ライフサイエンスコーパス: adenosine A1 receptor

1 tion than that produced by activation of the adenosine A1 receptor.

2 irments could be ameliorated by blocking the adenosine A1 receptor.

3 a subunits rescued presynaptic inhibition by adenosine A1 receptors.

4 ction by ethanol is mediated through myocyte adenosine A1 receptors.

5 ry effect appears to be due to activation of adenosine A1 receptors.

6 europrotection through activation of central adenosine A1 receptors.

7 more heterogeneous activation of presynaptic adenosine A1 receptors.

8 could transiently be provoked after blocking adenosine A1 receptors.

9 opamine D2, metabotropic glutamate mGlu5 and adenosine A1 receptors.

10 r/middle lateral RA had significantly higher adenosine A1 receptor (2.7+/-1.7-fold; P<0.01) and GIRK4

11 tency (hA1, Ki=7 nM) and selectivity for the adenosine A1 receptor (915-fold versus adenosine A2A rec

12 Adenosine A1 receptor (A1-AdoR) function in rat ventricl

13 ic and diuretic action of a highly selective adenosine A1 receptor (A1AdoR) antagonist, 1,3-dipropyl-

14 the hypothesis that a partial agonist of the adenosine A1 receptor (A1AdoR) may cause a greater atten

15 In this study, we targeted the cochlear adenosine A1 receptor (A1AR) by trans-tympanic injection

16 In this study, we show that the adenosine A1 receptor (A1AR) protects against cisplatin

17 Adenosine A1 receptor (A1AR) subtype present on renal pr

18 Allosteric modulation of adenosine A1 receptors (A1ARs) offers a novel therapeuti

19 Adenosine A1 receptor (A1R) agonist N6-cyclopentyl-adeno

20 CPA, a stable adenosine A1 receptor (A1R) agonist, did not affect KDR

21 l blockade of A1 receptor signaling using an adenosine A1 receptor (A1R) antagonist, 8-cyclopentyl-1,

22 ne induces cortical actin polymerization via adenosine A1 receptor (A1R) induction of a Rho GTPase CD

23 The adenosine A1 receptor (A1R) is a key mediator of the neu

24 neuronal activity through activation of the adenosine A1 receptor (A1R), resulting in antinociceptio

25 els around synapses resulting in an enhanced adenosine A1 receptor (A1R)-dependent protective tone de

26 on upregulate adenosine concentration and/or adenosine A1 receptors (A1R) in the brain.

27 Activation of presynaptic adenosine A1 receptors (A1Rs) causes substantial synapti

28 Adenosine A1 receptors (A1Rs) in human and rodent brains

29 Because very little is known about adenosine A1 receptors (A1Rs) in the spinal cord, we det

30 In hippocampal neurons, activation of adenosine A1 receptors (A1Rs) or GABA(B) receptors on sy

31 seizures in mice by increasing activation of adenosine A1 receptors (A1Rs).

32 ce of heterosynaptic plasticity; blockade of adenosine A1 receptors abolished it.

33 ce of heterosynaptic plasticity: blockade of adenosine A1 receptors abolished weight dependence, whil

34 Adenosine A1 receptor activation also impaired the expre

35 algesic effect of acupuncture is mediated by adenosine A1 receptor activation at the acupuncture poin

36 The inhibitory modulation of adenosine A1 receptor activation by hydroxylamine sugges

37 Adenosine A1 receptor activation depresses excitatory tr

38 Adenosine A1 receptor activation dose-dependently and se

39 P inhibited excitatory neurotransmission via adenosine A1 receptor activation in spinal cord slices f

40 this model of trigeminovascular nociception, adenosine A1 receptor activation leads to neuronal inhib

41 een reported in response to agonist-mediated adenosine A1 receptor activation, the implications of A2

42 is study, we report a novel dual role of the adenosine A1 receptor (Adora1) as an E2/ERalpha target a

43 ssion of a potential glucagon inhibitor, the adenosine A1 receptor (Adora1), is gradually diminished

44 sponses are thought to require activation of adenosine A1 receptors (adorA1Rs) and release of transmi

45 -D-aspartate receptor antagonist MK-801; the adenosine A1 receptor agonist 2-chloro-N6-cyclopentylade

46 the GABA(B) receptor agonist baclofen or the adenosine A1 receptor agonist 2-chloroadenosine, short-t

47 These data are consistent with adenosine A1 receptor agonist actions on REM sleep media

48 the NO donor sodium nitroprusside (SNP), the adenosine A1 receptor agonist CCPA (2-chloro-N6-cyclopen

49 osine A2a receptor agonist APEC, but not the adenosine A1 receptor agonist CHA, attenuated c-Fos indu

50 Intrastriatal microinfusion of adenosine A1 receptor agonist N6-cyclohexyladenosine (CH

51 Pretreatment with the adenosine A1 receptor agonist N6-cyclohexyladenosine (CH

52 of the BF cholinergic neurons, the selective adenosine A1 receptor agonist N6-cyclohexyladenosine, ad

53 ditioning was mimicked by perfusion with the adenosine A1 receptor agonist N6-cyclopentyladenosine an

54 Microinjection of adenosine A1 receptor agonist or an inhibitor of adenyly

55 Direct injection of an adenosine A1 receptor agonist replicated the analgesic e

56 lisopropyl)-adenosine (R-PIA [50 nmol/L], an adenosine A1 receptor agonist), or 4 beta-phorbol 12-myr

57 The selective low efficacy adenosine A1 receptor agonist, GR190178 (30-1000 microg/

58 enous administration of the highly selective adenosine A1 receptor agonist, GR79236 (3-100 microg/kg)

59 N6-Cyclopentyl adenosine (adenosine A1 receptor agonist, Kd = 1 nmol/l) did not af

60 Systemic injection of the selective adenosine A1 receptor agonist, N(6)-cyclohexyladenosine

61 lure was studied with the use of a selective adenosine A1 receptor agonist, N6-cyclohexyl-2'-O-methyl

62 In Experiment 1, the selective adenosine A1 receptor agonist, N6-cyclopentyladenosine (

63 A, 48.4+/-5.5% with SfA; P<0.001), CCPA (the adenosine A1-receptor agonist, 200 nmol/L) (24.9+/-4.5%

64 the effects of capadenoson (CAP), a partial adenosine A1-receptor agonist, on left ventricular (LV)

65 The selective adenosine A1 receptor agonists 2-chloro-N6-cyclopentylad

66 flammatory sites was signficantly reduced by adenosine A1 receptor agonists injected through intrathe

67 is a considerable literature to suggest that adenosine A1 receptor agonists may have anti-nociceptive

68 onists, nitric oxide synthase inhibitors and adenosine A1 receptor agonists.

69 The results support development of partial adenosine A1-receptor agonists for the treatment of chro

70 Therapy with adenosine A1-receptor agonists, however, is limited by u

71 Overexpressing the adenosine A1 receptor also led to increased protection a

72 Allosteric enhancers of the adenosine A1 receptor amplify signaling by orthosteric a

73 amine D2 receptor, dopamine transporter, and adenosine A1 receptor and decreased adenosine A2A recept

74 al inhibition was blocked in the presence of adenosine A1 receptor and GABAB receptor blockade.

75 entry in RA areas with highest expression of adenosine A1 receptor and its downstream GIRK (G protein

76 denosine (2CA) and baclofen, agonists of the adenosine A1 receptor and the GABAB receptor, respective

77 previously produced up-regulation of central adenosine A1 receptors and created a state of opiate dep

78 e examined the manner in which activation of adenosine A1 receptors and GABAB receptors modulates syn

79 ynthesis, which was prevented by blockade of adenosine A1 receptors, and decreased expression of gene

80 f ATP-sensitive potassium (K(ATP)) channels, adenosine A1 receptors, and the effects of different lev

81 attenuated by adrenergic alpha 2-receptors, adenosine A1-receptors, and histamine H3-receptors.

82 Moreover, adenosine A1 receptor antagonism had larger effects on t

83 s to cardiac arrhythmias and seizures due to adenosine A1-receptor antagonism.

84 BTI), or exogenous adenosine, or a selective adenosine A1 receptor antagonist (8-cyclopentyl-1, 3-dim

85 The adenosine A1 receptor antagonist 1,3-dipopylcyclopentylx

86 (19.6 +/- 0.9%) by systemic injection of the adenosine A1 receptor antagonist 8-CPT (2.5 mg kg(-1)) a

87 was largely reversed in the presence of the adenosine A1 receptor antagonist 8-cyclopentyl-1, 3-dipr

88 The adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipro

89 denosine as a mediator of IPC, the selective adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipro

90 The selective adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipro

91 Both the adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipro

92 (NOS) inhibitor l-NAME (Group 1, n = 8) and adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipro

93 roduced by the administration of a selective adenosine A1 receptor antagonist but not by a selective

94 Prior administration of the selective adenosine A1 receptor antagonist dipropylcyclopentylxant

95 GR79236 could be inhibited by the selective adenosine A1 receptor antagonist DPCPX (300 microg/kg; P

96 fore and after administration of a selective adenosine A1 receptor antagonist DPCPX (8-cyclopentyl-1,

97 value of 0.4 nM for antagonism of CPA by the adenosine A1 receptor antagonist DPCPX (8-cyclopentyl-1,

98 The adenosine A1 receptor antagonist DPCPX did not affect th

99 Intracerebroventricular infusion of an adenosine A1 receptor antagonist produced a similar decr

100 Here, we show that the adenosine A1 receptor antagonist rolofylline (KW-3902) i

101 Controlled Randomized Study of the Selective Adenosine A1 Receptor Antagonist Rolofylline for Patient

102 is comparable to that of BG9928, a selective adenosine A1 receptor antagonist that is currently in cl

103 yl-1,3-dipropylxanthine (DPCPX), a selective adenosine A1 receptor antagonist that is permeable to th

104 Imidazoline 14 is a competitive adenosine A1 receptor antagonist with a pA2 value of 8.8

105 -i]purin-5(4H)-one, is a particularly potent adenosine A1 receptor antagonist with good selectivity o

106 In the search for a selective adenosine A1 receptor antagonist with greater aqueous so

107 e presence of SPWs in slices treated with an adenosine A1 receptor antagonist, a finding that links t

108 ices treated with either a glial toxin or an adenosine A1 receptor antagonist.

109 blocked by protein kinase A inhibitor and an adenosine A1 receptor antagonist.

110 s with ADHF and volume overload, KW-3902, an adenosine A1-receptor antagonist, enhances the response

111 e hypothesis that the use of rolofylline, an adenosine A1-receptor antagonist, would improve dyspnea,

112 fibrillation were abolished or prevented by adenosine A1 receptor antagonists (50 mumol/L theophylli

113 The inhibition was blocked by adenosine A1 receptor antagonists and by agents that dis

114 vel tricyclic imidazoline antagonists of the adenosine A1 receptor are described.

115 cardial ischemia-reperfusion injury and that adenosine A1 receptors are required for this protective

116 These results indicate that adenosine A1 receptors are selectively upregulated durin

117 Adenosine A1 receptor blockade abolished the protection

118 67156) inhibition of nucleotide breakdown or adenosine A1 receptor blockade and reduced by apyrase in

119 Adenosine A1 receptor blockade with 4.5 mg/kg DPCPX admi

120 ht to evaluate the dose-dependent effects of adenosine A1-receptor blockade on diuresis and renal fun

121 yclopentyl-1, 3-dipropylxanthine (DPCPX) (an adenosine A1 receptor blocker).

122 manipulated by microperfusing nephrons with adenosine A1 receptor blocker, A1-agonist, or 5'-nucleot

123 gated by TRPV4 channel, GABAB, as well as an adenosine A1 receptor blocker.

124 iated by increased activation of presynaptic adenosine A1 receptors by endogenous adenosine.

125 Adenosine A1 receptor control of the homeostatic regulat

126 antisense oligodeoxynucleotide targeting the adenosine A1 receptor desensitized the animals to subseq

127 haracterize SAN structure, SAN function, and adenosine A1 receptor expression in control (n=17) and 4

128 ption of caffeine during adulthood increased adenosine A1 receptor expression in the NAc, but no othe

129 d that its anti-nociceptive actions required adenosine A1 receptor expression.

130 were conducted to examine the importance of adenosine A1 receptors for the acquisition and expressio

131 chemia might be attributable to the enhanced adenosine A1 receptor function on synaptic transmission,

132 lized in lateral RA regions with the highest adenosine A1 receptor/GIRK4 expression.

133 To inhibit K(ATP) channels or adenosine A1 receptors, glibenclamide (0.1 mg/kg icv; n

134 5-cyano-2-thiopyrimidines as selective human adenosine A1 receptor (hA1AR) agonists with tunable bind

135 ffects, and we sought to explore the role of adenosine A1 receptors in a model of trigeminovascular n

136 Stimulation of renal adenosine A1 receptors in animal models has resulted in

137 blood brain barrier, we examine the role of adenosine A1 receptors in mediating cortical blood flow

138 d by endogenous GABAB, serotonin 5-HT1A, and adenosine A1 receptors in neurons coinfected with GIRK1+

139 In vitro studies supported roles for adenosine A1 receptors in promoting fatty acid synthesis

140 ncreases the concentrations of adenosine and adenosine A1 receptors in specific regions of the brain.

141 al (AAV) vector to focally delete endogenous adenosine A1 receptors in the hippocampus.

142 alothane level but not of K(ATP) channels or adenosine A1 receptors in the preconditioning effects of

143 entylxanthine, indicating the involvement of adenosine A1 receptors in the protection.

144 gical evidence supporting the involvement of adenosine A1 receptors in the regulation of the response

145 response (HVR), and investigated the role of adenosine A1 receptors in these SF effects in conscious

146 This effect requires functional adenosine A1 receptors, in line with the observation tha

147 (l-NAME, 1.5 mM), but was not affected by an adenosine A1 receptor inhibitor, 8-cyclopentyl-1,3-dipro

148 e first time in the mammalian fetus that the adenosine A1 receptor is an important mediator of brain

149 uction or oxygen consumption, suggesting the adenosine A1 receptor is involved in lowering metabolic

150 Furthermore, activation of adenosine A1-receptors markedly attenuated norepinephrin

151 l natriuretic peptide level, consistent with adenosine A1 receptor-mediated activity, was observed.

152 A3 receptors with Cl-IB-MECA antagonized the adenosine A1 receptor-mediated inhibition of excitatory

153 These data provide good evidence for an adenosine A1 receptor-mediated inhibition of mAChR-media

154 GABA does not appear to be involved in adenosine A1 receptor-mediated inhibition of neuronal fi

155 In addition, hydroxylamine reversed adenosine A1 receptor-mediated inhibition of the evoked

156 Agents that inhibit adenosine A1 receptors might be useful in the treatment

157 Adenosine A1 receptors modulate baseline synaptic transm

158 or agonists directly reduces tremor, whereas adenosine A1 receptor-null mice show involuntary movemen

159 Activation of either adenosine A1 receptors or GABAB receptors inhibits many

160 lly, we show that blocking the activation of adenosine A1 receptors prevents the long-term depression

161 This study revealed a 3-fold RA-to-LA adenosine A1 receptor protein expression gradient in the

162 Adenosine A1 receptor protein expression was significant

163 had no effect, but those for adrenergic and adenosine A1 receptors reduced firing.

164 er, our data indicate that activation of the adenosine A1 receptor reduces synaptic strength by modul

165 Upon solubilization, the retinal adenosine A1 receptor retained binding characteristics s

166 at caffeine, because of its ability to block adenosine A1 receptors, shares neurochemical properties

167 mals received intravitreal injections of the adenosine A1 receptor stimulant adenosine amine congener

168 The selectivity level over the adenosine A1 receptor subtype for some of the more activ

169 to be mediated by a pathway initiated at the adenosine A1 receptor that transduced signals through a

170 uction in IOP results from the activation of adenosine A1 receptors, the mechanisms responsible for t

171 sites flanking the major coding exon for the adenosine A1 receptor, this AAV-Cre markedly reduced A1

172 In chronic HF, adenosine A1 receptor upregulation in SAN pacemaker and

173 tivation of a postsynaptic K+ conductance by adenosine A1 receptors was used to determine the rate of

174 for GABA(B) receptors, 5HT1A receptors, and adenosine A1 receptors were essentially absent in mutant

175 As an example we show that the adenosine A1 receptor, when placed under the influence o

176 Activation of the adenosine A1 receptor with CCPA or the A3 receptor with