant departure from additivity.

10 ug to the statistical model could only yield additivity.

11 e alpha-CTD as a mechanism for their lack of additivity.

12 of Escherichia coli exhibits partial sensory additivity.

13 s that were greater than predicted by simple additivity.

14 greater than that predicted on the basis of additivity.

15 either Sp1 or NF1 alone, indicating lack of additivity.

16 xifloxacin zones of synergy, antagonism, and additivity.

17 D to a mixture and test the assumption of AH additivity.

18 se a structural mechanism that explains this additivity.

19 of (Gly)n are linear in n, suggesting group additivity.

20 ty and age class on the rate of compensation-additivity.

21 a simple metric for the rate of compensation-additivity.

22 well as negative deviations from the linear additivity.

23 f the same magnitude is termed an isobole of additivity.

24 SE additivity also has practical utility as the SEs can be

25 ombined toxicity according to the concept of additivity, although slight deviations from additivity w

26 SGNs under depolarizing conditions involves additivity among a depolarization-independent autocrine

27 free energy coupling limit suggested by this additivity analysis ( approximately 4 kcal/mol) is also

28 By applying a free energy additivity analysis to these variants, we quantified the

29 he context of NMDA's roles in neuronal super-additivity and as crucial for evidence integration for d

30 Assuming additivity and biallelism we estimate that identified QT

31 Data were analyzed using Loewe additivity and Bliss independence models for synergy, an

32 in cause-specific mortality exists, of which additivity and complete compensation constitute particul

33 lasmon resonance binding analysis to dissect additivity and cooperativity in a complex formed between

34 s assessed through departure from risk ratio additivity and multiplicativity after adjustment for age

35 Particularly remarkable is the lack of additivity and potential antagonism found between the pa

36 The method assumes additivity and scales linearly with the number of waters

37 ression alleles revealed substantial genetic additivity and some dominance for both system architectu

38 perimental agents used in combinations where additivity and synergy have been assessed.

39 n dek1 and cr4 showed elements of epistasis, additivity and synergy, suggesting that the gene product

40 The additivity and transferability hypotheses underlying thi

41 Assuming intrascaffolding additivity and using the Ka values obtained for OMTKY3 v

42 Spearman correlation, additivity and variance stabilization for regression for

43 We identify drugs with synergy, additivity, and antagonism with the Bruton's tyrosine ki

44 are structurally independent show energetic additivity, and changes that intersect show energetic ov

45 ve natural selection because of their higher additivity, and that the disruption of gene expression b

46 variation due to cis-regulation shows higher additivity; and (iv) genetic divergence between second c

47 liar distance properties, such as metric and additivity, appear to have much less effect on the perfo

48 Herein, we describe a Group Additivity approach to obtain Pourbaix diagrams with ful

49 The additivity approach was also compared with standard mole

50 However, deviations from additivity are common, and molecular interpretations are

51 demonstrate that: 1) curvilinear isoboles of additivity are predicted by a concerted transition model

52 However, it is not clear how much the additivity assumption affects the reliability of the res

53 We conclude that despite the fact that the additivity assumption does not fit the data perfectly, i

54 ts, combined with potential violation of the additivity assumption in many-species communities, sugge

55 actions with each species in the community ('additivity assumption').

56 hese studies the main conclusion is that the additivity assumption, usually applied in methods to sea

57 nergy could be approximated using a pairwise additivity assumption.

58 ecourse to crudely justified mean-field-like additivity assumptions.

59 amined for zones of synergy, antagonism, and additivity based on a whole exposure-response surface.

60 were consistent with the findings from Loewe additivity-based drug-interaction modeling.

61 an efficient inhibitor of subtilisin A by an additivity-based sequence to reactivity algorithm (Lasko

62 An additivity-based sequence to reactivity algorithm for th

63 ed, thus providing an additional test of the additivity-based sequence to reactivity algorithm.

64 ion is biased toward greater deviations from additivity because of recessive and dominant alleles, wh

65 est mean FICs for S. aureus, with synergy or additivity being seen in 60% to 80% of isolates.

66 e, while the N218A/I99A variant disrupts the additivity between P2 and P4 specificity.

67 We have previously shown additivity between Taxol and the MEK inhibitor, U0126 in

68 ghly specific soluble receptors suggest that additivity between VEGFR and PDGFRbeta inhibition depend

69 larger NITM than the EMMs and exhibited NITM additivity, but the EOMs also exhibited prolonged decay

70 I measured quantitative genetic additivity by heritability.

71 I analysed metabolic additivity by the distribution of epistatic effects of p

72 lows successful application of the component additivity (CA) approach based surface complexation mode

73 phases of F-Area sediments), and a component-additivity (CA) based surface complexation model (SCM) w

74 Although the isobole of additivity can be a straight line in some special cases,

75 indicate that epistasis is common, and that additivity can be an emergent property of underlying gen

76 design, the accuracy limitations of pairwise additivity can now be eliminated via polarizable or quan

77 f the scaled-particle theory model, assuming additivity, can also describe the behavior of mixtures o

78 tivity in this system, and allow some of the additivity coefficients to be rationalized on a structur

79 Such non-additivity, commonly termed an emergent multi-predator e

80 We draw thermodynamic additivity cycles analyzing the interdependence of P(1)

81 Deviations from bond enthalpy additivity (DeltaBEA) are frequently used to assess the

82 Metabolic additivity describes the interaction between changes in

83 llic acid, caffeic acid, trolox), synergy or additivity effects were noticed.

84 result under dominance and potentially under additivity, even in populations where associated overdom

85 CA) and independent action (IA) to formulate additivity expectations, and Schild plot analyses to inv

86 rimination-with-noise and the brightness-non-additivity experiments showed a double-dissociation betw

87 Additivity experiments suggested the distinct epitopes w

88 n between metabolic and quantitative genetic additivity explained some of the variation in performanc

89 n process adsorption energies based on group additivity fingerprints, combined with transition-state

90 chemical-specific approach that assumes dose additivity for carcinogenic PAHs and (ii) a bioassay-bas

91 the nature of the interactions tended toward additivity for most bath salts mixtures, supra-additive

92 in alpha-lytic proteinase, interscaffolding additivity for OMTKY3 and eglin C holds well for the fou

93 hly connected networks had greater metabolic additivity for perturbations to individual networks, but

94 ative pairwise interactions produce apparent additivity for the stabilizing effects of the single mut

95 t be ruled out as it shows similar levels of additivity for two to three substituent systems, which w

96 For those cases where group additivity (GA) results are available, the thermodynamic

97 y new sources of APR have been reported, and additivity has been described for some of these resistan

98 nce onto multisensory sites exhibiting supra-additivity has been proposed as the principal mechanism

99 odes of gene action were observed, including additivity, high- and low-parent dominance, underdominan

100 The degree of additivity, however, was typically small in terms of the

101 However, the deviation from additivity, if it exists, is small.

102 nds, cluster calculations also reveal linear additivity in beta(vec) with catenation for all benzoic

103 hoice of concentration scale and demonstrate additivity in DeltaG(tr) of the peptide backbone unit fo

104 hat on the gamma and delta subunits shows an additivity in free energy changes for carbamylcholine an

105 Several combinations of inhibitors exhibited additivity in impairing LS or CLSE activity at a lower c

106 Dark-release experiments showing additivity in phase advances suggest that the arrthymici

107 Thus, vitronectin and mAbs demonstrated additivity in the effects on the reaction with target pr

108 Dominance deviance-deviation from additivity in the main or interaction effects-is key to

109 haps surprisingly high degree of substituent additivity in this system, and allow some of the additiv

110 Our data confirmed additivity in those cells lines that undergo paclitaxel-

111 Cytotoxicity assays demonstrated at least additivity in three of the cell lines.

112 ng a bioassay-derived method (BDM) (i.e., an additivity-independent approach).

113 Thus, partial additivity indicates cooperativity, synergy indicates an

114 The principal origin of non-additivity involves the so-called indirect component of

115 As additivity is a very useful property for a distance meas

116 Additivity is defined analogously to a fractional inhibi

117 The high degree of additivity is reflected in a summary statistic for adapt

118 The implication of complete additivity is that structures resistant to both agents (

119 ause of the precomputations and the regional additivities, it is nearly as fast to compute as gammaA

120 e, yet they display a strong and predictable additivity leading to a kinetic resolution of imines der

121 case of endocrine disruption, deviation from additivity may occur and render predictions inconclusive

122 single network, whereas quantitative genetic additivity measures the consistency of phenotypic effect

123 This bond-centered group additivity method for the thermochemical properties of P

124 n of the widely employed atom-centered group additivity method originally proposed by Benson.

125 or ion activity) of the varied metal and the additivity model (concentration-addition or independent-

126 n energies can be accurately described by an additivity model with four parameters that describe the

127 gO(100) bond energies within a pairwise bond additivity model.

128 ) of the varied metal but independent of the additivity model.

129 The strong functional additivity observed for MA-8H9D4 and MA-55F4C12 demonstr

130 uble mutants was studied to characterize the additivity of binding at such sites.

131 ers of such cationic groups of each protein (additivity of binding enthalpies).

132 rse and offers a quantitative definition for additivity of drug effects, relative to which synergism

133 ) provides a useful metric of departure from additivity of effects on a relative risk scale.

134 h within the bubble, confirming the expected additivity of effects.

135 rigidity within molecular structure and non-additivity of free energy is demonstrated using a thermo

136 The principle of additivity of functional group contribution to partition

137 ip provides a unique system for studying the additivity of gene expression levels in reciprocal hybri

138 pectra of the constructs are consistent with additivity of independently and fully folded CC and CL d

139 s two-state folding is based on the observed additivity of individual mutations to the overall DeltaG

140 Monte Carlo simulations show that pairwise-additivity of nearest-neighbor interactions is inadequat

141 PMs, but not SMs, exhibited additivity of NITM.

142 The method relies on concepts of additivity of nucleic acids hybridization free energies

143 ne segment, is allele specific and shows non-additivity of phenotypes indicative of a physical intera

144 This additivity of phenotypic manifestations indicates that I

145 rt a simple thermodynamic model that assumes additivity of preferential interaction between GB and va

146 Assuming additivity of refractive index and using an appropriate

147 gic definition of "interaction" leads to the additivity of risk differences (RDA) as the fundamental

148 This study examined the degree of additivity of several physiologically relevant protein a

149 The additivity of shifts, holding with no exception so far,

150 nt structure and biological activity, assess additivity of substituent effects, identify missing anal

151 tion, a freedom that can explain the partial additivity of the aspartate and maltose responses that i

152 cutoff effect of long-chain alcohols and the additivity of the effect of general and local anesthetic

153 the wild-type enzyme, indicating approximate additivity of the effects of the two arginine mutants on

154 of this study was to experimentally test the additivity of the electrostatic substituent effects (SEs

155 activity as evidenced by (1) the absence of additivity of the Ha-Ras- and c-Fos-mediated inhibition

156 Pairwise additivity of the hydrophobic effect is indicated by rel

157 X and Y positions appears to reflect simple additivity of the individual residues, except when X is

158 of this ordering from Z is attributed to the additivity of the inductive stabilization of XYZCO(-) by

159 uted oligonucleotides were used to probe the additivity of the interactions.

160 By using burst pairs, temporal additivity of the muscle responses was demonstrated both

161 The additivity of the SEs was assessed using a small molecul

162 The additivity of the two drugs on glutamate release is cons

163 mixture could not be accounted for by simple additivity of the two individual spectra, indicating a c

164 r of the singly modified Hbs, with a partial additivity of the two modifications.

165 Of these, 408 proteins showed quantitative additivity of the two parental profiles in T. mirus (bot

166 Several studies imply pervasive non-additivity of transcription, transgressive segregation a

167 rmally fluctuating DNA, we conclude that the additivity of writhe applies also to randomly distorted

168 epidemiologists believe that departure from additivity on a log scale implies that two factors inter

169 lations reveal strong deviations from linear additivity on a prototypical surface comprising surface

170 n of both pairs is consistent with models of additivity on either the log odds of the penetrance, or

171 We assessed departures from additivity on the absolute risk scale between 9 establis

172 and Idd5 we would also not reject a model of additivity on the penetrance scale, which might indicate

173 : (i) combination therapy is consistent with additivity or (ii) combination therapy is equivalent to

174 s represent limiting cases of either partial additivity or antagonism.

175 Even when drug combinations exhibit additivity or synergy in pre-clinical models, patient-to

176 Exposures associated with additivity or synergy were then combined and the regimen

177 and various cancer cell lines, exert potent additivity or synergy with existing chemotherapeutics in

178 The additivity parameters reflect the role of fluorine as an

179 ood understanding of the synergistic and the additivity phenomena.

180 calculated from the assumption of component additivity possibly caused by surface modifications stem

181 Applying this Group Additivity-Pourbaix approach to Group 13 elements, we ar

182 This assay was validated through linearity, additivity, precision and recovery, demonstrating that t

183 capacity could be distinguished by applying additivity principles.

184 ned directly from the measurements using the additivity properties of polarization.

185 Departures from additivity reflect interaction of the two residues.

186 A similar additivity relationship describes the enthalpies of prot

187 in aqueous mixed-salt solution by using the additivity rule of the Setschenow coefficients of the in

188 ecific volume than that expected from volume additivity rules, indicative of specific protein-deterge

189 o those expected on the basis of bond dipole additivity rules.

190 An additivity scheme for approximating the energy of a mixe

191 A new additivity scheme, the layered composite method (LCM), y

192 Stabilities predicted on the basis of additivity show good agreement with experimental values

193 Pharmacological additivity studies showed that this Q-component contribu

194 cant anesthetic potency, individually and in additivity studies with hexanol, using immobility in tad

195 Cotransfection and additivity studies with the poly(A) RNase (PARN) demonst

196 Pairwise additivity suggests that the hydrophobic effect is prima

197 hods for data analysis for the assessment of additivity, synergy, and antagonism that can be applied

198 Additivity, synergy, or competition was observed with MI

199 cell culture; however, no determinations for additivity/synergy have been applied with these compound

200 Numerous studies have demonstrated additivity/synergy with several HDAC inhibitors and stan

201 tes in real proteins show significantly more additivity than those obtained from random simulations.

202 sites, and evaluated the assumption of dose additivity that is routinely employed to calculate the r

203 ially, however, on the deviation from payoff additivity that occurs when both interacting individuals

204 polyploids can show deviation from parental additivity (the arithmetic average of the parental expre

205 Assuming additivity, these five interactions can contribute 7.4 k

206 ured by real-time polymerase chain reaction, additivity to clinical factors, and reclassification of

207 controlled through controlling the amount of additivities using the MCU.

208 0 +/- 4.1 kcal/mol that agrees with the bond additivity value of 109.3 +/- 2.1 kcal/mol.

209 Neighbor-pair additivity was also observed for (dA@dT)-tracts at melti

210 Additivity was assessed by estimating the reduced excess

211 Good additivity was found for the concerted action of magaini

212 Additivity was found to work well for m-benzoquinone, bu

213 Considerable departure from additivity was not observed for other defects.

214 nonsilent sites than in silent sites, while additivity was observed only in silent sites.

215 dest additive antitumor effects; however, no additivity was observed with maximal VEGF inhibition in

216 as observed in intact cell studies, and this additivity was recapitulated in experiments in which act

217 To explain this unexpected additivity, we examined the Epo gene and found that its

218 However, no analyses for additivity were conducted in these studies.

219 additivity, although slight deviations from additivity were observed at a few mixture concentrations

220 ations to individual networks, but had lower additivity when measured by the average effect of a gene

221 t was with beta2GRK(-), with no evidence for additivity when PKA sites were also removed.

222 There was also evidence of PCB-DDE additivity, where exposure to both compounds reduced ant

223 consistent with neighbor-pair thermodynamic additivity, where the stability constant, sij , for diff

224 start with the evaluation of consistency and additivity with a sufficiently large number of different

225 dot1Delta, but rad18Delta and rad5Delta show additivity with bre1Delta, dot1Delta, and each other.

226 and degradation of this protein, and showed additivity with N-benzoyloxycarbonyl (Z)-Leu-Leu-leucina

227 ibiting synergy with platinating agents, and additivity with paclitaxel.

228 ver, this effect was transient and showed no additivity with shock.

229 Deviations from parental chromosome additivity within T. mirus individuals also did not reac

230 th the moxifloxacin-linezolid regimen in the additivity zone vs 0.083 +/- 0.011 per day with standard