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1 ude more slowly than excitations in a single adenine nucleotide.
2 release and subsequent dephosphorylation of adenine nucleotides.
3 or the binding of both Ca(2+)/calmodulin and adenine nucleotides.
4 imulated the reaction only in the absence of adenine nucleotides.
5 104 functions at the physiological levels of adenine nucleotides.
6 ondrial distress by regulating the levels of adenine nucleotides.
7 described so far with unique specificity for adenine nucleotides.
8 rmed by AK into a cytotoxic mixture of three adenine nucleotides.
9 GRK2 largely reflects its lower affinity for adenine nucleotides.
10 it confers energy sensor function by binding adenine nucleotides.
11 odulated by a number of regulators including adenine nucleotides.
12 ines, the enzyme was unable to interact with adenine nucleotides.
13 ntracellular NAD, the metabolic precursor of adenine nucleotide 2nd messengers implicated in TRPM2 ga
15 N) ring conformation of the ribose moiety of adenine nucleotide 3',5'-bisphosphate antagonists of P2Y
16 igo(U) tail by reading the position of a key adenine nucleotide (A102) and pausing 5 uridine residues
18 lass of herbicides and strongly suggest that adenine nucleotide accumulation is a metabolic trigger f
19 e binding assays show that SAM competes with adenine nucleotide activation of RyR2, and the effects o
21 h as phenylephrine show an increase in their adenine nucleotide (AdN) content, respiratory activity,
24 These studies demonstrate that 2-substituted adenine nucleotides allosterically inhibit basal and lig
26 he A5 bulge, which consists of five unpaired adenine nucleotides, alters the direction of the helical
29 to a 2-A shift in the bound position of the adenine nucleotide and bringing it near the bicarbonate
30 he RYR1 was dependent on the presence of the adenine nucleotide and calmodulin and reflected a select
31 and NADPH (the reduced forms of nicotinamide adenine nucleotide and nicotinamide adenine dinucleotide
32 ts demonstrate transcription coordination of adenine nucleotide and nucleoside signaling at the vascu
33 the central pore protein ANT is regulated by adenine nucleotide and the activity of mitochondrial res
37 ding constants and specificity of RPAI-1 for adenine nucleotides and its functional significance.
38 In series 3, AICAR increased ileal tissue adenine nucleotides and metabolites during the shock per
39 se findings indicate that in the presence of adenine nucleotides and Mg2+,Ca2+-induced PTP in non-syn
41 ctivity; loosening of binding as a result of adenine nucleotides and phosphorylation may instigate mo
42 review the regulation of the KATP channel by adenine nucleotides and present an equilibrium allosteri
43 edly diminished capacity to phosphohydrolyze adenine nucleotides and regulate platelet reactivity, su
46 llular metabolism to the membrane by sensing adenine nucleotides, and are thus instrumental in mediat
47 ative action on other cell types, adenosine, adenine nucleotides, and related analogs may also repres
48 arginase 1, asymmetric dimethylarginine, and adenine nucleotides are all products of hemolysis that p
49 ucleotides, thus supporting a model in which adenine nucleotides are enzymatically converted to adeno
50 also indicate that MMS-induced mutations at adenine nucleotides are significantly enriched on the no
52 tral to the mechanism by which adenosine and adenine nucleotides arrest proliferation in these cells.
53 ity, suggesting a failure to maintain matrix adenine nucleotides as a cause for premature delayed Ca(
54 P-binding site on Kir6.2, we used a range of adenine nucleotides as molecular measuring sticks to map
55 the native enzyme, utilizing acetyl-CoA and adenine nucleotides as preferred substrates and less eff
61 phy (HPLC) determination of tissue levels of adenine nucleotides (ATP, ADP, and AMP) and their interr
62 Adenylate kinase (AK)-catalyzed transfer of adenine nucleotide beta- and gamma-phosphoryls has been
66 form include quinone (capsaicin), copper and adenine nucleotide binding domains, and two cysteines es
68 within the Mdm2 RING, we mapped the specific adenine nucleotide binding region of Mdm2 to residues 42
69 d whether SAM exerts its effects through the adenine nucleotide binding sites on the RyR2 channel.
70 e determined the functional relevance of two adenine nucleotide binding sites through site-directed m
75 egral membrane glycoprotein, a member of the adenine nucleotide-binding cassette (ABC) transporter fa
76 quinone-binding domain of complex I, flavin adenine nucleotide-binding moiety and quinone-binding po
79 sed-phase HPLC method by which separation of adenine nucleotides can be performed rapidly, allowing m
80 te that a bacterial actin, when activated by adenine nucleotides, can modify the length distribution
84 inct supercoiling reactions depending on the adenine nucleotide cofactor that is present in the react
85 synthetase from Thermatoga maritima and the adenine nucleotide complexes of the synthetase from Sacc
86 osphotransferases that regulate the cellular adenine nucleotide composition and play a critical role
89 receptor antagonists of acyclic analogues of adenine nucleotides, containing two phosphate groups on
91 on 1 (ERO1) is a conserved eukaryotic flavin adenine nucleotide-containing enzyme that promotes disul
94 advantage of the preferential adsorption of adenine nucleotides (dA) on gold, as previously demonstr
97 i's disease erythrocytes exhibit accelerated adenine nucleotide depletion in response to an increase
99 ng different sensitivity to block by various adenine nucleotides (EC(50) of 0.79 microm for [ATP](i),
100 function of this activity, we have examined adenine nucleotide effects on interactions of Escherichi
101 Selective enzyme cleavage required bound adenine nucleotide, either ATP or ADP, in the presence o
102 the PCA via a novel mechanism that involves adenine nucleotide-evoked adenosine release and the subs
103 s presumably associated with a modulation of adenine nucleotide exchange between mitochondria and cyt
104 tic inhibitors of mitochondrial AACs blocked adenine nucleotide exchange by the Neocallimastix protei
105 ation disrupts the gene Sil1 that encodes an adenine nucleotide exchange factor of BiP, a crucial ER
109 of islet loss in culture, quantification of adenine nucleotides, flow cytometric measurement of viab
111 at diffusional anisotropy may lead to modest adenine nucleotide gradients in the myoplasm under physi
112 ortant autocrine/paracrine functions for the adenine nucleotides have been proposed in several tissue
114 ssue concentrations of creatine phosphate or adenine nucleotides; however, it did correlate with incr
116 nzyme that contributes to the homeostasis of adenine nucleotides in eukaryotic and prokaryotic cells.
118 idely recognized activation of the enzyme by adenine nucleotides in plants is mediated in this manner
119 rain estimates of diffusional anisotropy for adenine nucleotides in the cardiac myofibril, using homo
121 of inflammation, multiple cell types release adenine nucleotides in the form of ATP, ADP, 5'-AMP, and
122 ility (hypoxia), multiple cell types release adenine nucleotides in the form of ATP, ADP, and AMP.
123 efined structure including unpaired, stacked adenine nucleotides in the stem and an unusual syn adeni
124 cosidic torsion angles, chi, deduced for the adenine nucleotides in these complexes are 51 degrees, 3
125 ious studies demonstrated that 2-substituted adenine nucleotides, including 2-methylthioATP (2MeSATP)
127 biochemical techniques, we demonstrate that adenine nucleotides induce large asymmetric conformation
129 he kinetic and thermodynamic consequences of adenine nucleotide interaction with the low-affinity and
130 to other ABC transporters, we have examined adenine nucleotide interactions with the multidrug resis
131 (AK2), a mitochondrial enzyme that regulates adenine nucleotide interconversion within the intermembr
132 ular adenosine involves phosphohydrolysis of adenine nucleotide intermediates, and is regulated by th
134 Mitochondrial ATP-Mg/Pi carriers import adenine nucleotides into the mitochondrial matrix and ex
135 ously reported and that a preincubation with adenine nucleotide is essential for the large activation
136 the suggestion that allosteric inhibition by adenine nucleotides is a general characteristic of the f
137 The specificity of the catalytic site for adenine nucleotides is established by specific hydrogen
138 assembly and outer membrane permeability for adenine nucleotides leading to energy deficit, 2) excess
140 e extraction procedure given that changes in adenine nucleotide levels take place very quickly when A
141 annels) are designed as exquisite sensors of adenine nucleotide levels that signal changes in glucose
145 homo-dimers, but the translocation pore for adenine nucleotides lies in the center of the molecule a
147 ed that conformational changes, modulated by adenine nucleotides, mediate the interactions of MutL al
148 hypoxia signaling at several steps along the adenine nucleotide metabolism and adenosine receptor sig
149 e hypothesized that adenosine production via adenine nucleotide metabolism at the vascular surface tr
150 hat extracellular adenosine produced through adenine nucleotide metabolism during hypoxia is a potent
151 uggest that T cells express multiple NAD and adenine nucleotide-metabolizing activities that together
153 nd stored at 4 degrees C for 10days prior to adenine nucleotide (nmol/gw/w) profile determination.
155 enzyme in complex with CoA and show that the adenine nucleotide of this cofactor is bound in a distin
157 e (ecto-AK) contributes to the metabolism of adenine nucleotides on human airway epithelial surfaces
159 ynthesis DNA polymerase that readily inserts adenine nucleotides opposite photoproducts involving thy
161 a cancer-associated ENOX (tNOX or ENOX2) as adenine nucleotide or copper binding along with essentia
162 Adenosine may be formed intracellularly from adenine nucleotides or extracellularly through sequentia
163 diseases, where multiple cell types release adenine-nucleotides (particularly adenosine triphosphate
164 that adenosine, formed extracellularly from adenine nucleotides, plays a major role in the pathogene
165 point corresponds to reductions in the total adenine nucleotide pool (TAN) of approximately 30%, corr
166 anges in high-energy phosphate and the total adenine nucleotide pool are considered to be the critica
167 e latter two comprising >90% of the released adenine nucleotide pool as cells transitioned from the e
168 DF (150 nm) to produce growth inhibition and adenine nucleotide pool expansion comparable to that obs
169 chanisms that function to maintain the total adenine nucleotide pool in mature erythrocytes, which ar
170 -regulated to control the size of the matrix adenine nucleotide pool in response to cellular energeti
171 Adenylate kinase 2 (AK2), which balances adenine nucleotide pool, is a multi-functional protein.
173 g and loss of membrane ion gradients and the adenine nucleotide pool; (3) repair of damaged cell orga
174 in intracellular coenzyme A (CoA) esters and adenine nucleotide pools in microbial cells is described
175 t are triggered by Ca2+ and are modulated by adenine nucleotides, possibly from the matrix side of th
176 unctional ligands of GroEL such as Mg(2+) or adenine nucleotides produced differences in the observed
181 blood, is generated by phosphohydrolysis of adenine nucleotides released from cells and catabolized
183 ssing chamber studies of chloride secretion, adenine nucleotides released from the host by EPEC also
184 and hydropathy, and examined the effects on adenine nucleotide sensitivity in the absence and presen
185 nnel by Ca2+ and the block of the channel by adenine nucleotides show a mild voltage dependence, whic
186 a-ATP)) and exhibits sensitivity to block by adenine nucleotides similar to that of sulfonylurea rece
188 We determined the expression and function of adenine nucleotide-specific P2Y receptors on cord blood-
189 s with competing reactions that interconvert adenine nucleotides such as in permeabilized cells that
190 onin, or maintain outer membrane exchange of adenine nucleotide, such as Bcl-x(L), restored ADP-depen
197 various phosphorylated or non-phosphorylated adenine nucleotides that may even be better agonists tha
198 nse granule components such as serotonin and adenine nucleotides though near-normal numbers of dense
199 e of cellular activities; many of these bind adenine nucleotides through a conserved motif that is al
201 ect on the antiproliferative activity of the adenine nucleotides, thus supporting a model in which ad
206 een mitochondrial creatine kinase (MtCK) and adenine nucleotide translocase (ANT) can play an importa
210 nding puzzle is that in permeabilized cells, adenine nucleotide translocase (ANT) is less accessible
213 oside and bongkrekic acid, inhibitors of the adenine nucleotide translocase (ANT) that lock the trans
214 mely voltage-dependent anion channel (VDAC), adenine nucleotide translocase (ANT), and hexokinase II
215 or alpha induced RIP-dependent inhibition of adenine nucleotide translocase (ANT)-conducted transport
216 ibits all ADP-ATP-using reactions except the adenine nucleotide translocase (ANT)-mediated mitochondr
219 d increased proton transport activity of the adenine nucleotide translocase (dependent on fatty acids
220 ependent anion channel (outer membrane), the adenine nucleotide translocase (inner membrane) and cycl
221 hondria is known to be cardioprotective, and adenine nucleotide translocase 1 (ANT1) is a key mediato
223 ondria, to interact with and dephosphorylate adenine nucleotide translocase 1 (ANT1), a central molec
224 nd several mitochondrial proteins, including adenine nucleotide translocase 1 (ANT1), were more oxidi
225 olve saturated fatty acid stimulation of the adenine nucleotide translocase 2 (ANT2), an inner mitoch
226 increased oxygen consumption independent of adenine nucleotide translocase and uncoupling proteins,
228 cle depended on electron transport chain and adenine nucleotide translocase functionality, but it was
229 This study provides evidence for a role of adenine nucleotide translocase in the mechanism underlyi
231 ation, increased levels of the mitochondrial adenine nucleotide translocase stress-sensitive B (SesB)
232 the voltage-dependent anion channel and the adenine nucleotide translocase were similar in the two m
234 ction of both the F(1)F(O)-ATPase and of the adenine nucleotide translocase, which delivers nucleotid
235 ation/knockdown-induced dysregulation in the adenine nucleotide translocase, which results in a slowe
237 ds, these mitochondria also showed a greater adenine nucleotide translocase-catalysed proton conducta
242 rt (alpha-cyano-4-hydroxycinnamate, 0.5 mM), adenine nucleotide translocation (atractyloside, 0.3 mM)
245 d by the MPT because it was blocked with the adenine nucleotide translocator (ANT) ligand bongkrekic
246 e for cytosolic ADP(3-) via the electrogenic adenine nucleotide translocator (ANT) located in the mit
247 The authors hypothesized that mitochondrial adenine nucleotide translocator (ANT) reverses its activ
248 We examined the effect of inhibition of the adenine nucleotide translocator (ANT), a putative compon
249 the voltage-dependent anion channel (VDAC), adenine nucleotide translocator (ANT), and cyclophilin D
250 ays, we demonstrate that CyPD binding to the adenine nucleotide translocator (ANT), which is consider
251 parallel with accumulation of mitochondrial adenine nucleotide translocator (ANT), which provides a
252 e c oxidase subunit I (COI)] or nuclear DNA [adenine nucleotide translocator 1 (ANT1) and nicotinamid
253 Mutations in the heart and muscle isoform of adenine nucleotide translocator 1 (ANT1) are associated
254 n heavy chain-alpha, cardiac troponin-I, and adenine nucleotide translocator 1 (ANT1), have been iden
255 led inwardly rectifying K channel 2 (GIRK2), adenine nucleotide translocator 2 (ANT-2) and the growth
256 oteins and mPTP-regulatory elements, such as adenine nucleotide translocator and cyclophilin D (possi
257 e mechanisms of such degradation involve the adenine nucleotide translocator and mitochondrial permea
258 ealed GSH-adducted peptides corresponding to adenine nucleotide translocator and the alpha-subunit of
259 t by interacting with mitochondrial proteins adenine nucleotide translocator and voltage-dependent an
260 proach to "state 4" could be mimicked by the adenine nucleotide translocator inhibitor bongkrekic aci
261 rmed in mice in which the heart-muscle-brain adenine nucleotide translocator isoform 1 (ANT1) was ina
262 ltage-dependent anion channel protein or the adenine nucleotide translocator protein could not be dem
263 d or carboxyatractylate, suggesting that the adenine nucleotide translocator was not directly involve
264 ucleotides were abolished by blockade of the adenine nucleotide translocator with carboxyatractylosid
266 The mPT pore is thought to consist of the adenine nucleotide translocator, a voltage-dependent ani
267 ssette protein 1 (mABC1), phosphate carrier, adenine nucleotide translocator, and ATP synthase] assoc
268 ipitating proteins (succinate dehydrogenase, adenine nucleotide translocator, ATP synthase, inorganic
269 t contain voltage-dependent anion channel or adenine nucleotide translocator, were reconstituted into
276 oltage-dependent anion channel (VDAC) and/or adenine nucleotide transporter (ANT) or to inhibition of
279 serve a down-regulation of the mitochondrial adenine nucleotide transporter and suggest that this may
280 mitochondrial permeability transition pore, adenine nucleotide transporter and voltage-dependent ani
283 voltage-dependent anion channel, and/or the adenine nucleotide transporter, or by direct inhibition
288 ased mucosal perfusion, and increased tissue adenine nucleotides, which is consistent with preserved
289 ters a large part of the plastidial pools of adenine nucleotides, which limits photophosphorylation,
290 diated vesicle priming could be regulated by adenine nucleotides, which might provide a link between
291 residues had small effects on inhibition by adenine nucleotide, while substitution with neutral or n
295 constrained (N)-methanocarba modification of adenine nucleotides with other functionalities known to
296 ibition is mediated by direct interaction of adenine nucleotides with sGC, likely at the catalytic do
297 ly member with high sequence homology, binds adenine nucleotides with similar affinity and specificit
298 bolism, altering regulation of extracellular adenine nucleotides, with a resultant protective influen
299 om dephosphorylation was highly specific for adenine nucleotides, with ADP being the most effective l
300 dent changes in the intracellular pattern of adenine nucleotides, with AMP release dominating in the
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