ライフサイエンスコーパス: adenylated

1 inal fragment (40 kDa) was found to be fully adenylated.

2 he 3' end were accurately processed and then adenylated.

3 n the nucleoli was found to be processed and adenylated.

4 9/14-kDa proteins, was neither processed nor adenylated.

5 We show that ligases generate adenylated 5' ends containing a ribose characteristic of

6 that produces chemically adducted, toxic 5'-adenylated (5'-AMP) DNA lesions.

7 n events in eukaryotic cells can generate 5'-adenylated (5'-AMP) DNA termini that can be removed from

8 While pre-adenylated adapters can be chemically or enzymatically p

9 ofiling assays is adapter ligation using pre-adenylated adapters.

10 ErEN cleavage of an adenylated alpha-globin 3'UTR was accentuated upon deple

11 The adenylated Alu RNA as well as adenylated SRP RNA were bo

12 ervation indicates that the formation of the adenylated amino acid and its release are the rate-limit

13 Adenylated and uridylated forms of these RNAs accumulate

14 n-coding transcripts, Ube3a-ATS was not poly-adenylated and was localized exclusively in the nucleus.

15 that mRNAs entering the editing pathway are adenylated and, therefore, competent for post-editing A/

16 syl-pantetheine conjugate is phosphorylated, adenylated, and phosphorylated once more to generate a f

17 y indicated that the homogeneous protein was adenylated as isolated, and sedimentation velocity exper

18 able phosphoramidate-linked analogue of acyl-adenylated aspartic acid.

19 here find that maternal microRNAs are highly adenylated at their 3' ends in mature oocytes and early

20 N1 also failed to provide excision of the 5'-adenylated BER intermediate in mitochondrial extracts.

21 og N(2)-(carboxymethyl)-l-arginine (CMA) was adenylated by ATP in the crystal and represents a close

22 LF stimulates adenylation of LX complexes de-adenylated by pyrophosphate or following LX decharging d

23 oup and then forms a thioester bond with the adenylated C-terminal COOH group of the Ubl.

24 -mitochondrially encoded RNAs over their non-adenylated counterparts.

25 lso bind a second neurokine called pituitary adenylated cyclase-activating polypeptide (PACAP).

26 blocked repair intermediates containing a 5'-adenylated-deoxyribose phosphate (5'-AMP-dRP) group.

27 R) intermediates containing the 5'-AMP or 5'-adenylated-deoxyribose phosphate (5'-AMP-dRP) lesions ma

28 he differences in efficiency of ligating pre-adenylated DNA adapters to RNA 3'-ends.

29 ues 233 to 919) in complex with a nicked, 5' adenylated DNA intermediate.

30 simple method of enzymatic synthesis of pre-adenylated DNA linkers/adapters for next-generation sequ

31 nate with each other in processing of the 5'-adenylated dRP-containing BER intermediate.

32 theta and Ku70) were found to remove the 5'-adenylated-dRP group from the BER intermediate.

33 at MS2-Xp54 represses the translation of non-adenylated firefly luciferase mRNAs and that mutations i

34 horylated single-stranded DNA (ssDNA) to the adenylated form.

35 In vitro transcribed, capped, and adenylated granulocyte-macrophage colony stimulating fac

36 an McC maturation intermediate consisting of adenylated heptapeptide.

37 While mapping total and poly-adenylated human transcriptomes has now become routine,

38 DNA LIG k becomes adenylated in reactions with ATP, and the adenylate moie

39 of SRP RNA, is also accurately processed and adenylated in vitro.

40 eeds in two steps, including synthesis of an adenylated intermediate followed by biotin transfer to t

41 to either RNA 3'p or DNA 3'p to generate the adenylated intermediate.

42 These 3'-terminal phosphate-adenylated intermediates are substrates for deadenylatio

43 The formation of kinetically competent adenylated intermediates was suggested by the observatio

44 also found in a number of proteins that form adenylated intermediates.

45 e explains why nick sensing is restricted to adenylated ligase and why the 5' phosphate is required f

46 lysine residue prevented the formation of an adenylated ligase complex and consequently thwarted liga

47 reaction, the ATP-dependent formation of an adenylated ligase, was studied by measuring the formatio

48 formation of a DNA-bridging intermediate by adenylated LigIII that positions a pair of blunt-ended d

49 in the presence of ATP, suggesting that the adenylated lysine residue is part of the active site for

50 HI4) copurifies with a set of strongly bound adenylated metabolites.

51 f P. trichocarpa cells, we revealed that the adenylated miRNAs were degraded slower than others witho

52 RNAs, such as housekeeping mRNAs or the poly-adenylated mRNA population, are believed to be distribut

53 e deadenylases and repress translation of an adenylated mRNA.

54 te of phosphodiester bond formation at a pre-adenylated nick (step 3 of the ligation pathway) was slo

55 lyzes phosphodiester bond formation at a pre-adenylated nick (step 3).

56 When an adenylated nick is encountered by APTX, base pairing at

57 that formation of a phosphodiester at a pre-adenylated nick is subject to a rate limiting step that

58 and Asp65 suppressed ligase binding to a pre-adenylated nick, whereas Asp29, Glu67 and Glu161 mutants

59 effect on phosphodiester formation at a pre-adenylated nick.

60 ed in phosphodiester bond formation at a pre-adenylated nick.

61 ompetent to catalyze strand closure at a pre-adenylated nick.

62 lyzes phosphodiester bond formation at a pre-adenylated nick.

63 e show that Aprataxin acts preferentially on adenylated nicks and double-strand breaks rather than on

64 demonstrate a role for APTX in resolving 5'-adenylated nucleic acid breaks, however, APTX function i

65 The adenylated or activated biotin functions as the corepres

66 d REF/Aly-stabilized transcripts are further adenylated over time, consistent with previous reports l

67 nicks in double-stranded DNA to produce a 3'-adenylated product.

68 simplifies isolation and purification of the adenylated product.

69 synthetase (hLysRS) by proceeding through an adenylated protein intermediate.

70 Injection of mutant helicases or adenylated reporter mRNA abrogates this association.

71 omoted rapid deadenylation and decay of hypo-adenylated reporter mRNA.

72 e entire genome can be transcribed into poly-adenylated RNA when viewed at an evolutionary time scale

73 these results indicate that accumulation of adenylated RNA-DNA may contribute to neurological diseas

74 APTX efficiently repairs adenylated RNA-DNA, and acting in an RNA-DNA damage resp

75 t RNA ligase may act on a specific set of 3'-adenylated RNAs to regulate their processing and downstr

76 The adenylated Alu RNA as well as adenylated SRP RNA were bound to the SRP 9/14-kDa hetero

77 he third step (attack of the 3'-OH on the 5'-adenylated strand to form a phosphodiester) by a factor

78 ortant for the attack of the 3'-OH on the 5'-adenylated strand to form a phosphodiester, but dispensa

79 s the primary determinant for recognition of adenylated substrates.

80 However, the G617I mutant was only weakly adenylated, suggesting that a point mutation in the BRCT

81 placed in the 5'-leader region of capped and adenylated synthetic luciferase RNAs, conferred Arg-spec

82 siae thiazole synthase, was identified as an adenylated thiazole tautomer.

83 Fully adenylated TNF-alpha mRNA appeared within 15 min of LPS

84 Methionine is subsequently adenylated to S-adenosylmethionine (SAM), a cofactor tha

85 aracterize the phylogenetic turnover of poly-adenylated transcripts in a comprehensive sampling of ta

86 nd Gtl2 generates alternatively spliced poly-adenylated transcripts lacking a conserved open reading