ライフサイエンスコーパス: adenosine deaminase

1 12a and ent-14a were moderate substrates for adenosine deaminase.

2 (4)one, were screened against calf-intestine adenosine deaminase.

3 9a, 10a, and 11a are moderate substrates for adenosine deaminase.

4 ons were consistent with editing by host RNA adenosine deaminase.

5 alogues 11a and 12a were weak substrates for adenosine deaminase.

6 A by the enzyme double-stranded RNA-specific adenosine deaminase.

7 d from 2-amino-6-chloropurine riboside using adenosine deaminase.

8 n which 5'-methylthioinosine is generated by adenosine deaminase.

9 polyadenylation, and even RNA editing by an adenosine deaminase.

10 6a were moderately active as substrates for adenosine deaminase.

11 ed exoenzymes: apyrase, 5'-nucleotidase, and adenosine deaminase.

12 DO deaminase complexing protein 2 (CD26) and adenosine deaminase.

13 e by direct dehydroxylamination catalyzed by adenosine deaminase.

14 ding of a new series of potent inhibitors of Adenosine Deaminase.

15 a melanogaster and humans have both types of adenosine deaminases.

16 These effects were antagonized by CPT or adenosine deaminase (0.8 IU/ml), suggesting mediation by

17 e to inosine was completely inhibited by the adenosine deaminase 1 (ADA1) inhibitor erythro-9-(2-hydr

18 egulation of the editing enzyme RNA-specific adenosine deaminase 1 (ADAR1) was documented during acut

19 from the editing enzyme, double-stranded RNA adenosine deaminase 1.

20 me chromosome region, candidate 1), encoding adenosine deaminase 2 (ADA2), that were predicted to be

21 essive mutations in CECR1, the gene encoding adenosine deaminase 2 (ADA2).

22 Deficiency of adenosine deaminase 2 (DADA2) is caused by biallelic del

23 deaminase Arg and a predicted tRNA-specific adenosine deaminase 2 in A. thaliana.

24 rrel structure with structural similarity to adenosine deaminase, a relationship that is undetectable

25 inhibition characteristics of coformycins to adenosine deaminase, a series of analogues (1a-1h) conta

26 ded for antigen receptor development, one is adenosine deaminase--a purine salvage pathway enzyme, an

27 ated [Ca(2+)](i) responses were augmented by adenosine deaminase, A1, and A3R antagonists.

28 hydrolytic deamination process, catalyzed by adenosine deAminase acting on double-stranded RNA (ADAR)

29 zymes responsible for editing in mammals are adenosine deaminase acting on RNA (ADAR) 1 and 2.

30 in enzymatic activity of the editing enzyme adenosine deaminase acting on RNA (ADAR) 2, as deduced f

31 ary structure and the temporal expression of adenosine deaminase acting on RNA (ADAR) contribute to c

32 may be generated by RNA editing mediated by adenosine deaminase acting on RNA (ADAR) enzymes that re

33 e reduced posttranscriptional RNA editing by adenosine deaminase acting on RNA (ADAR) enzymes, but th

34 >I RNA editing is mediated by adenosine deaminase acting on RNA (ADAR) enzymes.

35 Yeasts and filamentous fungi do not have adenosine deaminase acting on RNA (ADAR) orthologs and a

36 Other DRBPs such as Staufen, adenosine deaminase acting on RNA (ADAR), and spermatid

37 UNE2/PCA3 double-stranded RNA that undergoes adenosine deaminase acting on RNA (ADAR)-dependent adeno

38 nts, and apply it to a genome-scale study of adenosine deaminase acting on RNA (ADAR)-mediated RNA ed

39 s changed to inosine in RNA, is catalyzed by adenosine deaminase acting on RNA (ADAR).

40 bors the inflammation-responsive RNA editase adenosine deaminase acting on RNA (ADAR)1 gene, occurs i

41 The human RNA-editing enzyme adenosine deaminase acting on RNA (ADAR1) carries a uniq

42 consistent with conversions catalyzed by the adenosine deaminase acting on RNA (ADAR1).

43 e repair, we exploit the catalytic domain of Adenosine Deaminase Acting on RNA (ADAR2) that deaminate

44 Adenosine Deaminase Acting on RNA 1 (ADAR1) is an RNA-ed

45 We show here that RNA editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) is critical

46 rotein kinase regulated by RNA (PKR) and the adenosine deaminase acting on RNA 1 (ADAR1).

47 and the sensing of viral RNA is regulated by adenosine deaminase acting on RNA 1 (ADAR1).

48 AC)7 with the Zalpha-binding domain of human adenosine deaminase acting on RNA 1 (ADAR1, hZalphaADAR1

49 n directly inhibits editing, we do show that adenosine deaminase acting on RNA 1 and 2 and fibrillari

50 iated knockdown demonstrated that editing is adenosine deaminase acting on RNA 1 and 2 dependent.

51 Adenosine deaminase acting on RNA 2 (ADAR2) is a nuclear

52 , a dysfunctional form of the editing enzyme adenosine deaminase acting on RNA B1 was found more comm

53 sine-to-inosine deaminase activity by ADAR2 (adenosine deaminase acting on RNA type 2) to transcripts

54 ADAR1 (adenosine deaminase acting on RNA) catalyzes the convers

55 ADAR1 (adenosine deaminase acting on RNA) catalyzes the deamina

56 ional modification of RNA, mediated by ADAR (adenosine deaminase acting on RNA) enzymes.

57 s report, we establish that Drosophila ADAR (adenosine deaminase acting on RNA) forms a dimer on doub

58 The members of the ADAR (adenosine deaminase acting on RNA) gene family are invol

59 ADAR1 (adenosine deaminase acting on RNA) is widely expressed i

60 Adar (adenosine deaminase acting on RNA) mutant flies expressi

61 ADAR1, the interferon (IFN)-inducible adenosine deaminase acting on RNA, catalyzes the C-6 dea

62 ites were characteristic of those favored by adenosine deaminase acting on RNA-1 (ADAR1), which catal

63 s contain motifs favoring recognition by the adenosine deaminase acting on RNA-1 (ADAR1).

64 adenosine-to-inosine RNA editing mediated by adenosine deaminase acting on RNA1 (ADAR1) promotes canc

65 Adenosine deaminases acting on double-stranded RNA (ADAR

66 o-inosine (A-to-I) RNA editing, catalyzed by Adenosine DeAminases acting on double-stranded RNA(dsRNA

67 enrichment with known features of targets of adenosine deaminases acting on RNA (ADAR) and validation

68 Adenosine deaminases acting on RNA (ADAR) convert adenos

69 ate synthetases-like (OASL)(rs1169279CT) and adenosine deaminases acting on RNA (ADAR)(rs1127309TC) g

70 n double-stranded RNA (dsRNA) is mediated by adenosine deaminases acting on RNA (ADAR).

71 in double-stranded RNA through the action of adenosine deaminases acting on RNA (ADAR).

72 Adenosine deaminases acting on RNA (ADAR1 and ADAR2) are

73 Adenosine deaminases acting on RNA (ADARs) are best know

74 Adenosine deaminases acting on RNA (ADARs) are involved

75 Adenosine deaminases acting on RNA (ADARs) catalyze the

76 Adenosine deaminases acting on RNA (ADARs) catalyze the

77 Adenosine deaminases acting on RNA (ADARs) catalyze the

78 Adenosine deaminases acting on RNA (ADARs) catalyze the

79 The adenosine deaminases acting on RNA (ADARs) comprise a fa

80 Adenosine deaminases acting on RNA (ADARs) hydrolyticall

81 Pre-mRNA editing by adenosine deaminases acting on RNA (ADARs) provides an a

82 ation of particular adenosines to inosine by adenosine deaminases acting on RNA (ADARs).

83 adenosine-to-inosine (A-to-I) RNA editing by adenosine deaminases acting on RNA (ADARs).

84 sine to inosine, a reaction catalyzed by the adenosine deaminases acting on RNA (ADARs).

85 Adenosine deaminases acting on RNAs (ADARs) convert aden

86 t anticodon position in tRNA is catalyzed by adenosine deaminases acting on tRNA (ADATs).

87 ar to the anticodon loop of tRNA targeted by adenosine deaminases acting on tRNA (ADATs).

88 Baseline 5-HT levels increased with adenosine deaminase, activation of A2Rs, and inhibition

89 Return of significant amount of tissue adenosine deaminase activity by 24 hrs and later recover

90 PKR-ADAR1 chimeras retained significant RNA adenosine deaminase activity measured with a synthetic d

91 Adenosine deaminase activity was similar in serum of pat

92 th dramatic increases in CD26 expression and adenosine deaminase activity were observed in PTMs durin

93 Little is known about the role of adenosine deaminase (ADA) 2 in regulation of immune resp

94 the source of the purine precursors, making adenosine deaminase (ADA) a key enzyme in the pathway of

95 adenosine receptor expression and decreased adenosine deaminase (ADA) activity in C57BL/6 animals.

96 3 overexpression on the levels of adenosine, adenosine deaminase (ADA) activity, and adenosine recept

97 functions that involve its interaction with adenosine deaminase (ADA) and other extracellular matrix

98 Genetic deficiency of adenosine deaminase (ADA) can cause profound lymphopenia

99 Adenosine deaminase (ADA) can localize to the cell surfa

100 version of AMP to adenosine, whereas soluble adenosine deaminase (ADA) catabolizes adenosine to inosi

101 Adenosine deaminase (ADA) catalyzes the hydrolysis of ad

102 Inherited defects in the function of adenosine deaminase (ADA) cause severe combined immunode

103 sed a retroviral vector containing the human adenosine deaminase (ADA) cDNA to transduce mature perip

104 Adenosine deaminase (ADA) deficiency causes severe cellu

105 Adenosine deaminase (ADA) deficiency in humans results i

106 Adenosine deaminase (ADA) deficiency is a rare, autosoma

107 Adenosine deaminase (ADA) deficiency is associated with

108 ly, we provide in vivo genetic evidence that adenosine deaminase (ADA) deficiency leads to excess pla

109 Adenosine deaminase (ADA) deficiency results in the accu

110 A case of a 17-month-old girl with adenosine deaminase (ADA) deficiency SCID in whom full h

111 Adenosine deaminase (ADA) deficiency, a cause of X-linke

112 Adenosine deaminase (ADA) gene defects are among the mos

113 opment, with a Zap70 transgene driven by the adenosine deaminase (ADA) gene enhancer, which is active

114 identified near the second exon of the human adenosine deaminase (ADA) gene.

115 T>A, in the last splice acceptor site of the adenosine deaminase (ADA) gene.

116 Mice deficient in the enzyme adenosine deaminase (ADA) have small lymphoid organs tha

117 ucleosides could be successfully resolved by adenosine deaminase (ADA) hydrolysis.

118 IMER columns were prepared by entrapment of adenosine deaminase (ADA) into sol-gel derived monolithi

119 The purine metabolic gene adenosine deaminase (ADA) is expressed along a defined s

120 In mammalian intestine, adenosine deaminase (ADA) is expressed at high levels on

121 Adenosine deaminase (ADA) is expressed intracellularly b

122 Adenosine deaminase (ADA) is the principal catabolic enz

123 investigate the mechanism by which a lack of adenosine deaminase (ADA) leads to a failure of T cell p

124 However, rapid degradation by adenosine deaminase (ADA) limits its overall therapeutic

125 Human adenosine deaminase (ADA) occurs as a 41-kDa soluble mon

126 The plasmodial enzyme adenosine deaminase (ADA) plays a central role in purine

127 Mutations in the gene encoding adenosine deaminase (ADA), a purine salvage enzyme, lead

128 In the absence of adenosine deaminase (ADA), adenosine and other purine me

129 Here we report that mice lacking adenosine deaminase (ADA), an enzyme necessary for the b

130 of adenosine, resulting from a deficiency in adenosine deaminase (ADA), developed renal dysfunction a

131 ond T cell costimulatory receptor component, adenosine deaminase (ADA), on the process of replicative

132 4(+)CD25(high) T cells express low levels of adenosine deaminase (ADA), the enzyme responsible for ad

133 is not a substrate for ADAR, in contrast to adenosine deaminase (ADA), which catalyzes a similar rea

134 n two independent animal models of priapism, adenosine deaminase (ADA)-deficient mice and SCD transge

135 Adenosine deaminase (ADA)-deficient mice develop progres

136 The current study utilized adenosine deaminase (ADA)-deficient mice to determine wh

137 To accomplish this, adenosine deaminase (ADA)-deficient mice were treated wi

138 dependent pulmonary inflammation observed in adenosine deaminase (ADA)-deficient mice.

139 two independent priapic models: SCD mice and adenosine deaminase (ADA)-deficient mice.

140 ted a gene therapy trial in 10 patients with adenosine deaminase (ADA)-deficient severe combined immu

141 Adenosine deaminase (ADA)-deficient severe combined immu

142 topoietic stem cell transplantation (HCT) of adenosine deaminase (ADA)-deficient severe combined immu

143 Adenosine deaminase (ADA)-severe combined immunodeficien

144 ation by the Zn(2+)-dependent protein enzyme adenosine deaminase (ADA).

145 on of the enzyme that metabolizes adenosine, adenosine deaminase (ADA).

146 vo because of rapid metabolic degradation by adenosine deaminase (ADA).

147 dAdo is maintained at low levels by adenosine deaminase (ADA).

148 Adenosine deaminase (ADA, EC 3.5.4.4) is a ubiquitous (b

149 of adenosines to inosines by dsRNA-specific adenosine deaminase (ADAR) can lead to the nuclear reten

150 ta domain from the human double-stranded RNA adenosine deaminase ADAR1 at 0.97 A, determined by singl

151 tigenome at the amber/W site by the host RNA adenosine deaminase ADAR1 is a critical step in the HDV

152 a preferred editing site for the RNA editing adenosine deaminase ADAR1.

153 The RNA-specific adenosine deaminase (ADAR1) and the RNA-dependent protei

154 h IFN-alpha/beta and IFN-gamma (RNA-specific adenosine deaminase [ADAR1] and RNA-dependent protein ki

155 T2CR editing is caused by down-regulation of adenosine deaminase ADAR2 and that editing of at least o

156 nuclear enzyme responsible for Q/R-editing, adenosine deaminase (ADAR2), is increased during differe

157 The RNA-editing adenosine deaminases (ADARs) catalyze deamination of ade

158 tent with RNA editing by one of the host RNA adenosine deaminases (ADARs).

159 Adenosine deaminases (ADAs) from human, bovine, and Plas

160 Recombinant ADGF-A and ADGF-D are active adenosine deaminases (ADAs), and they cause polarization

161 mutant analysis; however, the gene encoding adenosine deaminase (ADD) in H. pylori remained unidenti

162 Mononuclear cell adenosine deaminase after PT was inhibited 84%.

163 -dependently attenuated the activity of both adenosine deaminase and adenosine kinase (both p </= .00

164 Furthermore, both adenosine deaminase and adenosine kinase activity was si

165 CMSD is very similar to that of Zn-dependent adenosine deaminase and Fe-dependent cytosine deaminase,

166 armacophore leads to increased resistance to adenosine deaminase and purine nucleoside phosphorylase

167 o be susceptible to enzymatic conversions by adenosine deaminase and purine nucleoside phosphorylase,

168 identified by mass spectrometry include RNA adenosine deaminases and several novel factors.

169 mbination of inhibitors of adenosine kinase, adenosine deaminase, and the equilibrative nucleoside tr

170 phosphatases (inactive), CD-39-type apyrase, adenosine deaminases, and esterases.

171 smodium purine nucleoside phosphorylases and adenosine deaminases are inhibited.

172 oflavin biosynthesis, the chloroplastic tRNA adenosine deaminase Arg and a predicted tRNA-specific ad

173 oxycoformycin (pentostatin), an inhibitor of adenosine deaminase, as a postinsult, or prophylactic tr

174 tes from purine nucleoside phosphorylase and adenosine deaminase blockade but not when erythrocyte ad

175 rowth factor that is the major extracellular adenosine deaminase, can cause polyarteritis nodosa vasc

176 ogs of yeast (Saccharomyces cerevisiae) tRNA adenosine deaminases catalyze adenosine-to-inosine editi

177 The essential tRNA-specific adenosine deaminase catalyzes the deamination of adenosi

178 holinesterase; dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2); glucokinase (

179 the mechanism of APC variation, we measured adenosine deaminase concentration, adenosine uptake by r

180 ns (Hcrt, melanin-concentrating hormone, and adenosine deaminase-containing neurons) but not others (

181 This gene encodes a Drosophila pre-mRNA adenosine deaminase (dADAR) and is expressed almost excl

182 monary disease, asthma, cystic fibrosis, and adenosine deaminase deficiency (ADA(-/-)).

183 Adenosine deaminase deficiency is a disorder of purine m

184 Adenosine deaminase deficiency results in toxic accumula

185 inase 3 forms of SCID and greatly reduced in adenosine deaminase deficiency SCID but often present in

186 eletion recombinant excision circles and for adenosine deaminase deficiency using tandem mass spectro

187 complex inheritance; these diseases include adenosine deaminase deficiency-related severe combined i

188 Investigations of patients with adenosine deaminase deficient severe combined immunodefi

189 del of adenosine-mediated lung injury is the adenosine deaminase-deficient (Ada(-/-)) mouse.

190 Adenosine deaminase-deficient (ADA-deficient) mice devel

191 he pulmonary inflammation and injury seen in adenosine deaminase-deficient (ADA-deficient) mice, whic

192 CD4(-)CD8(-) stage is markedly inhibited in adenosine deaminase-deficient (ADA-deficient) murine fet

193 eic HSCT that has shown clinical benefit for adenosine deaminase-deficient (ADA-deficient) SCID when

194 ovides another treatment of the X-linked and adenosine deaminase-deficient forms of SCID, and we disc

195 py for severe combined immune deficiency-X1, adenosine deaminase-deficient forms of severe combined i

196 ue of the JCI, Sun et al. report findings in adenosine deaminase-deficient mice that suggest the occu

197 as BM from children on enzyme treatment for adenosine deaminase-deficient SCID (n = 2).

198 Gene therapy (GT) for adenosine deaminase-deficient severe combined immune def

199 A patient with adenosine deaminase-deficient severe combined immune def

200 dence of this DFSP in children affected with adenosine deaminase-deficient severe combined immunodefi

201 the underlying genetic defect, diagnosis of adenosine deaminase-deficient severe combined immunodefi

202 In dramatic contrast, 39 adenosine deaminase-deficient severe combined immunodefi

203 -inducible double-stranded (ds) RNA-specific adenosine deaminase, downregulates host innate responses

204 al to Saccharomyces cerevisiae AAH and human adenosine deaminase enzymes, respectively, catalyzes ade

205 onstrate the existence of a subfamily of the adenosine deaminase family characterized by their unique

206 riations in each of three genes (An. gambiae adenosine deaminase, fibrinogen-related protein 30, and

207 ed and screened in vitro against a mammalian adenosine deaminase for inhibitory activity.

208 transition states described recently for the adenosine deaminases from human, bovine, and Plasmodium

209 ox deficient G+C-rich promoter of the murine adenosine deaminase gene (Ada) requires a 48-bp minimal

210 rogenitors also require a signal mediated by Adenosine deaminase growth factor A (Adgf-A) arising fro

211 e, HRP-avidin was substituted with the human adenosine deaminase (hADA1)-streptavidin complex and ade

212 Pentostatin, a potent inhibitor of adenosine deaminase, has activity in acute GVHD.

213 Human adenosine deaminase (HsADA) is present in most mammalian

214 al TMN at four different times using Fos and adenosine deaminase immunohistochemistry and recordings

215 -containing neurons but not with the loss of adenosine deaminase-immunoreactive neurons.

216 s showed pentostatin significantly inhibited adenosine deaminase in canine lymphocytes.

217 The different roles played by each type of adenosine deaminase in humans and Drosophila remains to

218 and NBTI and were significantly inhibited by adenosine deaminase, indicating a role for extracellular

219 Pentostatin, a potent inhibitor of adenosine deaminase, induces lymphocyte apoptosis and ma

220 and S-(4-nitrobenzyl)-6-thioinosine and the adenosine deaminase inhibitor deoxycoformycin potentiate

221 ytho-9-(2-hydroxy-3-nonyl)adenine (EHNA), an adenosine deaminase inhibitor, for 48 hours increased GP

222 Pentostatin, an adenosine deaminase inhibitor, leads to lymphocyte deple

223 2'-deoxycoformycin (DCF), a potent adenosine deaminase inhibitor, reversed the inhibitory e

224 tment with adenosine and deoxycoformycin, an adenosine deaminase inhibitor, stimulated GVB in dbcAMP-

225 ADAR2 is a double-stranded RNA-specific adenosine deaminase involved in the editing of mammalian

226 ADAR2 is a double-stranded RNA-specific adenosine deaminase involved in the editing of mammalian

227 ADAR2 is a double-stranded-RNA-specific adenosine deaminase involved in the editing of mammalian

228 ADAR2 is a double-stranded RNA-specific adenosine deaminase involved in the editing of mammalian

229 d is phylogenetically related to a family of adenosine deaminases involved in RNA editing.

230 Furthermore, studies using adenosine deaminase knockout mice suggested that elevate

231 Deficiency of the purine salvage enzyme adenosine deaminase leads to SCID (ADA-SCID).

232 ence analyses indicated that the protein was adenosine deaminase-like protein isoform 1 (ADAL1).

233 oteins (AtTAD2 and AtTAD3, for tRNA-specific adenosine deaminase) localize to the nucleus and interac

234 We have shown that the mouse adenosine deaminase (MADA) gene locus is packaged into a

235 Murine adenosine deaminase (mADA) is a 40 kDa (beta/alpha)(8)-b

236 enger RNA was upregulated (p = .01), whereas adenosine deaminase messenger RNA was downregulated (p =

237 tion (CD39 and CD73) and breakdown (CD26 and adenosine deaminase) on T cells from blood, lymph nodes,

238 , treatment of wild-type mice with pegylated adenosine deaminase or CD73 antibodies also significantl

239 vitro transcription initiated at a GC-rich (adenosine deaminase) or TATA box-dependent (Ad2ML) promo

240 d the respiratory burst, and, in cocultures, adenosine deaminase overcame the inhibitory effects of e

241 t activity of another purine salvage enzyme, adenosine deaminase (PfADA), was normal.

242 However adenosine deaminase played a minor role in determining t

243 upon binding to the Zalpha domain of the RNA adenosine deaminase protein.

244 Drosophila PDGF/VEGF receptor), STAT92E, and adenosine deaminase-related growth factor A (ADGF-A).

245 protein family in Drosophila containing six adenosine deaminase-related growth factors (ADGFs), whic

246 a genetic analysis of a novel family of six adenosine deaminase-related growth factors (ADGFs).

247 ADARs are adenosine deaminases responsible for RNA-editing reactio

248 RNA (ADAR1 and ADAR2) are human RNA-editing adenosine deaminases responsible for the conversion of a

249 portant role for biased hypermutation via an adenosine deaminase, RNA-specific (ADAR)-like activity.

250 cancer transcriptomes demonstrate that ADAR (adenosine deaminase, RNA-specific)-mediated RNA editing

251 xenograft model used is not informative for adenosine deaminase-SCID, whereas hypomorphic mutations

252 mproved outcomes for 'difficult' conditions [adenosine deaminase-severe combined immunodeficiency (AD

253 entiation-associated) and lysosome function (adenosine deaminase) showed differential alternative spl

254 clic AMP production was reduced by exogenous adenosine deaminase, suggesting that A(2b) receptors sen

255 n-5-ylamino]ethyl)phe nol (ZM241385) but not adenosine deaminase, suggesting that constitutive activa

256 Bacterial tRNA-specific adenosine deaminase (TadA) catalyzes the essential deami

257 NA (dsRNA) substrate and is catalyzed by the adenosine deaminase that act on dsRNA (ADAR) family of e

258 gh a new pathway involving RNA editing by an adenosine deaminase that acts on double-stranded RNA (AD

259 Adenosine deaminase that acts on RNA (ADAR)1 and ADAR2 a

260 eporter sensitive to Drosophila melanogaster adenosine deaminase that acts on RNA (dADAR) activity an

261 Adenosine deaminase that acts on RNA -2 (ADAR2) is a mem

262 the endogenous targeting domains from human adenosine deaminase that acts on RNA 2 and replacing the

263 In this study, we identify adenosine deaminase that acts on RNA 3 (ADAR3) as an imp

264 ADAR (adenosine deaminase that acts on RNA) editing enzymes ta

265 The ADAR1 gene encodes an RNA-specific adenosine deaminase that alters the functional activity

266 ADAR1 is an RNA-specific adenosine deaminase that edits RNA sequences.

267 ne-to-inosine (A-to-I) editing, generated by adenosine deaminases that act on double-stranded RNA (AD

268 Hyperediting by adenosine deaminases that act on RNA (ADAR) enzymes was

269 Because transcript editing is regulated by adenosine deaminases that act on RNA (ADAR), we quantifi

270 Adenosine deaminases that act on RNA (ADARs) are RNA edi

271 Adenosine deaminases that act on RNA (ADARs) are RNA-edi

272 Adenosine deaminases that act on RNA (ADARs) carry out a

273 The adenosine deaminases that act on RNA (ADARs) catalyze th

274 An enzyme family known as adenosine deaminases that act on RNA (ADARs) catalyzes a

275 Adenosine deaminases that act on RNA (ADARs) constitute

276 Adenosine deaminases that act on RNA (ADARs) deaminate a

277 Although there are no reports that adenosine deaminases that act on RNA (ADARs) require a c

278 rgo extensive modification (hyperediting) by adenosine deaminases that act on RNA (ADARs), where up t

279 le-stranded RNA may undergo hyper-editing by adenosine deaminases that act on RNA (ADARs), where up t

280 rgo covalent modification (hyper-editing) by adenosine deaminases that act on RNA (ADARs), whereby up

281 one or more of the cellular enzymes known as adenosine deaminases that act on RNA (ADARs).

282 DNA (dsRNA) duplexes can be hyper-edited by adenosine deaminases that act on RNA (ADARs).

283 ADARs are adenosine deaminases that act on RNA and are responsible

284 Adenosine deaminases that act on RNA are a conserved fam

285 One or several members of the ADAR (adenosine deaminases that act on RNA) family are thought

286 In mammals, it is mediated by a family of adenosine deaminases that act on RNAs (ADARs).

287 the crystal structure are conserved in some adenosine deaminases that act on transfer RNA (tRNA) (AD

288 ADAR1 isoforms are adenosine deaminases that edit and destabilize double-st

289 " behavior, as illustrated by the ability of adenosine deaminase to deaminate (tz)A as effectively as

290 We evolved a transfer RNA adenosine deaminase to operate on DNA when fused to a ca

291 Treatment with pegylated adenosine-deaminase to enhance extracellular adenosine b

292 with extracellular ATP scavengers [apyrase + adenosine deaminase] versus 95 +/- 12% surviving cells w

293 The presence of adenosine deaminase was confirmed in the secreted produc

294 Breakdown of adenosine by adenosine deaminase was the major source of the inosine/

295 statin (2'-deoxycoformycin), an inhibitor of adenosine deaminase, was administered to mice immediatel

296 ed out by a cellular activity known as ADAR (adenosine deaminase), which acts on RNA substrates that

297 was also observed in mice lacking the enzyme adenosine deaminase, which degrades adenosine.

298 l agonist-potentiated waves are abolished by adenosine deaminase, which degrades extracellular adenos

299 effects of NBMPR were partially reversed by adenosine deaminase, which facilitates the metabolic deg

300 t Hp0267 represents a second enzyme class of adenosine deaminase whose phyletic distribution among pr