ライフサイエンスコーパス: adenovirus

1 obacter, Cryptosporidium, norovirus GII, and adenovirus.

2 his interaction regulates innate immunity to adenovirus.

3 rected evolution in the absence of wild-type adenovirus.

4 ox, and vaccinia, but not murine leukemia or adenovirus.

5 se tissue, we deleted hepatic Tsc1 using Cre adenovirus.

6 us, vesicular stomatitis virus, reovirus, or adenovirus.

7 ET interaction contributes to DDR evasion by adenovirus.

8 have been shown to carry a wide diversity of adenoviruses.

9 posed genome-capsid coassembly mechanism for adenoviruses.

10 plications for cancer therapy with oncolytic adenoviruses.

11 retrograde Cre-recombinase-expressing canine adenovirus-2 in combination with Cre-dependent inhibitor

12 administered a single dose of the chimpanzee adenovirus 3 (ChAd3) vaccine encoding the surface glycop

13 -controlled, phase 3 trial of the chimpanzee adenovirus 3 vaccine (ChAd3-EBO-Z) and the recombinant v

14 elopment of replication-defective chimpanzee adenovirus 3 vector vaccine expressing Zaire Ebola virus

15 The MBR achieved high log removals for adenovirus (3.9 to 5.5), norovirus GII (4.6 to 5.7), and

16 S/AS01 following a primary immunization with adenovirus 35 (Ad35) (ARR) vector expressing circumsporo

17 of the AERAS-402 live, replication-deficient adenovirus 35-vectored TB candidate vaccine, containing

18 e that the E4ORF1 peptide derived from human adenovirus 36 (Ad36) interacts with cells from adipose t

19 with the original methods, particularly for adenovirus 40/41 (around five times), Shigella spp or en

20 GII, Cryptosporidium, Shigella, ST-ETEC, and adenovirus 40/41 were also important.

21 n descending order, Shigella spp, rotavirus, adenovirus 40/41, ST-ETEC, Cryptosporidium spp, and Camp

22 tion reaction of DNA from two viruses (Human adenovirus 41, Phi X 174) and the bacterium Enterococcus

23 Using replication-incompetent adenovirus 5 (Ad5)-based vectors as a model, we investig

24 The cell-transforming activity of human adenovirus 5 (hAd5) E1A is mediated by the N-terminal ha

25 neutralizing antibody in complex with human adenovirus 5 hexon and show how these properties influen

26 Macaques were primed twice mucosally with adenovirus 5 host range mutant recombinants encoding SIV

27 as expressed in the viral vectors chimpanzee adenovirus 63 (ChAd63) and modified vaccinia virus Ankar

28 lts were vaccinated with either a chimpanzee adenovirus 63 and modified vaccinia virus Ankara-vectore

29 us agents covered in this assessment include adenovirus 8 and 19, herpes simplex virus (HSV) 1 and 2,

30 All 4 studies of adenovirus 8 concluded that after sodium hypochlorite (d

31 Enterovirus, adenovirus A, Salmonella spp., Campylobacter jejuni, bov

32 , acute viral infection of murine liver with adenovirus, a model for intrahepatic cross-presentation,

33 Adenovirus, a waterborne pathogen responsible for causin

34 Our understanding of adenovirus (Ad) biology is largely extrapolated from hum

35 The adenovirus (Ad) early region 4 (E4)-ORF3 protein regulat

36 endritic cells (DCs) combined with oncolytic adenovirus (Ad) expressing antitumor cytokines induces a

37 sons of conventional influenza vaccines with adenovirus (Ad) gene-based vaccines demonstrated that th

38 The human adenovirus (Ad) serotype 5 has been tested in malaria va

39 uscular (i.m.) injection of a nonreplicating adenovirus (Ad) vector carrying a secretory transgene of

40 CD4(+)T cell help is required at the time of adenovirus (Ad) vector immunization for the development

41 When treated with a Cre-expressing adenovirus (Ad-Cre), there was a localized knockdown of

42 se a newly designed tumor-targeted oncolytic adenovirus (Ad-TD) to deliver non-secreting (ns) IL-12 t

43 ression of MDA-5 via replication-incompetent adenovirus (Ad.Mda-5) initiates multiple signaling casca

44 Human adenoviruses (Ad) are double-stranded DNA (dsDNA) viruse

45 In this study, we examine a DNA and adenovirus (Ad5) combination regimen targeting guanylyl

46 The E3 transcription unit of human species C adenoviruses (Ads) encodes immunomodulatory proteins tha

47 Human adenoviruses (Ads) generally cause mild self-limiting in

48 Adenoviruses (Ads) subvert MHC class I Ag presentation a

49 nza virus 1 to 3 (PIV1, PIV2, and PIV3), and adenovirus (AdV) infections.

50 575 (24.8%) had rhinovirus, 347 (14.9%) had adenovirus (ADV), and 30 (1.3%) had influenza virus.

51 ), Epstein-Barr virus (EBV), BK virus (BKV), adenovirus (ADV), and human herpesvirus 6 (HHV6) were ev

52 n viral pathogens: Epstein-Barr virus (EBV), adenovirus (AdV), cytomegalovirus (CMV), BK virus (BKV),

53 for cytomegalovirus, Epstein-Barr virus, or adenovirus and genetically modified to express HER2-CARs

54 leach) offers effective disinfection against adenovirus and HSV, the viruses commonly associated with

55 emonstrated by incorporating and stabilizing adenovirus and MVA vaccines.

56 n shown to be more effective at inactivating adenovirus and other viruses than traditional monochroma

57 esviruses, papillomaviruses, polyomaviruses, adenoviruses and anelloviruses.

58 When mouse xenografts were treated with adenoviruses and ganciclovir, all animals showed decreas

59 atible with experimental data on unperturbed adenoviruses and polyomaviruses, at the same time provid

60 polyomavirus, human herpesvirus 6B, HHV-6A, adenovirus, and Epstein-Barr virus between days 0 and 10

61 uses AH1, AH3, and B, human metapneumovirus, adenoviruses, and bocavirus) and 3 pathogenic airway bac

62 susceptible to infection with certain human adenoviruses, and the pathology accompanying these infec

63 mount of adenoviruses resulted in fewer free adenovirus antibodies and thus smaller reflectivity chan

64 th their hosts over millions of years, other adenoviruses appear to have emerged through successful c

65 Although many adenoviruses are host specific and likely codiverged wit

66 Adenoviruses are prevalent human pathogens that can caus

67 Adenoviruses are respiratory, ocular and enteric pathoge

68 r hurdle to the efficacious use of oncolytic adenoviruses as cancer treatments.

69 embrane-containing proteins encoded by human adenoviruses, as a model system to survey the extracellu

70 cribed small RNA (BocaSR) diverges from both adenovirus-associated (VA) RNAs and Epstein-Barr virus-e

71 BocaSR is similar to the adenovirus-associated type I (VAI) RNA in terms of both

72 We also utilized adenovirus-associated virus-Cre to depleteLpcat3in the l

73 IgM antibodies against influenza A and human adenoviruses based on the color and position of the upco

74 se immunization in BCG-primed adults with an adenovirus-based tuberculosis vaccine elicits a repertoi

75 do not naturally express TLR5, we created an adenovirus-based vector for intratumor delivery, named M

76 Furthermore, adenovirus-based vectors are frequently used as experime

77 Despite human adenoviruses being a common and, in some instances, life

78 These new insights in basic adenovirus biology can be employed to develop novel drug

79 osis of infection with cytomegalovirus, EBV, adenovirus, BK virus, and/or human herpesvirus 6.

80 d structural characterization of a novel bat adenovirus (BtAdV) recovered from a Rafinesque's big-ear

81 uman defensin HD5 inactivates specific human adenoviruses by binding to capsid proteins and blocking

82 3-L1 adipocytes were cultured, infected with adenovirus carrying AAT1 gene or lentivirus carrying shR

83 consisting of a baculovirus conjugated to an adenovirus carrying the pro-apoptotic gene PUMA, has the

84 4.4%) red foxes were seropositive for canine adenovirus (CAV) by ELISA.

85 avirus, norovirus genotype 1/2 (GI/GII), and adenovirus compared to those of microbiological culture

86 S-402 is a replication-deficient serotype 35 adenovirus containing DNA expressing a fusion protein of

87 Here we describe how a small adenovirus core protein that localizes to host chromatin

88 onic fibroblasts with deletion of Ada3 using adenovirus Cre showed a critical role of ADA3 in cell cy

89 Specifically, we used adenovirus-Cre injections to generate MPNST in Nf1(Flox/

90 It was concluded that T. cruzi and adenovirus damage the host cell plasma membrane to hijac

91 Adenovirus-delivered MDA-7/IL-24 (Ad.mda-7) reduced the

92 e hypothesis, we first constructed oncolytic adenovirus Delta-24-RGDOX expressing the immune costimul

93 es are markedly more potent but risk causing adenovirus diseases in vaccine recipients and health car

94 nscription factor 3 (ATF3), which we show by adenovirus driven overexpression, decreases inflammatory

95 cells and cell types that do not express the adenovirus E1 gene as well as for the rescue of wild-typ

96 Transforming viral oncoproteins, such as adenovirus E1A and papillomavirus E7, inactivate Rb.

97 The N-terminal half of adenovirus e1a assembles multimeric complexes with host

98 ption of antiviral genes in association with adenovirus E1A, modulate cellular responses to polycomb-

99 protein) binding protein (CREBBP)) and P300 (adenovirus E1A-associated 300 kDa protein) are two close

100 ed role for mitophagy-inducing proteins BCL2/adenovirus E1B 19-kDa interacting protein 3 (BNIP3) and

101 ypoxia-regulated genes including BNIP3 (BCL2/adenovirus E1B 19-kDa protein-interacting protein 3) and

102 d expression of the mitophagy regulator BCL2/adenovirus E1B 19-kDa-interacting protein 3-like (BNIP3L

103 Main outcomes of interest were VR of adenovirus, EBV, human herpesvirus 6 (HHV6), cytomegalov

104 urotrophin receptor peptide (p75NTRp)-tagged adenovirus enabled the generation of hepatocyte-like cel

105 and mechanism of action of a nonreplicating adenovirus encoding a chimeric, membrane-bound CD40 liga

106 Intraluminal transduction of adenovirus encoding CaMKIIgammaC rescued expression to 3

107 We showed that co-delivery of adenovirus encoding EGFP-tagged Cas9 and lentivirus enco

108 wo-day-old ksr2(-/-) mice with a recombinant adenovirus encoding human IGF-1.

109 d and SM alpha-actin expression induced with adenovirus encoding myocardin-related transcription fact

110 oaded with OVA and CpG (PLGA(OVA + CpG)), an adenovirus encoding OVA (Ad5-OVA), and OVA delivered wit

111 efore, we developed a novel helper-dependent adenovirus/Epstein-Barr virus (HDAd/EBV) hybrid reprogra

112 arainfluenza, coronaviruses, rhinovirus, and adenovirus, especially in children, require further scru

113 The study improves our understanding of how adenoviruses establish infection in epithelial tissues a

114 Our study revealed how adenoviruses exploit a capsid-associated small PPxY pept

115 We constructed a novel recombinant adenovirus expressing Ad12 E1A (Ad-E1A12) that can stron

116 furanosyl-imidazole-4-carboxamide (AICAR) or adenovirus expressing constitutively active subunits of

117 nfusions of the AMPK inhibitor compound C or adenovirus expressing dominant-negative subunits of AMPK

118 expressing mouse APN (AdAPN) and as control, adenovirus expressing green florescent protein (AdGFP).

119 nduced plasma APN levels using a recombinant adenovirus expressing mouse APN (AdAPN) and as control,

120 Mice were immunized with Adenovirus expressing the H1-con, H2-con, H3-con and H5-

121 An adenovirus expressing VEGF-A (Ad-VEGF-A(164)) replicates

122 our studies, we generated three recombinant adenoviruses expressing wild type, constitutively active

123 electrode for optoelectronic sensing of fowl adenoviruses (FAdVs).

124 was corrected by delivering CRISPR/Cas9 with adenovirus followed by nucleoporation with a 70 nt singl

125 fe of a green fluorescent protein expressing adenovirus from approximately 48 h to 21 days at 37 degr

126 These drugs alter the cascade of adenovirus gene expression, acting after initiation of e

127 versed by transduction of MIN6 cells with an adenovirus gene shuttle vector that expressed human STIM

128 Using pharmacological methods and adenovirus gene transfer to bidirectionally regulate AMP

129 a/Syn3), a replication-deficient recombinant adenovirus gene transfer vector, for patients with high-

130 The adenovirus genome is packaged with protein VII, a virall

131 the linear double-stranded DNA nature of the adenovirus genome, the cellular DNA damage response (DDR

132 Comparable doses of CaMKIIdelta2 adenovirus had no effect.

133 obial peptides capable of neutralizing human adenovirus (HAdV) in vitro by binding capsid proteins an

134 Severe human adenovirus (HAdV) infections are an increasing threat fo

135 Human adenovirus (HAdV) types are associated with distinct dis

136 er, an appropriate viral surrogate for human adenovirus (HAdV), a medium-sized virus with a double-st

137 improved sensitivity for detection of human adenovirus (HAdV), compared to an earlier version (RP v1

138 The search for human adenovirus (HAdV)-specific antiviral drugs for the treat

139 Both drugs reduced the yields of four human adenoviruses (HAdV-A31, -B35, and -C5 and a species D co

140 ssive for the replication of species C human adenoviruses (HAdV-C).

141 Human adenoviruses (HAdVs) are highly contagious pathogens cau

142 Human adenoviruses (HAdVs) contain seven species (HAdV-A to -G

143 Human adenoviruses (HAdVs) shut down host cellular cap-depende

144 molecules is conserved among different human adenoviruses (HAdVs), but not in non-HAdVs.

145 CD4 reconstitution predicted reactivation of adenovirus (hazard ratio [HR], 0.995; P = .022), EBV (HR

146 unaltered ability to control infection in an adenovirus-HBV model.

147 njection of an integrating, helper-dependent adenovirus (HD-Ad5/35(++)) vector system.

148 , rotaviruses, astroviruses, picornaviruses, adenoviruses, herpesviruses) that constitute a serious p

149 ections including BK virus, cytomegalovirus, adenovirus, human herpesvirus 6, and Epstein-Barr virus.

150 The oncolytic adenovirus ICOVIR-15K was engineered to express an EGFR-

151 mplex biology defining the interplay between adenovirus immune recognition and cellular uptake mechan

152 holesterol that regulates innate immunity to adenovirus in endosomes.IMPORTANCE Early region 3 protei

153 tive that we investigate the pathogenesis of adenoviruses in a permissive animal model.

154 raphic distribution and genetic diversity of adenoviruses in bats and their close phylogenetic relati

155 Since the first description of adenoviruses in bats in 2006, a number of micro- and meg

156 ratumoral injection of this cBiTE-expressing adenovirus increased the persistence and accumulation of

157 Adenovirus-induced MYC activation promotes increased glu

158 g adenovirus replication as a means to block adenovirus-induced pathology.

159 highly immunosuppressive tumor environment, adenovirus-infected cells can nonetheless be efficiently

160 fections is similar to what is observed with adenovirus-infected human patients.

161 Respiratory adenovirus infection among military recruits is a seriou

162 be employed to develop novel drugs to treat adenovirus infection as well as be used as tools for gen

163 rotected mice from a subsequent OVA-encoding adenovirus infection in a CD8(+) cell-dependent manner a

164 ajor part of the mechanism by which systemic adenovirus infection induces pathology, as opposed to th

165 rly dynamics in an experimental system using adenovirus infection of human embryonic kidney (293) cel

166 , Cryptosporidium, rotavirus, norovirus, and adenovirus infections resulting from indirect wastewater

167 ndings validate a novel approach to treating adenovirus infections through the modulation of host cel

168 as antiviral agents for treatment of serious adenovirus infections.

169 an patients can develop severe, often lethal adenovirus infections.

170 essed the efficacy and safety of recombinant adenovirus interferon alfa with Syn3 (rAd-IFNalpha/Syn3)

171 bacteriophages and herpesviruses.IMPORTANCE Adenovirus is a double-edged sword to humans: it is a wi

172 gy resulting from intravenous infection with adenoviruses is caused mostly by replication in hepatocy

173 The phylogeny of human and chimpanzee adenoviruses is overlapping, and preexisting humoral and

174 esquii) in Kentucky, USA, which is the first adenovirus isolated from North American bats.

175 n may be enhanced by coadministering with an adenovirus lacking a transgene of interest.

176 o that observed in dsDNA viruses of the PRD1-adenovirus lineage, characterized by a major capsid prot

177 le evidence that innate immune activation by adenovirus may act as an adjuvant in such a manner that

178 out how CAdV A, and possibly other mammalian adenoviruses, may have emerged.

179 etabolism in C57Bl/6J male mice 1 week after adenovirus-mediated Acot1 knockdown.

180 Adenovirus-mediated delivery of hepatic GRbeta overexpre

181 In vivo, adenovirus-mediated depletion of COP1 ameliorates high-f

182 In contrast, adenovirus-mediated downregulation of hepatic LSD1 blunt

183 Adenovirus-mediated expression of endomucin under inflam

184 etic BMPC angiogenic function was rescued by adenovirus-mediated expression of IRE1alpha but not by t

185 Adenovirus-mediated expression of SIRT3 or an acetylatio

186 pulmonary fibrosis in vivo was studied using adenovirus-mediated gene transfer in mice.

187 Ex vivo intracoronary delivery of adenovirus-mediated gene transfer of recombinant human P

188 Adenovirus-mediated knockdown of PPARdelta in cultured h

189 Adenovirus-mediated liver-specific expression of SIRT1 o

190 Adenovirus-mediated miR-101 gene transfer in the mouse l

191 asing circulating FLD levels in mice through adenovirus-mediated overexpression (Ad-FLD) not only ind

192 ma)) and lipid droplet accumulation, whereas adenovirus-mediated overexpression of APCDD1 enhanced ad

193 Liver-specific knockout or adenovirus-mediated overexpression of DsbA-L exacerbates

194 Adenovirus-mediated overexpression of DUSP8 in cultured

195 t in Mir122 knockout mice was ameliorated by adenovirus-mediated overexpression of miR-122, underscor

196 Adenovirus-mediated PI16 overexpression inhibits HCAEC m

197 Adenovirus-mediated reconstitution of MTP expression pro

198 est this, we inhibited MCT1 expression using adenovirus-mediated transfection of a shRNA into the thi

199 vaccine formulations: replication-deficient adenovirus; modified vaccinia Ankara (a poxvirus); prote

200 The dependence of adenovirus on the host pre-RNA splicing machinery for ex

201 e proinflammatory properties of an oncolytic adenovirus (Onc.Ad) with a helper-dependent Ad (HDAd) th

202 plication but also a helper virus such as an adenovirus or a herpesvirus.

203 HREC) in vitro by EMCN over-expression using adenovirus or EMCN gene knockdown by siRNA.

204 uires coinfection with a helper virus (e.g., adenovirus or herpesvirus) or treatment with genotoxic a

205 cluding those of dsDNA/dsRNA bacteriophages, adenoviruses, poxviruses, herpesviruses, mimiviruses, me

206 Recently, we showed the adenovirus proteinase interacts productively with its pr

207 y two mucosal boosts with either recombinant adenovirus (rAd) or fowlpox virus (rFWPV) expressing SIV

208 t are being tested are replication-defective adenoviruses (RD-Ads).

209 nstitution abolished this negative effect of adenovirus reactivation (OS, P = .67; NRM, P = .64).

210 Adenovirus reactivation predicted lower OS (HR, 2.17; P

211 Duration of adenovirus reactivation was shorter with timely CD4 reco

212 The coxsackievirus and adenovirus receptor (CAR) is a member of the immunoglobu

213 t in the adult brain, the coxsackievirus and adenovirus receptor (CAR) is located on neuron projectio

214 One such receptor is Coxsackie and Adenovirus Receptor (CAR) that binds to Junctional Adhes

215 addressed the role of the coxsackievirus and adenovirus receptor (CAR), a single-pass cell adhesion m

216 d to stably express human coxsackievirus and adenovirus receptor [CAR]).

217 d by HCBP1 peptide rather than coxsackie and adenovirus receptor specific antibody.

218 is, apoptosis, lower CAR (Coxsackievirus and adenovirus receptor) expression and CVB3 copy number, an

219 TFH cells, initially induced by replicating adenovirus-recombinant priming, are long lived.

220 ings support the use of compounds inhibiting adenovirus replication as a means to block adenovirus-in

221 By blocking adenovirus replication at one or more steps beyond the o

222 sm(s) by which digoxin and digitoxin inhibit adenovirus replication will guide the development of nov

223 In ECs, overexpression of let-7 by adenovirus represses EC proliferation, migration, and ne

224 In this approach, a higher amount of adenoviruses resulted in fewer free adenovirus antibodie

225 is work describes testing newer single-cycle adenovirus (SC-Ad) vectors that replicate transgenes to

226 ectious virions, we developed "single-cycle" adenovirus (SC-Ad) vectors.

227 were associated with an expansion of enteric adenovirus sequences and this increase was independent o

228 lated influenza A/H1N1 and A/H5N1 as well as adenovirus serotype 2 and 5 hexon antigens along with po

229 eutic vaccination with Ad26/MVA (recombinant adenovirus serotype 26 (Ad26) prime, modified vaccinia A

230 and mucosal immune responses to a candidate adenovirus serotype 26 (Ad26) vectored HIV-1 envelop (En

231 2 HIV-1 vaccines (adenovirus serotype 26 with an HIV-1 envelope A insert [

232 e discovery of a new mechanism used by human adenovirus serotype 3 to overcome innate antiviral host

233 h an HIV-1 envelope A insert [Ad26.EnvA] and adenovirus serotype 35 with an HIV-1 envelope A insert [

234 Adenovirus serotype 5 (Ad5) is one of the most widely us

235 cyclase gene, VCA0848, into a nonreplicating adenovirus serotype 5 (AdVCA0848) that produces elevated

236 t coadministration of AdVCA0848 with another adenovirus serotype 5 vector expressing the HIV-1-derive

237 vaccine and a single-shot recombinant rhesus adenovirus serotype 52 vector vaccine, both expressing Z

238 accines, we engineered RD and SC versions of adenovirus serotype 6 (Ad6) to express the hemagglutinin

239 Adenovirus-short hairpin RNA knockdown (KD) of Syt-7 in

240 digitoxin, are potent inhibitors of multiple adenovirus species.

241 nt viral delivery systems such as retro- and adenoviruses suffer from limited DNA cargo capacity, thu

242 Although most adenoviruses tend to cause limited disease in their natu

243 NCE Early region 3 proteins encoded by human adenoviruses that attenuate immune-mediated pathology ha

244 tively activated and redirected by oncolytic adenoviruses that were armed with bispecific T-cell-enga

245 Our study has implications for oncolytic adenovirus therapy.IMPORTANCE Previously, it has been re

246 TRIM29 (-/-) mice have lower adenovirus titers in the lung, and are resistant to leth

247 an additional example of a strategy used by adenovirus to abrogate the host DDR and show how viruses

248 We designed one adenovirus to deliver the nickase Cas9(D10A) and guide R

249 We deliver the adenovirus to mice and compare molecular and cellular en

250 tural study of representative bat and canine adenoviruses to better understand the relationship betwe

251 support for the use of replication-deficient adenoviruses to induce humoral responses.

252 reservoir for the cross-species transfer of adenoviruses to other hosts, as theorized for CAdV.

253 ypanosoma cruzi, Listeria monocytogenes, and adenovirus) to promote their internalization into target

254 ion in primary HSCs using a Hh antagonist or adenovirus transduction decreased TB4 expression with th

255 ed mice and control mice with MERS-CoV after adenovirus transduction of the human dipeptidyl peptidas

256 t our recent work showing that endosomolytic adenoviruses trigger autophagy when entering cells.

257 Canine adenovirus type 1 (CAV-1) causes infectious canine hepat

258 Mouse adenovirus type 1 (MAV-1) infection causes encephalitis

259 ibutes to the encephalitis observed in mouse adenovirus type 1 (MAV-1) infection, using mice lacking

260 The role of canine adenovirus type 2 (CAV-2), primarily a respiratory patho

261 replication-defective recombinant chimpanzee adenovirus type 3-vectored ebolavirus vaccine (cAd3-EBO)

262 The biodistribution of adenovirus type 5 (Ad5) vector particles is heavily infl

263 ed a humanized monoclonal IgG1 against human adenovirus type 5 (AdV5) and a panel of Fc-engineered va

264 the pro-apoptotic gene PUMA to FLS via human adenovirus type 5 (HAdV5) vectors has been tested as a t

265 counting, we improved the structure of human adenovirus type 5 and confirmed our previous models of c

266 nated via three DNA primes and a recombinant adenovirus type 5 boost (weeks 0, 4, 8, and 24, respecti

267 Priming with replication-deficient human adenovirus type 5 constructs and boosting with ex vivo p

268 bricated to deliver a live recombinant human adenovirus type 5 vaccine vector (AdHu5) encoding HIV-1

269 concentrations, improve the storage time of adenovirus type 5.

270 mic period) 85% of typed isolates were human adenovirus type 8 (HAdV-D8), whereas only low level circ

271 y of the monovalent, recombinant, chimpanzee adenovirus type-3 vector-based Ebola Zaire vaccine (ChAd

272 Such memory pools may also be induced after adenovirus vaccination, and we recently defined common t

273 than r30 with an adjuvant and a recombinant adenovirus vaccine expressing r30.

274 utilized a replication-deficient chimpanzee adenovirus vaccine platform with an established human an

275 potency of replication-deficient chimpanzee adenovirus vaccine platforms.

276 Vibrio cholerae diguanylate cyclase into an adenovirus vaccine, fostering production of c-di-GMP as

277 Most adenovirus vaccines that are being tested are replicatio

278 latory factors (IRF) 7 and 3 delivered by an adenovirus vector [Ad5-poIRF7/3(5D)], is a new effective

279 Adenovirus vector carrying MMP2 sequence and specific sm

280 ogenicity of a recombinant, non-replicating, adenovirus vector expressing haemagglutinin and double-s

281 with a subset receiving the Ad26 vaccine, an adenovirus vector expressing the viral Env/Gag/Pol antig

282 hat absence of CD4(+) T cells at the time of adenovirus vector immunization of mice led to immediate

283 veness, antibody responses can be induced by adenovirus vector immunization or alum-adjuvanted protei

284 the oncolytic efficacy of a serotype 5-based adenovirus vector; and (iii) the demonstration that epit

285 We previously reported that adenovirus vectored vaccines are potent in priming Ab re

286 Ag-specific follicular Th cell responses to adenovirus vectored vaccines exceeded those induced by o

287 We report that adenovirus vectored vaccines induce Ag insert-specific G

288 These data indicate that very low doses of Adenovirus-vectored consensus vaccines induce superior l

289 ing the protective efficacy of a single dose adenovirus-vectored malaria vaccine in a mouse model of

290 or had been vaccinated using a recombinant, adenovirus-vectored vaccine 2 weeks before challenge.

291 randomly assigned to receive combinations of adenovirus vectors (Ad5 or Ad35) and HIV-1 envelope (Env

292 h as modified vaccinia virus Ankara, complex adenovirus, vesicular stomatitis virus, alphavirus-based

293 (A, B, and C) envelope (Env) DNA/recombinant adenovirus virus type 5 (rAd5) vaccine studied in HIV-1

294 Adenovirus was associated with CAP only among children <

295 of 858 employees with eye complaints (62%); adenovirus was detected by PCR in 44 of 542 suspected vi

296 quencing was used to determine serotype when adenovirus was detected.

297 ns were collected and molecular detection of adenoviruses was performed by nested PCR.

298 Specifically, adenoviruses were associated with an increased incidence

299 proposed dsDNA genome-capsid coassembly for adenoviruses, which resembles that of single-stranded RN

300 erall, our results show how arming oncolytic adenoviruses with BiTE can overcome key limitations in o