ライフサイエンスコーパス: adenylate

1 Thr) and non-hydrolyzable analog of threonyl adenylate.

2 way for preparation of more potent peptidyl-adenylates.

3 and various toxic nonhydrolyzable aminoacyl adenylates.

4 related antibiotics are Trojan-horse peptide-adenylates.

5 sferred to the nick 5'-phosphate to form DNA-adenylate; 3) the 3'-OH of the nick attacks DNA-adenylat

6 Using [adenylate-(32)P]NAD, we demonstrate that Npt1(Ct) expres

7 We show that ligases generate adenylated 5' ends containing a ribose characteristic of

8 g the abortive ligation product, i.e. the 5'-adenylate (5'-AMP) group, during DNA replication and rep

9 that produces chemically adducted, toxic 5'-adenylated (5'-AMP) DNA lesions.

10 n events in eukaryotic cells can generate 5'-adenylated (5'-AMP) DNA termini that can be removed from

11 While pre-adenylated adapters can be chemically or enzymatically p

12 ofiling assays is adapter ligation using pre-adenylated adapters.

13 in vivo by a resveratrol-displacing tyrosyl adenylate analogue.

14 zymes that function maintaining the cellular adenylate and guanylate nucleotide.

15 ry mechanism for balancing the intracellular adenylate and guanylate pools.

16 activation of the salicylic acid as an acyl-adenylate and ligation onto the acyl carrier protein (AC

17 Adenylated and uridylated forms of these RNAs accumulate

18 that mRNAs entering the editing pathway are adenylated and, therefore, competent for post-editing A/

19 tionships and inhibition mechanisms by alkyl adenylates and diarylated coumarins.

20 Firefly luciferase adenylates and oxidizes d-luciferin to chemically genera

21 syl-pantetheine conjugate is phosphorylated, adenylated, and phosphorylated once more to generate a f

22 tted element H4a/Psi3 required five upstream adenylates, and H4a/Psi3 was necessary for cooperative a

23 Microcin C is a heptapeptide-adenylate antibiotic produced by some strains of Escheri

24 unit in the complex with an analog of glycyl adenylate at 2.8 A resolution presents a conformational

25 here find that maternal microRNAs are highly adenylated at their 3' ends in mature oocytes and early

26 particularly sensitive to inhibition by the adenylates, ATP and ADP.

27 N1 also failed to provide excision of the 5'-adenylated BER intermediate in mitochondrial extracts.

28 pter at ~100% efficiency and can efficiently adenylate both DNA and RNA bases.

29 o detoxify several nonhydrolyzable aminoacyl adenylates but not processed McC.

30 lkaline pH and is significantly inhibited by adenylate-containing nucleotides.

31 selectivity of the three most commonly used adenylate cyclase (AC) inhibitors in a battery of cell l

32 PC12 cells express five adenylate cyclase (AC) isoforms, most abundantly AC6 and

33 vate phosphotransferase system (PEP-PTS) and adenylate cyclase (AC) IV (encoded by BB0723 [cyaB]) are

34 ects using soluble guanylyl cyclase (sGC) or adenylate cyclase (AC) specific inhibitors.

35 This effect was mimicked by activating adenylate cyclase (AC) with forskolin, and was blocked b

36 Our model toxin, the adenylate cyclase (CyaA) from Bordetella pertussis, is a

37 The adenylate cyclase (CyaA) toxin, a multidomain protein of

38 We show that Snf1 and adenylate cyclase (Cyr1) interact in a nutrient-independ

39 cies was less able to activate its effector, adenylate cyclase (Cyr1), unless tethered to the membran

40 We found that a di-adenylate cyclase (disA or dacA)-overexpressing M. tuber

41 e we report a globin-coupled heme containing adenylate cyclase (HemAC-Lm) in the unicellular eukaryot

42 cAMP source in the flagellum is the soluble adenylate cyclase (SACY).

43 nd the G protein-coupled receptor --> Gs --> adenylate cyclase --> cAMP --> neuritogenic cAMP sensor-

44 om the G protein-coupled receptor --> Gs --> adenylate cyclase --> cAMP --> PKA --> cAMP response ele

45 sense mutation c.3112C>T (p.Arg1038*) within adenylate cyclase 1 (ADCY1) was identified.

46 Three SNPs within adenylate cyclase 2 (ADCY2) showed the same direction of

47 Adenylate cyclase 3 (Adcy3) has been shown to colocalize

48 ing such as Galpha(i2) protein (Galpha(i2)), adenylate cyclase 3 (Adcy3), protein expression of tumor

49 Adenylate cyclase 5 catalyzes the production of cyclic A

50 hisms (SNPs) within the ADCY5 gene, encoding adenylate cyclase 5, are associated with elevated fastin

51 ide in introns of ADCY5, a gene that encodes adenylate cyclase 5.

52 kinase 2 (JAK2)/STAT5 cascade, up-regulated adenylate cyclase 6 (AC6), increased cAMP, enhanced JNK1

53 e silencing of Bicc1 target mRNAs, including adenylate cyclase 6 (AC6).

54 ancer: stromal cell-derived factor 1 (SDF1), adenylate cyclase 7 (ADCY7), and p21 protein-activated k

55 orphisms in the human adenylate cyclase gene adenylate cyclase 8 (ADCY8) that correlate with glioma r

56 ociated with known (TSHR, GNAS) or presumed (adenylate cyclase 9 [ADCY9]) alterations in cAMP pathway

57 on cardiovascular outcomes are determined by adenylate cyclase 9 gene polymorphisms.

58 genotyped for the rs1967309 polymorphism in adenylate cyclase 9.

59 However, both inhibition of adenylate cyclase A (ACA) with SQ22536 and incubation of

60 fly brains and transgenic RNAi, we show that adenylate cyclase AC3 underlies PDF signaling in M cells

61 PVN injections of the neuropeptide pituitary adenylate cyclase activating peptide (PACAP38) enhance S

62 S) has been shown to increase BNST pituitary adenylate cyclase activating polypeptide (PACAP) and its

63 recent evidence has suggested that pituitary adenylate cyclase activating polypeptide (PACAP) has cri

64 Pituitary adenylate cyclase activating polypeptide (PACAP) is an e

65 Pituitary adenylate cyclase activating polypeptide (PACAP; Adcyap1

66 rphism in the PACAP receptor gene ADCYAP1R1, adenylate cyclase activating polypeptide 1 receptor type

67 tionarily conserved neuropeptides, including adenylate cyclase activating polypeptide 1b (adcyap1b),

68 ave reported that the neuropeptide pituitary adenylate cyclase activating polypeptide 38 (PACAP38) al

69 he type I receptor (PAC1-R) of the pituitary adenylate cyclase activating polypeptide has been report

70 the effects of blocking glutamate, pituitary adenylate cyclase activating polypeptide, and microglia

71 Chemicals, such as glutamate and pituitary adenylate cyclase activating polypeptide, whose expressi

72 m these progenitors transform in response to adenylate cyclase activation from being UCP1 negative to

73 The adenylate cyclase activator forskolin (Fsk) significantl

74 agents, melanocortin 1 receptor activators, adenylate cyclase activators, phosphodiesterase 4D3 inhi

75 of cAMP on Fe(II) and 5hmC was confirmed by adenylate cyclase activators, phosphodiesterase inhibito

76 the valence in DRD mice with an increase in adenylate cyclase activity and blunted behavioural respo

77 tion results via bidirectional modulation of adenylate cyclase activity in presynaptic glutamatergic

78 (a putative cyaB homolog) was shown to have adenylate cyclase activity in vitro; however, mutants wi

79 nt in cytosol and oxygen directly stimulates adenylate cyclase activity in vivo and in vitro.

80 udomonas aeruginosa ExoY was shown to confer adenylate cyclase activity on the MARTX toxin.

81 , D1-dopamine receptors were supersensitive; adenylate cyclase activity, locomotor activity and stere

82 ns in Caenorhabditis elegans, the engineered adenylate cyclase affected worm behavior in a light-depe

83 mechanism is mediated through activation of adenylate cyclase and an increase of cAMP and intracellu

84 atory effects of the PEP-PTS are mediated by adenylate cyclase and cyclic AMP (cAMP) levels.

85 n the distal renal tubule), possibly through adenylate cyclase and cyclic AMP signaling and a cytopla

86 hese findings suggest that Fsk activation of adenylate cyclase and PKA can negatively regulate IL-2 s

87 -MSH))-induced increase in the activities of adenylate cyclase and tyrosinase, the rate-limiting enzy

88 imimetics promote CFTR opening by activating adenylate cyclase and we show that Ca(2+)-stimulated typ

89 contrast, mGluR3, whose activation inhibits adenylate cyclase but not calcium signaling, was express

90 otein kinase (AMPK) via direct inhibition of adenylate cyclase by AMP.

91 Blockade of adenylate cyclase by its inhibitor reversed PGE2-mediate

92 8 integrin and on delivery of its N-terminal adenylate cyclase catalytic domain (AC domain) into the

93 phaeroides bacteriophytochrome BphG1 and the adenylate cyclase domain from Nostoc sp. CyaB1.

94 Based on the discovery that the adenylate cyclase from Bordetella pertussis binds to the

95 n of the amino acid sequences of globins and adenylate cyclase from prokaryotic to eukaryotic organis

96 its stalk by expression of a light-activated adenylate cyclase from the ACA promoter and exposure to

97 we report genetic polymorphisms in the human adenylate cyclase gene adenylate cyclase 8 (ADCY8) that

98 y encode TFP, the Chp system, FimL, FimV and adenylate cyclase homologs, suggesting that surface sens

99 trafficking of olfactory signaling proteins, adenylate cyclase III (ACIII), and cyclic nucleotide-gat

100 , as we were unable to identify a functional adenylate cyclase in S. aureus and only detected 2',3'-c

101 nteracted with the RAS-binding domain of the adenylate cyclase in vitro, and the cAMP analogue 8-brom

102 se effects are reduced in the presence of an adenylate cyclase inhibitor, yet persist in the presence

103 zed by pretreatment with protein kinase A or adenylate cyclase inhibitors, H89 and di-deoxyadenosine,

104 se and we show that Ca(2+)-stimulated type I adenylate cyclase is expressed in the developing human l

105 clarify how O2-dependent cAMP generation by adenylate cyclase is likely to function in cellular adap

106 In addition, globin-coupled heme containing adenylate cyclase is undescribed in the literature.

107 ase of intracellular cAMP by an activator of adenylate cyclase or an analog of cAMP, or a blockade of

108 ellular cAMP and activate PKA (activators of adenylate cyclase or inhibitors of phosphodiesterase 4)

109 Globin and adenylate cyclase play individually numerous crucial rol

110 lmonella effector proteins were fused to the adenylate cyclase reporter (CyaA'), and each of them was

111 ough a mechanism involving somatic Galpha(s)-adenylate cyclase signaling and soma-to-germline gap-jun

112 ical concerns by expressing a photoactivated adenylate cyclase that allows light-sensitive control of

113 enetic strategy that uses a photoactivatable adenylate cyclase to achieve real-time regulation of cAM

114 Adenylate cyclase toxin (ACT or CyaA) plays a crucial ro

115 Adenylate cyclase toxin (ACT) is a critical factor in es

116 The adenylate cyclase toxin (ACT) is a multifunctional virul

117 with Bordetella pertussis, and the secreted adenylate cyclase toxin (ACT) is essential for the bacte

118 The adenylate cyclase toxin (ACT) of Bordetella pertussis in

119 B. pertussis uses pertussis toxin (PT) and adenylate cyclase toxin (ACT) to kill and modulate host

120 ent of whooping cough, secretes and releases adenylate cyclase toxin (ACT), which is a protein bacter

121 everal virulence factors, among which is the adenylate cyclase toxin (CyaA) that plays a crucial role

122 Here we found that the adenylate cyclase toxin (CyaA), a key virulence factor o

123 ding domain (RD) of the Bordetella pertussis adenylate cyclase toxin CyaA fused to the C terminus of

124 The adenylate cyclase toxin-hemolysin (CyaA) plays a key rol

125 The adenylate cyclase toxin-hemolysin (CyaA) plays a key rol

126 Adenylate cyclase translocation assays revealed 13 prote

127 Here we utilized the bacterial adenylate cyclase two-hybrid method and carried out a sa

128 ta1AR signal transduction cascade, including adenylate cyclase VI and the catalytic subunit of the cA

129 nesis of one of these fusions resulted in an adenylate cyclase with a sixfold photodynamic range.

130 Stimulation of endogenous adenylate cyclase with forskolin or inhibition of phosph

131 rs to translocate LF (a protease) and EF (an adenylate cyclase) into cells.

132 e counterpart, human RPS23RG1 interacts with adenylate cyclase, activating PKA/CREB, and inhibiting G

133 ption through a calcium-dependent isoform of adenylate cyclase, ADCY8, and the transcription factor,

134 types via a pathway involving G G proteins, adenylate cyclase, and cAMP-dependent protein kinase.

135 ivation of A1 receptors causes inhibition of adenylate cyclase, decreases in intracellular cyclic AMP

136 f AMP and related nucleotides, which inhibit adenylate cyclase, reduce levels of cyclic AMP and prote

137 ogous G-protein alpha subunits that activate adenylate cyclase, thereby serving as crucial mediators

138 d inwardly rectifying potassium channels and adenylate cyclase, were not modulated by GPR18 signaling

139 ssociation studies have implicated pituitary adenylate cyclase-activating peptide (PACAP) systems in

140 The activation of pituitary adenylate cyclase-activating peptide (PACAP) systems in

141 Pituitary adenylate cyclase-activating polypeptide (PACAP) and glu

142 Pituitary adenylate cyclase-activating polypeptide (PACAP) and its

143 found higher circulating levels of pituitary adenylate cyclase-activating polypeptide (PACAP) associa

144 There is a deficit of pituitary adenylate cyclase-activating polypeptide (PACAP) in pati

145 Pituitary adenylate cyclase-activating polypeptide (PACAP) is a ne

146 The pituitary adenylate cyclase-activating polypeptide (PACAP) is a tr

147 Recent work indicates that pituitary adenylate cyclase-activating polypeptide (PACAP) plays a

148 olypeptide type I receptor (PAC1), pituitary adenylate cyclase-activating polypeptide (PACAP)-38, or

149 n, a receptor for the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP).

150 nt melanopsin and the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP).

151 Growing evidence suggests that the pituitary adenylate cyclase-activating polypeptide (PACAP)/PAC1 re

152 tropin-releasing hormone (TRH) and pituitary adenylate cyclase-activating polypeptide (PACAP, also kn

153 During corticogenesis, pituitary adenylate cyclase-activating polypeptide (PACAP; ADCYAP1

154 Pituitary adenylate cyclase-activating polypeptide (PACAP; Adcyap1

155 The G protein-coupled pituitary adenylate cyclase-activating polypeptide receptor (PAC1R

156 with the endogenous agonist of the pituitary adenylate cyclase-activating polypeptide type I receptor

157 stromal-derived factor-1alpha, and pituitary adenylate cyclase-activating polypeptide, which may impr

158 rapeutic potential of neuropeptide pituitary adenylate cyclase-activating polypeptides (PACAP) in a m

159 , we developed a highly efficient detoxified adenylate cyclase-based vector (CyaA) capable of deliver

160 pends on the G(alpha) subunit via a G(alpha)-adenylate cyclase-cAMP cascade and requires participatio

161 turation functioning downstream of Galpha(s)-adenylate cyclase-PKA signaling.

162 ansduction from beta-adrenergic receptors to adenylate cyclase.

163 se through the LANCL2-mediated activation of adenylate cyclase.

164 omyocyte proliferation through inhibition of adenylate cyclase.

165 TX effector domain is a catalytically active adenylate cyclase.

166 d was rescued by pharmacological blockade of adenylate cyclase.

167 pression of genes such as cAMP receptors and adenylate cyclase.

168 (i)-mediated effects including inhibition of adenylate cyclase.

169 perform uncoupled respiration downstream of adenylate cyclase.

170 he specific inhibitory action of GnIH on the adenylate cyclase/cAMP/protein kinase A pathway, suggest

171 tion of synaptic transmission induced by the adenylate-cyclase activator forskolin in cultured cortic

172 uction within the inner ear, is catalyzed by adenylate cyclases (AC).

173 at targeted both GPCR signaling pathways and adenylate cyclases (ACs) improved photoreceptor cell sur

174 which still occurred in mutants lacking the adenylate cyclases ACG or ACR, or the cAMP phosphodieste

175 We deleted PKA and the adenylate cyclases AcrA and AcgA, which synthesize cAMP

176 ve evolution to accommodate the emergence of adenylate cyclases and thus the signaling molecule 3',5'

177 Adenylate cyclases convert intra- and extracellular stim

178 satility, naturally occurring photoactivated adenylate cyclases promote the synthesis of the second m

179 re, we tested this hypothesis by engineering adenylate cyclases regulated by light in the near-infrar

180 reported structures of mRNA capping enzymes, adenylate cyclases, and polyphosphate polymerases sugges

181 f a GAF (cGMP-stimulated phosphodiesterases, adenylate cyclases, FhlA) domain that binds BCAAs and a

182 blocked repair intermediates containing a 5'-adenylated-deoxyribose phosphate (5'-AMP-dRP) group.

183 R) intermediates containing the 5'-AMP or 5'-adenylated-deoxyribose phosphate (5'-AMP-dRP) lesions ma

184 e 3'UTR, suggesting that RdRp binding to the adenylates disrupts H4a/Psi3, leading to loss of H5/H4b

185 tes the alanine side chain of Ala-433 of the adenylating domain.

186 nate with each other in processing of the 5'-adenylated dRP-containing BER intermediate.

187 theta and Ku70) were found to remove the 5'-adenylated-dRP group from the BER intermediate.

188 ments showed that this activating enzyme can adenylate each of these sulphur-carrier proteins and pro

189 zed adherently yielded higher values for the adenylate energy charge (0.90 +/- 0.09 for adherent cell

190 llular response to metabolic modulators, the adenylate energy charge (AEC) levels for control and rot

191 animals had a higher condition index, higher adenylate energy charge and transcriptional profiling in

192 roducts, which were accompanied by decreased adenylate energy states and starch levels, and impaired

193 ion resulted in imbalances in both redox and adenylate energy.

194 the structure of SlgN1, a 3-methylaspartate-adenylating enzyme involved in the biosynthesis of the h

195 The adenylating enzyme MbtA catalyzes the first step of myco

196 interaction between MbtH-like domains and an adenylating enzyme.

197 the mechanism of their interaction with the adenylating enzymes has remained unknown.

198 ine interface between MbtH-like proteins and adenylating enzymes.

199 uc1-3, all members of the ANL superfamily of adenylating enzymes.

200 quires the activation of amino acids through adenylate formation.

201 noyl-AMP, where we see for the first time an adenylate-forming enzyme that does not adopt a closed co

202 ave arisen from simple modifications to acyl-adenylate-forming enzymes.

203 sequence similarity is not unusual for acyl-adenylate-forming enzymes.

204 f proteins in Arabidopsis and belongs to the adenylate-forming family of enzymes.

205 group of 34 FadD proteins that belong to the adenylate-forming superfamily.

206 eening using HIV-reverse transcriptase (RT), adenylate/guanylate kinase, and human DNA polymerase gam

207 an McC maturation intermediate consisting of adenylated heptapeptide.

208 While mapping total and poly-adenylated human transcriptomes has now become routine,

209 f the structures of two complexes with alkyl adenylate inhibitors has provided direct information, wi

210 itin or ubiquitin-like proteins (Ubl) via an adenylate intermediate and initiate the enzymatic cascad

211 ing, which hydrolyzes misactivated aminoacyl-adenylate intermediate via a nebulous mechanism that has

212 and the release of pyrophosphate to form the adenylate intermediate.

213 tor to form a covalent enzyme-(lysine-Nzeta)-adenylate intermediate.

214 to release PP(i) and form a covalent ligase-adenylate intermediate; 2) AMP is transferred to the nic

215 to either RNA 3'p or DNA 3'p to generate the adenylated intermediate.

216 s activate fatty acids with ATP to form acyl-adenylate intermediates, but only luciferases can activa

217 These 3'-terminal phosphate-adenylated intermediates are substrates for deadenylatio

218 lective rejection of a non-protein aminoacyl-adenylate is in addition to known kinetic discrimination

219 The enzyme adenylate kinase (ADK) features two substrate binding do

220 the closed-to-open transitions of the enzyme adenylate kinase (AdK) in its substrate-free form, we co

221 Adenylate kinase (AdK) is a phosphoryl-transfer enzyme w

222 tability, and function of a selected enzyme, adenylate kinase (Adk), by monitoring changes in its enz

223 HOBr with three well-characterized proteins [adenylate kinase (ADK), ribose binding protein, and bovi

224 lucosamine-6-phosphate deaminase (NagB), and adenylate kinase (Adk).

225 ional fluctuations in the phosphotransferase adenylate kinase (AK) throughout its active reaction cyc

226 utral cholesterol ester hydrolase 1 (Nceh1), adenylate kinase 1 (Ak1), inositol polyphosphate 5-phosp

227 ucleoside triphosphate diphosphohydrolase 5/ adenylate kinase 1/cytidine monophosphate kinase 1 axis

228 s such as glutamate dehydrogenase 2 (GLUD2), adenylate kinase 2 (AK2) and transketolase (TKT).

229 Adenylate kinase 2 (AK2), which balances adenine nucleot

230 Adenylate kinase 2 plays key roles in cellular energy an

231 ing two of high confidence, calreticulin and adenylate kinase 2.

232 The adenylate kinase active center probe P(1),P(5)-di(adenos

233 elevant concentrations of AMP, CFTR exhibits adenylate kinase activity (ATP + AMP &lrarr2; 2 ADP).

234 tenance of chromosome (SMC) protein, exhibit adenylate kinase activity in the presence of physiologic

235 Furthermore, the results suggest that adenylate kinase activity is important for normal CFTR c

236 ly activates the ATPase activity but not the adenylate kinase activity of Fap7, identifying Rps14 as

237 ve phosphotransfer mechanisms were explored; adenylate kinase activity was unaltered, and although GA

238 te photolabeling of the AMP-binding site and adenylate kinase activity were disrupted in Q1291F CFTR.

239 he increase of ATP in Glu(-) cells is due to adenylate kinase activity, transforming AMP into ADP whi

240 mal subunit with an uncommon dual ATPase and adenylate kinase activity.

241 maintenance of chromosome protein, also have adenylate kinase activity.

242 esent study identifies basal ADP content and adenylate kinase as key determinants of bioenergetics du

243 domain of an SMC protein in complex with the adenylate kinase bisubstrate inhibitor P(1),P(5)-di(aden

244 lly influence their interaction with the ABC adenylate kinase CFTR.

245 rther indicate that the active center of the adenylate kinase comprises ATP-binding site 2.

246 tive tissues, in which AMP is generated from adenylate kinase during states of high energy demand, th

247 e bond, we succeeded in arresting the enzyme adenylate kinase in a closed high-energy conformation th

248 However, little is known about how an ABC adenylate kinase interacts with ATP and AMP when both ar

249 ff, and suggests that the catalytic speed of adenylate kinase is an evolutionary driver for organisma

250 cale motions observed upon ligand binding to adenylate kinase is dominated by enzyme-substrate intera

251 to the conserved Q-loop glutamine during the adenylate kinase reaction.

252 wo CFTR ATP-binding sites is involved in the adenylate kinase reaction.

253 ying thermoadaptation of enzyme catalysis in adenylate kinase using ancestral sequence reconstruction

254 rements of the refolding of Escherichia coli adenylate kinase were analyzed.

255 Application to adenylate kinase, an allosteric enzyme composed of three

256 systems of broad biological interest such as adenylate kinase, ATP-driven calcium pump SERCA, leucine

257 e previously reported free energy surface of adenylate kinase, deformations along the first mode prod

258 AEW, and NaOCl treatments were identified as adenylate kinase, phosphoglycerate kinase, glyceraldehyd

259 ic concentrations of ADP and AMP were added, adenylate kinase-deficient Q1291F channels opened signif

260 n ABC transporter plays an important role in adenylate kinase-dependent CFTR gating.

261 idue in CFTR, Gln-1291, selectively disrupts adenylate kinase-dependent channel gating at physiologic

262 Adenylate kinases (AKs) are phosphotransferases that reg

263 All three ABC adenylate kinases bind and hydrolyze ATP in the absence

264 Based on data from non-ABC adenylate kinases, we hypothesized that ATP and AMP mutu

265 This method is capable of adenylating large amounts of adapter at ~100% efficiency

266 inase catalytic activity, whereas low energy adenylate ligands bound in the kinase active site promot

267 ecent studies have suggested that low energy adenylate ligands bound to one or more sites in the gamm

268 formation of a DNA-bridging intermediate by adenylated LigIII that positions a pair of blunt-ended d

269 e enzymes use ATP to activate lipoate to its adenylate, lipoyl-AMP, which remains tightly bound in th

270 Adenylate mutations eliminated one-site RdRp binding to

271 demonstrate a role for APTX in resolving 5'-adenylated nucleic acid breaks, however, APTX function i

272 The pool sizes of both pyridine and adenylate nucleotides in sta6 increased substantially to

273 cal salt-bridge contact with the 3'-terminal adenylate of aa-tRNA.

274 Adenylate phosphorylation state assays and mitochondrial

275 rget only the N7-methylated cap structure of adenylate-primed RNA substrates.

276 nicks in double-stranded DNA to produce a 3'-adenylated product.

277 e entire genome can be transcribed into poly-adenylated RNA when viewed at an evolutionary time scale

278 these results indicate that accumulation of adenylated RNA-DNA may contribute to neurological diseas

279 APTX efficiently repairs adenylated RNA-DNA, and acting in an RNA-DNA damage resp

280 t RNA ligase may act on a specific set of 3'-adenylated RNAs to regulate their processing and downstr

281 ovibrio ammonificans, TVa, were also able to adenylate ssDNA 3'p.

282 rate beetle luciferin into the corresponding adenylate that it subsequently oxidizes to oxyluciferin,

283 red by synthesis of biotinoyl-AMP (biotinoyl-adenylate), the intermediate in the ligation of biotin t

284 ction to deadenylate the 5'-AMP from the RNA-adenylate, thereby inhibiting step 3 reaction.

285 nylate; 3) the 3'-OH of the nick attacks DNA-adenylate to join the polynucleotides and release AMP.

286 aracterize the phylogenetic turnover of poly-adenylated transcripts in a comprehensive sampling of ta

287 The carrier Endoplasmic Reticulum Adenylate Transporter1 (ER-ANT1) resides in the endoplas

288 evels of substrates, demonstrating that both adenylate turnover and substrate supply can limit leaf R

289 adenylation and subsequent cleavage near the adenylate-uridylate (AU)-rich elements; (c) it does not

290 75% could be explained by a deactivation of adenylate-uridylate-rich element (ARE)-binding protein B

291 e observed AA-like symptoms in our IFN-gamma adenylate-uridylate-rich element (ARE)-deleted (del) mic

292 rotein tristetraprolin (TTP) and a conserved adenylate-uridylate-rich element in the TF mRNA 3' untra

293 nc-finger mRNA binding protein that binds to adenylate-uridylate-rich elements (AREs) in the 3'-untra

294 ificant role in regulating the expression of adenylate-uridylate-rich elements containing mRNAs.

295 ely regulates HIF1A expression by binding to adenylate-uridylate-rich elements in the 3'-UTR region o

296 MR mRNA, containing several highly conserved adenylate/uridylate-rich elements (AREs), were cloned do

297 leasing a nonhydrolyzable analog of aspartyl-adenylate, which inhibits aspartyl-tRNA synthetase.

298 toxic warhead-a nonhydrolyzable aspartamidyl-adenylate, which inhibits aspartyl-tRNA synthetase.

299 e a toxic warhead-a nonhydrolyzable aspartyl-adenylate, which inhibits aspartyl-tRNA synthetase.

300 acid proceeds by direct reaction of the acyl adenylate with amine nucleophiles.