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1 tructure determination of a basic isozyme of adenylosuccinate synthetase.
2 Vertebrates possess two isozymes of adenylosuccinate synthetase.
3 both Arg131 and Arg303 in the active site of adenylosuccinate synthetase.
4 in the crystal structure of Escherichia coli adenylosuccinate synthetase.
5 sponding positions in all known sequences of adenylosuccinate synthetase.
6 for SAICAR synthetase that parallels that of adenylosuccinate synthetase.
7 from IMP because of a developmental loss of adenylosuccinate synthetase.
8 e reported that 1.9 kilobase pairs of murine adenylosuccinate synthetase 1 gene (Adss1) 5'-flanking D
13 otide analogs directed to substrate sites in adenylosuccinate synthetase and adenylosuccinate lyase a
16 site of action of hydantocidin and establish adenylosuccinate synthetase as an herbicide target of co
17 nalysis of the mode of inhibition of a plant adenylosuccinate synthetase by the active metabolite 5'-
19 eriments, that suggest that Escherichia coli adenylosuccinate synthetase contains two shared active s
20 sults indicate that both subunits of dimeric adenylosuccinate synthetase contribute to each active si
21 of the stringent response, potently inhibits adenylosuccinate synthetase from Escherichia coli as an
24 mplete set of substrate/substrate analogs of adenylosuccinate synthetase from Escherichia coli induce
29 re not involved in the chemical mechanism of adenylosuccinate synthetase from Escherichia coli, yet t
35 including EF-Tu, Ypt1, rab-5, and FtsY, and adenylosuccinate synthetase have been reported to bind x
36 rved differences in ligand recognition among adenylosuccinate synthetases may be due in part to confo
38 ion was alluded to by use of mutant forms of adenylosuccinate synthetase previously prepared by site-
39 tered activity of the IMP utilizing enzymes, adenylosuccinate synthetase (PurA) and IMP dehydrogenase
40 IMP to XMP or AMP (IMP dehydrogenase, guaB; adenylosuccinate synthetase, purA, and ADE12), and unabl
41 Asp13 and His41 are essential residues of adenylosuccinate synthetase, putatively catalyzing the f
42 ure and site-directed mutagenesis of E. coli adenylosuccinate synthetase show that Arg303 interacts w
44 ertebrates have acidic and basic isozymes of adenylosuccinate synthetase, which participate in the fi
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