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1 ium of Neuro-2A cells or intracellularly via adenoviral 7B2 overexpression, blocked the neurocytotoxi
2 ing levels of potency demonstrated that anti-adenoviral activity is directly correlated with HD5 bind
3 at residue 29 is a major determinant of anti-adenoviral activity, and a chemical modification that pr
14 on, squirrel monkeys given ICV injections of adenoviral BDNF/noggin showed similar addition of striat
18 -office test can prevent the misdiagnosis of adenoviral conjunctivitis that leads to the spread of di
19 Hopkins Hospital with signs and symptoms of adenoviral conjunctivitis underwent evaluation by nurse
22 then randomized to targeted injection of an adenoviral construct (10 muL; 8x10(9) plaque forming uni
23 we demonstrated that in vivo delivery of an adenoviral construct optimized for the secretion of huma
26 e present study, injections of Cre-dependent adenoviral constructs were targeted to the ventrolateral
29 v/Wv mice by either intrabursal injection of adenoviral Cre or inclusion of the MISR2-Cre transgene a
31 KRAS(G12D) in the lung by nasal delivery of adenoviral Cre recombinase (Cre), here we show that KRAS
34 ograde pancreatic ductal injection of either adenoviral-Cre or lentiviral-Cre vectors allows titratab
35 n lung cells by intratracheal infection with adenoviral-Cre particles generated hyperplasias in all r
37 f increased prostacyclin (PGI2) derived from adenoviral cyclo-oxygenase (COX)-1/prostacyclin synthase
38 Increasing nuclear abundance of p27(kip1) by adenoviral delivery decreases the proliferative response
39 ression or downregulation was achieved using adenoviral delivery of CADM1 short hairpin RNAs or isofo
40 Tumorigenesis was triggered by intravenous adenoviral delivery of Cre recombinase in transgenic mic
43 ortality during hyperoxia, and lung-targeted adenoviral delivery of Hsp70 effectively rescues both Hs
44 e pulmonary disease airway disease utilizing adenoviral delivery of IL-1beta to determine that adapti
45 at HDACIs enhance MDA-7/IL-24 lethality, and adenoviral delivery of mda-7/IL-24 combined with tumor-s
50 sponse to VEGF, administered via intradermal adenoviral delivery or through systemic injection of rec
54 observed that endothelial cells responded to adenoviral DNA by phosphorylation of ATM and CHK2 and th
55 of DNA damage that can also be activated by adenoviral DNA, and on IRF1, a transcriptional regulator
56 s decreased in ApoER2(-/-) mice, and whereas adenoviral-driven apoE3 expression in wild-type mice has
57 efine a novel function of the antiapoptotic, adenoviral E1B 19K protein that may limit local host inn
61 r cells expressing MDA-7/IL-24, in which the adenoviral early region 1A (E1A) gene was driven by the
64 pharmacological inhibitor BI-D1870 or after adenoviral expression of a dominant negative RSK1 mutant
65 f ischemic skin flaps, which was reversed by adenoviral expression of ANKRD1, and delayed excisional
66 prevented in cultured human chondrocytes by adenoviral expression of catalase targeted to the mitoch
67 ion of a CF airway cell line (CF15 cells) by adenoviral expression of CFTR reduced the activation of
69 n and increased BK-beta1 expression, whereas adenoviral expression of MuRF1 in mouse coronary arterie
70 VEGF neutralization in mice, accomplished by adenoviral expression of soluble Flt1, resulted in 7-fol
71 in vivo attenuation of caspase activity via adenoviral expression of the biologic effector caspase i
74 ng cultured neonatal rat cardiomyocytes with adenoviral gene delivery and pharmacological inhibitors,
78 ad candidates for their capacity to increase adenoviral gene expression in an orthotopic in vivo mode
79 irst time that cationic polymers can enhance adenoviral gene expression in an orthotopic model of bla
80 o determine if cationic polymers can enhance adenoviral gene expression in cells that are difficult t
81 polymer NPGDE-1,4 Bis significantly enhanced adenoviral gene expression in the orthotopic model of bl
82 ide-based polymer paromomycin-BGDE, enhanced adenoviral gene expression within the bladder without ad
83 e similar in all groups, indicating that the adenoviral gene therapy was not associated with a higher
84 ly, further overexpression of vasohibin-1 by adenoviral gene transfer exerts multifold beneficial eff
86 cyte canalicular expression of hAQP1 through adenoviral gene transfer promotes biliary BS output by m
88 owing heterologous expression in myocytes by adenoviral gene transfer, wild-type telethonin became bi
90 E1A expression translates into inhibition of adenoviral genome replication, infectious particle produ
95 patocytes and mouse models of transgenic and adenoviral HBV expression, we show that HBV-expressing h
97 Recent work has shown that helper-dependent adenoviral (hdAD) vector-mediated plasma CocH reduced th
99 using ROSA(mTmG);Wt1(CreER) mice showed that adenoviral hSCF treatment increased Wt1(+) lineage-deriv
101 DC chemokine receptor ccr6 both protect from adenoviral IL-1beta-induced airway adaptive T cell immun
102 e insertion of artificial aptazymes into the adenoviral immediate early gene E1A enables small-molecu
103 tivity and PCR were employed to quantify the adenoviral inactivation rates using narrow bands of irra
110 ed using its specific inhibitor AS1842856 or adenoviral infection of constitutively active FOXO1.
111 inducing reactive oxygen species (ROS) after adenoviral infection of mda-7/IL-24 leads to greater tra
114 imental murine AIH (emAIH) by a self-limited adenoviral infection with the hepatic autoantigen formim
116 within 24 hours of LPS injection or HSV-1 or adenoviral infection, accompanied by a predominantly neu
117 /2 phosphorylation remained unchanged during adenoviral infection, suggesting specificity of JNK acti
118 ion was induced at a magnitude comparable to adenoviral infection, suggesting that AQP1 is primarily
120 es of graft failure, cytomegalovirus, and/or adenoviral infections and transplant-related mortality a
121 stream pathways mediate these Ito,f changes, adenoviral infections were used to inhibit CaMKIIdeltac,
124 receptor antagonist 7-chlorokynurenic acid, adenoviral injection of NR1 short hairpin RNA (shRNA), a
125 siRNA; affecting FGFR3-IIIb and -IIIc) or an adenoviral kinase-dead FGFR3-IIIc construct (kdFGFR3).
129 as applied as an imaging reporter to monitor adenoviral liver transduction with both nuclear and opti
130 safety and biologic efficacy of serotype 5, adenoviral-mediated aquaporin-1 cDNA transfer to a singl
131 y enzyme-linked immunosorbent assay, whereas adenoviral-mediated CSE overexpression in human umbilica
133 inically applicable gene therapy approach by adenoviral-mediated delivery of the bicistronic vector.
134 protected from pulmonary fibrosis induced by adenoviral-mediated expression of active TGF-beta1.
136 eed, selective inhibition of hepatic aPKC by adenoviral-mediated expression of kinase-inactive aPKC,
138 Effects of vasohibin-1 overexpression by adenoviral-mediated gene transfer on angiogenesis, fibro
139 xtent similar to isoproterenol exposure, and adenoviral-mediated knockdown of Epac1 prevented isoprot
147 e role of versican, a vitreous component, in adenoviral-mediated transgene expression was examined.
152 NF-kappaB activation involve infection of an adenoviral NF-kappaB-luciferase reporter into cell lines
157 This reduced expression was not restored by adenoviral overexpression of BiP (immunoglobulin-binding
158 ering RNA and genetic deletion of ChREBP and adenoviral overexpression of ChREBP in rodent and human
161 d endothelial cells, metformin treatment and adenoviral overexpression of constitutively active AMPK
164 on was impaired in CREBH-deficient mice, and adenoviral overexpression of FGF21 suppressed adipose ti
166 e decreased the vascular leakage compared to adenoviral overexpression of green fluorescent protein.
168 Using therapeutic silencing of miR-33 and adenoviral overexpression of miR-33, we show that miR-33
169 gely non-amyloidogenic degradation products, adenoviral overexpression of MMP-9 in amyloid-prone isle
175 t3 ablation sensitized mice to NASH, whereas adenoviral overexpression of Sirt3 alleviated the NASH p
179 Through a series of genetic silencing and adenoviral overexpression studies, we have defined GLUT1
180 h the PLD product, phosphatidic acid (PA) or adenoviral PLD1 expression in Pld1(-/-) hepatocytes, con
182 er proteins, maturational proteolysis by the adenoviral protease leads to the differential release of
183 nhanced inactivation at low wavelengths with adenoviral protein damage at those wavelengths, adding f
184 define a new function of the antiapoptotic, adenoviral protein E1B 19K, which we have termed "apopto
186 This research shows UV-induced damage to adenoviral proteins across the germicidal UV spectrum at
187 is and by promoting exit from mitosis, these adenoviral proteins act to prevent the infected cell fro
195 and the immunity induced by the recombinant adenoviral RSV vaccine administered by use of an intramu
197 /-) mice, using a recombinant nonreplicating adenoviral serotype 5 vector that contained the murine M
199 Importantly, acute hepatic knockdown by adenoviral shRNA targeting G9a abolishes Fgf21 repressio
207 Furthermore, overexpression of miR-133b via adenoviral system in vitro led to decreased CTGF express
210 r497/495 was reversed by micro-calpsiRNA and adenoviral transduced dominant negative protein kinase C
212 ukocytes from 112 Hispanic patients by using adenoviral transduction and 24-h culture, with quantitat
215 We overcame this obstacle through in vivo adenoviral transduction with matrix-targeted photoactiva
219 a chemical chaperone, phenylbutyric acid, or adenoviral transfection with ATF6 attenuated HNE-induced
220 d through transgenic overexpression of TFF2, adenoviral transfer of TFF2 or transplantation of TFF2-e
221 and prolonged following vaccination with an adenoviral vaccine encoding GP linked to Ii compared wit
223 the lymphatic network in the defected area, adenoviral vascular endothelial growth factor C (VEGF-C)
224 clones, gene correction by helper-dependent adenoviral vector (HDAdV) or Transcription Activator-Lik
225 er vaccination with a rhesus macaque-derived adenoviral vector (simian adenovirus 7 [SAdV-7]) enhance
227 rus receptor (sCAR-Fc) was expressed from an adenoviral vector and 2 short hairpin RNAs (shRdRp2.4) d
229 sduction in the presence of vitreous with an adenoviral vector containing an IL-12-coding transgene i
231 thway, rats were intravenously injected with adenoviral vector encoding a decoy VEGF receptor (Ad-Flk
232 ritic cells transduced with the adjuvant, an adenoviral vector encoding a dominant negative isoform o
233 Intranodally injected adenoviral VEGF-C and adenoviral vector encoding control gene LacZ induced mac
234 neural targets of the VMHdm by injecting an adenoviral vector encoding Cre recombinase (Cre)-regulat
235 lymphoblastoid cell lines transduced with an adenoviral vector expressing either LMP2 alone (n = 17)
236 genital administration of an IL-4-expressing adenoviral vector greatly increased in vivo ESC prolifer
238 er vaccination with a rhesus macaque-derived adenoviral vector in rhesus macaques enhances mucosal CD
239 The results showed that vaccination with an adenoviral vector indeed increases activation of mucosal
241 that a genetically engineered RSV-F-encoding adenoviral vector provides protective immunity against R
242 of immunocompetent mice with low doses of an adenoviral vector resulted in persistent HBV infection;
243 cancer cell line (HT29) transfected with an adenoviral vector that expressed Ad VP16hLXRalpha, compa
245 in preBotC astrocytes bilaterally (using an adenoviral vector to specifically express tetanus toxin
247 hese data implicate versican G1 in enhancing adenoviral vector transgene expression in a hyaluronic a
249 intracerebroventricular (ICV) delivery in an adenoviral vector triggers the addition of new neurons t
260 patients were vaccinated using heterologous adenoviral vectors (ChAd3-NSmut and Ad6-NSmut) encoding
263 ssed and CD63 was knocked down in mice using adenoviral vectors AdTIMP1 or AdshCD63, respectively.
264 t liver detargeting and tumor retargeting of adenoviral vectors after coating with synthetic dendrime
266 3, and 5 hours after injury) transduced with adenoviral vectors carrying IL8RA, IL8RB, and IL8RA/RB (
267 n astrocytes of mouse cortex by injection of adenoviral vectors containing a strong and astrocyte-spe
268 ouse corneas infected with Slurp1-expressing adenoviral vectors displayed reduced signs of inflammati
270 in vitro experiments with HSCs infected with adenoviral vectors encoding LacZ, Dyn2K44A, or Dyn2WT.
271 B/c (L. monocytogenes-susceptible) mice with adenoviral vectors encoding natural L. monocytogenes-der
272 ion of XBP1 was knocked down by injection of adenoviral vectors encoding small hairpin RNAs against X
273 and why this is so, we have generated potent adenoviral vectors encoding the endogenous tumor Ags (TA
275 ERS-CoV infection by prior transduction with adenoviral vectors expressing the human host-cell recept
276 xpressing Cyclo-oxygenase-2 by 600-fold, and adenoviral vectors expressing the pro-apoptotic gene Bax
277 o overcome these hurdles in order to develop adenoviral vectors for combination of systemic oncolytic
278 antibodies, which can selectively immobilize adenoviral vectors for gene delivery of growth factors.
281 SK-N-DZ neuroblastoma cells transduced with adenoviral vectors in the presence of versican respond w
282 Chronic central administration of MCH and adenoviral vectors increasing MCH signaling were perform
283 nd suggest that E1B 19K-deleted, replicating adenoviral vectors might induce greater inflammatory res
284 king the kappa opioid receptor (kappaOR) and adenoviral vectors overexpressing or silencing kappaOR w
286 lymphocytic choriomeningitis virus model and adenoviral vectors to compare a vaccine expressing unmod
288 lls (HUVEC) were transduced with recombinant adenoviral vectors to express wild-type, constitutively
298 ii) ear angiogenic responses to intradermal adenoviral-VEGF injection, and iii) vascular flow recove
299 tivation profiles and binding affinities for adenoviral virus-associated RNA I (VA RNAI) and HIV-1 tr
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