ライフサイエンスコーパス: adenosylmethionine

1 ting agents, even physiological ones (e.g. S-adenosylmethionine).

2 Stackebrandtia phosphonoglycan arise from S-adenosylmethionine.

3 th the donor methyl group of the cofactor, S-adenosylmethionine.

4 e to a reduced conversion of methionine to S-adenosylmethionine.

5 fected by intermolecular interactions with S-adenosylmethionine.

6 reactions that occur via the generation of S-adenosylmethionine.

7 silon-amino group for methyl transfer with S-adenosylmethionine.

8 s a mechanism for allosteric activation by S-adenosylmethionine.

9 on of tetrahydrofolate and biosynthesis of S-adenosylmethionine.

10 most all cellular methylation reactions is S-adenosylmethionine.

11 he position equivalent to the sulfonium of S-adenosylmethionine.

12 extent of allosteric activation of CBS by S-adenosylmethionine.

13 roximately 15-fold higher than the K m for S-adenosylmethionine.

14 t also by the endogenous methylating agent S-adenosylmethionine.

15 detergent Triton X-100 and the methyldonor S-adenosylmethionine.

16 The S-adenosylmethionine-1 (SAM-I) riboswitch mediates express

17 ersisted 1 month, whereas the methyl donor S-adenosylmethionine (500 mum) had an opposite effect on c

18 S-adenosylmethionine administration at these early stages

19 S-adenosylmethionine (AdoMet or SAM)-dependent methyltrans

20 hmt resulted in a 43% reduction in hepatic S-adenosylmethionine (AdoMet) (p < 0.01) and a 3-fold incr

21 amin B9) is utilized for synthesis of both S-adenosylmethionine (AdoMet) and deoxythymidine monophosp

22 t invariably catalyzed by enzymes that use S-adenosylmethionine (AdoMet) as the methyl group donor.

23 MoaA is a radical S-adenosylmethionine (AdoMet) enzyme that catalyzes a comp

24 phate synthase; EC 4.1.99.17) is a radical S-adenosylmethionine (AdoMet) enzyme that uses a [4Fe-4S](

25 S-adenosylmethionine (AdoMet) lies at an intersection of n

26 Under anaerobic conditions, S-adenosylmethionine (AdoMet) radical chemistry is used.

27 nsertion, LipA uses a [4Fe-4S] cluster and S-adenosylmethionine (AdoMet) radical chemistry; the remai

28 oded proteins, a cobalamin (Cbl)-dependent S-adenosylmethionine (AdoMet) radical enzyme, OxsB, and an

29 The S-adenosylmethionine (AdoMet) radical superfamily of enzym

30 multiple methyltransferase domains for the S-adenosylmethionine (AdoMet) reactions.

31 The S-adenosylmethionine (AdoMet) salvage enzyme 5'-methylthio

32 ThiC is a member of the radical S-adenosylmethionine (AdoMet) superfamily and catalyzes th

33 talyze the transfer of a methyl group from S-adenosylmethionine (AdoMet) to a peptidylarginine on a p

34 e (ACS), which catalyzes the conversion of S-adenosylmethionine (AdoMet) to ACC, the precursor of eth

35 talyzes the transfer of methyl groups from S-adenosylmethionine (AdoMet) to acceptor lysine residues

36 se (COMT) catalyzes a methyl transfer from S-adenosylmethionine (AdoMet) to dopamine.

37 Inclusion of the PIMT co-substrate, S-adenosylmethionine (AdoMet), during panning permitted PI

38 use MATbeta lowers the Ki of MATalpha2 for S-adenosylmethionine (AdoMet), this allowed steady-state A

39 CBS (hCBS) is allosterically activated by S-adenosylmethionine (AdoMet), which binds to the regulato

40 of methyl groups for methyltransferases is S-adenosylmethionine (AdoMet), which in most cells is synt

41 S-adenosylmethionine (AdoMet)-based methylation is integra

42 Small (>1) BIEs are observed for an S-adenosylmethionine (AdoMet)-binary and abortive ternary

43 omain lysine methyltransferases (KMTs) are S-adenosylmethionine (AdoMet)-dependent enzymes that catal

44 TrmA catalyzes S-adenosylmethionine (AdoMet)-dependent methylation of U54

45 nvestigated METTL12, a mitochondrial human S-adenosylmethionine (AdoMet)-dependent methyltransferase

46 elegans synthesizes phosphocholine via two S-adenosylmethionine (AdoMet)-dependent phosphoethanolamin

47 PFL by the PFL-AE in a reaction requiring S-adenosylmethionine (AdoMet).

48 sensitivities to the allosteric effector, S-adenosylmethionine (AdoMet); whereas T257M and T257I are

49 I in complex with its DNA substrate and an S-adenosylmethionine analog (Sinefungin).

50 EP50 (methylosome protein 50), bound to an S-adenosylmethionine analog and a peptide substrate derive

51 e form (2.2 A resolution) and bound to the S-adenosylmethionine analog S-adenosylhomocysteine (SAH, 2

52 balamin (coenzyme B(12)), simpler, such as S-adenosylmethionine and an iron-sulfur cluster (i.e., poo

53 thylarginine formation when incubated with S-adenosylmethionine and hypomethylated ribosomes prepared

54 itochondrial fatty-acid synthesis type II, S-adenosylmethionine and iron-sulfur clusters.

55 nd ALT levels, betaine treatment increased S-adenosylmethionine and up-regulated Dnmt3b levels, and b

56 inamide adenine dinucleotide phosphate and S-adenosylmethionine) and its partner enzyme, the enoyl re

57 on metabolites such as acetyl-coenzyme A, S-adenosylmethionine, and NAD+, among others.

58 Ursodeoxycholic acid and S-adenosylmethionine are anti-fibrotic in bile duct ligati

59 characterized pathway uses decarboxylated S-adenosylmethionine as the aminopropyl group donor to for

60 ncentrations of the methionine metabolites S-adenosylmethionine, betaine, and cystathionine in MS gra

61 Oscillatory production of S-adenosylmethionine, betaine, choline, phosphocholine, gl

62 s hydrogen bond and subsequently abolishes S-adenosylmethionine binding and its methyltransferase act

63 re dimeric with each monomer containing an S-adenosylmethionine binding domain with a core Rossmann f

64 ocysteine revealed RebM to adopt a typical S-adenosylmethionine-binding fold of small molecule O-meth

65 ransferase fold, which besides the typical S-adenosylmethionine-binding site ((SAM)P) also contains a

66 lated to purine catabolism, methionine and S-adenosylmethionine biosynthesis and methionine salvage,

67 ific contributions made by thymidylate and S-adenosylmethionine biosynthesis to CRC risk.

68 ivated one-carbons between thymidylate and S-adenosylmethionine biosynthesis.

69 cate LaeA may perform novel chemistry with S-adenosylmethionine but also provide new insights into th

70 Four other metabolites, S-adenosylmethionine, carbamoyl phosphate, UDP-glucose, an

71 affecting the production of decarboxylated S-adenosylmethionine (dcSAM) and polyamine synthesis.

72 ic genes encoding spermidine biosynthesis: S-adenosylmethionine decarboxylase (AdoMetDC) and spermidi

73 S-adenosylmethionine decarboxylase (AdoMetDC) catalyzes a

74 S-adenosylmethionine decarboxylase (AdoMetDC) is a critica

75 S-Adenosylmethionine decarboxylase (AdoMetDC) is a key enz

76 Previously we showed that trypanosomatid S-adenosylmethionine decarboxylase (AdoMetDC), a key enzym

77 Instead trypanosomatid S-adenosylmethionine decarboxylase (AdoMetDC), which catal

78 fusions of polyamine biosynthetic enzymes S-adenosylmethionine decarboxylase (AdoMetDC, speD) and am

79 In the present study, S-adenosylmethionine decarboxylase (SAMDC), a key gene inv

80 Among the new tumour suppressors are adenosylmethionine decarboxylase 1 (AMD1) and eukaryotic

81 stems from mTORC1-dependent regulation of S-adenosylmethionine decarboxylase 1 (AMD1) stability.

82 ort X-ray structures of Trypanosoma brucei S-adenosylmethionine decarboxylase alone and in functional

83 trescine amidohydrolase in archaea, and of S-adenosylmethionine decarboxylase and ornithine decarboxy

84 rmidine from putrescine by the key enzymes S-adenosylmethionine decarboxylase and spermidine synthase

85 zone (MGBG), a polyamine analog and potent S-adenosylmethionine decarboxylase inhibitor, decreases HI

86 ase), speC (ornithine decarboxylase), spe D (adenosylmethionine decarboxylase), speE (spermidine synt

87 hyltetrahydrofolate:Hcy methyltransferase, S-adenosylmethionine decarboxylase, DNA methyltransferase

88 anosomatid spermidine biosynthetic enzyme, S-adenosylmethionine decarboxylase, is regulated by hetero

89 imental frameshift frequencies measured in S-adenosylmethionine-decarboxylase and antizyme mutants, a

90 ll living organisms, mostly relies on SAM (S-adenosylmethionine)-dependent methyltransferases.

91 S-Adenosylmethionine-dependent DNA methyltransferases (MTa

92 The S-adenosylmethionine-dependent enzyme MoaA, in concert wit

93 recent evidence supporting a role for the S-adenosylmethionine-dependent enzyme NifB in the incorpor

94 thylation of lysine residues, catalyzed by S-adenosylmethionine-dependent lysine methyltransferases (

95 identify a previously undescribed class of S-adenosylmethionine-dependent methylases that convert a p

96 hyltransferase (PLMT) enzymes catalyze the S-adenosylmethionine-dependent methylation of ethanolamine

97 ion may be attributed to the interference of adenosylmethionine-dependent methylation.

98 s via 2'-O-methylation, carried out by the S-adenosylmethionine-dependent methyltransferase (MTase) H

99 ATP binding region-containing proteins and S-adenosylmethionine-dependent methyltransferase proteins.

100 deazaneplanocin A (DZNep), an inhibitor of S-adenosylmethionine-dependent methyltransferase that targ

101 hanocaldococcus jannaschii encodes a novel S-adenosylmethionine-dependent methyltransferase, now iden

102 7, is predicted to belong to the family of S-adenosylmethionine-dependent methyltransferases characte

103 belongs to the family of seven-beta-strand S-adenosylmethionine-dependent methyltransferases.

104 cribed the in vitro characterization of an S-adenosylmethionine-dependent O-methyltransferase (NcsB1)

105 Phosphatidylcholine (PC) produced via the S-adenosylmethionine-dependent phosphatidylethanolamine (P

106 verall architecture with a large family of S-adenosylmethionine-dependent proteins.

107 one-carbon metabolism due to their common S-adenosylmethionine-dependent transmethylation and has im

108 and transposon derepression indicate that S-adenosylmethionine-dependent transmethylation is inhibit

109 -linked peptide formed by MftC through two S-adenosylmethionine-dependent turnovers.

110 tronger inhibitor of BHMT-2 than BHMT, and S-adenosylmethionine does not inhibit BHMT but is a weak i

111 ate that it is a new member of the radical S-adenosylmethionine enzyme superfamily.

112 Here we demonstrate that BzaF is a radical S-adenosylmethionine enzyme that catalyzes the remarkable

113 MoaA, a radical S-adenosylmethionine enzyme, catalyzes the first step in m

114 It is repaired by a radical SAM (S-adenosylmethionine) enzyme, the spore photoproduct lyase

115 cessory proteins, two of which are radical S-adenosylmethionine enzymes (HydE, HydG) and one of which

116 emical characterization of these 8 radical S-adenosylmethionine enzymes and, in the context of human

117 n this minireview, we describe the radical S-adenosylmethionine enzymes involved in the biosynthesis

118 ba57p, which aconitase and certain radical S-adenosylmethionine enzymes require for activity.

119 current state of knowledge of the radical S-adenosylmethionine enzymes required for synthesis of the

120 HydE and HydG are radical S-adenosylmethionine enzymes that chemically modify a H-cl

121 (2)-sensitive [4Fe-4S] clusters in radical S-adenosylmethionine enzymes.

122 , two of which (HydE and HydG) are radical S-adenosylmethionine enzymes.

123 he RhlI reaction proceeds via acylation of S-adenosylmethionine, followed by lactonization.

124 ose and 2,6-diaminopurine produced 2-amino-S-adenosylmethionine for hydrolytic conversion to 2AMTA.

125 nine (SAM) enzyme that reductively cleaves S-adenosylmethionine, generating 5'-deoxyadenosyl radicals

126 rine-glycine-one-carbon pathway coupled to S-adenosylmethionine generation.

127 affecting essential pathways that utilize S-adenosylmethionine in addition to methionine.

128 r that the enzyme converting methionine to S-adenosylmethionine in mESCs, methionine adenosyltransfer

129 produces 5-methylthioadenosine (MTA) from S-adenosylmethionine in polyamine biosynthesis; however, R

130 IC(50) (6-13 micromol/L) by competing with S-adenosylmethionine in the methylation reaction.

131 ygen atom of Tyr(154) to lock the cofactor S-adenosylmethionine inside the binding cavity.

132 hyl incorporation of radioactively labeled S-adenosylmethionine into recombinant fragments of OmpB.

133 S-Adenosylmethionine is widely used in a variety of biolog

134 ty (KD of 0.14-2.2 muM) than the substrate S-adenosylmethionine (KD of 22-43 muM), which indicates pr

135 ficiency, as demonstrated by reductions in S-adenosylmethionine levels and in global DNA methylation.

136 Huh7 cells overexpressing MAT1A had higher S-adenosylmethionine levels but lower bromodeoxyuridine in

137 rotein and methylation potential [ratio of S-adenosylmethionine (major methyl donor):S-adenosylhomocy

138 SAH catabolism is linked to S-adenosylmethionine metabolism, and the development of SA

139 ate binding pocket, the binding site for the adenosylmethionine methyl donor, or a critical tyrosine

140 er choline, which can serve as a source of S-adenosylmethionine methyl groups, influences PC-DHA or t

141 sp. CX-1, and identified a gene encoding a S-adenosylmethionine methyltranserase termed BlArsM with l

142 ion can be mediated by the enzyme arsenite S-adenosylmethionine methyltransferase (ArsM) or through t

143 catalyzed by the enzyme arsenite (As[III]) S-adenosylmethionine methyltransferase (ArsM).

144 lts suggest that BlArsM is a novel As(III) S-adenosylmethionine methyltransferase requiring only two

145 lly, we demonstrate that ChuW is a radical S-adenosylmethionine methyltransferase that catalyzes a ra

146 We found that binding by the cofactor S-adenosylmethionine mitigates this autoinhibited structur

147 It seems that the level of S-adenosylmethionine must be regulated in response to deve

148 responsive to the known modulators of CBS: S-adenosylmethionine, NO, and CO.

149 s monomeric in the absence and presence of S-adenosylmethionine or S-adenosylhomocysteine.

150 apo form and in complex with its cofactor S-adenosylmethionine or S-adenosylhomocysteine.

151 factocin biosynthesis is one example of an S-adenosylmethionine protein-dependent RiPP pathway.

152 ubset of these pathways depends on radical S-adenosylmethionine proteins to modify the RiPP-produced

153 oxal 5'-phosphate (PLP) for catalysis, and S-adenosylmethionine regulates the activity of human CBS,

154 ed methyl cycle (AMC), which generates the S-adenosylmethionine required by methyltransferases and re

155 three putative cobalamin-dependent radical S-adenosylmethionine (RS) enzymes, ThnK, ThnL, and ThnP, a

156 Radical S-adenosylmethionine (RS) enzymology has emerged as a majo

157 PqqE is a radical S-adenosylmethionine (RS) protein with a C-terminal SPASM

158 ed to be catalyzed by two putative radical S-adenosylmethionine (rSAM) enzymes, PoyB and PoyC.

159 overy of four different classes of radical S-adenosylmethionine (rSAM) methyltransferases that methyl

160 S-Adenosylmethionine, S-adenosylhomocysteine, S-ribosylhom

161 cystathionine (P<0.01), and the decreased S-adenosylmethionine/S-adenosyl homocysteine ratio (P<0.01

162 This was associated with a higher S-adenosylmethionine/S-adenosylhomocysteine ratio and lowe

163 IKV NS5 methyltransferase bound to a novel S-adenosylmethionine (SAM) analog in which a 4-fluoropheny

164 levels of which are reliant upon adequate S-adenosylmethionine (SAM) and inhibited by S-adenosylhomo

165 arbide originates from the methyl group of S-adenosylmethionine (SAM) and that it is inserted into th

166 methylates nicotinamide (vitamin B3) using S-adenosylmethionine (SAM) as a methyl donor.

167 ite (rVSV-K1651A, -D1762A, and -E1833Q) or S-adenosylmethionine (SAM) binding site (rVSV-G1670A, -G16

168 ecombinant hMPVs carrying mutations in the S-adenosylmethionine (SAM) binding site in CR VI of L prot

169 ly days, radical enzyme reactions that use S-adenosylmethionine (SAM) coordinated to an Fe-S cluster,

170 velopment and fertility via the methionine/S-Adenosylmethionine (SAM) cycle and breaks down the short

171 (Mat1a) knockout (KO) mice express hepatic S-adenosylmethionine (SAM) deficiency and increased ERK ac

172 The studies revealed GilMT as a typical S-adenosylmethionine (SAM) dependent O-methyltransferase,

173 We found that the methyl donor S-adenosylmethionine (SAM) disrupts the SAMTOR-GATOR1 comp

174 iviral protein that belongs to the radical S-adenosylmethionine (SAM) enzyme family.

175 The radical S-adenosylmethionine (SAM) enzyme HydG lyses free l-tyrosi

176 koshii Dph2 (PhDph2) is an unusual radical S-adenosylmethionine (SAM) enzyme involved in the first st

177 tigation of the incredibly diverse radical S-adenosylmethionine (SAM) enzyme superfamily, PPP aided i

178 DesII is a radical S-adenosylmethionine (SAM) enzyme that catalyzes the C4-de

179 Viperin is an IFN-inducible radical S-adenosylmethionine (SAM) enzyme that inhibits viral repl

180 Biotin synthase is a radical S-adenosylmethionine (SAM) enzyme that reductively cleaves

181 TsrM, an annotated radical S-adenosylmethionine (SAM) enzyme, catalyzes the methylati

182 AprD4 is shown to be a radical S-adenosylmethionine (SAM) enzyme, catalyzing homolysis of

183 ss-link, which is installed by the radical S-adenosylmethionine (SAM) enzyme, StrB.

184 SPL is a radical S-adenosylmethionine (SAM) enzyme, utilizing the 5'-deoxya

185 Radical S-adenosylmethionine (SAM) enzymes account for nearly 2% o

186 Radical S-adenosylmethionine (SAM) enzymes are emerging as a major

187 e and is a member of a subclass of radical S-adenosylmethionine (SAM) enzymes called radical SAM (RS)

188 Radical S-adenosylmethionine (SAM) enzymes catalyze an astonishing

189 Radical S-adenosylmethionine (SAM) enzymes exist in organisms from

190 RimO and MiaB are radical S-adenosylmethionine (SAM) enzymes that catalyze the attac

191 Radical S-adenosylmethionine (SAM) enzymes use a [4Fe-4S] cluster

192 Radical S-adenosylmethionine (SAM) enzymes use a [4Fe-4S] cluster

193 Radical S-adenosylmethionine (SAM) enzymes use the oxidizing power

194 We determined two radical S-adenosylmethionine (SAM) enzymes, one each from an SNP g

195 embly scaffolds by the activity of radical S-adenosylmethionine (SAM) enzymes.

196 s been shown to be a member of the radical S-adenosylmethionine (SAM) family of enzymes, [4Fe-4S] clu

197 structures that is typical of the radical S-adenosylmethionine (SAM) family of proteins.

198 sferase (MAT2A) catalyzes the formation of S-adenosylmethionine (SAM) from ATP and methionine.

199 S-Adenosylmethionine (SAM) is both the methyl donor and th

200 nance of proper levels of the methyl donor S-adenosylmethionine (SAM) is critical for a wide variety

201 The methyl donor S-adenosylmethionine (SAM) is produced in most cells throu

202 S-adenosylmethionine (SAM) is the methyl donor for biologi

203 on, Hcy, S-adenosylhomocysteine (SAH), and S-adenosylmethionine (SAM) levels, and SAM/SAH ratios in m

204 mily of proteins that perform both radical-S-adenosylmethionine (SAM) mediated sulfur insertion and S

205 We found that threonine and S-adenosylmethionine (SAM) metabolism are coupled in pluri

206 ational changes upon Mg(2+) compaction and S-adenosylmethionine (SAM) metabolite binding.

207 how that NosN, a predicted class C radical S-adenosylmethionine (SAM) methylase, catalyzes both the t

208 sion of the arsM gene encoding the As(III) S-adenosylmethionine (SAM) methyltransfase from Rhodopseud

209 using CysS, a cobalamin-dependent radical S-adenosylmethionine (SAM) methyltransferase.

210 of the arsM gene that encodes the As(III) S-adenosylmethionine (SAM) methyltransferase.

211 Members of every kingdom have ArsM As(III) S-adenosylmethionine (SAM) methyltransferases that methyla

212 s of a methyl group partially derived from S-adenosylmethionine (SAM) onto electrophilic sp(2)-hybrid

213 domains in apo form as well as with bound S-adenosylmethionine (SAM) or S-adenosylhomocysteine (SAH)

214 The radical S-adenosylmethionine (SAM) protein PqqE is predicted to fu

215 LipA is a member of the radical S-adenosylmethionine (SAM) superfamily of enzymes and uses

216 TsrM is a member of the radical S-adenosylmethionine (SAM) superfamily of enzymes, but it

217 RimO is a member of the growing radical S-adenosylmethionine (SAM) superfamily of enzymes, which u

218 ductase (MTHFR) provides methyl donors for S-adenosylmethionine (SAM) synthesis and methylation react

219 of the liver-specific MAT1A gene, encoding S-adenosylmethionine (SAM) synthesizing isozymes MATI/III,

220 ial [4Fe-4S] cluster to reductively cleave S-adenosylmethionine (SAM) to generate a reactive 5'-dA ra

221 alyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to glycine generating S-adenosy

222 lyze the transfer of the methyl group from S-adenosylmethionine (SAM) to lysine residues in histone t

223 fundamental bacterial metabolic pathways: S-adenosylmethionine (SAM) utilization, polyamine biosynth

224 spiration from Nature's methylating agent, S-adenosylmethionine (SAM), allowed for the design and dev

225 PBMC DNA methylation, plasma folate, blood S-adenosylmethionine (SAM), and concentrations of As in dr

226 betaine, S-adenosylhomocysteine (SAH), and S-adenosylmethionine (SAM), and higher percentages of men

227 llular concentrations of the methyl donor, S-adenosylmethionine (SAM), and increasing the demethylate

228 phosphocholine cytidylyltransferase (PCT), S-adenosylmethionine (SAM), and S-adenosylhomocysteine (SA

229 Here we review the roles of acetyl-CoA and S-adenosylmethionine (SAM), donor substrates for acetylati

230 c steatohepatitis, with reduction in liver S-adenosylmethionine (SAM), elevation in liver S-adenosylh

231 e nutrients, S-adenosylhomocysteine (SAH), S-adenosylmethionine (SAM), homocysteine, cysteine, and di

232 oswitch, one of several classes that binds S-adenosylmethionine (SAM), represses translation upon bin

233 Met is the obligate precursor of S-adenosylmethionine (SAM), the methyl donor utilized by a

234 eno-pyrimidones that were competitive with S-adenosylmethionine (SAM), the physiological methyl donor

235 1p represses genes that maintain levels of S-adenosylmethionine (SAM), the substrate for most methylt

236 expression of SIN3 leads to an increase in S-adenosylmethionine (SAM), which is the major cellular do

237 id methionine is a metabolic precursor for S-adenosylmethionine (SAM), which serves as a coenzyme for

238 catalyzes the formation of 5 from 3 in a (S)-adenosylmethionine (SAM)-dependent manner.

239 pends on the integrity of the helicase and S-adenosylmethionine (SAM)-dependent methyltransferase-lik

240 S-Adenosylmethionine (SAM)-dependent methyltransferases ar

241 SAH is a potent feedback inhibitor of S-adenosylmethionine (SAM)-dependent methyltransferases th

242 programming and is most often achieved by S-adenosylmethionine (SAM)-dependent methyltransferases.

243 nd oxygenation through the action of eight S-adenosylmethionine (SAM)-dependent mycolic acid methyltr

244 Several members of a distinct family of S-adenosylmethionine (SAM)-dependent N-methyltransferases

245 The S-adenosylmethionine (SAM)-I riboswitch is a noncoding RNA

246 lecular dynamics simulation studies of the S-adenosylmethionine (SAM)-II riboswitch that is involved

247 sing almost exclusively upon Mg(2+) and/or S-adenosylmethionine (SAM)-induced folding of full-length

248 ch recycles adenine and methionine through S-adenosylmethionine (SAM)-mediated methylation reactions,

249 The S(MK) (SAM-III) box is an S-adenosylmethionine (SAM)-responsive riboswitch found in

250 h represents one of three known classes of S-adenosylmethionine (SAM)-responsive riboswitches, regula

251 purified enzyme contains internally-bound S-adenosylmethionine (SAM).

252 nine boosts synthesis of the methyl donor, S-adenosylmethionine (SAM).

253 cilitate the unusual acyl conjugation with S-adenosylmethionine (SAM).

254 the MCD diet-induced depletion of hepatic S-adenosylmethionine (SAM).

255 lesser degree, of its metabolic precursor S-adenosylmethionine (SAM).

256 in bacterial mRNAs that specifically binds S-adenosylmethionine (SAM).

257 S-Adenosylmethionine (SAM, also known as AdoMet) radical e

258 nt with ursodeoxycholic acid (UDCA) and/or S-adenosylmethionine (SAMe) affects the expression of thes

259 S-Adenosylmethionine (SAMe) and its metabolite 5'-methylth

260 ich have chronically low levels of hepatic S-adenosylmethionine (SAMe) and spontaneously develop stea

261 er disease often leads to impaired hepatic S-adenosylmethionine (SAMe) biosynthesis, and mice with SA

262 Ursodeoxycholic acid (UDCA) or S-adenosylmethionine (SAMe) prevented the LCA-induced decr

263 are the primary genes involved in hepatic S-adenosylmethionine (SAMe) synthesis and degradation, res

264 The principal methyl donor of the cell, S-adenosylmethionine (SAMe), is produced by the highly con

265 were found for replicated studies testing S-adenosylmethionine (SAMe), methylfolate, omega-3 (primar

266 ine N-methyltransferase (GNMT) catabolizes S-adenosylmethionine (SAMe), the main methyl donor of the

267 e in peripheral nerve myelination and that S-adenosylmethionine (SAMe), the principal methyl donor in

268 S-Adenosylmethionine (SAMe), the principal methyl donor th

269 ransferase (MAT) catalyzes biosynthesis of S-adenosylmethionine (SAMe), the principle methyl donor.

270 heir liver tissues have abnormal levels of S-adenosylmethionine (SAMe).

271 bon cycle, which produces the methyl donor S-adenosylmethionine (SAMe).

272 id pathway, we excluded a toxic effect of Se-adenosylmethionine, Se-adenosylhomocysteine, or of any c

273 alpha5, beta3, and alpha6, increasing the S-adenosylmethionine site solvent exposure.

274 ue and becomes much more dramatic when the S-adenosylmethionine substrate is present in the enzyme ac

275 nt uncovered a nitrogen-, methionine-, and S-adenosylmethionine-sufficiency response, resulting in re

276 methylsynthases that belong to the radical S-adenosylmethionine superfamily of enzymes.

277 s been shown to be a member of the radical S-adenosylmethionine superfamily of proteins, suggesting t

278 n of worm methionine synthase (metr-1) and S-adenosylmethionine synthase (sams-1) imply metformin-ind

279 ins have diverse cellular roles, including S-adenosylmethionine synthesis, respiration, and host tran

280 AdoMet formation is catalyzed by S-adenosylmethionine synthetase (ATP: L-methionine S-adeno

281 zymes central to all cellular methylation, S-adenosylmethionine synthetase and S-adenosylhomocysteine

282 is (Arabidopsis thaliana), one of the four S-adenosylmethionine synthetase genes, METHIONINE ADENOSYL

283 o identified highly induced levels of four S-adenosylmethionine synthetase genes, the EARLY-RESPONSIV

284 The S-adenosylmethionine synthetase type 1 (MAT1A) gene encode

285 ch contains serine metabolic enzymes, SAM (S-adenosylmethionine) synthetases, and an acetyl-CoA synth

286 te, which is required for the synthesis of S-adenosylmethionine, the methyl donor for cellular methyl

287 ovo synthesis of purines, thymidylate, and S-adenosylmethionine, the primary cellular methyl donor.

288 ansferase (MAT) catalyzes the synthesis of S-adenosylmethionine, the principal methyl donor, and is e

289 (3-MeA) is formed in DNA by reaction with S-adenosylmethionine, the reactive methyl donor, and by re

290 been found to catalyze alkyl transfer from S-adenosylmethionine to halide ions.

291 The enzyme utilizes S-adenosylmethionine to methylate a variety of phosphonate

292 by a typical Sn2-type methyl transfer from S-adenosylmethionine to pEA.

293 s, and utilizes an iron-sulfur cluster and S-adenosylmethionine to repair SP by a direct reversal mec

294 f GSH to oxidized forms of glutathione and S-adenosylmethionine to S-adenosylhomocysteine levels, res

295 r of donor methyl groups from the cofactor S-adenosylmethionine to specific acceptor lysine residues

296 Transfer of a methyl group from S-adenosylmethionine to the target RNA is performed by fib

297 tracellular concentration of methionine or S-adenosylmethionine was increased.

298 ated sulfonium ions that were analogues of S-adenosylmethionine were investigated by computational me

299 euterated 5'-deoxyadenosine and deuterated S-adenosylmethionine when the reaction is carried out in D

300 Incubation of geranyl diphosphate and S-adenosylmethionine with a mixture of both SCO7700 and SC