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1 d was rescued by pharmacological blockade of adenylate cyclase.
2 pression of genes such as cAMP receptors and adenylate cyclase.
3 (i)-mediated effects including inhibition of adenylate cyclase.
4 1 Ser845 than when PKA is anchored away from adenylate cyclase.
5 ent of an anthrax toxin that functions as an adenylate cyclase.
6 , inhibits forskolin-mediated stimulation of adenylate cyclase.
7 r signal-regulated kinases and inhibition of adenylate cyclase.
8 and nucleoside triphosphatase; it is not an adenylate cyclase.
9 perform uncoupled respiration downstream of adenylate cyclase.
10 ansduction from beta-adrenergic receptors to adenylate cyclase.
11 se through the LANCL2-mediated activation of adenylate cyclase.
12 omyocyte proliferation through inhibition of adenylate cyclase.
13 TX effector domain is a catalytically active adenylate cyclase.
14 teomes, nearly all of which are annotated as adenylate cyclases.
15 The present study investigates the role of adenylate cyclase 1 (AC1) in developmental refinement of
18 ice carrying a targeted null mutation of the adenylate cyclase 1 gene (AC1-KO) and wild-type litterma
21 ing such as Galpha(i2) protein (Galpha(i2)), adenylate cyclase 3 (Adcy3), protein expression of tumor
23 hisms (SNPs) within the ADCY5 gene, encoding adenylate cyclase 5, are associated with elevated fastin
25 kinase 2 (JAK2)/STAT5 cascade, up-regulated adenylate cyclase 6 (AC6), increased cAMP, enhanced JNK1
27 ancer: stromal cell-derived factor 1 (SDF1), adenylate cyclase 7 (ADCY7), and p21 protein-activated k
28 th identified conserved human-mouse changes, adenylate cyclase 7 (ADCY7), on threat-associated amygda
29 orphisms in the human adenylate cyclase gene adenylate cyclase 8 (ADCY8) that correlate with glioma r
30 ociated with known (TSHR, GNAS) or presumed (adenylate cyclase 9 [ADCY9]) alterations in cAMP pathway
34 ry cascade consisting of three receptor-like adenylate cyclases, a Crp-like regulator, and a target g
37 selectivity of the three most commonly used adenylate cyclase (AC) inhibitors in a battery of cell l
39 vate phosphotransferase system (PEP-PTS) and adenylate cyclase (AC) IV (encoded by BB0723 [cyaB]) are
43 ular matrix protein laminin (LMN), decreases adenylate cyclase (AC)/cAMP and increases beta(2)-adrene
45 fly brains and transgenic RNAi, we show that adenylate cyclase AC3 underlies PDF signaling in M cells
46 olfactory receptors (ORs), olfactory-related adenylate cyclase (AC3) and the olfactory G protein (G(o
47 jected with small interfering RNA for type 7 adenylate cyclase (AC7), with or without VIP treatment.
48 which still occurred in mutants lacking the adenylate cyclases ACG or ACR, or the cAMP phosphodieste
50 at targeted both GPCR signaling pathways and adenylate cyclases (ACs) improved photoreceptor cell sur
51 denylate cyclase, the neuropeptide Pituitary Adenylate Cyclase Activating Peptide (PACAP) impacts lev
52 ons and hippocampal autapses using pituitary adenylate cyclase activating peptide (PACAP) to induce n
53 PVN injections of the neuropeptide pituitary adenylate cyclase activating peptide (PACAP38) enhance S
54 tment or agonist (isoproterenol or pituitary adenylate cyclase activating peptide-27) stimulation of
55 S) has been shown to increase BNST pituitary adenylate cyclase activating polypeptide (PACAP) and its
56 recent evidence has suggested that pituitary adenylate cyclase activating polypeptide (PACAP) has cri
59 rphism in the PACAP receptor gene ADCYAP1R1, adenylate cyclase activating polypeptide 1 receptor type
60 tionarily conserved neuropeptides, including adenylate cyclase activating polypeptide 1b (adcyap1b),
61 ave reported that the neuropeptide pituitary adenylate cyclase activating polypeptide 38 (PACAP38) al
62 he type I receptor (PAC1-R) of the pituitary adenylate cyclase activating polypeptide has been report
63 the effects of blocking glutamate, pituitary adenylate cyclase activating polypeptide, and microglia
64 Chemicals, such as glutamate and pituitary adenylate cyclase activating polypeptide, whose expressi
65 e counterpart, human RPS23RG1 interacts with adenylate cyclase, activating PKA/CREB, and inhibiting G
66 ctive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP) and their c
69 ssociation studies have implicated pituitary adenylate cyclase-activating peptide (PACAP) systems in
70 tive intestinal peptide (VIP), and pituitary adenylate cyclase-activating peptide (PACAP) which contr
72 It is regulated by neural (e.g., pituitary adenylate cyclase-activating peptide), hormonal (e.g., g
73 endocrine cell neuritogenesis, and pituitary adenylate cyclase-activating polypeptide (PACAP) activat
76 found higher circulating levels of pituitary adenylate cyclase-activating polypeptide (PACAP) associa
77 ucagon family of related peptides, pituitary adenylate cyclase-activating polypeptide (PACAP) binding
84 r endogenous neuropeptides such as pituitary adenylate cyclase-activating polypeptide (PACAP) or subs
87 at intracerebral administration of pituitary adenylate cyclase-activating polypeptide (PACAP), an end
88 tonin gene-related peptide (CGRP), pituitary adenylate cyclase-activating polypeptide (PACAP), and va
89 olypeptide type I receptor (PAC1), pituitary adenylate cyclase-activating polypeptide (PACAP)-38, or
92 Growing evidence suggests that the pituitary adenylate cyclase-activating polypeptide (PACAP)/PAC1 re
93 tropin-releasing hormone (TRH) and pituitary adenylate cyclase-activating polypeptide (PACAP, also kn
97 to other neuritogenic treatments (pituitary adenylate cyclase-activating polypeptide and 12-O-tetrad
98 erve growth factor, or addition of pituitary adenylate cyclase-activating polypeptide had no effect o
100 e-releasing hormone, incretin, and pituitary adenylate cyclase-activating polypeptide receptors.
101 with the endogenous agonist of the pituitary adenylate cyclase-activating polypeptide type I receptor
102 The neurotrophic peptide PACAP (pituitary adenylate cyclase-activating polypeptide) elevates cAMP
103 r corticotrophin-releasing factor, pituitary adenylate cyclase-activating polypeptide, and gastric in
104 stromal-derived factor-1alpha, and pituitary adenylate cyclase-activating polypeptide, which may impr
105 rapeutic potential of neuropeptide pituitary adenylate cyclase-activating polypeptides (PACAP) in a m
106 protein-coupled receptor ligands, pituitary adenylate cyclase-activating protein (20 pmol/L, >8-fold
107 m these progenitors transform in response to adenylate cyclase activation from being UCP1 negative to
112 cked by alpha2 antagonists, cAMP analogs, an adenylate cyclase activator, and a cAMP-specific phospho
113 enosine monophosphate (cAMP) analogue, or an adenylate cyclase activator, indicating that nimodipine
114 tion of synaptic transmission induced by the adenylate-cyclase activator forskolin in cultured cortic
115 agents, melanocortin 1 receptor activators, adenylate cyclase activators, phosphodiesterase 4D3 inhi
116 of cAMP on Fe(II) and 5hmC was confirmed by adenylate cyclase activators, phosphodiesterase inhibito
117 Biological assays for binding affinities and adenylate cyclase activities for the hMC1R, hMC3R, hMC4R
119 tion with native PA and an EF mutant lacking adenylate cyclase activity (EF-K346R) failed to enhance
120 acis edema factor (EF) mutant having reduced adenylate cyclase activity (i.e., EF-S414N) enhances ant
121 ular matrix protein, laminin (LMN) decreases adenylate cyclase activity and beta(1)-adrenergic recept
122 the valence in DRD mice with an increase in adenylate cyclase activity and blunted behavioural respo
123 reduces aquaporin 2 expression by modulating adenylate cyclase activity and cAMP generation, thereby
124 handling, upregulating beta(1) receptors and adenylate cyclase activity and suppressing G(i)-coupled
125 eceptors acts via FAK/PI-(3)K/Akt to inhibit adenylate cyclase activity and thereby down-regulates be
126 mary, a fully functional PA and a minimum of adenylate cyclase activity are needed for EdTx to act as
127 tion results via bidirectional modulation of adenylate cyclase activity in presynaptic glutamatergic
128 (a putative cyaB homolog) was shown to have adenylate cyclase activity in vitro; however, mutants wi
133 pression of cAMP production by inhibition of adenylate cyclase activity or augmentation of cAMP degra
135 ugs inhibited 10 microM forskolin-stimulated adenylate cyclase activity with potencies similar to the
136 , D1-dopamine receptors were supersensitive; adenylate cyclase activity, locomotor activity and stere
137 e melanocortin receptor type 1 and activated adenylate cyclase activity, which in turn activated Xero
141 that knocking down the calmodulin-activated adenylate cyclase ADCY8 makes retinal axons insensitive
142 ption through a calcium-dependent isoform of adenylate cyclase, ADCY8, and the transcription factor,
143 ns in Caenorhabditis elegans, the engineered adenylate cyclase affected worm behavior in a light-depe
145 mechanism is mediated through activation of adenylate cyclase and an increase of cAMP and intracellu
147 proteins and ultimately in the activation of adenylate cyclase and cyclic AMP (cAMP) production.
148 n the distal renal tubule), possibly through adenylate cyclase and cyclic AMP signaling and a cytopla
149 cAMP-dependent signaling occurs upstream of adenylate cyclase and downstream of receptor activation.
151 -protein-mediated transduction cascades, the adenylate cyclase and phospholipase C (PLC) pathway, pro
152 hese findings suggest that Fsk activation of adenylate cyclase and PKA can negatively regulate IL-2 s
153 vidence that the G-proteins involved in both adenylate cyclase and PLC pathways are present in squid
154 in, which bypasses the beta-AR in activating adenylate cyclase and protein kinase A, did not increase
155 ptors to provide PACAP-saturable coupling to adenylate cyclase and to drive PACAP-dependent different
156 a(1) signalling is due to down-regulation of adenylate cyclase and to gain insight into the signallin
157 n the constitutive activation of Gsalpha and adenylate cyclase and to lead to the autonomous synthesi
158 ble mutant of B. bronchiseptica, which lacks adenylate cyclase and type III secretion, as a vaccine c
159 -MSH))-induced increase in the activities of adenylate cyclase and tyrosinase, the rate-limiting enzy
160 imimetics promote CFTR opening by activating adenylate cyclase and we show that Ca(2+)-stimulated typ
161 ve evolution to accommodate the emergence of adenylate cyclases and thus the signaling molecule 3',5'
162 Transcriptome analysis of cyaA (encoding adenylate cyclase) and crp (encoding cAMP receptor prote
163 a-Melanocortin and forskolin, which activate adenylate cyclase, and 12-O-tetradecanoylphorbol-13-acet
164 types via a pathway involving G G proteins, adenylate cyclase, and cAMP-dependent protein kinase.
165 -specific phosphodiesterases, cyanobacterial adenylate cyclases, and formate hydrogen lyase transcrip
166 reported structures of mRNA capping enzymes, adenylate cyclases, and polyphosphate polymerases sugges
168 , we developed a highly efficient detoxified adenylate cyclase-based vector (CyaA) capable of deliver
169 alpha(2)-NA stimulation was not dependent on adenylate cyclase but instead required activation of a P
170 contrast, mGluR3, whose activation inhibits adenylate cyclase but not calcium signaling, was express
174 pends on the G(alpha) subunit via a G(alpha)-adenylate cyclase-cAMP cascade and requires participatio
175 he specific inhibitory action of GnIH on the adenylate cyclase/cAMP/protein kinase A pathway, suggest
176 8 integrin and on delivery of its N-terminal adenylate cyclase catalytic domain (AC domain) into the
180 tic active component of Bordetella pertussis adenylate cyclase (Cya) was translocated into both mamma
181 on assay as well as the calmodulin-dependent adenylate cyclase (CyaA) assay in the surrogate host L.
183 as restricted in its ability to inject a T3E-adenylate cyclase (CyaA) injection reporter into PTI-ind
188 cies was less able to activate its effector, adenylate cyclase (Cyr1), unless tethered to the membran
190 ivation of A1 receptors causes inhibition of adenylate cyclase, decreases in intracellular cyclic AMP
191 sion seen upon deletion of the gene encoding adenylate cyclase (Deltacya) was reversed by supplementa
192 tethered APP intracellular domain results in adenylate cyclase-dependent activation of PKA (protein k
194 Forskolin, which like AlF(4)(-) activates adenylate cyclase, did not redistribute perilipin 3, but
197 hracis virulence factors and consists of the adenylate cyclase edema factor (EF) and protective antig
198 (ET), composed of protective antigen and an adenylate cyclase edema factor (EF), elicits edema in ho
199 imulations show that PKA colocalization with adenylate cyclase, either in the spine head or in the de
202 Furthermore, we demonstrate that the Rv0386 adenylate cyclase facilitates delivery of bacterial-deri
203 f a GAF (cGMP-stimulated phosphodiesterases, adenylate cyclases, FhlA) domain that binds BCAAs and a
205 n of the amino acid sequences of globins and adenylate cyclase from prokaryotic to eukaryotic organis
206 its stalk by expression of a light-activated adenylate cyclase from the ACA promoter and exposure to
208 we report genetic polymorphisms in the human adenylate cyclase gene adenylate cyclase 8 (ADCY8) that
211 pac-independent signaling pathway: PACAP --> adenylate cyclase --> cAMP --> ERK --> neuritogenesis ha
212 nd the G protein-coupled receptor --> Gs --> adenylate cyclase --> cAMP --> neuritogenic cAMP sensor-
213 om the G protein-coupled receptor --> Gs --> adenylate cyclase --> cAMP --> PKA --> cAMP response ele
214 e we report a globin-coupled heme containing adenylate cyclase (HemAC-Lm) in the unicellular eukaryot
215 y encode TFP, the Chp system, FimL, FimV and adenylate cyclase homologs, suggesting that surface sens
217 er blocking PI3K, could be suppressed by the adenylate cyclase III (ACIII) blockers MDL12330A (cis-N-
218 trafficking of olfactory signaling proteins, adenylate cyclase III (ACIII), and cyclic nucleotide-gat
220 , as we were unable to identify a functional adenylate cyclase in S. aureus and only detected 2',3'-c
221 nteracted with the RAS-binding domain of the adenylate cyclase in vitro, and the cAMP analogue 8-brom
222 )AR than 2-H and 2-F, functional efficacy in adenylate cyclase inhibition varied, and introduction of
224 se effects are reduced in the presence of an adenylate cyclase inhibitor, yet persist in the presence
225 zed by pretreatment with protein kinase A or adenylate cyclase inhibitors, H89 and di-deoxyadenosine,
227 se and we show that Ca(2+)-stimulated type I adenylate cyclase is expressed in the developing human l
228 clarify how O2-dependent cAMP generation by adenylate cyclase is likely to function in cellular adap
230 The findings suggest ADCY7 is probably the adenylate cyclase isoform most relevant to PACAP's actio
231 , and demonstrate that Galpha(S) coupling to adenylate cyclase mediates membrane-tethered APP intrace
232 ase of intracellular cAMP by an activator of adenylate cyclase or an analog of cAMP, or a blockade of
233 ellular cAMP and activate PKA (activators of adenylate cyclase or inhibitors of phosphodiesterase 4)
234 ntagonized by LT-IIb; however, inhibitors of adenylate cyclase or protein kinase A reversed this anta
235 bromo-cyclic AMP; 8-Br-cAMP), stimulation of adenylate cyclase, or prostanoids known to drive cAMP re
236 ng RNA approaches, a PGE2/E prostanoid (EP)2/adenylate cyclase pathway was implicated in these suppre
239 satility, naturally occurring photoactivated adenylate cyclases promote the synthesis of the second m
240 f AMP and related nucleotides, which inhibit adenylate cyclase, reduce levels of cyclic AMP and prote
241 re, we tested this hypothesis by engineering adenylate cyclases regulated by light in the near-infrar
243 lmonella effector proteins were fused to the adenylate cyclase reporter (CyaA'), and each of them was
245 nal fusions with a Cya (Bordetella pertussis adenylate cyclase) reporter indicate that HrpH and HopP1
247 d to encode class I, class IV, and class III adenylate cyclases, respectively, have been identified i
249 ough a mechanism involving somatic Galpha(s)-adenylate cyclase signaling and soma-to-germline gap-jun
250 ally large when MSP is present and Galpha(s)-adenylate cyclase signaling in the gonadal sheath cells
251 and cytoplasmic streaming require Galpha(s)-adenylate cyclase signaling in the gonadal sheath cells,
252 ion events in the germline require Galpha(s)-adenylate cyclase signaling in the gonadal sheath cells.
253 sent genetic evidence that MSP and Galpha(s)-adenylate cyclase signaling regulate oocyte growth and m
255 we show that the major effector of Galpha(s)-adenylate cyclase signaling, protein kinase A (PKA), is
256 N'-tetraacetic acid-acetoxymethyl ester, the adenylate cyclase stimulant forskolin, and a specific pr
258 ical concerns by expressing a photoactivated adenylate cyclase that allows light-sensitive control of
260 a factor, the catalytic subunit of ET, is an adenylate cyclase that impairs host defenses by raising
261 It produces edema toxin (EdTx), a powerful adenylate cyclase that increases cyclic AMP (cAMP) level
262 sting that Galpha(z) is a tonic inhibitor of adenylate cyclase, the enzyme responsible for the conver
264 ensitive transcription (git) genes, encoding adenylate cyclase, the PKA catalytic subunit, and seven
265 ogous G-protein alpha subunits that activate adenylate cyclase, thereby serving as crucial mediators
266 ransmembrane communication by activating the adenylate cyclase through the N-terminal region of both
268 enetic strategy that uses a photoactivatable adenylate cyclase to achieve real-time regulation of cAM
272 with Bordetella pertussis, and the secreted adenylate cyclase toxin (ACT) is essential for the bacte
276 B. pertussis uses pertussis toxin (PT) and adenylate cyclase toxin (ACT) to kill and modulate host
277 The catalytic domain of Bordetella pertussis adenylate cyclase toxin (ACT) translocates directly acro
278 ertussis and B. bronchiseptica, which encode adenylate cyclase toxin (ACT), are functionally intercha
280 l toxins, including pertussis toxin (PT) and adenylate cyclase toxin (ACT), which have both been show
281 ent of whooping cough, secretes and releases adenylate cyclase toxin (ACT), which is a protein bacter
282 everal virulence factors, among which is the adenylate cyclase toxin (CyaA) that plays a crucial role
284 analysis showed that cyaA, the gene encoding adenylate cyclase toxin (CyaA), was the most downregulat
285 ding domain (RD) of the Bordetella pertussis adenylate cyclase toxin CyaA fused to the C terminus of
286 This allowed the engineering of recombinant adenylate cyclase toxin from Bordetella pertussis for th
287 t advances in understanding the functions of adenylate cyclase toxin, a type 1 secretion system (T1SS
292 ction was confirmed using beta-lactamase and adenylate cyclase translocation assays, and a C-terminal
294 loned E. coli DNA fragments in the bacterial adenylate cyclase two-hybrid system, we found that trans
295 ta1AR signal transduction cascade, including adenylate cyclase VI and the catalytic subunit of the cA
296 g, cAMP-dependent protein kinase A (PKA) and adenylate cyclase, were abnormally elevated in nucleus a
297 d inwardly rectifying potassium channels and adenylate cyclase, were not modulated by GPR18 signaling
298 lly inhibited 10 microM forskolin-stimulated adenylate cyclase, whereas the other drugs produced part
299 nesis of one of these fusions resulted in an adenylate cyclase with a sixfold photodynamic range.
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