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1 the damaged DNA strand on both sides of the adduct.
2 dehydration process is mediated by the A5OH adduct.
3 iperidines from a readily available bicyclic adduct.
4 nsity for inserting a wrong nt opposite this adduct.
5 d by silylative esterification of a mono-CO2 adduct.
6 me involved in the formation of the covalent adduct.
7 rearrangement produces the formal [6F + 4T] adduct.
8 ion, presumably containing the beta-anomeric adduct.
9 enables error-prone DNA replication past the adduct.
10 nine amino acid peptide containing the OPNA adduct.
11 Si)2O, yielding the [(Me3SiO)Ce(IV)(TriNOx)] adduct.
12 cal formation of a cysteinyl-flavin covalent adduct.
13 rally characterized hyponitrito-dicopper(II) adduct.
14 2-fold higher than that induced by 8-oxo-dG adduct.
15 tal observation of formation of a stable CO2 adduct.
16 w propensity to form electrospray ionization adducts.
17 single exposures and measuring up to several adducts.
18 metabolism of BaP, and formation of DNA-BaP adducts.
19 th substrate atoms and the axial ligation of adducts.
20 elective formation of the halofunctionalized adducts.
21 (high in beta) in forming the probe-protein adducts.
22 obtained absolute configuration of the final adducts.
23 gate the mechanochemical activation of these adducts.
24 n triggered by boranes to afford cAAC-borane adducts.
25 sis for detecting ultratrace levels of these adducts.
26 ws that soluble proteins acquire fewer lipid adducts.
27 tro-Diels-Alder reactions of furan/maleimide adducts.
28 amics of hard-hard, hard-soft, and soft-soft adducts.
29 to generate four stereoisomeric BP-N (2)-dG adducts.
30 e efficient synthesis of Rauhut-Currier-type adducts.
31 algorithm can be used to detect putative DNA adducts.
32 hat can lead to both of the proposed [6 + 4] adducts.
33 th online trapping to enrich bulky, nonpolar adducts.
34 G challenge or to accumulation of MG protein adducts.
35 can react with DNA to form carcinogenic DNA adducts.
36 to energetically more stable diastereomeric adducts.
37 ragmentation spectra (MS2) of peptide-ligand adducts.
38 , than capillary LC-NSI/MS/MS assay of these adducts.
39 enecarbenes, were intercepted as Diels-Alder adducts.
40 identification of hydrophobic peptide-ligand adducts.
41 can react with DNA in the films to form DNA adducts.
42 rotein modification that furnish homogeneous adducts.
43 me electrophilicity of the putative C-NacNac adducts.
44 uely blocks excision repair of cisplatin-DNA adducts, 1,2-intrastrand cross-links, to potentiate the
45 xidation of naphthazarin quinone Diels-Alder adduct 10 is additionally demonstrated and enables us to
47 lective radical cyclization of the resulting adducts 3 to provide the cyclized gem-difluoromethylenat
49 ses in formation of 4-hydroxynonenal protein adducts accompanied by evidence of stellate cell activat
54 Product mass suggests formation of a GDP(S) adduct along with a second thiophosphorylation, implying
56 solubility and ionization of peptide-ligand adducts and collision-induced adduct loss hinder the acq
58 ly after summing the signal intensity of all adducts and corresponding monoprotonated molecular ions
60 f ultraviolet-induced cyclobutane pyrimidine adducts and elevated sensitivity to ultraviolet, demonst
62 nates low-intensity fragments, isotopes, and adducts and may exclude relevant low-intensity compounds
64 ves (up to the undecamer), vinyl and ethanol adducts, and xanthene and xanthylium salt derivatives wh
67 ulfur atom and the Ru-H bond, the hydroalane adducts are found to be stronger Lewis acids and electro
71 vated by the Ru-S bond, but these hydroalane adducts are not to be mistaken as sulfur-stabilized alum
72 ride-ion affinities (FIAs) of the hydroalane adducts as well as DIBAL-H in its aggregation states sup
73 CLA both non-covalently and to form covalent adducts at Cys-34, suggesting potential modes for system
74 s of indoor combustion products, we profiled adducts at the Cys34 locus of human serum albumin (HSA)
75 n {Mo154}, which contains the supramolecular adduct based on the symmetric encapsulation of the Dawso
76 ve variant of this method gives access to an adduct bearing vicinal, highly substituted sp(3) stereoc
77 Remarkably, the thermally active distal-exo adduct becomes inert under tension due to poor mechanoch
78 ion of the BP-derived stereoisomeric guanine adducts.Benzo[a]pyrene (BP) is a carcinogen in cigarette
79 bis-adduct regioisomer and an uncommon mono-adduct beta-malonate C70 derivative were synthesized by
80 of a transient mixed-disulfide intermediate adduct between a protein cysteine and an attacking low m
81 e-equilibrium formation of a hydrogen-bonded adduct between TEMPOH and the pyridine base, and the add
84 used to locate "twin" ion peaks of peptides adducted by NAPQI and for shotgun proteomics via tandem
86 We demonstrate that a highly reactive CF3(-) adduct can be synthesized from alkali metal hydride, HCF
89 choring protein 12 (AKAP12) impeded platinum adduct clearance and prevented cAMP-mediated enhancement
93 In particular, formation of the GSH-N single adduct contradicts the traditional view that S alkylatio
95 in sensitivity, specificity, and breadth of adduct coverage to other tested adductomic methods with
97 und use as electron acceptors, because these adducts currently require laborious and time-consuming s
102 Wide-SIM/MS(2) successfully detected DNA adducts, derived from chemicals in the diet and traditio
103 the conformationally stable host/guest metal adducts display architectural ordering comparable to tha
105 , and peak height similarity to identify ion adducts, duplicate peak reports, and isotopic features o
106 ate key aspects of mitochondria electrophile adduct excretion and cell endocytic and exocytic pathway
108 the equilibrium between mono- and dipyridine adducts (extrapolated Keq,0 approximately 0.5 at 25 degr
109 the green intermediate is an oxo atom donor adduct, Fe-O horizontal lineI-Ph, or an Fe(V) horizontal
113 of the hydrogen atom transfer (HAT), radical adduct formation (RAF), sequential proton loss electron
114 d that the fast reaction corresponds to beta-adduct formation (the kinetic product), while the slow r
115 us electrophilic compounds, through covalent adduct formation at the C7-C8 olefin of PL, whereas the
117 nous FA causes only a modest increase in DNA adduct formation compared with the amount of adducts for
120 To some degree, hydride abstraction and adduct formation is observed, leading to [Ar*SnH2 (PtBu3
121 To this end, chemoassay analyses of the adduct formation of GSH with nine alpha,beta-unsaturated
122 roximately 180 degrees in response to either adduct formation or reduction of the isoalloxazine ring
123 ines, metabolite-generated DNA oxidation and adduct formation turnover rates from the array correlate
124 oved renal tubular damage, 4-hydroxynanoneal adduct formation, neutrophil infiltration, fibrosis, and
125 /-) silencing on steatosis, 4-hydroxynonenal adduct formation, oxidative stress, serum alanine amino
128 ect of transcription factor binding on bulky adducts formation varies, depending on the specific tran
129 sulting in the formation of BPDE-N(2)-dG, an adduct formed between deoxyguanosine and a diol epoxide
130 ion has been embodied as the Lewis acid-base adduct formed by metal halides (serve as Lewis acid) and
133 adduct formation compared with the amount of adducts formed by endogenous FA, raising the possibility
135 ine was present in free and hydrogen sulfite adduct forms and the measured total, free and percentage
137 unsaturated fatty acids by formation of urea adducts from three different sources was studied to eluc
138 the most common method for biomonitoring DNA adducts, generally targeting single exposures and measur
142 A catalytically relevant catalyst-substrate adduct has been observed, and its constitution elucidate
143 elivery of vesicles loaded with AX-B-protein adducts has been explored by microscopy techniques.
144 human DNA upon acid hydrolysis, BPDE-N(2)-dG adducts have rarely if ever been observed directly in hu
145 e chemical constitution of the retrieved DNA adducts hint at a direct link with an increase in NOCs a
146 report CD and UV-Vis spectroscopy studies of adducted human Hb that revealed loss of alpha-helical co
147 between X-OH and the N-atom of 3 to form the adduct IIIb, followed by chloride delivery from Me3SiCl
148 chondria, a source, yet not a sink, of AcroB adducts, illustrating that a mitochondrial constitutive
152 osed to constitute efficient Lewis acid-base adduct in the SnI2 deposition step to modulate its volum
153 vely, which is equivalent to 0.056 and 0.065 adducts in 10(8) normal nucleotides in 50 mug of DNA.
154 structures provide a view of cis-BP-N (2)-dG adducts in a DNA polymerase active site, and offer a bas
157 s a single diastereomer of the corresponding adducts in good to high yields, which, in turn, can be e
158 he interpretation that formation of AFB1-DNA adducts in hepatocytes seeds a population of mutations,
159 Importantly, the detection of cysteine-delta-adducts in human urine provided evidence for the biologi
161 enhanced clearance of intrastrand cisplatin-adducts in melanocytes or MC1R-transfected HEK293 cells.
162 reagent and used to identify peptide-steroid adducts in MS1 spectra via the stable heavy isotope pair
164 y inhibits repair of the major cisplatin-DNA adducts in TGCT cells by using the human TGCT excision r
165 icals, by simultaneously detecting their DNA adducts in the genome; some of which may induce cancer-c
166 Several anticancer agents that form DNA adducts in the minor groove interfere with DNA replicati
169 pturing oligonucleotides carrying bulky base adducts, including UV-induced cyclobutane pyrimidine dim
170 and carbamate prodrugs of aldehyde bisulfite adduct inhibitors were synthesized in order to improve t
172 sociation (CAD) of these methanol-eliminated adduct ions (MS(3) experiments) produced characteristic
173 The resulting boronate/thiosemicarbazone adduct is a medium-sized ring that forms rapidly and irr
174 all amount of dimethyl sulfoxide (DMSO), the adduct is able to move to a solvent-exposed conformation
176 R studies suggest that a R(1)R(2)HP.B(C6F5)3 adduct is initially formed and undergoes partial dissoci
177 We found that replication through the 3-dMeA adduct is mediated via three different pathways, depende
179 etween TEMPOH and the pyridine base, and the adduct is then oxidized by the ferrocenium in a bimolecu
180 ion of blocked ends with protein or chemical adducts is believed to be initiated by the MRN complex i
183 ted acetylation, an acetyl-cysteine covalent adduct, lending direct support to the 'ping-pong'-like c
188 peptide-ligand adducts and collision-induced adduct loss hinder the acquisition of quality MS2 spectr
189 database searches because collision-induced adduct loss was the dominant feature of collision-induce
191 LC-FAIMS-MS analysis of the doubly sodiated adducts ([M + 2Na - H](+)) of isobaric and coeluting ste
195 uctures of yeast Rev1 with three BP-N (2)-dG adducts, namely the 10S (+)-trans-BP-N (2)-dG, 10R (+)-c
196 NMR reveals that the drugs form a covalent adduct near the Ub-binding pocket leading to the disrupt
197 nd cross-links (ICLs) and bulky minor groove adducts normally recognized by Fanconi anemia and nucleo
198 that the 1,4-dihydropyridine-type of lysine adducts observed in atherosclerosis lesions are likely p
200 ding to the formation of a six-membered ring adduct, occurs through a very favorable pathway and that
205 f Cs-symmetric tris- and C2v-symmetric tetra-adducts of C70, which are the precursors of the mono- an
207 ability and can be extended to the bisulfite adducts of common warheads employed in the design of tra
208 discussion includes a comparison with cyclic adducts of GSH and furan metabolites as reported in lite
209 ant (CCS and K0) using singly charged sodium adducts of poly(ethylene oxide) monomethyl ether (CH3O-P
210 able to scavenge Lewis acidic MCl2; cagelike adducts of the in,in isomer, trans- Cl2(P((CH2)14)3 P) (
212 xal (MG) is a reactive metabolite that forms adducts on cysteine, lysine and arginine residues of pro
216 able to recognize both organophosphorus BChE adducts (OP-BChE) and BChE and provided equal binding af
220 When the primer terminates across from the adduct position, the addition of DMSO leads to the forma
224 ur knowledge, this is the most sensitive DNA adduct quantitation method yet reported, exceeding the s
230 Loss of this subunit impedes alkylation adduct repair kinetics and increases sensitivity to alky
231 leolytic cleavage of DNA at sites of protein adducts requires ATP hydrolysis at both sites, as does t
232 e sensor, formation of intrastrand Pt(II)-AG adducts rigidifies the oligo-AG probe, resulting in a co
233 een NO and the thiol produces a free radical adduct RSNOH(*), which reacts with a second NO molecule
237 DNA alkylation by NMs is a cationic NM-N7-dG adduct that can yield the imidazole ring-fragmented lesi
238 olecules and facilitates the formation of Ng adducts that are not detected with reactive cations such
240 lowed for the efficient synthesis of sulfone adducts that could be used as branch points for further
241 sulfonamide functionality formed diagnostic adducts that had lost a methanol molecule upon reactions
242 olymerases are unable to synthesize past DNA adducts that result from diverse chemicals, reactive oxy
243 zation sequence to afford formal Diels-Alder adducts that undergo a smooth gold-catalyzed double bond
244 malignancies by creating DNA lesions (i.e., adducts) that can result in mutations if left unrepaired
247 We incorporated a model for acylfulvene adducts, the stable 3-deaza-3-methoxynaphtylethyl-adenos
250 e performance of native mass spectrometry by adducting to protein and protein complex ions, thereby r
251 ting all organophosphorus nerve agent (OPNA) adducts to human butyrylcholinesterase (BChE) was develo
253 RNAPII targets these transcription-blocking adducts to undergo more rapid excision repair than adduc
254 NA adductome; the levels of 22 different DNA adduct types significantly increased upon the consumptio
256 ccluded DNA ends by removing Ku or other DNA adducts via an Mre11-dependent nucleolytic reaction.
257 corresponding Cf(III)-ligand-protein ternary adduct was characterized by X-ray diffraction analysis.
260 ial increase in the abundance of [M + Na](+) adducts was observed in samples from spinal cord with de
261 ation, while the intensity of the [M + K](+) adducts was stronger in those sections from mechanically
264 , and the proteomic analysis showed that ACR-adducts were formed on cysteine residues of some synapti
265 omers were obtained, while different solvent adducts were formed upon the use of different reagents.
266 of glyoxal, levels of these two cross-linked adducts were found to be significantly higher in nonsmok
267 In-vitro studies found that APAP protein adducts were increased at 1 h, followed by ALT increases
271 action was characterized and carbonyl-phenol adducts were produced firstly by epoxide-ring opening in
276 of a Lewis base generates a tetracoordinate adduct, which serves as an activating group, enabling fu
277 he four possible stereoisomeric BP-N (2) -dG adducts, which gives insights how Rev1 achieves error-fr
278 nt (kon (CN)) but a much more stable cyanide adduct with 3 orders of magnitude slower koff (CN) rate.
280 ral vicinal diamine forms an enamine-iminium adduct with alpha-ketoenones, and this undergoes a catio
284 cothiolates and reduces a mycothiol arsenate adduct with kinetic properties different from those of M
285 The simplest CI, CH2OO, is detectable as an adduct with protonated ethers, preferably with protonate
286 ich then forms a slowly reversible, covalent adduct with the thiolate form of active-site Cys191 2-VI
290 unambiguously the structure of the spin trap adducts with alpha-pinene CIs, the reaction was tested i
291 ynyl-tagged curcumin analog yielded abundant adducts with cellular protein that were decreased by pre
293 t reductive deoxygenation of the Diels-Alder adducts with Fe2(CO)9 followed by oxidative aromatizatio
294 ters may form also single, double and triple adducts with GSH involving beta-carbon attack at the muc
295 do complexes can form thiolato and sulfenato adducts with GSH, and react with H2 O2 generating hydrox
297 SPAAC reactive species, which rapidly forms adducts with RNA containing 2'-azidoadenosine (2'N3-A).
298 hod, we measured the levels of the three DNA adducts with the use of 10 mug of DNA isolated from cult
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