ライフサイエンスコーパス: adenosyl

1 -C bond dissociation energies in the related adenosyl- and methylcobinamides (41.5 +/- 1.2 and 44.6 +

2 to the cofactor forms methyl-Cbl (MeCbl) and adenosyl-Cbl (AdoCbl) is required for the function of tw

3 (Cbl)), in the cofactor forms methyl-Cbl and adenosyl-Cbl, is required for the function of the essent

4 er RNAs, appears to be regulated by a single adenosyl cobalamine (AdoCbl)-responsive riboswitch.

5 nd HotDog domains implicated in binding DNA, adenosyl compounds, and CoA-containing compounds respect

6 obalamin (coenzyme B 12) by transferring the adenosyl group from cosubstrate ATP to a transient Co (1

7 methylenetetrahydrofolate reductase (Mthfr), adenosyl-homocysteinase (Ahcy), and methylenetetrahydrof

8 enzyme, PaMTH1-SAM (co-factor), and PaMTH1-S-adenosyl homocysteine (by-product) co-complexes refined

9 matography/mass spectrometry (LC/MS)-based S-adenosyl homocysteine (SAH) detection assay for histone

10 Here, we describe a suite of S-adenosyl homocysteine (SAH) photoreactive probes and the

11 hyltransferase mechanisms, the addition of S-adenosyl homocysteine (SAH), which is the by-product and

12 n the free form and a ternary complex with S-adenosyl homocysteine and a histone H3 peptide and bioch

13 the expression of DNMT1, MMP9, TIMP1, and S-adenosyl homocysteine hydrolase (SAHH) and upregulated m

14 We show here that the cofactor analogue S-adenosyl homocysteine promotes this promiscuous DNA clea

15 1), and the decreased S-adenosylmethionine/S-adenosyl homocysteine ratio (P<0.01).

16 hen PIMT protein binding was poisoned with S-adenosyl homocysteine.

17 ce and absence of its methyl donor product S-adenosyl-homocysteine (SAH) and its ortholog scTrm10 fro

18 ility possibly reflected in high levels of S-adenosyl-homocysteine (SAH) and low levels of S-adenosyl

19 AM), which is converted via methylation to S-adenosyl-homocysteine (SAH), which accumulates during ag

20 that 1 equiv each of 5'-deoxyadenosine and S-adenosyl-homocysteine are produced for each methylation

21 aelis-Menten kinetics, and is inhibited by S-adenosyl-homocysteine.

22 e the resulting peptide with tritiated S-(5'-adenosyl)-l-methionine.

23 The S-adenosyl- l-homocysteine (AdoHcy) hydrolases (SAHH) from

24 TPMT, as a binary complex with the product S-adenosyl- l-homocysteine and as a ternary complex with S

25 homocysteine and as a ternary complex with S-adenosyl- l-homocysteine and the substrate 6-mercaptopur

26 ne by methylating them in a reaction using S-adenosyl- l-methionine as the donor.

27 at is generated by a reductive cleavage of S-adenosyl- l-methionine.

28 itors and immunoprecipitation of RyR2 from S-adenosyl-l-[methyl-(3)H]methionine ([(3)H]SAM) pretreate

29 from yeast cells radiolabeled in vivo with S-adenosyl-l-[methyl-(3)H]methionine.

30 analysis of Rpl3 radiolabeled in vivo with S-adenosyl-l-[methyl-(3)H]methionine.

31 d reductant and then incubated with excess S-adenosyl-l-[methyl-d3]methionine in the presence of subs

32 e determined for MycE bound to the product S-adenosyl-L-homocysteine (AdoHcy) and magnesium, both wit

33 PRMT7 in complex with its cofactor product S-adenosyl-l-homocysteine (AdoHcy) at 2.8 A resolution and

34 hydrolase (AHCY) hydrolyzes its substrate S-adenosyl-L-homocysteine (AdoHcy) to L-homocysteine (Hcy)

35 es of human NTMT1 in complex with cofactor S-adenosyl-L-homocysteine (SAH) and six substrate peptides

36 The affinity of S-adenosyl-l-homocysteine (SAH) for SAM binding proteins w

37 e and sensitive fluorescent biosensors for S-adenosyl-l-homocysteine (SAH) that provide a direct "mix

38 HH) catalyzes the reversible conversion of S-adenosyl-L-homocysteine (SAH) to adenosine (ADO) and L-h

39 product of the methyltransferase reaction, S-adenosyl-l-homocysteine (SAH), is converted into adenine

40 uence (5'-(m7)G0pppA1G2U3U4G5U6U7-3'), and S-adenosyl-l-homocysteine (SAH), the by-product of the met

41 and the second SAM (SAM2) is converted to S-adenosyl-l-homocysteine (SAH).

42 ein alpha-amine, resulting in formation of S-adenosyl-l-homocysteine and alpha-N-methylated proteins.

43 l-l-methionine (AdoMet) to glycine to form S-adenosyl-l-homocysteine and sarcosine.

44 mational state complexed with the products S-adenosyl-L-homocysteine and sinapaldehyde.

45 or the malonyl moiety and was inhibited by S-adenosyl-L-homocysteine and sinefungin.

46 with concomitant exchanges of the product S-adenosyl-l-homocysteine and the methyl donor substrate S

47 hDNMT1, residues 351-1600) in complex with S-adenosyl-l-homocysteine at 2.62A resolution.

48 associated inhibiting H3K27M peptide and a S-adenosyl-l-homocysteine cofactor.

49 nsition in the active site relative to the S-adenosyl-L-homocysteine complexes, suggesting a mechanis

50 res with bound S-adenosyl-L-methionine and S-adenosyl-L-homocysteine confirm that the cofactor bindin

51 S-Adenosyl-L-homocysteine hydrolase (AHCY) hydrolyzes its

52 S-Adenosyl-L-homocysteine hydrolase (SAHH) catalyzes the r

53 ophila homologs of the SAH hydrolase Ahcy (S-adenosyl-L-homocysteine hydrolase [SAHH[), CG9977/dAhcyL

54 anyl S-thiolodiphosphate (GSPP) along with S-adenosyl-L-homocysteine in the cofactor binding site, re

55 -linked continuous assay that converts the S-adenosyl-L-homocysteine product of DNA methylation to a

56 rK-Ser in complex with aclacinomycin T and S-adenosyl-L-homocysteine refined to 1.9-A resolution reve

57 S-Adenosyl-L-homocysteine remains bound in the active site

58 re of (s-s)MetH(CT) with cob(II)alamin and S-adenosyl-L-homocysteine represents the enzyme in the rea

59 '-O-methyltransferase RebM in complex with S-adenosyl-l-homocysteine revealed RebM to adopt a typical

60 plex with human tRNA3(Lys) and the product S-adenosyl-L-homocysteine show a dimer of heterodimers in

61 re of the ZIKV NS5 protein in complex with S-adenosyl-L-homocysteine, in which the tandem methyltrans

62 complex with its desmethylated cosubstrate S-adenosyl-l-homocysteine.

63 tide small RNA duplex and cofactor product S-adenosyl-l-homocysteine.

64 In this assay, S-adenosyl-l-homocystine (AdoHcy/SAH), the by-product of P

65 onsistent with its effect on the predicted S-adenosyl-l-Met binding site, dim1A plants lack the two 1

66 Here, 4-azidobut-2-enyl derivative of S-adenosyl-L-methionine (Ab-SAM) was reported as a suitabl

67 Recombinant TrmO employs S-adenosyl-L-methionine (AdoMet) as a methyl donor to meth

68 > m(7)GpppA-RNA --> m(7)GpppAm-RNA), using S-adenosyl-l-methionine (AdoMet) as a methyl donor.

69 Most of these MTases use the cofactor S-adenosyl-l-Methionine (AdoMet) as a methyl source.

70 TrmD enzymes are known to use S-adenosyl-l-methionine (AdoMet) as substrate; we have sho

71 The biological methyl donor S-adenosyl-l-methionine (AdoMet) is spontaneously degraded

72 nucleophilic attack of cytosine C5 on the S-adenosyl-L-methionine (AdoMet) methyl group is concerted

73 enase from Bacillus circulans (BtrN) is an S-adenosyl-l-methionine (AdoMet) radical enzyme.

74 substrate, catalyzes methyl transfer from S-adenosyl-l-methionine (AdoMet) to glycine to form S-aden

75 mmalian CBS is modulated by the binding of S-adenosyl-l-methionine (AdoMet) to its regulatory domain,

76 talyze the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the 5-position of cyto

77 A substrate and the methyl donor cofactor, S-adenosyl-l-methionine (AdoMet), displayed AdoMet non-com

78 uctive cleavage of the sulfonium center of S-adenosyl-L-methionine (AdoMet), generating methionine an

79 For example, how both the methyl donor S-adenosyl-l-methionine (AdoMet), which is water-soluble,

80 at 1.7 A and found that it belongs to the S-adenosyl-L-methionine (AdoMet)-dependent alpha/beta-knot

81 Modification of protein residues by S-adenosyl-L-methionine (AdoMet)-dependent methyltransfera

82 S-adenosyl-L-methionine (AdoMet)-dependent O-methyltransfe

83 reduced flavodoxin and a methyl group from S-adenosyl-L-methionine (AdoMet).

84 homocysteine, methyltetrahydrofolate, and S-adenosyl-l-methionine (AdoMet).

85 and a regulatory C-terminal domain binding S-adenosyl-l-methionine (AdoMet).

86 d an enzyme-coupled luminescence assay for S-adenosyl-l-methionine (AdoMet/SAM)-based PMTs.

87 We describe a new metabolite, carboxy-S-adenosyl-l-methionine (Cx-SAM), its biosynthetic pathway

88 omposed of enzymes that reductively cleave S-adenosyl-l-methionine (SAM or AdoMet) to generate a 5'-d

89 s and is catalyzed by multiple families of S-adenosyl-L-methionine (SAM or AdoMet)-dependent methyltr

90 S-adenosyl-L-methionine (SAM) acts as a signal and binds t

91 h, specific PMTs are engineered to process S-adenosyl-L-methionine (SAM) analogs as cofactor surrogat

92 ctivity of vSET in vivo with an engineered S-adenosyl-l-methionine (SAM) analogue as methyl donor cof

93 he synthesis of an azide-bearing N-mustard S-adenosyl-L-methionine (SAM) analogue, 8-azido-5'-(diamin

94 emoenzymatic platform for the synthesis of S-adenosyl-L-methionine (SAM) analogues compatible with do

95 of CliEn-seq involves in vivo synthesis of S-adenosyl-L-methionine (SAM) analogues from cell-permeabl

96 NSD2 binds to S-adenosyl-l-methionine (SAM) and nucleosome substrates to

97 nventional methyltransferases that utilize S-adenosyl-L-methionine (SAM) as a cofactor.

98 Molecular modeling and competitive S-adenosyl-l-methionine (SAM) binding assay suggest that t

99 ectroscopy on the resting oxidized and the S-adenosyl-l-methionine (SAM) bound forms of pyruvate form

100 at value in the conversion of 5'-ClDA into S-adenosyl-l-methionine (SAM) but a reduced kcat value in

101 oute to biodiesel produces FAMEs by direct S-adenosyl-L-methionine (SAM) dependent methylation of fre

102 n-2 in a chemical reaction catalysed by an S-adenosyl-L-methionine (SAM) dependent Methyltransferase

103 S-adenosyl-l-methionine (SAM) dependent O-methyltransferas

104 Lysine 2,3-aminomutase (LAM) is a radical S-adenosyl-L-methionine (SAM) enzyme and, like other membe

105 DesII, a radical S-adenosyl-l-methionine (SAM) enzyme from Streptomyces ven

106 tients have mutations in MOCS1A, a radical S-adenosyl-l-methionine (SAM) enzyme involved in the conve

107 ere we demonstrate that a putative radical S-adenosyl-L-methionine (SAM) enzyme superfamily member en

108 by DesII, which is a member of the radical S-adenosyl-L-methionine (SAM) enzyme superfamily.

109 DesII is a radical S-adenosyl-l-methionine (SAM) enzyme that can act as a dea

110 Tryptophan lyase (NosL) is a radical S-adenosyl-l-methionine (SAM) enzyme that catalyzes the fo

111 se activating enzyme (PFL-AE) is a radical S-adenosyl-l-methionine (SAM) enzyme that installs a catal

112 Viperin is predicted to be a radical S-adenosyl-l-methionine (SAM) enzyme, but it is unknown wh

113 SPL is a radical S-adenosyl-l-methionine (SAM) enzyme, which uses a [4Fe-4S

114 Radical S-adenosyl-l-methionine (SAM) enzymes are widely distribut

115 The radical S-adenosyl-L-methionine (SAM) enzymes RlmN and Cfr methyla

116 Radical S-adenosyl-L-methionine (SAM) enzymes use an iron-sulfur c

117 e to a family of proteins known as radical S-adenosyl-l-methionine (SAM) enzymes.

118 ing isotope effects (BIEs) of the cofactor S-adenosyl-l-methionine (SAM) for SET8-catalyzed H4K20 mon

119 nsferases (MATs) catalyze the formation of S-adenosyl-l-methionine (SAM) inside living cells.

120 S-adenosyl-L-methionine (SAM) is converted to 5'-chloro-5'

121 S-Adenosyl-l-methionine (SAM) is recognized as an importan

122 S-adenosyl-L-methionine (SAM) is the sole methyl-donor cof

123 The radical S-adenosyl-L-methionine (SAM) methyl synthases, RlmN and C

124 Many cobalamin (Cbl)-dependent radical S-adenosyl-l-methionine (SAM) methyltransferases have been

125 These results indicate that the radical S-adenosyl-L-methionine (SAM) protein PylB mediates a lysi

126 of bciD, which encodes a putative radical S-adenosyl-l-methionine (SAM) protein, are unable to synth

127 nt enzymes that are members of the radical S-adenosyl-l-methionine (SAM) superfamily was previously p

128 QueE is a member of the radical S-adenosyl-l-methionine (SAM) superfamily, all of which us

129 nslational riboswitches were identified in S-adenosyl-l-methionine (SAM) synthetase metK genes in mem

130 to cytosine (Cyt) C6, methyl transfer from S-adenosyl-l-methionine (SAM) to Cyt C5, and proton abstra

131 ate a 3-amino-3-carboxypropyl radical from S-adenosyl-L-methionine (SAM) to form a C-C bond.

132 hree cysteines in a CX(3)CX(2)C motif, and S-adenosyl-L-methionine (SAM) to generate a 5'-deoxyadenos

133 sis is the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to magnesium protoporphyrin

134 of the 3-amino-3-carboxypropyl group from S-adenosyl-l-methionine (SAM) to the histidine residue of

135 a DNA cofactor in order to stably bind to S-adenosyl-l-methionine (SAM), suggesting that it proceeds

136 S-Adenosyl-l-methionine (SAM), the primary methyl group do

137 thionine, a precursor for the synthesis of S-adenosyl-l-methionine (SAM), which is the most commonly

138 The highly conserved S-adenosyl-l-methionine (SAM)-binding residues of the DxG

139 structures of Bud23-Trm112 in the apo and S-adenosyl-L-methionine (SAM)-bound forms.

140 Here we report a versatile S-adenosyl-l-methionine (SAM)-dependent enzyme, LepI, that

141 evealing new metalloenzymes, flavoenzymes, S-adenosyl-L-methionine (SAM)-dependent enzymes and others

142 nthesis protein NifB catalyzes the radical S-adenosyl-L-methionine (SAM)-dependent insertion of carbi

143 ic analyses predicted EftM to be a Class I S-adenosyl-l-methionine (SAM)-dependent methyltransferase.

144 gent enzyme evolution has been observed in S-adenosyl-L-methionine (SAM)-dependent methyltransferases

145 ed by O-methyltransferases, members of the S-adenosyl-l-methionine (SAM)-dependent O-methyltransferas

146 roposed to comprise two distinct groups of S-adenosyl-l-methionine (SAM)-dependent RNA enzymes, namel

147 elta position of the piperazyl scaffold is S-adenosyl-l-methionine (SAM)-dependent.

148 troduced methyl group is assembled from an S-adenosyl-L-methionine (SAM)-derived methylene fragment a

149 -substrate for methyltransferase activity, S-adenosyl-l-methionine (SAM).

150 influence accumulation of the methyl donor S-adenosyl-L-methionine (SAM).

151 n known families of riboswitches that bind S-adenosyl-l-methionine (SAM).

152 e and the 3-amino-3-carboxypropyl group of S-adenosyl-l-methionine (SAM).

153 lis yitJ S-box (SAM-I) riboswitch bound to S-adenosyl-L-methionine (SAM).

154 , the highly abundant methylation cofactor S-adenosyl-l-methionine (SAM).

155 share a binding site for the methyl donor S-adenosyl-l-methionine and are inhibited by individual am

156 yl-homoserine lactones (AHL) signals using S-adenosyl-l-methionine and either cellular acyl carrier p

157 Two structures with bound S-adenosyl-L-methionine and S-adenosyl-L-homocysteine conf

158 hibitors, by mimicking each substrate, the S-adenosyl-l-methionine and the deoxycytidine, and linking

159 ng many methyltransferase enzymes that use S-adenosyl-l-methionine as a cofactor.

160 d by human S-COMT in the presence of S-[(3)H]adenosyl-l-methionine as a methyl group donor.

161 and shed light on the structural basis of S-adenosyl-L-methionine binding and methyltransferase acti

162 lone adenylation domain interrupted by the S-adenosyl-l-methionine binding region of a methyltransfer

163 ligands, including the first structure of S-adenosyl-l-methionine bound to a KsgA/Dim1 enzyme in a c

164 ructure of this enzyme in complex with the S-adenosyl-l-methionine cofactor at 1.7 A resolution confi

165 demonstrate that the pyruvoyl cofactor of S-adenosyl-L-methionine decarboxylase (AMD1) is dynamicall

166 The radical S-adenosyl-L-methionine enzyme DesII from Streptomyces ven

167 The radical S-adenosyl-L-methionine enzyme HydG lyses free tyrosine to

168 Here we show that PhnJ is a novel radical S-adenosyl-L-methionine enzyme that catalyses C-P bond cle

169 Intriguingly, radical S-adenosyl-L-methionine enzymes are vital for the assembly

170 HydG is a member of the radical S-adenosyl-L-methionine family of enzymes that transforms

171 The radical S-adenosyl-l-methionine HydG, the best characterized of th

172 proach designed to target specifically the S-adenosyl-l-methionine pocket of catechol O-methyl transf

173 ases to provide the substrates of LipA, an S-adenosyl-L-methionine radical enzyme that inserts two su

174 Numerous cellular processes involving S-adenosyl-l-methionine result in the formation of the tox

175 The response to S-adenosyl-L-methionine stimulation or thermal activation

176 far better acceptor of methyl groups from S-adenosyl-L-methionine than was malonyl-CoA.

177 iles of PsACS [encode enzymes that convert S-adenosyl-L-methionine to 1-aminocyclopropane-1-carboxyli

178 (S)G in DNA can be methylated by S-adenosyl-l-methionine to give S(6)-methylthioguanine (S(

179 tes HA by transferring a methyl group from S-adenosyl-l-methionine to HA, and is the only well-known

180 ecifically transfers the methyl group from S-adenosyl-L-methionine to O-4 of alpha-D-glucopyranosylur

181 ic acid (ACC) synthases (ACS) that convert S-adenosyl-l-methionine to the immediate precursor ACC.

182 alyzes the transfer of a methyl group from S-adenosyl-L-methionine to the N6 position of an adenine,

183 the transfer of the methyl group from the S-adenosyl-l-methionine to the protein alpha-amine, result

184 ansferase belongs to the diverse family of S-adenosyl-l-methionine transferases.

185 ope effects.(36)S-labeled l-methionine and S-adenosyl-l-methionine were synthesized from elemental su

186 Posttranslational methylation by S-adenosyl-L-methionine(SAM)-dependent methyltransferases

187 only compete with the enzyme cofactor SAM (S-adenosyl-L-methionine) but not the substrate nucleosome.

188 Streptomyces venezuelae is a radical SAM (S-adenosyl-l-methionine) enzyme that catalyzes the deamina

189 ding excess substrate for DNA methylation (S-adenosyl-L-methionine) rescues the suppression of mEPSCs

190 ransferase catalytic tetrad, interact with S-adenosyl-l-methionine, and contribute to autoguanylation

191 rom a solution of MoaA incubated with GTP, S-adenosyl-L-methionine, and sodium dithionite in the abse

192 e, resulting from in situ demethylation of S-adenosyl-L-methionine, at 2.05 or 1.82 A resolution, res

193 g the methylation site, in the presence of S-adenosyl-L-methionine, reveals a V-like protein structur

194 ncluding acupuncture, omega-3 fatty acids, S-adenosyl-L-methionine, St. John's wort [Hypericum perfor

195 rtue of the strong electrophilic nature of S-adenosyl-l-methionine, the transmethylation of the demet

196 quires a redox-active [4Fe-4S]-cluster and S-adenosyl-L-methionine, which is reductively cleaved to L

197 M.EcoRI, a bacterial sequence-specific S-adenosyl-L-methionine-dependent DNA methyltransferase, r

198 uA, and the methylthiolase MiaB, a radical S-adenosyl-L-methionine-dependent enzyme involved in the m

199 RsmC is a class I S-adenosyl-L-methionine-dependent methyltransferase compos

200 demonstrated that genetic deletion of the S-adenosyl-L-methionine-dependent methyltransferase from t

201 The S-adenosyl-L-methionine-dependent methyltransferase KsgA i

202 We characterized Rv0560c as an S-adenosyl-L-methionine-dependent methyltransferase that N

203 terization of a C. roseus cDNA encoding an S-adenosyl-L-methionine-dependent N methyltransferase that

204 Data from time course experiments and S-adenosyl-l-methionine-dependent O-methyltransferase inhi

205 NovP is an S-adenosyl-l-methionine-dependent O-methyltransferase that

206 of NcsB1, unveiling that: (i) NcsB1 is an S-adenosyl-L-methionine-dependent O-methyltransferase; (ii

207 A conserved S-adenosyl-l-methionine-dependent RNA methyltransferase, H

208 d in vitro enzyme studies identified a new S-adenosyl-l-methionine-dependent S-MT (TmtA) that is, sur

209 factors, heme, pyridoxal-5'-phosphate, and S-adenosyl-l-methionine.

210 y molecular mechanism of CBS activation by S-adenosyl-l-methionine.

211 h (2.1 A) and without (2.0 A) its cofactor S-adenosyl-L-methionine.

212 exchange with a fresh molecule of cofactor S-adenosyl-L-methionine.

213 5-phosphate and methane in the presence of S-adenosyl-L-methionine.

214 hylthioguanine (S(6)mG) in the presence of S-adenosyl-l-methionine.

215 omocysteine and the methyl donor substrate S-adenosyl-l-methionine.

216 s function or for allosteric regulation by S-adenosyl-L-methionine.

217 till responded to allosteric activation by S-adenosyl-L-methionine.

218 transfers a methyl group originating from S-adenosyl-l-methionine.

219 lation of H3K36 using specifically labeled S-adenosyl-l-methionine.

220 d in the TPsiC-loop of tRNA, from cofactor S-adenosyl-L-methionine.

221 have obtained a cDNA encoding S-[methyl-14C]adenosyl-l-methionine:t-anol/isoeugenol O-methyltransfer

222 steady-state kinetics with the SAM analog Se-adenosyl-l-selenomethionine (SeAM) as a cofactor surroga

223 ort a SAM surrogate, ProSeAM (propargylic Se-adenosyl-l-selenomethionine), as a reporter of methyltra

224 genous application of ethylene precursors, S-adenosyl-Met and 1-aminocyclopropane-1-carboxylic acid,

225 length and targets mRNAs encoding several S-adenosyl-Met-dependent carboxyl methyltransferase family

226 tion adjacent to the tRNA anticodon, using S-adenosyl methionine (AdoMet) as the methyl donor.

227 of genes involved in aromatic amino acid, S-adenosyl methionine (SAM) and folate biosynthetic pathwa

228 Colorado strains carrying mutations in the S-adenosyl methionine (SAM) binding site in the CR VI of L

229 istration of the (endogenous) methyl donor S-adenosyl methionine (SAM) did not affect CpG methylation

230 the assembly of the H cluster, the radical S-adenosyl methionine (SAM) enzyme HydG lyses the substrat

231 Additionally, we find that the cofactor S-adenosyl methionine (SAM) is necessary for stable intera

232 deprivation, and that supplementation with S-adenosyl methionine (SAM) prevents both the increase in

233 NifB utilizes two equivalents of S-adenosyl methionine (SAM) to insert a carbide atom and f

234 binding cleft and lacks a properly formed S-adenosyl methionine (SAM)-binding pocket necessary for n

235 S-Adenosyl methionine (SAM)-dependent C-methyltransferases

236 omolecules by a large and diverse class of S-adenosyl methionine (SAM)-dependent methyltransferases (

237 me A 3-O-methyltransferase (CCoAOMT) is an S-adenosyl methionine (SAM)-dependent O-methyltransferase

238 re, we explore the mechanism for tuning of S-adenosyl methionine (SAM)-I riboswitch folding.

239 nal switching, we constructed models of an S-adenosyl methionine (SAM)-I riboswitch RNA segment incor

240 he by-product and competitive inhibitor of S-adenosyl methionine (SAM)-mediated methyltransferase rea

241 catalyze the formation of the methyl donor S-adenosyl methionine (SAM).

242 methionine, which is in turn converted to S-adenosyl methionine (SAM; the major methyl donor).

243 S-adenosyl methionine (SAMe) improves interferon signaling

244 Hepatic S-adenosyl methionine (SAMe) levels decrease in methionine

245 The use of S-adenosyl methionine (SAMe), a naturally occurring molecu

246 gars, and other small molecules, including S-adenosyl methionine and glutathione, through top-down MS

247 s conversion involves methyl transfer from S-adenosyl methionine and is critical to minimize tRNA fra

248 In the absence of the methyl donor S-adenosyl methionine and under certain permissive reactio

249 synthesis requires unique enzymes that use S-adenosyl methionine as an acyl acceptor and amino acid d

250 with its histone H4 peptide substrate and S-adenosyl methionine cofactor.

251 ith lysidine, those derived using modified S-adenosyl methionine derivatives and those using TET/JBP-

252 emonstrated by detecting the human radical S-adenosyl methionine domain containing 2 (RSAD2) gene, a

253 d enhanced expression of the IRGs, radical S-adenosyl methionine domain containing 2 and myxovirus re

254 fected cell lines showed that the internal S-adenosyl methionine domains of viperin were essential fo

255 ase) that accept analogues of the cofactor S-adenosyl methionine have been widely deployed for alkyl-

256 ase activity through changes in folate and S-adenosyl methionine metabolism.

257 Serine starvation increased the methionine/S-adenosyl methionine ratio, decreasing the transfer of me

258 enzymes stearoyl-CoA-desaturases (SCD) and S-adenosyl methionine synthetase (sams-1) activates the UP

259 We show that the MccD enzyme uses S-adenosyl methionine to transfer 3-amino-3-carboxypropyl

260 at use different cofactors, primarily SAM (S-adenosyl methionine), NAD (nicotinamide adenine dinucleo

261 e recruitment of the methyl donor, AdoMet (S-adenosyl methionine), to RNMT.

262 ch is required for efficient production of S-adenosyl methionine, an essential methyltransferase cofa

263 ifying the Npl4 zinc finger domain through S-adenosyl methionine-dependent cysteine methylation.

264 thyltransferases (TMTs) might resemble the S-adenosyl methionine-dependent enzymes described for meth

265 The third largest dsRNA encodes an S-adenosyl methionine-dependent methyltransferase capping

266 ch is known to lead to increased levels of S-adenosyl methionine-the key methyl donor for DNA methyla

267 um with a mixture of labeled and unlabeled S-adenosyl methionine.

268 stitution of TbtI, the responsible radical S-adenosyl-methionine (rSAM) C-methyltransferase, which ca

269 e describe the structures of RlmH bound to S-adenosyl-methionine (SAM) and the methyltransferase inhi

270 Antimorphic mutants in S-adenosyl-methionine (SAM) synthetase genes also induce t

271 Methionine generates the methyl donor S-adenosyl-methionine (SAM), which is converted via methyl

272 nosyl-homocysteine (SAH) and low levels of S-adenosyl-methionine (SAM).

273 are critical for catalysis and binding to S-adenosyl-methionine and phosphoethanolamine substrates.

274 Using S-adenosyl-methionine as the methyl donor, caffeic acid O-

275 mutations, we determined the apo-form and S-adenosyl-methionine binary complex SbCOMT crystal struct

276 NtMTHFR did not affect the methionine and S-adenosyl-methionine levels in the knockdown lines.

277 the H3K9 methyltransferase Clr4 in a SAM (S-adenosyl-methionine)-dependent manner, and Clr4 is trapp

278 e, which is then used for the synthesis of S-adenosyl-methionine, a universal methyl donor for numero

279 iated with the methyl cycle that generates S-adenosyl-methionine, an essential methyltransferase cofa

280 and then placebo for 2 weeks, 65 received S-adenosyl-methionine, and 34 received no specific treatme

281 ive donor substrate of glycan methylation, S-adenosyl-methionine, from the cytoplasm to the Golgi was

282 eatment with the EZH2 inhibitor, selective S-adenosyl-methionine-competitive small-molecule (GSK126),

283 e that GSK126, a potent, highly selective, S-adenosyl-methionine-competitive, small-molecule inhibito

284 fication of two previously uncharacterized S-adenosyl-methionine-dependent O-methyltransferase genes,

285 anthine phosphoribosyltransferase, and the S-adenosyl-methionine-I riboswitch from the B. subtilis yi

286 ans with various assays, including in vivo S-adenosyl-[methyl-(3)H]methionine labeling, targeted in v

287 roblast growth factor receptor 2, methionine adenosyl methyltransferase 1A, and caspase 1 was validat

288 dition of certain small molecules containing adenosyl moieties, including 5'-deoxyadenosine, AMP, ADP

289 sferases (ACAs) catalyze the transfer of the adenosyl moiety from ATP to cob(I)alamin via a four-coor

290 nts (Br- and N3-) can be introduced at the 8-adenosyl position of NAADP while preserving high potency

291 -position of the nicotinic acid and at the 8-adenosyl position was also recognized although the agoni

292 of initial hydrogen atom abstraction by the adenosyl radical and advances a mechanistic proposal for

293 AM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyviny

294 this reaction involving the addition of the adenosyl radical to the substrate double bond to form a

295 life, and all of these proteins generate an adenosyl radical via the homolytic cleavage of the S-C(5

296 ibose C3' hydrogen atom is abstracted by the adenosyl radical.

297 ld to generate cob(II)alamin and a transient adenosyl radical.

298 y methionine, consistent with binding at the adenosyl region of the active site.

299 ies regulate these processes: members of the adenosyl-ribosylation factor family of small G-proteins

300 ic subunit of the heterodimeric methionine S-adenosyl transferase-2 (MAT2A) with fluorinated N,N-dial