ライフサイエンスコーパス: adduct formation

1 and 11-HETE but did not inhibit HepsilondGuo-adduct formation.

2 nderstanding the mechanistic implications of adduct formation.

3 mbiguous assignment of the regiochemistry of adduct formation.

4 contact with the cysteine sulfur involved in adduct formation.

5 hotochemistry indicative of cysteinyl-flavin adduct formation.

6 much interest has focused on the role of DNA adduct formation.

7 (ERK)2 with hypothemycin confirmed covalent adduct formation.

8 s in 4-hydroxy-2-nonenal and 3-nitrotyrosine adduct formation.

9 relationship between PhIP metabolism and DNA adduct formation.

10 hat thiols serve to scavenge dopaquinones by adduct formation.

11 governing detoxification through the rate of adduct formation.

12 5'-neighboring (Me)C inhibited O(6)-guanine adduct formation.

13 hannels include multiple proton transfer and adduct formation.

14 fusion in vitro as measured by nitrotyrosine adduct formation.

15 s no increase in the extent of cisplatin-DNA adduct formation.

16 cisplatin inactivation or inhibition of DNA adduct formation.

17 perties inherent to phenolic compounds after adduct formation.

18 ut do not reduce the extent of cisplatin-DNA adduct formation.

19 , and subsequent dehydration is proposed for adduct formation.

20 t with the perturbations expected upon C(4a) adduct formation.

21 , genomic hypomethylation, and/or enzyme-DNA adduct formation.

22 flavin charge-transfer intermediate prior to adduct formation.

23 -1-pyrroline N-oxide (DMPO) hydroxyl radical adduct formation.

24 ique class of fatty acids involved in HNE-dG adduct formation.

25 in a mechanism-based reaction involving heme adduct formation.

26 d by O3 exposure causes observable lipid-LXR adduct formation.

27 to and including enzyme-nucleotide covalent adduct formation.

28 ation at the active site and not to covalent adduct formation.

29 ible relevant biological context for in vivo adduct formation.

30 added base is suppressed by Lewis acid/base adduct formation.

31 ion of two mechanisms, gene reactivation and adduct formation.

32 ion by AFB1 epoxide contributes favorably to adduct formation.

33 nd TOR significantly enhanced endogenous DNA adduct formation.

34 (RNA-p-DNA) is a poor substrate for covalent adduct formation.

35 nsfer, hydrogen atom abstraction and radical adduct formation.

36 ol moiety, thus leading to catalyst-acceptor adduct formation.

37 ess through reversal of formaldehyde-protein adduct formation.

38 tensity enhancement concomitant with protein adduct formation.

39 ation, and there are no complications due to adduct formation.

40 503034 (boceprevir) benefited from covalent adduct formation.

41 ound that this insult leads to retinal isoLG-adduct formation.

42 rresponds to H154R of L-A Gag, abolishes cap adduct formation.

43 target for thiol-reactive molecules through adduct formation.

44 loxifene bioactivation, based on glutathione adduct formation.

45 n of metal-BMAA complexes in addition to the adduct formation.

46 operoxide was responsible for endogenous DNA-adduct formation.

47 and, at the same time, reduces analyte-salt adduct formation.

48 Feeding 5% LBRs also significantly inhibited adduct formation (64%) after NMBA administration at 0.50

49 However, MDA adduct formation, a marker of lipid peroxidation, was no

50 os found in vivo resulted in protein monomer-adduct formation across a range of concentrations.

51 hown that benzo(a)pyrene diol epoxide (BPDE) adduct formation along the nontranscribed strand of the

52 Slow adduct formation also occurs starting with NADH and INH,

53 ation of even-electron molecular ions due to adduct formation also plays a major role in ion formatio

54 pendent aspects, i.e., (i) peak splitting by adduct formation and (ii) protein ion suppression.

55 tation of LKB1 lysine residue 97 reduced HNE adduct formation and attenuated the effect of HNE on LKB

56 correlations were found between pimonidazole adduct formation and both baseline tumor R2* (r = -0.54,

57 The frequency of DNA adduct formation and c-Ha-ras mutations was the same in

58 and the H154R mutation abolishes both m(7)Gp adduct formation and cap snatching.

59 ations demonstrate a correlation between DNA adduct formation and carcinogenicity for these compounds

60 prevented 5, 5-dimethyl-1-pyrroline N-oxide adduct formation and changed the spectra of the MNP and

61 NE (10 mum for 1 h) and assayed for HNE-LKB1 adduct formation and changes in LKB1 kinase activity.

62 he cause and effect relationship between HNE adduct formation and COX inhibition was examined in vitr

63 Kinetic analysis of O2(*-) adduct formation and decay using singular value decompos

64 The kinetics of adduct formation and decay were measured which enabled q

65 ed only marginal protection against [3H]BPDE adduct formation and did not affect sensitivity to BPDE-

66 t not arginine completely abrogated covalent adduct formation and DNA cleavage, whereas the DNA-bindi

67 O-aspirin 2 inhibited [3H]benzo[a]pyrene-DNA adduct formation and DNA damage elicited by TCDD or benz

68 for dichloromethane genotoxicity (i.e., DNA adduct formation and gene mutations in target tissues in

69 HNE adduct formation and HO-1 expression were assessed by im

70 h tandem mass spectrometry confirmed monomer adduct formation and identified the major adduct species

71 have developed methods to measure cisplatin adduct formation and its repair at single-nucleotide res

72 ultraviolet A-induced 8-methoxypsoralen-DNA adduct formation and p53 protein accumulation were inhib

73 These findings demonstrate that adduct formation and protein ion suppression are indeed

74 direct proof of CYP1B1-mediated, E2-induced adduct formation and provide the experimental basis for

75 of NAEbeta mutants revealed slower rates of adduct formation and reduced adduct affinity for the mut

76 vely or quantitatively about MMC-induced DNA adduct formation and repair in vivo.

77 Both sequence-dependent adduct formation and repair may contribute to these muta

78 ults strongly suggest that both preferential adduct formation and slow repair lead to hotspots for mu

79 quitin adducts suggest that both the rate of adduct formation and the affinity between the adduct and

80 nd determine the relationship between stable adduct formation and turnover.

81 nge assays, and both a slow rate of covalent adduct formation and weak adduct binding to Uba6 contrib

82 g domain, protects the protein against DOPAL adduct formation and, consequently, inhibits DOPAL-induc

83 d a protective effect at the initiation (DNA adduct formation) and promotional (aberrant crypt foci)

84 s metabolic stability, plasma stability, GSH adduct formation, and aniline mutagenicity.

85 -Im induce cytoprotective genes, inhibit DNA adduct formation, and dramatically block hepatic tumorig

86 We quantified the cytotoxicity, DNA adduct formation, and induction of mutations in the cII

87 hich involves redox cycling and nucleophilic adduct formation, and it suggests possible routes of syn

88 cumulation and extravasation, chlorotyrosine adduct formation, and liver injury were reduced.

89 ation of nonmolecular ions, which arise from adduct formation, and the possibility of distinguishing

90 Covalent flavin adduct formation appears to be the only modification bec

91 For most carbonyls, rate coefficients for adduct formation approach the predicted maximum collisio

92 interactions), and product stabilization via adduct formation are found to be crucial for facilitatin

93 gene, suggesting that factors other than NNK adduct formation are responsible for mutagenesis at thes

94 Sites of the 2'-O-adduct formation are subsequently scored as stops to pri

95 rrelation suggests that H-abstraction and Cl-adduct formation are the major reaction mechanisms.

96 and also on intermediate markers such as DNA adduct formation, are discussed.

97 The method has application in studies of DNA adduct formation as a biological marker of exposure to c

98 arly complete protection against HNE-protein adduct formation as well as HNE-induced apoptosis.

99 both stable and unstable (depurinating) DNA adduct formation as well as reactive oxygen species.

100 The extent of adduct formation at (15)N-labeled guanine was determined

101 Overall, the precise location of adduct formation at C5 vs C8 of guanine appears to be di

102 t codon 14 but did not affect carcinogen-DNA adduct formation at codon 12.

103 codon 12 also did not enhance carcinogen-DNA adduct formation at codon 12.

104 of codon 14, greatly enhanced carcinogen-DNA adduct formation at codon 14 but did not affect carcinog

105 This preferential carcinogen-DNA adduct formation at codons 12 and 14 could result from e

106 In contrast, this preferential DNA adduct formation at codons 12 and 14 was not observed in

107 positive effect of 5-methylcytosine on BPDE adduct formation at CpG sites was also documented with s

108 reveal that RNF4 depletion impairs ubiquitin adduct formation at DSB sites and causes persistent hist

109 duct formation at those sites while reducing adduct formation at non-CpG sequences.

110 us electrophilic compounds, through covalent adduct formation at the C7-C8 olefin of PL, whereas the

111 ge) protein, couples light-induced cysteinyl adduct formation at the flavin ring to conformational ch

112 CpG sites greatly enhances MC and MS-NMA DNA adduct formation at those sites while reducing adduct fo

113 sures to aflatoxin (AFB1) and subsequent DNA adduct formation being a significant driver.

114 high in magnitude as -4, with the degree of adduct formation being inversely related to dendrimer ge

115 asis for this effect, demonstrating covalent adduct formation between 1 and the protein.

116 CO poisoning also causes adduct formation between myelin basic protein (MBP) and

117 uppression of the effect of the variation of adduct formation between samples, and (4) normalization

118 The reaction proceeds by preliminary adduct formation between the alkyne and OH radical, with

119 RIP3-deficient mice had no effect on protein adduct formation but attenuated all other parameters, in

120 tract the proton from Ser 195 in tetrahedral adduct formation but not so strong that its conjugate ac

121 tion hotspots coincided with sites of strong adduct formation, but not all of the adduct hotspots wer

122 e laboratories observed different amounts of adduct formation, but this did not appear to be related

123 e related to carcinogenesis, we measured DNA adduct formation by (32)P-postlabeling in liver, kidney,

124 an hepatic cytosolic samples to catalyze DNA adduct formation by 3-NBA.

125 n hepatic microsomal samples to catalyze DNA adduct formation by 3-NBA.

126 Intrastrand adduct formation by DEB was investigated by a novel meth

127 Inhibition of adduct formation by dicoumarol, an NQO1 inhibitor, suppo

128 able to conditions of immunoprecipitation or adduct formation by eight cross-linkers of diverse space

129 e mutagenicity and potential consequences of adduct formation by reactive intermediates in target ute

130 The kinetics of reversal of adduct formation by release of the conjugated 2,4-diene

131 Covalent adduct formation by sulfamethoxazole hydroxylamine was d

132 d in the minor groove of DNA is critical for adduct formation by the endogenous mutagens MDA and base

133 rders of magnitude than the rate of covalent adduct formation by the wild-type topoisomerase, but is

134 forth in which silane is activated via sigma-adduct formation cis to the ReX bond followed by heterol

135 Furthermore, sodium adduct formation commonly occurs using positive ion ESI

136 nous FA causes only a modest increase in DNA adduct formation compared with the amount of adducts for

137 on; (b) glutathione levels; (c) platinum-DNA adduct formation; (d) platinum-DNA adduct removal; and (

138 The rate of a given adduct formation depended on the combination of the solu

139 multiple proton transfer, with the degree of adduct formation dependent upon both the size of the pol

140 A sequences, with over 5-fold differences in adduct formation depending on sequence context.

141 nding with low-energy barriers or stable CO2 adduct formation depending on the phosphines donor abili

142 to a significant extent by HNE, but some HNE-adduct formation did occur.

143 Adduct formation disrupts hydrogen bonding in the active

144 e potential and terminating in oxidative DNA adduct formation, DNA strand breakage, and cell death.

145 east) an F(+) for O transposition occurs via adduct formation followed by 1,3-atom transfer and then

146 )2) showed that it proceeded by initial MeNC adduct formation followed by an isomerization involving

147 Several mechanisms are proposed for O2 adduct formation followed by decomposition to NO3- or by

148 Y(2)BCl, or by initial (heteroarene)AlCl(3) adduct formation followed by deprotonation and transmeta

149 the CYP1B1-mediated oxidation reaction, the adduct formation followed Michaelis-Menten kinetics.

150 Corresponding changes in spin adduct formation, found with electron paramagnetic reson

151 utilizes discrete oxidizing species in heme adduct formation from aldehydes.

152 mechanism of tumorigenesis that involves DNA adduct formation from COX-2-mediated lipid peroxidation

153 LS are reported to increase hydroxyl radical adduct formation from hydrogen peroxide as measured by s

154 nine markedly decreased the observed O(2)(.) adduct formation; however, O(2)(.) generation from the e

155 rmore, vitamin E diminished aldehyde-protein adduct formation in activated extracts, which suggests t

156 The method can be applied to compare AA-DNA adduct formation in cells and tissues.

157 psoralen, have been shown to direct psoralen adduct formation in cells, leading to mutagenesis or rec

158 induced cytotoxicity, mutagenicity, and DNA adduct formation in Chinese hamster ovary (CHO) cells.

159 e charge carriers show essentially exclusive adduct formation in converting protonated peptides and p

160 LOV2 showed a nearly 5-fold slowing of adduct formation in D(2)O relative to H(2)O, indicating

161 , the results suggest a causal role for drug adduct formation in diclofenac enteropathy.

162 ulted in 70-90% reduction in the covalent 3H-adduct formation in DNA or RNA isolated from the GSTP1-t

163 Adduct formation in duplex DNA was somewhat dependent on

164 ces liver tumors in rodents and covalent DNA adduct formation in hepatic DNA.

165 Inhibition of DNA adduct formation in human liver microsomes by alpha-lipo

166 ization, and a lack of information regarding adduct formation in mass spectrometry techniques utilizi

167 only one low-energy transition structure for adduct formation in mPW1K calculations, but quasiclassic

168 nuclear DNA mutations and demonstrated B[a]P adduct formation in mtDNA.

169 sk factor for breast cancer, we measured DNA adduct formation in normal breast tissues treated in vit

170 Dapsone hydroxylamine also caused covalent adduct formation in normal human epidermal keratinocytes

171 used to investigate the question of TAM-DNA adduct formation in primates.

172 not due solely to the blocking of sensitizer adduct formation in skin.

173 ptake, aqueous reactivity, and extent of DNA adduct formation in the A2780 ovarian carcinoma cells fo

174 associated with increased nitrotyrosine (NT) adduct formation in the lungs, heart, and plasma and inc

175 m treated women, suggesting that dG-N(2)-tam adduct formation in the p53 gene is not a prerequisite f

176 By comparing 3-NBA-DNA adduct formation in the presence of cofactors of NAD(P)H

177 nding were evinced by inhibition of covalent adduct formation in the presence of salt and magnesium.

178 of analytes in the MALDI plume and reducing adduct formation in the resulting mass spectra.

179 h which to evaluate the potential for LG-DNA adduct formation in vivo.

180 the possible pathways of MMC metabolism and adduct formation in vivo.

181 Hepatic DNA adduct formation, in vivo mutagenicity, and hepatocarcin

182 ) were added to cytosolic samples, 3-NBA-DNA adduct formation increased 10- to 35-fold.

183 etween the 2 sexes with higher levels of DNA adduct formation, increased CYP1A1 expression, decreased

184 Analysis of initial rates of adduct formation indicated that these reactions did not

185 h potassium cyanide prevented detectable MNP adduct formation, indicating heme involvement in the rea

186 By increasing DNA-platinum adduct formation, indicating increased access of the dru

187 of NDH significantly inhibited NDH-DMPO spin adduct formation, indicating involvement of protein thiy

188 17 alone, indicating that Seco A-LXR protein adduct formation inhibits LXR activation by traditional

189 derived from the clustering of platinum-DNA adduct formation into three distinct groups spanning a 3

190 ion electrospray mass spectra indicate that adduct formation involves coupling of the DNA to the ant

191 DNA damage by adduct formation is a critical step for the initiation o

192 results suggest that targeted carcinogen-DNA adduct formation is a major reason for the observed high

193 alase-peroxidase (KatG) function, and IN-NAD adduct formation is catalyzed in vitro by M. tuberculosi

194 The monopyridine adduct formation is confirmed in solution by (1)H DOSY (

195 d substrate-assisted inhibition via covalent adduct formation is entirely consistent with the three-s

196 Calculations predict that the trans adduct formation is favored in alkoxycarbonyl nitrones,

197 ut the free energy loss in the initial Cu/Pd adduct formation is high.

198 Adduct formation is mediated through the boron atom of A

199 es, respectively, suggesting that bis-N7G-BD adduct formation is more efficient under low exposure co

200 Adduct formation is not prevented by mutating any of the

201 To some degree, hydride abstraction and adduct formation is observed, leading to [Ar*SnH2 (PtBu3

202 A structural model of adduct formation is presented, and binding constants are

203 To test whether a selectivity of AFB1 adduct formation is related to this peculiar mutational

204 s not induce p53R2, suggesting that DNMT/DNA adduct formation is the molecular trigger for p53R2 indu

205 Because VC acts by genotoxic mechanisms, DNA adduct formation is thought to be a sensitive biomarker

206 The stoichiometry of the adduct formation is two mole of TEMPOL consumed for one

207 exposure does not change the total BPDE-DNA adduct formation, it significantly inhibited the repair

208 percoiling, indicating that acrolein-protein adduct formation itself does not directly interfere with

209 Adduct formation itself is not associated with cisplatin

210 The rate constant for monofunctional adduct formation, k(MF), for 1 (0.87 M(-1) s(-1)) is 3.5

211 Despite DNA adduct formation, localized fork stalling was abrogated

212 Experimental evidence suggests that PAH-DNA adduct formation may preferentially target methylated ge

213 their vulnerability to cytotoxicity and DNA adduct formation mediated by activated PhIP metabolites.

214 d PIAS4 are required for effective ubiquitin-adduct formation mediated by RNF8, RNF168 and BRCA1 at s

215 The rate of adduct formation mediated by wild-type KatG was about 20

216 ulted in glutathione depletion, APAP-protein adduct formation, mitochondrial oxidant stress and perox

217 oved renal tubular damage, 4-hydroxynanoneal adduct formation, neutrophil infiltration, fibrosis, and

218 Sulfenamide, sulfinamide, and sulfonamide adduct formation occurred at Cys(34) (AalphaC-Cys(34)).

219 However, no increase in heptanone-etheno adduct formation occurred in the aspirin-treated cells.

220 To this end, chemoassay analyses of the adduct formation of GSH with nine alpha,beta-unsaturated

221 osslinked moiety with a free SH group; (iii) adduct formation of the latter with the N-maleimide moie

222 specificity and time course of covalent DNA adduct formation of the novel platinum-acridine conjugat

223 In addition, this study reports cationic adduct formation of urinary pteridines under ESI-positiv

224 2) in the presence of BSA were indicative of adduct formation of VO(acac)(2) with albumin of 1:1 stoi

225 esis that HNE inhibits LKB1 activity through adduct formation on a specific reactive residue of the p

226 the structural perturbations induced by DAQ adduct formation on each of the three cysteine residues

227 as well as the influence of protonation and adduct formation on the conformations of drug metabolite

228 To determine whether oxidative adduct formation or heme oxygenase-1 (HO-1) expression a

229 roximately 180 degrees in response to either adduct formation or reduction of the isoalloxazine ring

230 ciated with a change in either cisplatin-DNA adduct formation or repair over time.

231 s for quantitative detection due to variable adduct formation over many compound classes.

232 kg) caused glutathione depletion and protein adduct formation, oxidant stress, mitochondrial release

233 /-) silencing on steatosis, 4-hydroxynonenal adduct formation, oxidative stress, serum alanine amino

234 Adduct formation, [(phen)M(C6H11O2)](+), occurs with Pt

235 es-Acr(+) is observed to engage in off-cycle adduct formation, presumably as buildup of PhS(-) become

236 e oxygen species generation, Michael protein adduct formation, protein tyrosine phosphorylation, acti

237 Adduct formation provides an explanation for the dopamin

238 of the hydrogen atom transfer (HAT), radical adduct formation (RAF), sequential proton loss electron

239 electron proton transfer (SEPT), and radical adduct formation (RAF).

240 cated to measure reactive metabolite and DNA-adduct formation rates relevant to genotoxicity screenin

241 m mass spectrometry using acetonitrile as an adduct formation reagent.

242 and ADP, instead of ATP, indicating that the adduct formation reflects hydrolysis of ATP.

243 Adduct formation resulted in marked inhibition of alphaK

244 tion inhibition correlated with the level of adduct formation (S-59 > AMT > 8-MOP).

245 Between pH 3.7 and 9.5, adduct formation showed minimal pH dependence, and adduc

246 CR method, we have determined DB[a,l]PDE-DNA adduct formation sites and repair rates in carcinogen-ex

247 rimate showed discrete areas of pimonidazole adduct formation surrounding necrotic and caseous region

248 herent to nebulization, and thus avoids salt-adduct formation that can complicate ESI mass spectra.

249 s accompanied by concentration-dependent HNE adduct formation that was consistent with those found in

250 vant mutants demonstrates that for ubiquitin-adduct formation the presence or absence of the NH2-term

251 d that the fast reaction corresponds to beta-adduct formation (the kinetic product), while the slow r

252 Following adduct formation, the process of hydrazone formation may

253 (3) Psoralen-DNA adduct formation: The combination of 1.9 Joules/cm2 UVA

254 arbene 23a, and the mechanisms of the borane adduct formation to 26a-h, NMR spectroscopic investigati

255 of unstable PAH adducts, we compared stable adduct formation to apurinic site formation.

256 the first study directly linking tubulin-ITC adduct formation to cell growth inhibition.

257 r 11beta, which supplements conventional DNA adduct formation to promote cancer cell death.

258 ines, metabolite-generated DNA oxidation and adduct formation turnover rates from the array correlate

259 xyguanosine-N(2)-yl)-tamoxifen (dG-N(2)-TAM) adduct formation using TAM-DNA (DNA modified with dG-N(2

260 Phase I and Phase II drug metabolism on MMC adduct formation, using either glutethimide, 3,4,3',4'-t

261 of that in the parental line at 1 h, and DNA adduct formation varied from 10 to 38% of that in the se

262 ect of transcription factor binding on bulky adducts formation varies, depending on the specific tran

263 oxicity, cDDP cellular accumulation, and DNA adduct formation was compared in the CLDN3- and CLDN4-ex

264 No adduct formation was detected between lysine and the oth

265 e this with gene expression studies, PAH-DNA adduct formation was determined.

266 Adduct formation was inhibited by extracellular domain o

267 ence of ion-pairing reagents and solvents on adduct formation was investigated.

268 On the contrary, radical adduct formation was not affected in peroxisome prolifer

269 A significant elevation of free radical adduct formation was observed in the penumbra region dur

270 Similar adduct formation was observed when T(pT)(8) was treated

271 Significant adduct formation was seen at the third base of codon 249

272 The degree of adduct formation was significantly affected by MS settin

273 Therefore, DNA-adduct formation was studied in C57BL/6JAPC(min) mice, a

274 Radical adduct formation was suppressed by aminoguanidine, N-(3-

275 etabolic activation of 3-NBA, catalyzing DNA adduct formation, was also examined using microsomes of

276 Because oxidative stress and aldehydic adduct formation were high after arrest, we tested a sma

277 ependent T-cell responses and SMX-NO-protein adduct formation were observed in the spleen and in ingu

278 es, which resulted in increased APAP protein adduct formation, were observed in livers of APAP-treate

279 rations of salts lead to ion suppression and adduct formation, which mask or complicate ion signals.

280 asure site-specific cytosine methylation and adduct formation will improve our ability to understand

281 Baseline separation was achieved after adduct formation with alkali metal ions, however, and ef

282 Also, cholesteryl esters were detected via adduct formation with ammonium cations.

283 ovine serum albumin (BSA) resulted in linear adduct formation with both proteins.

284 ganic chelates of VO(2+) may be dependent on adduct formation with BSA and possibly other serum trans

285 have prepared [1-(13)C]MAP and evaluated the adduct formation with hemoglobin using (1)H-(13)C HMQC a

286 Comparisons of the extent of adduct formation with losses in enzymatic activity indic

287 Ipso adduct formation with protein thiols was demonstrated wi

288 Compound 9 was subsequently stabilized by adduct formation with pyridine (10).

289 PC cations undergo charge inversion via adduct formation with subsequent methyl cation and proto

290 bolites of paracetamol was mimicked by their adduct formation with the antioxidant glutathione.

291 er mitochondria could be attributable to HNE adduct formation with the enzyme complex.

292 by selenite is presumed to be the result of adduct formation with the essential thiols of this trans

293 roduct ion spectra characteristic of B[a]PDE adduct formation with the phosphate group of the 2'-deox

294 Thus, a folate analogue that is capable of adduct formation with the substrate on the enzyme active

295 mmation via mechanisms that are triggered by adduct formation with thiol redox switches.

296 pparent correlation between the rates of the adduct formation with thiols and of the topoisomerase II

297 ngle cysteine residues as reactive sites for adduct formation within each of the three subunits of th

298 Elevation of free radical adduct formation within the penumbra region during cereb

299 ted quinones also undergo arylation (Michael adduct formation) yielding covalent bonds with nucleophi

300 stry generated lysine radicals and led to C8 adduct formation, yielding 8-Lys-Sp and 5,8-diLys-Sp.