ライフサイエンスコーパス: adenosine A2A receptor

1 y cytokines most likely by activation of the adenosine A2a receptor.

2 in a high-resolution structure of the human adenosine A2A receptor.

3 occurred when PKA was activated through the adenosine A2a receptor.

4 egulates the macrophage response through the adenosine A2A receptor.

5 wakefulness by antagonizing function of the adenosine A2A receptor.

6 the NTS by way of activation of presynaptic adenosine A2a receptors.

7 ion by neutrophils via occupancy of specific adenosine A2A receptors.

8 lular adenosine and activation of Gs-coupled adenosine A2A receptors.

9 al spike patterns and requires activation of adenosine A2A receptors.

10 (or Galpha(olf)) coupled to dopamine D1 and adenosine A2A receptors.

11 n response to pharmacological stimulation of adenosine A2A receptors.

12 r the adenosine A1 receptor (915-fold versus adenosine A2A receptor; 12-fold versus adenosine A2B rec

13 te dose of caffeine (antagonist for A1Rs and adenosine A2A receptors; 4 mg/kg intraperitoneally; diss

14 The adenosine A2A receptor (A(2A)R) plays a key role in tran

15 adenosine receptor antagonist) and selective adenosine A2A receptor (A2A R) blockade alleviate neurod

16 The duration of action of adenosine A2A receptor (A2A) agonists is critical for th

17 ese regions also have the highest density of adenosine A2a receptors (A2a) in the brain.

18 We previously demonstrated that adenosine A2A receptor (A2AR) agonism attenuates lung is

19 Adenosine A2A receptor (A2AR) agonists are known to pote

20 Adenosine A2A receptor (A2AR) agonists reduce invariant

21 Adenosine A2A receptor (A2AR) agonists with Toll-like re

22 inoid receptors present in the striatum, ie, adenosine A2A receptor (A2AR) and cannabinoid CB1 recept

23 ced in the mutants and this was dependent on adenosine A2A receptor (A2AR) and tropomyosin-related ki

24 ith depression and memory deterioration, and adenosine A2A receptor (A2AR) antagonists emerge as cand

25 Endogenous adenosine acting at the adenosine A2A receptor (A2AR) can modify brain injury in

26 e describe the spontaneous reconstitution of adenosine A2A receptor (A2AR) during the de novo formati

27 this study was to examine the regulation of adenosine A2A receptor (A2AR) gene expression during hyp

28 We produced mice with a floxed adenosine A2A receptor (A2AR) gene, Adora2a, and show th

29 The adenosine A2A receptor (A2AR) has long been implicated i

30 ealed a 43-fold upregulation of mRNA for the adenosine A2A receptor (A2AR) in WT allografts compared

31 The adenosine A2A receptor (A2AR) is a particularly interest

32 We previously used adenosine A2A receptor (A2AR) knockout (KO) mice and bon

33 thanol-induced sleep using C57BL/6Slac mice, adenosine A2A receptor (A2AR) knockout mice, and their w

34 Activation of adenosine A2A receptor (A2AR) promotes fibrosis and coll

35 Adenosine A2a receptor (A2aR) signaling acts as a barrie

36 Synergy between Toll-like receptor (TLR) and adenosine A2A receptor (A2AR) signaling switches macroph

37 Adenosine A2A receptor (A2AR) stimulation promotes wound

38 umans by counteracting overactivation of the adenosine A2A receptor (A2AR), which is upregulated in t

39 e reduced oxygen-induced neural apoptosis by adenosine A2A receptor (A2AR)-dependent mechanism, as re

40 sed basal synaptic transmission and enhanced adenosine A2A receptor (A2AR)-dependent synaptic plastic

41 Adenosine A2A receptor (A2AR)-dopamine D2 receptor (D2R)

42 to investigate the mechanism underlying the adenosine A2a receptor (A2aR)-mediated positive inotropi

43 sity and morphology, and upregulation of the adenosine A2A receptor (A2AR).

44 Activation of adenosine A2A receptors (A2AR) has been shown to antagon

45 Adenosine A2A receptors (A2AR) modulate dopamine and glu

46 Striatal adenosine A2A receptors (A2AR) play an essential role in

47 Although T cells express inhibitory adenosine A2A receptors (A2AR) that suppress their activ

48 Cerebral adenosine A2A receptors (A2ARs) are attractive therapeut

49 Adenosine A2A receptors (A2ARs) are enriched in the stri

50 Adenosine A2A receptors (A2ARs) are highly expressed in

51 Since adenosine A2A receptors (A2ARs) control lysosome traffic

52 d reference memory through the antagonism of adenosine A2A receptors (A2ARs) controlling synaptic pla

53 In contrast, adenosine A2A receptors (A2ARs) did not coprecipitate or

54 Activation of adenosine A2A receptors (A2ARs) stimulates bone formatio

55 ladenant) was developed for mapping cerebral adenosine A2A receptors (A2ARs) with PET.

56 ced by lymphocyte depletion or activation of adenosine A2A receptors (A2ARs) with the selective agoni

57 We recently found that adenosine A2A receptors (A2ARs), which control synaptic

58 lzheimer's disease through the antagonism of adenosine A2A receptors (A2ARs).

59 tivation/deactivation mechanism of the human adenosine A2A receptor (AA2AR), a member of the class A

60 h pathways were modulated by dopamine D2 and adenosine A2A receptors, acting through cAMP/PKA.

61 Instead, adenosine A2A receptor activation of G alpha(s/olf) seem

62 However, the combination of adenosine A2A receptor activation with either isoflurane

63 induced a better neuroprotective effect than adenosine A2A receptor activation, isoflurane preconditi

64 Through adenosine A2A receptor activation, MTX promotes reverse

65 volve CaMKII inhibition, but may not involve adenosine A2A receptor activation.

66 Accordingly, reducing adenosine A2A receptor activity in Adk(Deltabrain) mice

67 Here, we show that the adenosine A2a receptor (ADORA2A) promotes hypoxia-induci

68 Studies with CGS21680, a specific agonist of adenosine A2A receptor (AdoRA2A), and ZM241385, an AdoRA

69 agonist N6-cyclohexyladenosine (CHA) or the adenosine A2a receptor agonist 2-[(2-aminoethylamino)car

70 In contrast, the adenosine A2A receptor agonist 2-p-(2-carboxyethyl)-phen

71 Pretreatment with the adenosine A2a receptor agonist APEC, but not the adenosi

72 The selective adenosine A2A receptor agonist binodenoson results in an

73 nosine and a second study with the selective adenosine A2A receptor agonist binodenoson, using 1 of 4

74 PA (2-chloro-N6-cyclopentyladenosine) or the adenosine A2A receptor agonist CGS 21680 (2-p-(2-carboxy

75 We hypothesized that a selective adenosine A2A receptor agonist would induce coronary vas

76 in maximal vessel response to CGS-21680, an adenosine A2A receptor agonist, but did not alter the co

77 arboxamidoadenosine (CGS 21680), a selective adenosine A2a receptor agonist, for 5 min prior to the S

78 The adenosine A2A receptor and PDE2, 3, 4, and 7 are importa

79 These effects are mediated via the adenosine A2A receptor and protein kinase A (PKA).

80 VEGF gene expression through stimulation of adenosine A2a receptor and subsequent activation of the

81 ly explained by genetic polymorphisms of the adenosine A2A receptors and alpha(2)-adrenergic receptor

82 a partner for the carboxyl-terminal tail of adenosine A2A receptors and showing that this interactio

83 ckade of a transactivation pathway that uses adenosine A2a receptors and src-family kinases (SFKs).

84 bbles by 70% (P<0.01), whereas inhibition of adenosine-A2a receptors and epoxyeicosatrienoic acids ha

85 in response to adenosine (via activation of adenosine A2A receptors) and to further determine the si

86 TrkB, adenosine A2a receptors, and SFKs associate into complex

87 The adenosine A2a receptor antagonist 8-(3-chlorostyryl)caff

88 kade of glutamate release by perfusion of an adenosine A2A receptor antagonist in the pmNAc shell blo

89 The novel adenosine A2A receptor antagonist KW-6002 has been exami

90 Different doses of an adenosine A2A receptor antagonist MSX-3 [3,7-dihydro-8-[

91 Tozadenant (SYN115) is an oral, selective adenosine A2A receptor antagonist that improves motor fu

92 pentyl-1,3-dipropylxanthine), or a selective adenosine A2A receptor antagonist ZM 241385.

93 en demonstrated to be a potent and selective adenosine A2a receptor antagonist, although with limited

94 te mice, C57BL/6 mice, and mice treated with adenosine A2A receptor antagonist.

95 1 receptor antagonist but not by a selective adenosine A2A receptor antagonist.

96 hibitory effects were reduced by addition of adenosine A2A receptor antagonist.

97 mine D2 receptor agonist and ZM 241385 as an adenosine A2A receptor antagonist.

98 esulted in discovery of potent and selective adenosine A2A receptor antagonists bearing substituted 1

99 Adenosine A2A receptor antagonists provide a promising n

100 These results suggest that selective adenosine A2A receptor antagonists represent a new class

101 structural information for the discovery of adenosine A2A receptor antagonists that have potential t

102 ly expressed in striatonigral neurons, while adenosine A2a receptors are preferentially expressed in

103 tissue-nonspecific alkaline phosphatase, and adenosine A2a receptors are significantly increased in d

104 A receptor ligand, showed that the number of adenosine A2A receptor binding sites was similarly incre

105 We therefore examined whether adenosine A2A receptors contribute to the pathogenesis o

106 Adenosine A2A receptor-deficient and A2A receptor antago

107 leomycin-induced dermal fibrosis model using adenosine A2A receptor-deficient wild-type littermate mi

108 Herein we describe adenosine A2A receptor distribution, signaling pathways,

109 ha), from dopamine D1 receptor-expressing or adenosine A2a receptor-expressing medium spiny neurons (

110 ter, and adenosine A1 receptor and decreased adenosine A2A receptor expression in the NAc.

111 olution X-ray crystal structure of the human adenosine A2A receptor (hA2AAR), in which the allosteric

112 The adenosine A2A receptor has emerged as an attractive non-

113 Adenosine A2A receptor immunoreactivity (A2A-LI) has bee

114 collagen production after stimulation of the adenosine A2A receptor in a dose-dependent fashion.

115 Blockade of the adenosine A2A receptor in striatopallidal neurons reduce

116 s- and Golf-coupled dopamine D1 receptor and adenosine A2A receptor in the brain and other organs, el

117 Adenosine A2A receptors in striatum are selectively loca

118 It was also apparent that this population of adenosine A2a receptors in the NTS desensitized within 2

119 These results show that adenosine A2A receptor-induced protection is most likely

120 ncology despite the safe clinical profile of adenosine A2A receptor inhibitors (A2ARi) in Parkinson d

121 on pathways by which occupancy of neutrophil adenosine A2A receptors inhibits superoxide anion genera

122 The adenosine A2A receptor is a G-protein-coupled receptor (

123 The adenosine A2A receptor is a prototypical rhodopsin-like

124 The cerebral adenosine A2A receptor is an attractive therapeutic targ

125 VHD, and the pharmacologic activation of the adenosine A2A receptor is protective.

126 -isomer (Sp-cAMPS), prostaglandin E1, or the adenosine A2A receptor is sufficient to cause epsilonPKC

127 ntially therapeutic dopamine D1 receptor and adenosine A2A receptor ligands with functionally selecti

128 Adenosine A2A receptor ligation stimulated ERK phosphory

129 We observed that the striatal adenosine A2A receptor links adenosine tone and psychomo

130 ening inflammation through signaling via the adenosine A2A receptor may limit tissue damage but may a

131 termine the signaling mechanisms involved in adenosine A2A receptor-mediated promotion of collagen pr

132 cological inhibitors of signal transduction, adenosine A2A receptor-mediated stimulation of procollag

133 al-regulated kinase (erk), but surprisingly, adenosine A2A receptor-mediated stimulation of procollag

134 The adenosine A2a receptor mediates a new cyclic AMP-indepen

135 tributes to the development of OA; targeting adenosine A2A receptors might treat or prevent OA.

136 Adenosine A2A receptor occupancy promoted collagen produ

137 pression of CD39/CD73 on T reg cells and the adenosine A2A receptor on activated T effector cells gen

138 rior studies indicate that adenosine and the adenosine A2A receptor play a role in hepatic fibrosis b

139 These results demonstrate that adenosine A2A receptors play an active role in the patho

140 egulates inflammation and tissue repair, and adenosine A2A receptors promote wound healing by stimula

141 aspartate (NMDA) receptors, or activation of adenosine A2A receptors resulted in reduction of the OGD

142 on, we demonstrate that beta2-adrenergic and adenosine A2A receptors scramble lipids, suggesting that

143 Selective agonism of the adenosine A2A receptor should result in a similar degree

144 These results indicate that adenosine A2A receptors signal for increased collagen pr

145 2 (CK2) negatively regulates dopamine D1 and adenosine A2A receptor signaling in the striatum.

146 27-hydroxylase and ABCA1 was blocked by the adenosine A2A receptor-specific antagonist ZM241385.

147 and this modulation is primarily through the adenosine A2a receptor subtype.

148 cal GPCRs with known crystal structures: the adenosine A2A receptor, the beta2-adrenergic receptor an

149 latory response is mediated primarily by the adenosine A2A receptors, these side effects result from

150 immediate tissue-protecting mechanisms, with adenosine A2A receptors triggering "OFF" signals in acti

151 on of Th1 and Th2 cells in vitro depended on adenosine A2A receptors, which were also required for th

152 esent study, we demonstrate that blockade of adenosine A2A receptors with caffeine or a selective A2A