ライフサイエンスコーパス: adenylyl

1 strates with the alkynyl reporter in lieu of adenylyl 5'-monophosphate (AMP) allows their subsequent

2 we report that this toxin is a dual soluble adenylyl and guanylyl cyclase that results in intracellu

3 ses, including membrane-integral and soluble adenylyl and guanylyl cyclases, are central components i

4 amp enzyme conformations locked by either 5'-adenylyl beta,gamma-imidodiphosphate or the anticancer d

5 GRK5 in complex with the ATP analog 5'-adenylyl beta,gamma-imidodiphosphate or the nucleoside s

6 pha A486V crystallized in the presence of 5'-adenylyl beta,gamma-imidodiphosphate.

7 h a nonhydrolyzable ATP analog, adenosine 5'-adenylyl-beta,gamma-imidodiphosphate (AMP-PNP), was dete

8 ivity and activation by the weak agonist, 5'-adenylyl-beta,gamma-imidodiphosphate (AMP-PNP).

9 in four catalytically relevant complexes, 5'-adenylyl-beta,gamma-imidodiphosphate (AMPPNP).Mg(2+), AM

10 2 bound to the nonhydrolyzable ATP analog 5'-adenylyl-beta,gamma-imidodiphosphate exhibits altered DN

11 Adenylyl cyclase (AC) activity relies on multiple effect

12 2 receptors that are linked to activation of adenylyl cyclase (AC) and an increase in cyclic adenosin

13 le cells, prostaglandin E2 (PGE2) stimulates adenylyl cyclase (AC) and attenuates the increase in int

14 I-induced SA requires continuing activity of adenylyl cyclase (AC) and cAMP-dependent protein kinase

15 eptors via D4 receptors (D4R), which inhibit adenylyl cyclase (AC) and reduce PKA activity.

16 Here, adenylyl cyclase (AC) and the alpha-subunit of the AC-st

17 Adenylyl cyclase (AC) converts ATP into cyclic AMP (cAMP

18 There are abundant adenylyl cyclase (AC) coupled GPCRs for these neuromodul

19 cAMP analogues and stimulation of adenylyl cyclase (AC) directly or through G-protein-coup

20 g heterotrimeric Gi/Go proteins resulting in adenylyl cyclase (AC) inhibition.

21 Several adenylyl cyclase (AC) isoforms could mediate cAMP accumu

22 We have previously identified a subset of adenylyl cyclase (AC) isoforms that interact with Yotiao

23 acts not only with PKA but also with various adenylyl cyclase (AC) isoforms.

24 PTH activates adenylyl cyclase (AC) through PTH 1 receptors and stimul

25 Adenylyl cyclase (AC) toxin is an essential toxin that a

26 n mammalian cells, an intramitochondrial CO2-adenylyl cyclase (AC)-cyclic AMP (cAMP)-protein kinase A

27 ncrease was blocked by G15, linking GPR30 to adenylyl cyclase (AC).

28 0 facilitates a complex containing TPRV1 and adenylyl cyclase (AC).

29 anion exchanger 2 (Cl(-) /HCO3 (-) AE2), and adenylyl cyclase (AC)8 (proteins regulating large biliar

30 coupling of odorant receptors to the type 3 adenylyl cyclase (AC3) in olfactory cilia.

31 udy in humans has recently implicated type 3 adenylyl cyclase (AC3; ADCY3) in MDD.

32 wed that AKAP79/150 clusters PKA with type 5 adenylyl cyclase (AC5) to assemble a negative feedback l

33 reasons that remain unclear, whether type 5 adenylyl cyclase (AC5), 1 of 2 major AC isoforms in hear

34 Intriguingly, type III adenylyl cyclase (ACIII), a key protein in olfactory sig

35 We found that SSTR3 and type III adenylyl cyclase (ACIII), proteins normally enriched in

36 ntify that, in Fmr1 knockout neurons, type 1 adenylyl cyclase (Adcy1) mRNA translation is enhanced, l

37 enic mouse model expressing a photoactivated adenylyl cyclase (bPAC) in sperm.

38 The failure of cells lacking adenylyl cyclase (cyr1Delta) to form hyphae has suggeste

39 We hypothesized that a photoactivatable adenylyl cyclase (PAC) can be employed to modulate cAMP

40 First, Rutabaga adenylyl cyclase (Rut-AC), a putative molecular coincide

41 raction between Nf1 and the rutabaga-encoded adenylyl cyclase (Rut-AC).

42 cAMP sources, involving the atypical soluble adenylyl cyclase (sAC) in addition to transmembrane aden

43 Soluble adenylyl cyclase (sAC) is a novel source of cAMP subject

44 addition, the cAMP-producing enzyme soluble adenylyl cyclase (sAC) is expressed in pigment cells, an

45 , we show that bicarbonate-sensitive soluble adenylyl cyclase (sAC) is highly expressed in the ciliar

46 study, significant overexpression of soluble adenylyl cyclase (sAC), an alternative source of cAMP, w

47 increased expression and activity of soluble adenylyl cyclase (sAC), an evolutionarily conserved bica

48 brane adenylyl cyclases (tmACs), and soluble adenylyl cyclase (sAC).

49 ly and biochemically distinct enzyme soluble adenylyl cyclase (sAC).

50 TASK, ROMK), and the bicarbonate-stimulated adenylyl cyclase (sAC).

51 d the expression and function of the soluble adenylyl cyclase (sAC, ADCY10) in CNS retinal ganglion c

52 mimics the action of the endogenous soluble adenylyl cyclase (SACY) that is required for motility an

53 ck gene Npas2, and the clock-controlled gene adenylyl cyclase 1 (Adcy1) in a subset of retinal gangli

54 The enzyme that synthesizes cAMP, adenylyl cyclase 3 (AC3), is coexpressed in olfactory se

55 lase LSD1 and the OR-dependent expression of adenylyl cyclase 3 (Adcy3) as requirements for initiatio

56 ATF5 induces the transcription of adenylyl cyclase 3 (Adcy3), which relieves the UPR.

57 ated basal ciliary cAMP level is a result of adenylyl cyclase 5 and 6 activity that depends on ciliar

58 Activity of both adenylyl cyclase 5 and extracellular signal-regulated ki

59 cells contains a protein complex comprising adenylyl cyclase 5/6 (AC5/6), A-kinase anchoring protein

60 tion of this signaling complex is disrupted, adenylyl cyclase 5/6 no longer associates with caveolin

61 tan and pasireotide, which indirectly reduce adenylyl cyclase 6 (AC6) activity, have hence proven eff

62 udy tested the hypothesis that activation of adenylyl cyclase 6 (AC6) expression in cardiac myocytes

63 Previously we demonstrated that adenylyl cyclase 6 (AC6), a membrane-bound enzyme enrich

64 roximal tubule-derived, PC1-knock-out cells, adenylyl cyclase 6 and 3 (AC6 and -3) are both expressed

65 The Ca(2+)-dependent adenylyl cyclase 8 (AC8, expressed by large cholangiocyt

66 d for chemoattractant-mediated activation of adenylyl cyclase 9 (AC9), which converts ATP into cAMP a

67 ocess mediated through the activation of the adenylyl cyclase 9 (AC9).

68 Synthesis of cAMP receptor and adenylyl cyclase A (ACA) is inhibited, and activation of

69 gnaling cascade leading to the activation of adenylyl cyclase A (ACA), the synthesis and secretion of

70 iological pacing using the Ca(2+)-stimulated adenylyl cyclase AC1 gene expressed alone or in combinat

71 although salmeterol shows weak efficacy for adenylyl cyclase activation and G protein-coupled recept

72 rts demonstrating that signaling by PGE2 and adenylyl cyclase activation are associated with macropha

73 CB1b blockade by JD-5037 results in stronger adenylyl cyclase activation compared to rimonabant and i

74 cate that morphine tolerance is dependent on adenylyl cyclase activation.

75 btype is required to couple this receptor to adenylyl cyclase activation.

76 f PGI2 on stress fibres were mimicked by the adenylyl cyclase activator forskolin and prevented by in

77 Furthermore, treatment with the adenylyl cyclase activator forskolin diminishes cytosoli

78 The adenylyl cyclase activator forskolin facilitates synapti

79 Repeated microinjections of morphine or the adenylyl cyclase activator NKH477 into the vlPAG decreas

80 iacylglycerol analog), but not forskolin (an adenylyl cyclase activator) or elevated extracellular ca

81 ntractile agonist acetylcholine (ACh) or the adenylyl cyclase activator, forskolin (FSK), a dilatory

82 inhibitors, two calpain inhibitors, and one adenylyl cyclase activator, forskolin.

83 thermore, we demonstrated that forskolin, an adenylyl cyclase activator, significantly increased the

84 ive against MEK2 cleavage by lethal toxin or adenylyl cyclase activity by edema toxin in human kidney

85 cyclase, partly due to reduced inhibition of adenylyl cyclase activity by pertussis toxin-sensitive G

86 cellular cAMP consistent with an increase in adenylyl cyclase activity for both mutants relative to w

87 to the field, CB1b is a potent regulator of adenylyl cyclase activity in peripheral metabolic tissue

88 DOR-KOR heteromer agonist 6'-GNTI inhibited adenylyl cyclase activity in vitro as well as PGE(2)-sti

89 BlaC had adenylyl cyclase activity that was negligible in the dar

90 tissues may be, in part, caused by enhanced adenylyl cyclase activity, but inhibition of cAMP degrad

91 two compounds are equipotent for inhibiting adenylyl cyclase activity, these results suggest that Co

92 mitochondrial ROS and subsequent increase of adenylyl cyclase activity.

93 istration is associated with upregulation of adenylyl cyclase activity.

94 etaAR desensitization as measured by cardiac adenylyl cyclase activity.

95 tant pertussis toxin-sensitive inhibition of adenylyl cyclase activity.

96 hibit prostaglandin E(2) (PGE(2))-stimulated adenylyl cyclase activity.

97 tretch-induced GRK2 activation, and restored adenylyl cyclase activity.

98 cAMP levels through effects on transmembrane adenylyl cyclase activity.

99 Furthermore, bPAC replaces endogenous adenylyl cyclase activity.

100 Although the HCO3(-)-dependent soluble adenylyl cyclase Adcy10 plays a role in motility, less i

101 CD34(+) cell culture model, we show that the adenylyl cyclase agonist forskolin inhibits megakaryocyt

102 l because PGE2 could be substituted with the adenylyl cyclase agonist forskolin, and CCR8 expression

103 both the stimulatory G protein (Gs) for the adenylyl cyclase and arrestin pathways, synthetic ligand

104 ugh Galphas G-proteins and via activation of adenylyl cyclase and cAMP-dependent protein kinase, but

105 in) agonists to inhibit forskolin-stimulated adenylyl cyclase and increase mitogen-activated protein

106 In addition, we report that CRY1 binds to adenylyl cyclase and limits cAMP production.

107 Furthermore, the diurnal oscillation of adenylyl cyclase and MAPK activities in the hippocampus

108 Recently, we discovered that adenylyl cyclase and MAPK activities undergo a circadian

109 ined hippocampus-dependent memory as well as adenylyl cyclase and MAPK activities.

110 dynamic regulation of betaAR complexes with adenylyl cyclase and phosphodiesterase enzymes and the i

111 AR(2) causes Galphas-dependent activation of adenylyl cyclase and PKA, which activates TRPV4 and sens

112 Adenylyl cyclase and PKA-mediated elastase-induced activ

113 is induced by neuronal activity via soluble adenylyl cyclase and protein kinase A (PKA) signaling.

114 that express a mutated PTH1R that activates adenylyl cyclase and protein kinase A (PKA) via Gsalpha

115 Pre-LTP also involves adenylyl cyclase and protein kinase A and is expressed v

116 and stimulated neuronal hyperexcitability by adenylyl cyclase and protein kinase A-dependent mechanis

117 PGE2 via EP2 receptors activated macrophage adenylyl cyclase and protein kinase A.

118 obutamine, reflecting its better coupling to adenylyl cyclase and the reliance of dopamine on dopamin

119 ue, Inda et al. show that different forms of adenylyl cyclase are activated at the plasma membrane ve

120 ctions was recently shown to include soluble adenylyl cyclase as a local source of the second messeng

121 These 2 receptors have opposing actions on adenylyl cyclase because of differential G-protein coupl

122 tal terminal segments enhanced activation of adenylyl cyclase by 50-75% and diminished activation of

123 mal cAMP resulting from direct activation of adenylyl cyclase by forskolin (15,689 +/- 7038% of contr

124 /- myocytes fail to respond to activation of adenylyl cyclase by forskolin, and the localized express

125 ensable, but Ras1 is found to associate with adenylyl cyclase Cac1 through the conserved Ras associat

126 A transmembrane adenylyl cyclase cAMP-dependent protein kinase cascade m

127 component protective antigen (PA) and of the adenylyl cyclase catalytic moiety, edema factor (EF).

128 These results show that the upregulation of adenylyl cyclase caused by repeated vlPAG morphine admin

129 hese studies was to test the hypothesis that adenylyl cyclase contributes to opioid tolerance by modu

130 e cytosolic portion of the membrane-integral adenylyl cyclase Cya from Mycobacterium intracellulare i

131 ified an S-helix of about 25 residues in the adenylyl cyclase CyaG from Arthrospira maxima.

132 Moreover, the adenylyl cyclase Cyr1 activity is present in mitochondri

133 The two-metal catalysis by the adenylyl cyclase domain of the anthrax edema factor toxi

134 is abolished in a strain lacking MT1302, an adenylyl cyclase encoding gene.

135 h muscle actin, vimentin, alpha-actinin, and adenylyl cyclase II.

136 Feedback inhibition of adenylyl cyclase III (ACIII) via Ca(2+)-induced phosphor

137 This study used immunohistochemistry for adenylyl cyclase III (ACIII), a marker of primary cilia,

138 tivation of odorant receptors (ORs) leads to adenylyl cyclase III activation, cAMP increase, and open

139 whereas the presence of the effector enzyme adenylyl cyclase III remained largely unaltered.

140 localization of ciliary proteins ARL13B and adenylyl cyclase III.

141 domembrane-associated trimeric G protein and adenylyl cyclase immediately after endocytosis.

142 e of UDP-glucose for promoting inhibition of adenylyl cyclase in C6 glioma cells stably expressing th

143 on activation of NMDA and AMPA receptors and adenylyl cyclase in D1 receptor-expressing cells.

144 r instance, expression of the Rutabaga (Rut) adenylyl cyclase in gamma neurons is sufficient to resto

145 nase activities attenuate the stimulation of adenylyl cyclase in response to catecholamines.

146 forms a local signaling system with soluble adenylyl cyclase in the matrix, which regulates the acti

147 ex, implicating enhanced Galpha(i)-dependent adenylyl cyclase inhibition as a possible causative fact

148 n of G proteins with all Galphai/o subunits, adenylyl cyclase inhibition, and beta arrestin recruitme

149 otein activation, beta-arrestin recruitment, adenylyl cyclase inhibition, and extracellular signal-re

150 activated G-protein-dependent calcium flux, adenylyl cyclase inhibition, and the rapid activation of

151 was attenuated by PAR2 or TRPV4 deletion and adenylyl cyclase inhibition.

152 ocked by the CFTR inhibitor CFTR_inh172, the adenylyl cyclase inhibitor MDL 12330A, and the protein k

153 Conversely, microinjection of the adenylyl cyclase inhibitor SQ22536 reversed both the dev

154 rosclerosis triggers a de novo expression of adenylyl cyclase isoform 8 (AC8), associated with the pr

155 or more of the nine different transmembrane adenylyl cyclase isoforms that generate the cAMP signal

156 t Plin5 is phosphorylated, and activation of adenylyl cyclase leads to phosphorylation of Plin5, sugg

157 f betaARs as well as Gi inhibition of type 1 adenylyl cyclase may underlie the experimental observati

158 s of ADCY5-the first definitive link between adenylyl cyclase mutation and human disease.

159 Inhibition of adenylyl cyclase or PKA activity blocked p65 and CREB ph

160 roperties toward the beta(1)AR in either the adenylyl cyclase or the mitogen-activated protein kinase

161 T6) receptor constitutively activates the Gs/adenylyl cyclase pathway in various cell types, includin

162 The inhibitory effects of agonists on the adenylyl cyclase pathway were investigated.

163 with either IBMX or forskolin, activates the adenylyl cyclase pathway, and the effect of VIP and fors

164 gents, alone or in combination, modulate the adenylyl cyclase pathway, the accumulation of intracellu

165 AMP signaling are suggested by low levels of adenylyl cyclase protein in Deltaric8 mutants and suppre

166 in NMJ growth and plasticity, including the adenylyl cyclase Rutabaga, the Ig-CAM Fasciclin II, the

167 miR-212-enhanced Raf1 activity, resulting in adenylyl cyclase sensitization and increased expression

168 nonical negative interaction at the level of adenylyl cyclase signaling, to a strong recruitment of b

169 Results of experiments with the adenylyl cyclase stimulator forskolin and with the PKA i

170 s the enzyme to a specific, light-stimulated adenylyl cyclase that catalyzes the formation of cAMP fr

171 l of c-di-AMP is modulated by activity of di-adenylyl cyclase that produces c-di-AMP and phosphodiest

172 CD99 signals through soluble adenylyl cyclase to activate PKA to trigger ongoing targ

173 oups converge on the same signaling cascade--adenylyl cyclase to cAMP to protein kinase A--but with o

174 Stimulation of adenylyl cyclase to form cAMP induces hyphal morphogenes

175 FSI axon terminals and negatively couple to adenylyl cyclase to induce a long-term depression of GAB

176 ntly decreases the colonization abilities of adenylyl cyclase toxin-producing bacteria, such as ETEC.

177 ght and also indicate that cAMP generated by adenylyl cyclase type 1 is required for phosphorylation

178 In mice missing the gene for adenylyl cyclase type 1, levels of phosphorylated GRK1 w

179 N-methyl-D-aspartate receptor activation of adenylyl cyclase type 1.

180 lous DM(high)-VL(low) expression gradient of adenylyl cyclase type 3 appears, which coincides with al

181 via onset of the stimulus-transducing enzyme adenylyl cyclase type 3.

182 Adenylyl cyclase type 5 knockout (AC5KO) mice have incre

183 bited by STIM1 inhibitors or by silencing of adenylyl cyclase type 6 (AC6).

184 Adenylyl cyclase type 9 (AC9) is found tightly associate

185 To assess this, we studied mice deficient in adenylyl cyclase type VI specifically in the principal c

186 nctions to inhibit the production of cAMP by adenylyl cyclase upon Hh stimulation, thus maximizing si

187 In summary, these data suggest that adenylyl cyclase VI mediates vasopressin-stimulated ENaC

188 xperiments revealed that acute activation of adenylyl cyclase with forskolin increased the frequency

189 In HF, activation of adenylyl cyclase with forskolin rescued the Ca2+ transie

190 sion in YY1(T372R) tumors included ADCY1 (an adenylyl cyclase) and CACNA2D2 (a Ca(2+) channel); both

191 ependence of the enzymes that generate cAMP (adenylyl cyclase) and degrade it (phosphodiesterase).

192 e CatSper1 (Ca(2+) channel), Adcy10 (soluble adenylyl cyclase) and Slo3 (K(+) channel) KO mice.

193 t (expected to activate matrix-bound soluble adenylyl cyclase) increased intramitochondrial cAMP, but

194 G protein, Gs (the stimulatory G protein for adenylyl cyclase) on formation of a complex with agonist

195 D2 receptor (D2R) to inhibit G(i/o)-mediated adenylyl cyclase, a recent study has shown that many APD

196 al mu-opioid signaling through inhibition of adenylyl cyclase, activation of MAPK and G protein-gated

197 This cascade includes soluble adenylyl cyclase, an atypical bicarbonate-stimulated ade

198 gulated cyclic nucleotide phosphodiesterase, adenylyl cyclase, and E. coli transcription factor FhlA

199 olfaction, coupling D1 and A2a receptors to adenylyl cyclase, and histone H3 phosphorylation.

200 cyclase, an atypical bicarbonate-stimulated adenylyl cyclase, and is mediated by protein kinase A an

201 -293 cells, ostensibly through inhibition of adenylyl cyclase, decreases intracellular levels of cAMP

202 mutations that disrupt Ca(2+)/CaM-dependent adenylyl cyclase, demonstrating a convergence of K(+) ch

203 rotein, followed by subsequent activation of adenylyl cyclase, elevation of cyclic AMP levels, and pr

204 R in a sequential manner, such as G protein, adenylyl cyclase, Epac-1 protein, and inositol 1,4,5-tri

205 ivation of Gs, the stimulatory G protein for adenylyl cyclase, has long been a model system for GPCR

206 ructure of Gs, the stimulatory G protein for adenylyl cyclase, in complex with the alpha2 adrenergic

207 RPV1 via activation of TRPA1, which involves adenylyl cyclase, increased cAMP, subsequent translocati

208 Edema factor (EF), a potent adenylyl cyclase, is one of the toxin components.

209 sticity was dependent on the Rutabaga type I adenylyl cyclase, linking cAMP-dependent plasticity to b

210 tant residues for the enhanced activation of adenylyl cyclase, partly due to reduced inhibition of ad

211 dor receptors couple to G-protein activating adenylyl cyclase, producing cAMP.

212 work we used a HAMP containing mycobacterial adenylyl cyclase, Rv3645, as a reporter enzyme in which

213 TRPV4 currents in Xenopus laevis oocytes by adenylyl cyclase- and protein kinase A (PKA)-dependent m

214 ough the activation of phospholipase Cbeta-, adenylyl cyclase-, mitogen-activated protein kinase-, an

215 alpha7 nAChR, CFTR, and adenylyl cyclase-1 are physically and functionally assoc

216 ofiles of the corresponding mutated enzymes, adenylyl cyclase-5 and retinal guanylyl cyclase-1.

217 validation of 3 predicted relevant proteins, adenylyl cyclase-associated protein 1 (CAP1), SHC-transf

218 CAP (adenylyl cyclase-associated protein) was first identifie

219 o reduced activity of the downstream cascade adenylyl cyclase-cAMP-PKA-cAMP response element-binding

220 pase C-coupled D1R agonist (but not a D2R or adenylyl cyclase-coupled D1R agonist) decreased the pers

221 ated betaAR couple to Gs protein, leading to adenylyl cyclase-dependent increases in secondary-messen

222 blocked STa/GCC-dependent, but not forskolin/adenylyl cyclase-dependent, cystic fibrosis transmembran

223 multiple G protein alpha subunits, including adenylyl cyclase-inhibitory (Galpha(i)) subunits and tho

224 brane-permeable 8Br-cAMP under inhibition of adenylyl cyclase-mediated cAMP production by MDL 12330A.

225 er-Arnt-Sim) and poly-HAMP (histidine kinase-adenylyl cyclase-methyl-accepting chemotaxis protein-pho

226 reabsorption in the collecting duct through adenylyl cyclase-stimulated cyclic AMP, which exists as

227 nt with reports that CO2 directly stimulates adenylyl cyclase.

228 ich can specifically inhibit the activity of adenylyl cyclase.

229 te kinase M2 (PKM2) interaction with soluble adenylyl cyclase.

230 cium influx and Gi/o-dependent inhibition of adenylyl cyclase.

231 ly rectifying potassium channels, as well as adenylyl cyclase.

232 the beta(3a)-AR, caveolin-1, Galpha(s), and adenylyl cyclase.

233 to biological agents involving activation of adenylyl cyclase.

234 AMP response requires mechanisms upstream of adenylyl cyclase.

235 ecifically, we hypothesize that AMP inhibits adenylyl cyclase.

236 s measure pH via bicarbonate-sensing soluble adenylyl cyclase.

237 a(2+)](i), through activation of a G protein/adenylyl cyclase/cAMP/Epac-1/IP(3) pathway.

238 rusion connecting the cGMP phosphodiesterase/adenylyl cyclase/FhlA (GAF) and phytochrome-specific (PH

239 for the photosensing cGMP phosphodiesterase/adenylyl cyclase/FhlA (GAF) domain from Thermosynechococ

240 ore buried within the cGMP phosphodiesterase/adenylyl cyclase/FhlA (GAF) domain, and a well-ordered h

241 es of the 23-kDa GAF (cGMP phosphodiesterase/adenylyl cyclase/FhlA) domain fragment of phytochrome fr

242 ent on the SCN-controlled oscillation of the adenylyl cyclase/MAPK pathway in the hippocampus.

243 on one of its cognate receptor, TAS2R43, and adenylyl cyclase; and (ii) reduced by homoeriodictyol (H

244 terol showed weak efficacy for activation of adenylyl cyclase; however, its efficacy in the complex d

245 inase A isoform (PKAI) signaling pathway, as adenylyl-cyclase and PKAI inhibition prevented adenosine

246 choline, dopamine, and adenosine signals via adenylyl-cyclase coupled GPCRs in shaping the dopamine-d

247 In striatal neurons, D(1)R activates adenylyl-cyclase through Galpha(olf), a protein upregula

248 nction of the encoded protein, Galphaolf, an adenylyl-cyclase-stimulatory G-protein highly enriched i

249 Regulation of multiple adenylyl cyclases (AC) provides unique inputs to mediate

250 d corals have both transmembrane and soluble adenylyl cyclases (AC).

251 s, cAMP is synthesized by nine transmembrane adenylyl cyclases (ACs) and one soluble AC (sAC).

252 atids and detailed studies of trypanosomatid adenylyl cyclases (ACs) and phosphodiesterases (PDEs) si

253 Ca(2+)-stimulated adenylyl cyclases (ACs) have recently been shown to play

254 ited cAMP levels after direct stimulation of adenylyl cyclases (ACs) with forskolin (FSK), as determi

255 eptors are responsible for the activation of adenylyl cyclases (ACs), which increase intracellular cy

256 ock-out mice (DKO) lacking both type 1 and 8 adenylyl cyclases (ACs).

257 ered by the presence of at least 15 distinct adenylyl cyclases (ACs).

258 cAMP is synthesized by one of 10 homologous adenylyl cyclases (ACs): nine transmembrane enzymes and

259 h hormonal stimulation of cAMP generation by adenylyl cyclases (activation phase) and cAMP hydrolysis

260 that for the structurally related membranous adenylyl cyclases (mACs) 1, 2, 5 and the purified mAC ca

261 Transmembrane adenylyl cyclases (tmACs) are another possible source of

262 ylyl cyclases synthesize cAMP, transmembrane adenylyl cyclases (tmACs), and soluble adenylyl cyclase

263 l cyclase (sAC) in addition to transmembrane adenylyl cyclases (tmACs).

264 termined by the balance of cAMP synthesis by adenylyl cyclases and degradation by phosphodiesterases

265 Adenylyl cyclases are widely distributed across all king

266 We make an argument for adenylyl cyclases being central to the formation and mai

267 rmone- and G protein-regulated transmembrane adenylyl cyclases or via the widely expressed and struct

268 In neurons, two families of adenylyl cyclases synthesize cAMP, transmembrane adenyly

269 occur in mice lacking calmodulin-stimulated adenylyl cyclases, a mouse strain that learns but cannot

270 phs stimulated by forskolin, an activator of adenylyl cyclases, and by membrane-permeable cAMP analog

271 minal GAF (cGMP-specific phosphodiesterases, adenylyl cyclases, and FhlA) domain and two EAL motifs w

272 mediate cAMP-induced stimulation of chimeric adenylyl cyclases, cAMP binding did not stimulate the PD

273 egion; a cytoplasmic HAMP (histidine kinase, adenylyl cyclases, methyl-accepting chemotaxis proteins,

274 otifs first identified in histidine kinases, adenylyl cyclases, methyl-accepting chemotaxis proteins,

275 uction of cAMP (G protein-coupled receptors, adenylyl cyclases, phosphodiesterases (PDEs)), and recep

276 ccurs through Ca(2+) entry and activation of adenylyl cyclases, protein kinase A, and PKC.

277 Adenylyl cyclases, the enzymatic source of cAMP producti

278 pha subunit of heterotrimeric G proteins and adenylyl cyclases.

279 ransgenic mice lacking calmodulin-stimulated adenylyl cyclases.

280 was restricted to the transmembrane class of adenylyl cyclases.

281 ins, e.g. in histidine kinases and bacterial adenylyl cyclases.

282 is mediated by calcium/calmodulin-stimulated adenylyl cyclases.

283 ng (SOcAMPS) and activating Ca(2+) regulated adenylyl cyclases.

284 in inactivate GTPases through addition of an adenylyl group (also referred to as AMPylation).

285 ynthetic pathway, reversibly transferring an adenylyl group from ATP to 4'-phosphopantetheine (PhP) t

286 NeqAB in complex with nucleotides, ADP, and adenylyl-imidodiphosphate (non-hydrolysable analog of AT

287 with 1 mM of the kinesin inhibitor AMP-PNP (adenylyl-imidodiphosphate) and by anti-kinesin antibody

288 e addition of a non-hydrolyzable ATP analog (adenylyl-imidophosphate), whereas ADP had no effect beyo

289 were accelerated in the presence of DDX1 and adenylyl-imidophosphate, while the dissociation rates re

290 in some cases an effector domain such as an adenylyl or guanylyl cyclase, all encoded in a single pr

291 tes possessing either a 5'-phosphate or a 5'-adenylyl phosphate.

292 enylylate formation by reaction with ATP; 2) adenylyl transfer to a 5'-phosphorylated polynucleotide

293 stinct chemical steps: enzyme adenylylation, adenylyl transfer to DNA, and nick sealing.

294 ce factor, nicotinamide mononucleotide (NAD) adenylyl transferase (NMNAT), a protein that has both NA

295 thesizing enzyme nicotinamide mononucleotide adenylyl transferase 1 (Nmnat1) has been shown to be neu

296 Nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2) is a key neuronal mainte

297 Nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2) is neuroprotective in nu

298 Nicotinamide adenylyl transferase condenses nicotinamide mononucleoti

299 expression studies of sat, encoding sulfate adenylyl transferase, showed increased levels in the D.

300 ive function for nicotinamide mononucleotide adenylyl transferases (NMNATs).