ライフサイエンスコーパス: adenovirus E1A protein

1 acts with the p160 coactivators and with the adenovirus E1A protein.

2 nsformation not only by Myc, but also by the adenovirus E1A protein.

3 virus 40 T antigen, by oncogenic ras, or by adenovirus E1a protein.

4 and were equally sensitive to inhibition by adenovirus E1A protein.

5 d repression of E2F could not be reversed by adenovirus E1A protein.

6 activation and tumorigenesis mediated by the adenovirus E1A protein.

7 racts with the domain of CBP/p300 that binds adenovirus E1A protein.

8 y of pRB was examined by in vitro binding to adenovirus E1A protein.

9 , which is functionally conserved in E2F and adenovirus E1A proteins.

10 ays are blocked in HeLa cells expressing the adenovirus E1A proteins.

11 Human adenovirus E1A protein abrogated cotransactivation by CB

12 The adenovirus E1A protein acts within the nucleus to regula

13 oan Mediator subunit that interacts with the adenovirus E1A protein and functions in a mitogen-activa

14 hich is related to conserved region 1 of the adenovirus E1A protein and importantly contributes to ce

15 on is shown in vivo by overexpression of the adenovirus E1A protein and mutant forms of E1A that lack

16 unmutated, because it bound normally to the adenovirus E1A protein and showed nuclear localization b

17 AV promoters (p5, p19, and p40) requires the adenovirus E1a protein and the AAV nonstructural (Rep) p

18 Since both the adenovirus E1A protein and transcriptional activation by

19 This activation is enhanced by the adenovirus E1A protein, and evidence for interaction bet

20 The adenovirus E1A proteins are involved in the transcriptio

21 Adenovirus E1A proteins are known to induce the expressi

22 ranscriptional machinery is inhibited by the adenovirus E1A protein as a result of E1A's binding to t

23 Previously, we reported that adenovirus E1a protein behaves as a tumor suppressor in

24 esults reinforce the general conclusion that adenovirus E1A proteins block IFN signaling pathways by

25 The adenovirus E1A protein both activates and represses gene

26 It is well established, however, that the adenovirus E1A protein can sensitize these cells to the

27 We report here that the adenovirus E1A protein creates an S phase environment in

28 tumorigenesis because it is targeted by the adenovirus E1A protein during oncogenic transformation.

29 rovide support to the idea that the p202 and adenovirus E1A protein functionally counteract each othe

30 A segment of the adenovirus E1A protein fused to a transformation-defecti

31 The adenovirus E1A protein has been implicated in increasing

32 The adenovirus E1A protein has been shown to bind to p300 an

33 of E2F-1 and DP-1 proteins or microinjected adenovirus E1A protein, however, could induce S phase in

34 Adenovirus E1A proteins immortalize primary animal cells

35 s binding is reduced by competition with the adenovirus E1a protein, indicating that binding occurs t

36 Adenovirus E1A proteins influence cell growth and phenot

37 We show that the adenovirus E1A protein inhibits NO production by decreas

38 Here we report that the adenovirus E1A protein inhibits the acetyltransferase ac

39 Since adenovirus E1A proteins interact with CBP/p300 proteins,

40 first identified by its ability to bind the adenovirus E1A protein, interacts both with gene-specifi

41 The adenovirus E1A protein interferes with regulators of apo

42 The amino terminus of the adenovirus E1A protein is involved in E1A transforming f

43 ion of Rb and p21 through the binding of the adenovirus E1A protein leads to the induction of DNA rep

44 Adenovirus E1A protein mimics the effects of Twist by in

45 Despite data suggesting that the adenovirus E1A protein of 243 amino acids creates an S-p

46 The adenovirus E1A protein of 243 amino acids has been shown

47 Adenovirus E1A proteins prepare the host cell for viral

48 Adenovirus E1A proteins repress tissue-specific gene exp

49 se hamster ovary and L-cells, HPV E7 and the adenovirus E1A protein repressed the transduced hPCNA pr

50 ly, we have found that overexpression of the adenovirus E1A protein represses expression of a reporte

51 The CR3 activation domain of the human adenovirus E1A protein stimulates transcription by formi

52 Coexpression of wild-type and mutant adenovirus E1a proteins that sequester p300/CBP eliminat

53 Because CBP/p300-binding is required for the adenovirus E1A protein to regulate transcription of many

54 The E4orf6 protein also cooperates with the adenovirus E1A protein to transform primary baby rat kid

55 n be abrogated through direct binding by the adenovirus E1A protein, we overexpressed E1A in cardiac

56 The adenovirus E1A protein, which also binds to both Rb and

57 of TBP, RNA interference, and expression of adenovirus E1A protein, which inactivates TBP.