ライフサイエンスコーパス: adenosine A(2A) receptor

1 wakefulness by antagonizing function of the adenosine A2A receptor.

2 y cytokines most likely by activation of the adenosine A2a receptor.

3 in a high-resolution structure of the human adenosine A2A receptor.

4 occurred when PKA was activated through the adenosine A2a receptor.

5 egulates the macrophage response through the adenosine A2A receptor.

6 (or Galpha(olf)) coupled to dopamine D1 and adenosine A2A receptors.

7 n response to pharmacological stimulation of adenosine A2A receptors.

8 lular adenosine and activation of Gs-coupled adenosine A2A receptors.

9 the NTS by way of activation of presynaptic adenosine A2a receptors.

10 ion by neutrophils via occupancy of specific adenosine A2A receptors.

11 al spike patterns and requires activation of adenosine A2A receptors.

12 drug design approaches as antagonists of the adenosine A(2A) receptor.

13 s T cell inhibition was mediated through the adenosine A(2A) receptor.

14 istent with the postsynaptic localization of adenosine A(2A) receptors.

15 Exercise hyperaemia is partly mediated by adenosine A(2A)-receptors.

16 r the adenosine A1 receptor (915-fold versus adenosine A2A receptor; 12-fold versus adenosine A2B rec

17 te dose of caffeine (antagonist for A1Rs and adenosine A2A receptors; 4 mg/kg intraperitoneally; diss

18 The adenosine A(2A) receptor (A(2A) R) is a potential drug t

19 hat nerve growth factor (NGF) down-regulates adenosine A(2A) receptor (A(2A)AR) mRNA in PC12 cells.

20 Adenosine A(2A) receptor (A(2A)R) agonists synergize wit

21 (TLR) 2, 4, 7, and 9 agonists, together with adenosine A(2A) receptor (A(2A)R) agonists, switch macro

22 Adenosine A(2A) receptor (A(2A)R) blockade enhances inna

23 Inactivation of the adenosine A(2A) receptor (A(2A)R) consistently protects

24 The adenosine A(2A) receptor (A(2A)R) is a G-protein-coupled

25 The adenosine A(2A) receptor (A(2A)R) is abundantly expresse

26 The human adenosine A(2A) receptor (A(2A)R) is an integral membran

27 The adenosine A(2A) receptor (A(2A)R) is increasingly recogn

28 that SCD causes a 9- and 6-fold induction of adenosine A(2A) receptor (A(2A)R) mRNA in mouse pulmonar

29 We previously reported that the adenosine A(2A) receptor (A(2A)R) specific agonist, ATL1

30 Tissue-derived adenosine, acting via the adenosine A(2A) receptor (A(2A)R), is emerging as an imp

31 tal structures of the thermostabilized human adenosine A(2A) receptor (A(2A)R-GL31) bound to its endo

32 Deletion of adenosine A(2A) receptors (A(2A)ARs) has been reported t

33 Adenosine A(2A) receptors (A(2A)Rs) are highly enriched

34 The function of striatal adenosine A(2A) receptors (A(2A)Rs) is well recognized b

35 The adenosine A2A receptor (A(2A)R) plays a key role in tran

36 adenosine receptor antagonist) and selective adenosine A2A receptor (A2A R) blockade alleviate neurod

37 The duration of action of adenosine A2A receptor (A2A) agonists is critical for th

38 ese regions also have the highest density of adenosine A2a receptors (A2a) in the brain.

39 We previously demonstrated that adenosine A2A receptor (A2AR) agonism attenuates lung is

40 Adenosine A2A receptor (A2AR) agonists are known to pote

41 Adenosine A2A receptor (A2AR) agonists reduce invariant

42 Adenosine A2A receptor (A2AR) agonists with Toll-like re

43 inoid receptors present in the striatum, ie, adenosine A2A receptor (A2AR) and cannabinoid CB1 recept

44 ced in the mutants and this was dependent on adenosine A2A receptor (A2AR) and tropomyosin-related ki

45 ith depression and memory deterioration, and adenosine A2A receptor (A2AR) antagonists emerge as cand

46 Endogenous adenosine acting at the adenosine A2A receptor (A2AR) can modify brain injury in

47 e describe the spontaneous reconstitution of adenosine A2A receptor (A2AR) during the de novo formati

48 this study was to examine the regulation of adenosine A2A receptor (A2AR) gene expression during hyp

49 We produced mice with a floxed adenosine A2A receptor (A2AR) gene, Adora2a, and show th

50 The adenosine A2A receptor (A2AR) has long been implicated i

51 ealed a 43-fold upregulation of mRNA for the adenosine A2A receptor (A2AR) in WT allografts compared

52 The adenosine A2A receptor (A2AR) is a particularly interest

53 We previously used adenosine A2A receptor (A2AR) knockout (KO) mice and bon

54 thanol-induced sleep using C57BL/6Slac mice, adenosine A2A receptor (A2AR) knockout mice, and their w

55 Activation of adenosine A2A receptor (A2AR) promotes fibrosis and coll

56 Adenosine A2a receptor (A2aR) signaling acts as a barrie

57 Synergy between Toll-like receptor (TLR) and adenosine A2A receptor (A2AR) signaling switches macroph

58 Adenosine A2A receptor (A2AR) stimulation promotes wound

59 umans by counteracting overactivation of the adenosine A2A receptor (A2AR), which is upregulated in t

60 e reduced oxygen-induced neural apoptosis by adenosine A2A receptor (A2AR)-dependent mechanism, as re

61 sed basal synaptic transmission and enhanced adenosine A2A receptor (A2AR)-dependent synaptic plastic

62 Adenosine A2A receptor (A2AR)-dopamine D2 receptor (D2R)

63 to investigate the mechanism underlying the adenosine A2a receptor (A2aR)-mediated positive inotropi

64 sity and morphology, and upregulation of the adenosine A2A receptor (A2AR).

65 Activation of adenosine A2A receptors (A2AR) has been shown to antagon

66 Adenosine A2A receptors (A2AR) modulate dopamine and glu

67 Striatal adenosine A2A receptors (A2AR) play an essential role in

68 Although T cells express inhibitory adenosine A2A receptors (A2AR) that suppress their activ

69 Cerebral adenosine A2A receptors (A2ARs) are attractive therapeut

70 Adenosine A2A receptors (A2ARs) are enriched in the stri

71 Adenosine A2A receptors (A2ARs) are highly expressed in

72 Since adenosine A2A receptors (A2ARs) control lysosome traffic

73 d reference memory through the antagonism of adenosine A2A receptors (A2ARs) controlling synaptic pla

74 In contrast, adenosine A2A receptors (A2ARs) did not coprecipitate or

75 Activation of adenosine A2A receptors (A2ARs) stimulates bone formatio

76 ladenant) was developed for mapping cerebral adenosine A2A receptors (A2ARs) with PET.

77 ced by lymphocyte depletion or activation of adenosine A2A receptors (A2ARs) with the selective agoni

78 We recently found that adenosine A2A receptors (A2ARs), which control synaptic

79 lzheimer's disease through the antagonism of adenosine A2A receptors (A2ARs).

80 CRs): the beta-2 adrenoreceptor (ADRB2), the adenosine A(2A) receptor (AA2AR), and the sphingosine 1-

81 tivation/deactivation mechanism of the human adenosine A2A receptor (AA2AR), a member of the class A

82 h pathways were modulated by dopamine D2 and adenosine A2A receptors, acting through cAMP/PKA.

83 derably in their responsiveness to selective adenosine A(2A) receptor activation, the phosphorylation

84 Instead, adenosine A2A receptor activation of G alpha(s/olf) seem

85 However, the combination of adenosine A2A receptor activation with either isoflurane

86 induced a better neuroprotective effect than adenosine A2A receptor activation, isoflurane preconditi

87 Through adenosine A2A receptor activation, MTX promotes reverse

88 volve CaMKII inhibition, but may not involve adenosine A2A receptor activation.

89 Accordingly, reducing adenosine A2A receptor activity in Adk(Deltabrain) mice

90 Here, we show that the adenosine A2a receptor (ADORA2A) promotes hypoxia-induci

91 Studies with CGS21680, a specific agonist of adenosine A2A receptor (AdoRA2A), and ZM241385, an AdoRA

92 ntracellular cyclic AMP (cAMP) increase upon adenosine A(2A) receptor agonism by CGS21680 (CGS).

93 remia induced by intravenous infusion of the adenosine A(2A) receptor agonist ATL-146e (0.3 micro g/k

94 behavioral and neurochemical effects of the adenosine A(2A) receptor agonist CGS 21680 [2-p-(2-carbo

95 An adenosine A(2a) receptor agonist did not alter the local

96 evidence that an exogenous agent such as an adenosine A(2A) receptor agonist increases neovasculariz

97 5'-N-ethylcarboxamidoadenosine(CGS 21680; an adenosine A(2A) receptor agonist).

98 Specifically, the adenosine A(2A) receptor agonist, CGS 21680, was used to

99 carboxamido-adenosine (CGS21680), a specific adenosine A(2A) receptor agonist, modestly increases VEG

100 on in wounds, we sought to determine whether adenosine A(2A) receptor agonist-augmented wound healing

101 ffeine on the vasodilatory properties of the adenosine A(2A)-receptor agonist ATL-146e (ATL).

102 ATL is a new adenosine A(2A)-receptor agonist proposed as a vasodilat

103 agonist N6-cyclohexyladenosine (CHA) or the adenosine A2a receptor agonist 2-[(2-aminoethylamino)car

104 In contrast, the adenosine A2A receptor agonist 2-p-(2-carboxyethyl)-phen

105 Pretreatment with the adenosine A2a receptor agonist APEC, but not the adenosi

106 The selective adenosine A2A receptor agonist binodenoson results in an

107 nosine and a second study with the selective adenosine A2A receptor agonist binodenoson, using 1 of 4

108 PA (2-chloro-N6-cyclopentyladenosine) or the adenosine A2A receptor agonist CGS 21680 (2-p-(2-carboxy

109 We hypothesized that a selective adenosine A2A receptor agonist would induce coronary vas

110 in maximal vessel response to CGS-21680, an adenosine A2A receptor agonist, but did not alter the co

111 arboxamidoadenosine (CGS 21680), a selective adenosine A2a receptor agonist, for 5 min prior to the S

112 that involves the synergistic interaction of adenosine A(2A) receptor agonists through A(2A) receptor

113 idence indicates that topical application of adenosine A(2A) receptor agonists, unlike growth factors

114 e on pharmacologic stress using adenosine or adenosine A(2A)-receptor agonists should be evaluated in

115 acological signature consistent with that of adenosine A(2A) receptors and are expressed at similar l

116 The adenosine A2A receptor and PDE2, 3, 4, and 7 are importa

117 These effects are mediated via the adenosine A2A receptor and protein kinase A (PKA).

118 VEGF gene expression through stimulation of adenosine A2a receptor and subsequent activation of the

119 ly explained by genetic polymorphisms of the adenosine A2A receptors and alpha(2)-adrenergic receptor

120 a partner for the carboxyl-terminal tail of adenosine A2A receptors and showing that this interactio

121 ckade of a transactivation pathway that uses adenosine A2a receptors and src-family kinases (SFKs).

122 bbles by 70% (P<0.01), whereas inhibition of adenosine-A2a receptors and epoxyeicosatrienoic acids ha

123 in response to adenosine (via activation of adenosine A2A receptors) and to further determine the si

124 cleus accumbens also contain high numbers of adenosine A(2A) receptors, and, for that reason, the beh

125 TrkB, adenosine A2a receptors, and SFKs associate into complex

126 re significantly attenuated by the selective adenosine A(2A) receptor antagonist 4-(2-{7-amino-2-(2-f

127 's disease (PD) pathophysiology, a selective adenosine A(2A) receptor antagonist, istradefylline, sho

128 The adenosine A2a receptor antagonist 8-(3-chlorostyryl)caff

129 kade of glutamate release by perfusion of an adenosine A2A receptor antagonist in the pmNAc shell blo

130 The novel adenosine A2A receptor antagonist KW-6002 has been exami

131 Different doses of an adenosine A2A receptor antagonist MSX-3 [3,7-dihydro-8-[

132 Tozadenant (SYN115) is an oral, selective adenosine A2A receptor antagonist that improves motor fu

133 pentyl-1,3-dipropylxanthine), or a selective adenosine A2A receptor antagonist ZM 241385.

134 en demonstrated to be a potent and selective adenosine A2a receptor antagonist, although with limited

135 te mice, C57BL/6 mice, and mice treated with adenosine A2A receptor antagonist.

136 1 receptor antagonist but not by a selective adenosine A2A receptor antagonist.

137 hibitory effects were reduced by addition of adenosine A2A receptor antagonist.

138 mine D2 receptor agonist and ZM 241385 as an adenosine A2A receptor antagonist.

139 Adenosine A(2A) receptor antagonists are psychomotor sti

140 Adenosine A(2a) receptor antagonists reduce symptom seve

141 been demonstrated to be potent and selective adenosine A(2a) receptor antagonists with oral activity

142 esulted in discovery of potent and selective adenosine A2A receptor antagonists bearing substituted 1

143 Adenosine A2A receptor antagonists provide a promising n

144 These results suggest that selective adenosine A2A receptor antagonists represent a new class

145 structural information for the discovery of adenosine A2A receptor antagonists that have potential t

146 Thus, accumbens adenosine A(2A) receptors appear to regulate behavioral

147 The adenosine A(2A) receptor appears required for neurotoxic

148 Results of biophysical mapping of the adenosine A(2A) receptor are presented.

149 Adenosine A(2A) receptors are colocalized with D(2) rece

150 Adenosine A(2A) receptors are predominantly expressed in

151 Adenosine A(2A) receptors are preferentially expressed i

152 ly expressed in striatonigral neurons, while adenosine A2a receptors are preferentially expressed in

153 tissue-nonspecific alkaline phosphatase, and adenosine A2a receptors are significantly increased in d

154 A receptor ligand, showed that the number of adenosine A2A receptor binding sites was similarly incre

155 Activation of adenosine A(2A) receptors can broadly inactivate inflamm

156 We therefore examined whether adenosine A2A receptors contribute to the pathogenesis o

157 Adenosine A2A receptor-deficient and A2A receptor antago

158 leomycin-induced dermal fibrosis model using adenosine A2A receptor-deficient wild-type littermate mi

159 These results indicate that stimulating adenosine A(2A) receptors diminishes BSR without produci

160 Stimulation of accumbens adenosine A(2A) receptors disrupted performance of an in

161 Herein we describe adenosine A2A receptor distribution, signaling pathways,

162 ha), from dopamine D1 receptor-expressing or adenosine A2a receptor-expressing medium spiny neurons (

163 Finally, Western blot analysis of adenosine A(2A) receptor expression indicated that the s

164 ter, and adenosine A1 receptor and decreased adenosine A2A receptor expression in the NAc.

165 olution X-ray crystal structure of the human adenosine A2A receptor (hA2AAR), in which the allosteric

166 The adenosine A2A receptor has emerged as an attractive non-

167 agonist- and agonist-bound structures of the adenosine A(2A) receptor have revealed much about how a

168 xperimentally enabled homology models of the adenosine A(2A) receptor, identifying a diverse range of

169 that project to the ventral pallidum showed adenosine A(2A) receptors immunoreactivity.

170 Adenosine A2A receptor immunoreactivity (A2A-LI) has bee

171 (PD), we determined whether deletion of the adenosine A(2A) receptor in knockout (KO) mice protects

172 that HIF-2alpha but not HIF-1alpha regulates adenosine A(2A) receptor in primary cultures of human lu

173 ccurately define the spatial distribution of adenosine A(2A) receptors in fetal sheep diencephalon, w

174 tory cytokines on function and expression of adenosine A(2A) receptors in the human monocytic cell li

175 ant implications for the functional roles of adenosine A(2A) receptors in the thalamus and pineal of

176 ut not A(2A)-/- mice, confirming the role of adenosine A(2A) receptors in this pathway.

177 collagen production after stimulation of the adenosine A2A receptor in a dose-dependent fashion.

178 Blockade of the adenosine A2A receptor in striatopallidal neurons reduce

179 s- and Golf-coupled dopamine D1 receptor and adenosine A2A receptor in the brain and other organs, el

180 Adenosine A2A receptors in striatum are selectively loca

181 It was also apparent that this population of adenosine A2a receptors in the NTS desensitized within 2

182 An antagonist selective for adenosine A(2A) receptors induced feeding and locomotion

183 These results show that adenosine A2A receptor-induced protection is most likely

184 sine is an immunosuppressive nucleoside, and adenosine A(2A) receptors inhibit T-cell activation.

185 ncology despite the safe clinical profile of adenosine A2A receptor inhibitors (A2ARi) in Parkinson d

186 on pathways by which occupancy of neutrophil adenosine A2A receptors inhibits superoxide anion genera

187 Thus, targeting the adenosine A(2A) receptor is a novel approach to promotin

188 The adenosine A2A receptor is a G-protein-coupled receptor (

189 The adenosine A2A receptor is a prototypical rhodopsin-like

190 The cerebral adenosine A2A receptor is an attractive therapeutic targ

191 VHD, and the pharmacologic activation of the adenosine A2A receptor is protective.

192 -isomer (Sp-cAMPS), prostaglandin E1, or the adenosine A2A receptor is sufficient to cause epsilonPKC

193 nosine) on wound closure and angiogenesis in adenosine A(2A) receptor knockout mice and their wild-ty

194 ntially therapeutic dopamine D1 receptor and adenosine A2A receptor ligands with functionally selecti

195 Adenosine A2A receptor ligation stimulated ERK phosphory

196 We observed that the striatal adenosine A2A receptor links adenosine tone and psychomo

197 ening inflammation through signaling via the adenosine A2A receptor may limit tissue damage but may a

198 termine the signaling mechanisms involved in adenosine A2A receptor-mediated promotion of collagen pr

199 cological inhibitors of signal transduction, adenosine A2A receptor-mediated stimulation of procollag

200 al-regulated kinase (erk), but surprisingly, adenosine A2A receptor-mediated stimulation of procollag

201 The adenosine A2a receptor mediates a new cyclic AMP-indepen

202 tributes to the development of OA; targeting adenosine A2A receptors might treat or prevent OA.

203 ese studies were to determine the effects of adenosine A(2A) receptor modulation in the NAc on cocain

204 Adenosine A2A receptor occupancy promoted collagen produ

205 pression of CD39/CD73 on T reg cells and the adenosine A2A receptor on activated T effector cells gen

206 The adenosine A(2A) receptor pharmacologic signature of the

207 rior studies indicate that adenosine and the adenosine A2A receptor play a role in hepatic fibrosis b

208 These results demonstrate that adenosine A2A receptors play an active role in the patho

209 ted adenosine can trigger a cAMP response in adenosine A(2A) receptor-positive but not A(2A) receptor

210 egulates inflammation and tissue repair, and adenosine A2A receptors promote wound healing by stimula

211 We have recently reported that activation of adenosine A(2A) receptors promotes collagen synthesis by

212 affeine and more specific antagonists of the adenosine A(2A) receptor recently have been found to be

213 aspartate (NMDA) receptors, or activation of adenosine A2A receptors resulted in reduction of the OGD

214 on, we demonstrate that beta2-adrenergic and adenosine A2A receptors scramble lipids, suggesting that

215 The adenosine A(2A) receptor-selective agonists 2-p-(2-carbo

216 Selective agonism of the adenosine A2A receptor should result in a similar degree

217 These results indicate that adenosine A2A receptors signal for increased collagen pr

218 e physiological and behavioral correlates of adenosine A(2A) receptor signaling have been extensively

219 PKA were evaluated as potential mediators of adenosine A(2A) receptor signaling in the striatum.

220 2 (CK2) negatively regulates dopamine D1 and adenosine A2A receptor signaling in the striatum.

221 27-hydroxylase and ABCA1 was blocked by the adenosine A2A receptor-specific antagonist ZM241385.

222 f the following PKA targets is responsive to adenosine A(2A) receptor stimulation in this tissue: Ser

223 and this modulation is primarily through the adenosine A2a receptor subtype.

224 cal GPCRs with known crystal structures: the adenosine A2A receptor, the beta2-adrenergic receptor an

225 latory response is mediated primarily by the adenosine A2A receptors, these side effects result from

226 he contributions of endogenous adenosine and adenosine A(2A) receptors to skin fibrosis.

227 immediate tissue-protecting mechanisms, with adenosine A2A receptors triggering "OFF" signals in acti

228 high affinity and excellent selectivity for adenosine A(2a) receptor versus the adenosine A(1) recep

229 (1) and beta(2) adrenergic receptors and the adenosine A(2a) receptor were determined in the antagoni

230 on of Th1 and Th2 cells in vitro depended on adenosine A2A receptors, which were also required for th

231 esent study, we demonstrate that blockade of adenosine A2A receptors with caffeine or a selective A2A