ライフサイエンスコーパス: adduction

1 observed in concomitant esotropia in maximal adduction.

2 had lid fissure narrowing and retraction in adduction.

3 a change to this residue, specifically, DMPO adduction.

4 al fissure narrowing and globe retraction in adduction.

5 within cytochrome c as novel sites of NAC-BQ adduction.

6 amino acids contribute to the selectivity of adduction.

7 ent (OCD) averaged 41 +/- 7 mum in 30-degree adduction.

8 kward 4 degrees farther in abduction than in adduction.

9 mycin activation and nucleophile (MeOH, DNA) adduction.

10 on, and retraction of the globe on attempted adduction.

11 , supraduction, infraduction, abduction, and adduction.

12 agments as the site of 5a-formylbicyclomycin adduction.

13 gaze, elevation, depression, abduction, and adduction.

14 ions included changes in gait, mobility, and adduction.

15 ted toward the 5'-direction from the site of adduction.

16 ure and retraction of the globe on attempted adduction.

17 eoxy structure of SNO-Hb that accommodate NO adduction.

18 observed at template sites 5' to the site of adduction.

19 e with hindlimb-specific defects in gait and adduction.

20 remental amounts of acyl-glycine ethyl ester adduction.

21 and, has essentially no effect on alkali ion adduction.

22 rmal duplex velocities returned to normal in adduction.

23 on via tyrosine nitration and 4-OH-2-nonenol adduction.

24 went oxidative dehalogenation or glutathione adduction.

25 B1, has been reported to be inhibited by HNE adduction.

26 dentify the sites and extent of iso[4]LGE(2) adduction.

27 topoisomerase II via redox-dependent protein adduction.

28 oach to detect styrene oxide-derived protein adduction.

29 DOX; immunoprecipitation confirmed Mrp1-HNE adduction.

30 ecially for downward saccades with the PE in adduction; (2) vertical drift was backward after upward

31 Reactive carbonyl (RC) adduction, a common feature of oxidative stress, has bee

32 ligonucleotide analysis arises due to sodium adduction, a problem that increases with molecular weigh

33 At low levels of adduction, addition of MutS to the reaction further decr

34 In 20-degree and 30-degree adduction, all eyes exhibited significant progressive te

35 Both adduction and abduction compress the peripapillary choro

36 olled central gaze and multiple positions of adduction and abduction in 26 orbits of 15 normal volunt

37 pillary choroid averaged 9-19 mum thinner in adduction and abduction than in central gaze (P < .02).

38 gaze and increasing (10, 20, and 30 degrees) adduction and abduction.

39 ome attributed to a combination of metal ion adduction and analyte conformation.

40 t is demonstrated that both N3-methyladenine adduction and cytotoxicity can be inhibited in vivo with

41 In addition, the adduction and femoral rotation increased internally at t

42 igosaccharides are described in which sodium adduction and fragmentation are avoided.

43 y is hindered by two processes: alkali metal adduction and fragmentation of the intact ionized molecu

44 negative ion electrospray MS in which sodium adduction and fragmentation were avoided.

45 However, success has been limited by cation adduction and high detection limits.

46 During abduction and adduction and internal and external rotation maneuvers w

47 of glenohumeral motion during abduction and adduction and internal and external rotation.

48 x additive can successfully eliminate cation adduction and lower the detection limits for DNA in the

49 ished research on aromatic amine-induced DNA adduction and mutagenesis are discussed.

50 In this model system, AFB(1)-induced DNA adduction and mutagenesis recapitulate the unique mutati

51 summarizes our current knowledge on the DNA adduction and mutagenicity of aromatic amines in relatio

52 a genotoxic mode of action, specifically DNA adduction and mutagenicity, for aromatic amines, which m

53 c pressure and the force exerted during claw adduction and observed a strong correlation between forc

54 rrelation was found between the sites of DNA adduction and positions of base substitution, as adducts

55 for some complexes to reduce high levels of adduction and to obtain accurate molecular mass measurem

56 orbit during primary gaze, upgaze, downgaze, adduction, and abduction were analyzed digitally to dete

57 including multimerization, nonproton cation adduction, and in-source fragmentation complicate interp

58 aut or lax in extension, flexion, abduction, adduction, and internal and external rotation.

59 triction or absence of abduction, restricted adduction, and narrowing of the palpebral fissure and re

60 ypically by absence of abduction, restricted adduction, and retraction of the globe on attempted addu

61 icular type of protein modification, pyrrole adduction, and that this may contribute to the pathogene

62 he most for downward saccades with the PE in adduction; and (5) the peak velocity-amplitude relations

63 such as the peak adduction moment (AddM) and adduction angular impulse (AddImp).

64 However, only the knee adduction angular impulse differed between subjects with

65 knee adduction moment and the external knee adduction angular impulse for the whole stance and for t

66 the peak knee adduction moment and the knee adduction angular impulse increased with K/L radiographi

67 Moreover, knee adduction angular impulse provides additional informatio

68 Peak knee adduction moment and knee adduction angular impulse were 19% and 30% higher, respe

69 external knee adduction moment and the knee adduction angular impulse were determined.

70 r suppressor gene that can result from these adductions are in turn correlated with specific cancers.

71 ss sections are largely independent of metal adduction as long as in-source excitation is minimized.

72 ant mutators identifies persistent cisplatin adduction as the cause for this acquired genome instabil

73 ated by analysis of kinetics for HNE Michael adduction at six targeted HSA histidine residues.

74 p elucidate the complex relationship between adduction at specific sites in DNA and the cytotoxicity

75 Adduction at the N7-position of G4 ([M]G, 4) is characte

76 uplex that were localized to the site of the adduction at X(7) x C(18) and its neighboring base pair,

77 ead to a significant reduction in sodium ion adduction but are not as effective as acetonitrile, acet

78 Adduction but not abduction was associated with signific

79 nward after downward saccades with the PE in adduction, but backward for downward saccades with the P

80 H242 adducts may be preferred products of adduction by lipophilic electrophiles and may comprise a

81 Enhancement of acrolein-DNA adduction by methylating CpGs in the supF sequence did n

82 thyl cytosines (MeC) on kinetics of p53 gene adduction by model metabolite benzo[a]pyrene-7,8-dihydro

83 ulations to improve understanding of protein adduction by N-phenylhydroxylamine (PhNHOH) and nitrosob

84 ryanodine receptor (RyR1) undergoes covalent adduction by nitric oxide (NO), redox-induced shifts in

85 ar, only Cys-3635, which undergoes selective adduction by NO, has been identified.

86 on the MALDI target plate was used to reduce adduction by sodium and other cations that are normally

87 Sodium adduction can preclude useful measurements when limited

88 etrics decreased when the viewing eye was in adduction, compared with primary position or abduction.

89 ied by mass spectrometry as sites of quinone adduction: Cys170, Cys392, Cys405, and Cys455.

90 pecific with respect to the AB&CR agent, and adduction depends upon the presence of endogenous levels

91 (1) misalignment (10-12 degrees vertical in adduction, down; 10-12 degrees torsional in abduction, d

92 In vitro studies revealed that RC adduction enhanced Ag presentation with Th2 polarization

93 Five classes of limb movements (abduction, adduction, extension, retraction, elevation) and four cl

94 The microenvironment at the site of adduction governs both the initial specificity and the s

95 Water adduction helps stabilize conformers that are otherwise

96 The functional relevance of this adduction, however, had not been evaluated.

97 ance imaging and biomechanical evidence that adduction imposes strain on the ONH and peripapillary ti

98 formation of 4-HNE-inhibitor of kappaBalpha adduction in both 4-HNE-treated hepatocytes and in the l

99 Sites of HNE adduction in human WRN were identified at Lys577, Cys727

100 ated HCC, we investigated AFB(1)-induced DNA adduction in relation to mutagenesis in transgenic mouse

101 opia and a posterior shift from abduction to adduction in simulated Brown syndrome.

102 Thus, tamoxifen-DNA adduction in the liver may not have as significant biolo

103 a mitotically quiescent organ, tamoxifen-DNA adduction in the liver may, at least partially, prevent

104 ch organic vapor exposure reduces alkali ion adduction in the positive mode involves the depletion of

105 the extent and site of 5a-formylbicyclomycin adduction, indicates an overall C6 symmetry for rho subu

106 The inability to elevate an eye in adduction is a common problem with a number of possible

107 ken together, the results show that (i) drug adduction is at T22 on the full-length substrate; (ii) t

108 Styrene oxide-cysteine adduction is predominantly involved in protein covalent

109 eness of this method for reducing sodium ion adduction is related to the low proton affinity (PA) val

110 soluble lysates is preferentially adducted, adduction is stereospecific with respect to the AB&CR ag

111 uggests that the mechanism for reducing salt adduction is the formation of small initial droplets wit

112 Because the major site of HSA adduction is the single free sulfhydryl group at Cys34,

113 the drug; (iii) it is most likely that drug adduction is via its C6 position to the 5' carbon of T22

114 Analysis of adduction kinetics together with HSA structure and targe

115 nds, in positive and negative mode and Cs(+) adduction, leads to a conclusive composition of Au329(SR

116 urements for even more complex systems where adduction levels have precluded study of intact complexe

117 Maximal adduction levels of 613-1130 pmol alachlor-albumin adduc

118 site of small ubiquitin-like modifier (SUMO) adduction, Lys-679 of Bcl11b, in a protein isolated from

119 ers of dynamic knee loading such as the peak adduction moment (AddM) and adduction angular impulse (A

120 hoes, there was an 18% reduction in the knee adduction moment (KAM) by 24 weeks with the mobility sho

121 Peak knee adduction moment and knee adduction angular impulse were

122 re is a significant relationship between the adduction moment and OA disease severity.

123 Prior to THR, the peak external knee adduction moment and peak medial compartment load were s

124 was used to calculate the peak external knee adduction moment and the external knee adduction angular

125 it analysis, and both the peak external knee adduction moment and the knee adduction angular impulse

126 Both the peak knee adduction moment and the knee adduction angular impulse

127 We found that greater adduction moment at the knee during activities contribut

128 ic knee pain was associated with higher peak adduction moment at the knee during activities, measured

129 have supported earlier findings that a high adduction moment at the knee during ambulation was most

130 The adduction moment at the knee during gait is the primary

131 If the adduction moment contributes to progression of osteoarth

132 The adduction moment correlated with the K-L grade in the le

133 d only 8.9% of the variation in maximum knee adduction moment for the group of patients with knee OA.

134 HA) level with disease severity and with the adduction moment in a subset of patients.

135 taken to investigate the hypothesis that the adduction moment normalized for weight and height is ass

136 improved, and statistical reductions in the adduction moment resulted in lower levels of vastus medi

137 he partial correlation between K-L grade and adduction moment was 0.71 in the left knees and 0.61 in

138 In the gait substudy, the adduction moment was greater in knees with a thrust comp

139 associated with the potential to reduce the adduction moment when walking at slower speeds and could

140 ed an 8% reduction in the peak external knee adduction moment with the mobility shoe compared with se

141 ed a 12% reduction in the peak external knee adduction moment with the mobility shoe compared with th

142 cessary to determine the contribution of the adduction moment, and its contribution in conjunction wi

143 ion beyond that available from the peak knee adduction moment, and may therefore be an important gait

144 For every 1.0-unit increase in adduction moment, there was a 0.63-mm decrease in joint

145 e knees, particularly the peak external knee adduction moment, which has been associated with the pro

146 The severity of the disease influenced the adduction moment-walking speed relationship; the individ

147 g, with an 11.9% reduction noted in the knee adduction moment.

148 gait analysis to determine the maximum knee adduction moment.

149 nt space width (r = -0.55), but not with the adduction moment.

150 late with joint space width but not with the adduction moment.

151 ith more-severe OA had significantly greater adduction moments (mean +/- SD 3.80 +/- 0.89% body weigh

152 ients with more severe knee OA had lower hip adduction moments compared with their matched control su

153 op new chronic knee pain had higher baseline adduction moments for all activities (P = 0.01), ranging

154 elf-selected walking speeds and maximum knee adduction moments of 44 patients with medial tibiofemora

155 e severe knee OA had greater first peak knee adduction moments than their matched control subjects (P

156 ed medial tibiofemoral OA should have higher adduction moments.

157 The subjects performed abduction-adduction movements of the index and little fingers and

158 The frequency content of abduction and adduction movements was recorded in 12 index fingers and

159 rve (nIV) produces intorsion, elevation, and adduction (not abduction).

160 d by IAB or BMCC in vitro indicated that IAB adduction occurred primarily in the central linker domai

161 Biotin-labeled OA-NO(2) showed this adduction occurs preferentially with latent forms of MMP

162 ia a novel mechanism that includes transient adduction of 3-DG by PM followed by irreversible PM-medi

163 Adduction of a 190-kDa protein with the reactive lipid p

164 istinct molecular ion species, involving the adduction of a singly charged cation, two singly charged

165 Sites of adduction of AalphaC to albumin were identified by data-

166 ansferases (GSTs) have been shown to inhibit adduction of activated PhIP metabolites to DNA in cell-f

167 The targeted adduction of aflatoxin B1- exo -8,9-epoxide (AFB1- exo -

168 In addition to previously reported adduction of beta(93)Cys of human Hb, two novel sites of

169 HNE adduction of blood proteins, such as human serum albumin

170 These data indicate that the bifunctional adduction of Cr to DNA phosphates (ICLs) constitutes a m

171 These findings indicate that adduction of Cys392 and Cys405 is important for the acti

172 dependent fashion indicative of irreversible adduction of dopaquinone to its nucleophilic active-site

173 S analysis of the peptide fragment confirmed adduction of either Tyr 127 or Tyr 129 residues.

174 ng environment upon electrophilic fatty acid adduction of functionally significant, nucleophilic cyst

175 The adduction of GAPDH and GSH by nitroalkenes significantly

176 e lipoxygenation of arachidonic acid and the adduction of glutathione to this eicosanoid backbone.

177 naling that acts to regulate the cholesterol adduction of Hh ligand or to affect Hh signaling in the

178 Adduction of IsoK to model proteasome substrates signifi

179 hesized that this was due to extremely rapid adduction of IsoLGs to proteins.

180 Taken together, our results suggest that adduction of LKB1 Lys-97 mediates the inhibitory effect

181 O3-derived oxysterols, our data demonstrate adduction of LXR with Seco A.

182 Covalent adduction of meta-azipropofol in vivo prolongs the prima

183 In vitro adduction of model peptides containing nucleophilic side

184 y regulated by S-nitrosylation, the covalent adduction of nitric oxide (NO)-derived nitrosyl groups t

185 The shift in mass was consistent with adduction of NQO1 by the reactive iminium derived from E

186 loenzymes produced a concentration-dependent adduction of PP2A subunits, as observed by Western blot

187 known whether these two effects result from adduction of quinone to the same amino acid residue(s) i

188 , as well as to prevent and even reverse the adduction of retinal proteins by the toxic aldehyde was

189 Adduction of salt to protein ions decreases with decreas

190 oMMP-7 and proMMP-9 proteolytic activity via adduction of the conserved cysteine switch domain thiola

191 pectrometry extended our previous finding of adduction of the FAD in the active site of NQO2 by an in

192 antibody light chains in a process involving adduction of the hydrophobic aldehyde to lysine side cha

193 A novel mechanism involving adduction of the NCS-chrom C-6 radical, generated by 2-m

194 Tail-slaps were initiated by an adduction of the pectoral fins, a manoeuvre that changed

195 Pick up, medial rotation and adduction of the stone would employ a two-muscle chain o

196 large human thumb accompanied by the strong adduction of the thenar, hypothenar, and palmar inteross

197 ysfunction (VCD) typically involves abnormal adduction of the vocal cords during inspiration, mimics

198 he pharynx was associated with brief partial adduction of the vocal cords.

199 te, these results reveal that the reversible adduction of thiols by nitro-fatty acids is a mechanism

200 method is applied to ubiquitin with multiple adductions of sodium and potassium, single and mixed pol

201 near regression showed significant effect of adduction on absolute OCD (slope 1.09 +/- 0.36 mum/degre

202 ecular modeling, the impact of BQ and NAC-BQ adduction on cytochrome c was visualized, revealing the

203 sines increased the rate constant 3-fold for adduction on G at the major reactive CpG in codon 248 vs

204 rganic vapors can dramatically reduce sodium adduction on protein ions in positive ion mass spectra.

205 ione-Cr(III)-DNA crosslinks with the site of adduction on the phosphate backbone.

206 e that was to be merged with a fast discrete adduction or abduction in the shoulder triggered by an a

207 ackward after upward saccades with the PE in adduction or abduction, onward after downward saccades w

208 ng reaching 3.1 +/- 0.4 degrees in 30-degree adduction (P < .0001).

209 both gantacurium and AV002 via the cysteine adduction pathway.

210 DNPs, which in turn result in increased DNA adduction, play a role.

211 Cys(34) adduction products and Cys-SO2H, Cys-SO3H, and Met(329)

212 sulfinamides were identified as the primary adduction products, which were stable following tryptic

213 hich is consistent with its preferential DNA adduction profile.

214 These studies revealed that isoketal adduction profoundly altered protein function, inhibitin

215 In addition, divalent metal adduction provided improved positive mode ionization eff

216 methylthiophenylethanols with an alpha-/beta-adduction ratio of 1.5.

217 The rate of this water adduction reaction can be used to distinguish the four h

218 Use of the water adduction reaction rate or the unreactive ratio provides

219 The selectivity of HNE in competing adduction reactions was evaluated by analysis of kinetic

220 These adduction reactions were inhibited by free KLH and by re

221 include analyte multiple charging and cation adduction (reduced sensitivity), oxidation of analyte on

222 es robustly correlated with the extent of RC adduction, regardless of the means of their generation.

223 me-modifying fragments and the nature of the adduction remain to be established conclusively, the inc

224 ich damage proteins and DNA through covalent adduction resulting in "oxidative injury".

225 identified AMPK as a direct target of 4-HNE adduction resulting in inhibition of both H2O2 and 5-ami

226 y adversely affect sensitivity and metal ion adduction results in an inaccurate molecular weight dete

227 ts indicate that site selectivity of protein adduction should be a critical determinant of the abilit

228 led to the identification of the 14-3-3 zeta adduction site (K120) by mass spectrometry.

229 eine of TR1 was characterized as the primary adduction site of the IQ-derived reactive iminium using

230 ween residues 68 and 80 in TM1 as the ligand adduction site.

231 most pronounced within the preferential DNA adduction sites along the cII gene after the treatment w

232 gene neither the preferential N-OH-AABP DNA adduction sites nor the induced mutational hotspots are

233 al methodologies to localize the binding and adduction sites of the photoactivatable irreversible coc

234 Five preferential DNA adduction sites were established, of which four were maj

235 ral gaze reaching 49 +/- 10 mum in 30-degree adduction (standard error of mean, P < .0001).

236 Further, the DNA adduction studies with the calf thymus DNA led to a mixt

237 Adduction temporally tilts and displaces the prelaminar

238 s a degree of crown-crown contact during jaw adduction that is unmatched among known crocodyliforms,

239 ith/without alkaline or alkaline earth metal adduction, the ratio of product ions resulting from eith

240 h we hypothesized was due to extremely rapid adduction to amines.

241 rans-dG-N(2)-BPDE and (-)-trans-dG-N(2)-BPDE adduction to be 26.5% and 17.5%, respectively.

242 s inhibited by electrophilic lipids by their adduction to Cys521 proximal to its catalytic center.

243 activation studies demonstrated irreversible adduction to hSERT by all ligands, but the reduced (S)-c

244 with G85R mutation show no difference in HNE adduction to NFH compared with controls.

245 en together, these studies indicate that HNE adduction to NFH is physiological, and its constancy fro

246 for biological effects mediated by covalent adduction to protein thiols.

247 This method of reducing sodium ion adduction to proteins is simple and requires no experime

248 significantly lower the extent of sodium ion adduction to the molecular ions of proteins and protein

249 and methylglyoxal while nonoxidative glucose adduction to the protein did not affect protein function

250 ons strongly support the hypothesis that HNE-adduction to tubulin is the primary mechanism involved i

251 the obtained results, we postulate that HNE adduction to WRN is a post-translational modification, w

252 These results suggest that Keap1 adduction triggers a switching of Cul3-dependent ubiquit

253 istance and to provide humeral abduction and adduction under cortical control.

254 s were in the 3'-direction from the sites of adduction; upfield changes associated with the styrene a

255 ot the major site of AFB1 adducts and strong adduction was also observed at codons 226, 243, 244, 245

256 This sulfate adduction was determined to result from migration of neu

257 tals, the functional consequence of isoketal adduction was examined using a model membrane protein (a

258 n-dependent increase in both alpha- and beta-adduction was observed in mouse liver microsomes incubat

259 Adduction was still observed while using the device, sug

260 e CpG methylation may intensify acrolein-DNA adduction, we examined whether the extent of CpG methyla

261 beta(93)Cys of human Hb, two novel sites of adduction were found; alpha(104)Cys and beta(112)Cys.

262 he primary sites of acyl-glycine ethyl ester adduction were located in the alpha2-helix of Ugi at Glu

263 en eyes had limitation of both abduction and adduction, whereas two had limitations only of abduction

264 Conversely, NBu4Cl does not cause any adduction, while dramatically reducing the protein ion y

265 h normal lung function, expiratory laryngeal adduction with closure of the upper airway occurs and li

266 generated by eNOS or iNOS regulates protein adduction with GSH.

267 in addition to that in sarcolemma; however, adduction with HNE inhibits Mrp1 activity.

268 LDL are efficiently sequestered by covalent adduction with LDL-based amino groups.

269 o compete with GSH and cellular proteins for adduction with reactive metabolites of APAP in vitro.

270 PCs are ionized via adduction with salts, whereas PSs ionize via hydrogen ab

271 ation of abduction, or of both abduction and adduction, with palpebral fissure narrowing and globe re