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1 and hydrolysis of ATP, cAMP, AMP, and NAD to adenosine.
2 MBF to the same level as a standard dose of adenosine.
3 te than resting indices and does not require adenosine.
4 with the 5' splice site and the branch-point adenosine.
5 on MBF due to hypercapnia was compared with adenosine.
6 nitive performance do not explicitly include adenosine.
7 hancing the production of the ATP derivative adenosine.
8 increase in the generation of extracellular adenosine.
10 t requires the following: Gs-protein-coupled adenosine 2A receptor activation, new TrkB synthesis, an
12 th pharmacological and genetic inhibition of adenosine-2A receptor (A2AR) in culture and Lrp4 mutant
13 endent activating transcription factor (ATF)-adenosine 3',5'-monophosphate (cAMP) response element-bi
15 displayed reduced aggregation in response to adenosine 5'-diphosphate and epinephrine, but variable a
16 numerous agonists (collagen-related peptide, adenosine 5'-diphosphate, A23187, thrombin, or U46619).
17 negative and positive allosteric regulators, adenosine 5'-monophosphate (AMP) and fructose 1,6-bispho
18 tivity was stimulated to a greater extent by adenosine 5'-O-(thiotriphosphate) (ATPgammaS) than with
19 of the sulfate reductive pathway key enzyme, adenosine 5'-phosphosulfate reductase (APR, EC 1.8.99.2)
21 ins alter gene expression both by catalyzing adenosine (A) to inosine (I) RNA editing and binding to
24 ncreases the concentrations of adenosine and adenosine A1 receptors in specific regions of the brain.
25 inoid receptors present in the striatum, ie, adenosine A2A receptor (A2AR) and cannabinoid CB1 recept
26 e describe the spontaneous reconstitution of adenosine A2A receptor (A2AR) during the de novo formati
28 e reduced oxygen-induced neural apoptosis by adenosine A2A receptor (A2AR)-dependent mechanism, as re
31 esulted in discovery of potent and selective adenosine A2A receptor antagonists bearing substituted 1
32 s- and Golf-coupled dopamine D1 receptor and adenosine A2A receptor in the brain and other organs, el
34 ntially therapeutic dopamine D1 receptor and adenosine A2A receptor ligands with functionally selecti
36 ha), from dopamine D1 receptor-expressing or adenosine A2a receptor-expressing medium spiny neurons (
37 on of Th1 and Th2 cells in vitro depended on adenosine A2A receptors, which were also required for th
38 [2,1-f]purine-2,4-dione derivatives as human adenosine A3 receptor (hA3R) antagonists to determine th
42 hod for determining specificity of synthetic adenosine agonist compounds for the A2A and A2B receptor
44 ts, the stable 3-deaza-3-methoxynaphtylethyl-adenosine analog (3d-Napht-A), and smaller 3-deaza-adeno
45 ine analog (3d-Napht-A), and smaller 3-deaza-adenosine analogs, into DNA oligonucleotides to assess R
46 to test the hypothesis that changes in both adenosine and A1 receptor concentrations can capture cha
47 ttern implies that differences in endogenous adenosine and A1AR availability might be causal for indi
48 airments and increases the concentrations of adenosine and adenosine A1 receptors in specific regions
52 Mean perfusion defect volumes measured with adenosine and hypercapnia were significantly correlated
53 te, adenosine monophosphate) and nucleoside (adenosine and inosine) levels were quantified by high-pe
54 with endogenous activators of PKA, including adenosine and prostaglandin E2, results in a profound de
55 the quantum yield of 8-DEA-tC mispaired with adenosine and, separately, opposite an abasic site show
56 ridine monophosphate, inosine monophosphate, adenosine, and guanosine) and kokumi (gamma-l-glutamyl-l
57 tinal tract and unveil an important role for adenosine as a regulator of host-microbe interactions.
59 osition that overlaps with the native ligand adenosine, but its methoxyphenyl group extends to an exo
61 subject, (3) stress perfusion and CFR after adenosine compared with dipyridamole, (4) heterogeneity
63 Here we show that, apart from NAD+, another adenosine-containing cofactor FAD and highly abundant ur
65 e repair, we exploit the catalytic domain of Adenosine Deaminase Acting on RNA (ADAR2) that deaminate
66 AC)7 with the Zalpha-binding domain of human adenosine deaminase acting on RNA 1 (ADAR1, hZalphaADAR1
67 n directly inhibits editing, we do show that adenosine deaminase acting on RNA 1 and 2 and fibrillari
68 sine-to-inosine deaminase activity by ADAR2 (adenosine deaminase acting on RNA type 2) to transcripts
70 eic HSCT that has shown clinical benefit for adenosine deaminase-deficient (ADA-deficient) SCID when
71 o-inosine (A-to-I) RNA editing, catalyzed by Adenosine DeAminases acting on double-stranded RNA(dsRNA
74 ownregulate the adenosine triphosphate (ATP)/adenosine diphosphate (ADP) metabolite ratio which stron
75 sphate (ATP) and its first five catabolites: adenosine diphosphate (ADP), adenosine monophosphate (AM
77 e redox potential and adenosine triphosphate/adenosine diphosphate failed to reach a new steady state
79 2365 patients enrolled in the Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal
84 r 1) prevents it from inhibiting PARP1 [poly(adenosine diphosphate-ribose) polymerase], a critical DN
88 The effects of patient characteristics on adenosine dose required to produce atrioventricular bloc
89 t characteristic significantly predicted the adenosine dose to produce atrioventricular block or dura
90 e mRNA level, a disease-causing guanosine to adenosine (G > A) mutation in the mouse MeCP2 DNA bindin
91 These data support the thesis that local adenosine generated by cells at the injury site is criti
92 denosine levels supported a critical role of adenosine generated by proximal tubule CD73 expression i
94 etin and its isomer, while its reaction with adenosine generated kinetin riboside, as confirmed by co
99 aCO2) can increase MBF to that observed with adenosine in 3 groups of canines: without coronary steno
101 the pro- and anti-viral effects of methyl-6-adenosine in distinct viral life cycles, the role of 2'
102 ression, reducing the level of intracellular adenosine in endothelial cells, and activating the trans
103 nce exists for the role of immunosuppressive adenosine in promoting tumor growth and spread in a numb
104 we define a novel antimicrobial activity of adenosine in the gastrointestinal tract and unveil an im
107 was a close agreement of maximal saline- and adenosine-induced coronary flow reserve (intraclass corr
108 ography scans using rubidium-82 with various adenosine infusion protocols identified (1) the protocol
110 significantly 15.7% higher than the 4-minute adenosine infusion with rubidium-82 injection at 2 minut
111 rs are located in A-IC apical membranes, and adenosine injection increased urine adenosine concentrat
114 ing the stem leads to destabilization unless adenosine is the opposing basepair of 8-oxoGua; (ii) mod
115 ucleotidase (CD73), an enzyme that generates adenosine, is functionally important in modifying CB sen
116 al CO2 (PaCO2), particularly with respect to adenosine, is not well characterized because of challeng
117 Here we show that concentrations of ATP and adenosine, its metabolite, fall after treatment of mouse
120 We report that in healthy lowlanders, plasma adenosine levels are rapidly induced by initial ascent t
121 ent studies showed no change in total kidney adenosine levels in treated mice compared with vehicle-t
122 enzymatic activity of CD73 and extracellular adenosine levels supported a critical role of adenosine
125 stream metabolic changes, such as increasing adenosine levels, which might have effects on seizure co
126 report that methylation at the 6 position of adenosine (m(6)A) in RNA is rapidly (within 2 min) and t
127 on of a methyl group to the N(6) position of adenosine (m(6)A), has been shown to affect splicing, tr
132 6.0 Kcal/mole and for all of them the edited adenosines mis-paired with cytosines on the pre-miRNA st
134 otein 1 (PABP1) were covalently linked to an adenosine moiety as in the AdoMet cofactor to generate t
135 e nucleotide signaling molecule 3',5'-cyclic adenosine monophosphate (3',5'-cAMP) plays important phy
136 ve catabolites: adenosine diphosphate (ADP), adenosine monophosphate (AMP), inosine monophosphate (IM
139 udies exploring the importance of the cyclic adenosine monophosphate (cAMP) cascade in major depressi
140 bunit through formation of a PDE-PKAR-cyclic adenosine monophosphate (cAMP) complex (the termination
141 phodiesterase (PDE4) and elevation of cyclic adenosine monophosphate (cAMP) has emerged as a promisin
144 were treated with Angiopoietin 1 and cyclic adenosine monophosphate (cAMP) to vary the Pd of the HUV
145 f phenylalanine, acetylhistidine, and cyclic adenosine monophosphate (cAMP) were found in urine sampl
146 rmore, we demonstrated that Tregs use cyclic adenosine monophosphate (cAMP)-dependent protein kinase
148 lutamatergic, monoaminergic, calcium, cyclic adenosine monophosphate [cAMP], dopamine- and cAMP-regul
149 culture and decidualized with 8-bromo-cyclic adenosine monophosphate and medroxyprogesterone acetate.
151 n of the cardiac stress marker NR4A1; cyclic adenosine monophosphate levels; and cyclic adenosine mon
152 ional activity and phosphorylation of cyclic adenosine monophosphate response element binding protein
153 ated the functional regulation of the cyclic adenosine monophosphate response element binding protein
154 promoter region as well as increased cyclic adenosine monophosphate response element-mediated transc
155 Nucleotide (ATP, adenosine diphosphate, adenosine monophosphate) and nucleoside (adenosine and i
156 educed renal ATP, adenosine diphosphate, and adenosine monophosphate, but not adenosine levels, durin
158 (PTEN) induces activation of the phospho-5' adenosine monophosphate-activated protein kinase and pho
159 adou et al. report that the metabolic sensor adenosine monophosphate-activated protein kinase influen
160 rectly targets the 3' untranslated region of adenosine monophosphate-activated protein kinase subunit
161 c adenosine monophosphate levels; and cyclic adenosine monophosphate-dependent protein kinase A-media
163 m of ICAM-4 activation occurs via the cyclic adenosine monophosphate-protein kinase A (cAMP-PKA)-depe
164 GS-5734 is a monophosphate prodrug of an adenosine nucleoside analog that showed therapeutic effi
169 sults suggest that controlling access to the adenosine pocket can contribute to substrate specificity
170 iprocal alterations were made to enlarge the adenosine pocket of EhACK and reduce that of MtACK.
172 investigate the contribution of CD73-derived adenosine produced by T cells to cardiac remodeling afte
174 with the 3/6-minute protocol, the 2/4-minute adenosine protocol would potentially have changed 332 of
176 of compound 25 as a potent and selective A2A adenosine receptor (A2AAdoR) antagonist with reasonable
177 MR) spectroscopy with the wild-type-like A2A adenosine receptor (A2AAR) in solution provides a compre
179 The cAMP-elevating, Gs protein-coupled A2a adenosine receptor (A2aR) is an evolutionarily conserved
180 overexpress mRNA for dopamine receptor 2 and adenosine receptor 2a in the striatum, markers of medium
182 ry synapses from basolateral amygdala via A1 adenosine receptor activation and enhanced inhibitory sy
184 The effect of inosine was mimicked by the adenosine receptor agonist NECA and the A2B receptor ago
185 le of enantiospecific recognition at the A2B adenosine receptor and opens new possibilities in ligand
187 Caffeine (5, 10, or 15 mg/kg), a nonspecific adenosine receptor antagonist, dose-dependently and at h
188 n against OIR, effective therapeutic window, adenosine receptor mechanisms, and neuroglial involvemen
189 of BRAF and MEK in combination with the A2A adenosine receptor provided significant protection again
191 ge, new cholesterol-binding sites on the A2A adenosine receptor, a G-protein-coupled receptor that is
192 MD/FEP) in fragment optimization for the A2A adenosine receptor, a pharmaceutically relevant G protei
193 at integrates gap junction coupling into the adenosine receptor-dependent signalling of endothelial c
195 tent binding across therapeutically relevant adenosine receptors (A1, A2a, and A3) as well as a poten
196 to G protein-coupled receptors including the adenosine receptors (AR), which are involved in a pletho
198 characterize the physiological link between adenosine receptors and the gap junction coupling in end
200 These effects were mimicked by antagonism of adenosine receptors with 8-(p-sulfophenyl) theophylline.
201 or), opioid receptors, adrenergic receptors, adenosine receptors, dopamine receptor, and sphingosine
203 e, poxviruses remodel host ribosomes so that adenosine repeats erroneously generated by slippage of t
206 , modulation of heterosynaptic plasticity by adenosine represents an endogenous mechanism that transl
209 y is active in melanoma patients and whether adenosine restricts the efficacy of clinically approved
210 t within the GC facilitates an extracellular adenosine-rich milieu, which serves to limit TFH frequen
212 ogether, our results establish A2AR-mediated adenosine signaling as an intrinsic negative regulator o
214 ed antitumor immunity.Significance: Ablating adenosine signaling is found to promote natural killer c
215 is promoted by a cross-talk between HA, CD73/adenosine signaling, and other profibrotic mediators.
219 ght dependence of heterosynaptic plasticity: adenosine strengthened weight dependence of heterosynapt
222 aluation of stable angina symptoms underwent adenosine-stress dynamic computed tomography myocardial
223 ter in a pocket surrounding the branch point adenosine, suggesting a competitive mode of action.
224 e fold but remarkably, unlike tuberculosinol adenosine synthase and other cis-prenyl transferases (e.
225 veloped a novel receptor-ligand model of the adenosine system to test the hypothesis that changes in
227 hows that medullary A-ICs respond to luminal adenosine through ADORA2A and ADORA2B receptors in a cAM
228 deletion allows rapid accumulation of plasma adenosine to counteract hypoxic tissue damage in mice.
229 re required for paraspeckles, as well as for adenosine to inosine (A to I) RNA editing of Ctn RNA in
232 and innate immune sensing, and functions of adenosine to inosine modifications in retroviral life cy
234 of The Cancer Genome Atlas and identified 19 adenosine-to-inosine (A-to-I) RNA editing hotspots.
237 alytically inactive Cas13 (dCas13) to direct adenosine-to-inosine deaminase activity by ADAR2 (adenos
238 igate whether angiomiR miR487b is subject to adenosine-to-inosine editing or 2'-O-ribose-methylation
243 es adenosine tone) and brain state (elevated adenosine tone increases sleep pressure), modulation of
245 relate of activity level (activity increases adenosine tone) and brain state (elevated adenosine tone
246 c environment in the catalytic space of gp17-adenosine triphosphatase (ATPase) determines the rate at
247 y component of the system is the proteasomal adenosine triphosphatase (ATPase) Mpa, which captures, u
248 necessary for packaging in such viruses: the adenosine triphosphatase (ATPase) that powers DNA transl
249 Sarcoplasmic/endoplasmic reticulum Ca(2+) adenosine triphosphatase (SERCA)2a, a critical regulator
250 tion through inhibition of the vacuolar H(+)-adenosine triphosphatase (V-ATPase) increased the lumina
251 lectron microscopy structure reveals how the adenosine triphosphatases (ATPases) form a closed spiral
252 es are conserved members of the AAA+ family (adenosine triphosphatases associated with diverse cellul
253 a key purinergic enzyme in the hydrolysis of adenosine triphosphate (ATP) and increased CD39 enzymati
254 and accurate method for the determination of adenosine triphosphate (ATP) and its first five cataboli
255 sly showed that patients with BD show normal adenosine triphosphate (ATP) and phosphocreatine levels
256 es on host cells for essential nutrients and adenosine triphosphate (ATP) for a productive infection.
258 METHOD: Mitochondrial O2 consumption and adenosine triphosphate (ATP) synthesis rates of osteosar
259 es have demonstrated that in the presence of adenosine triphosphate (ATP) the human RAD51 (HsRAD51) r
260 lectrostatic lock to prevent coordination of adenosine triphosphate (ATP) to the catalytic site.
262 re harboring disease-causing variants in the adenosine triphosphate (ATP)-binding cassette subfamily
263 plex loaded onto DNA directly interacts with adenosine triphosphate (ATP)-bound DnaA and stimulates t
264 al part of the chromatin landscape shaped by adenosine triphosphate (ATP)-dependent chromatin remodel
265 nt study, H2O2 dose-dependently impaired the adenosine triphosphate (ATP)-induced Ca(2+) response, wh
266 fically, ketamine tended to downregulate the adenosine triphosphate (ATP)/adenosine diphosphate (ADP)
267 ic machinery for hydrolysis of extracellular adenosine triphosphate and nicotinamide adenine dinucleo
268 xylic acids to aldehydes using the cofactors adenosine triphosphate and nicotinamide adenine dinucleo
269 r neurons-acetylcholine and a combination of adenosine triphosphate and nitric oxide, respectively.
270 l lumen via the sterol-exporting heterodimer adenosine triphosphate binding cassette subfamily G memb
273 that adopts two distinct folds, and the post-adenosine triphosphate hydrolysis state of KaiC create a
274 ae condensin is a molecular motor capable of adenosine triphosphate hydrolysis-dependent translocatio
277 diac energetic status (phosphocreatine/gamma-adenosine triphosphate ratio, 1.3+/-0.1 versus 1.9+/-0.1
278 ly discovered that absence of ABCC6-mediated adenosine triphosphate release from the liver and conseq
279 gnificantly impairs platelet aggregation and adenosine triphosphate secretion induced by numerous ago
280 and IL18; cells were incubated with LPS and adenosine triphosphate to activate the NLRP3 complex.
281 e leaving group of the native substrate with adenosine triphosphate, enabling sensitive detection via
282 By characterization of a Petunia hybrida adenosine triphosphate-binding cassette (ABC) transporte
283 in; KCNN4, the Gardos channel; and ABCB6, an adenosine triphosphate-binding cassette family member, i
284 JNK1 or JNK2 or treatment with JNK-IN-8, an adenosine triphosphate-competitive irreversible pan-JNK
286 eltapsi-driven presequence translocation and adenosine triphosphate-driven import motor activity.
289 ide adenine dinucleotide redox potential and adenosine triphosphate/adenosine diphosphate failed to r
290 that DDX3X, like Ded1p, utilizes exclusively adenosine triphosphates to unwind helices, oligomerizes
291 pha1-, and alpha2- adrenergic receptors, and adenosine type 1 receptor (A1R), tethered to Galphas-XL,
295 der hypercapnia was 2.1 +/- 0.9 mL/min/g and adenosine was 2.2 +/- 1.1 mL/min/g; these were significa
296 ified with carboxymethyl-cytosine instead of adenosine was described, but no biological activity of t
297 a transvenous pacing catheter was placed and adenosine was given following a dose-escalation protocol
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