ライフサイエンスコーパス: adenylyl cyclase

1 nt with reports that CO2 directly stimulates adenylyl cyclase.

2 ich can specifically inhibit the activity of adenylyl cyclase.

3 te kinase M2 (PKM2) interaction with soluble adenylyl cyclase.

4 cium influx and Gi/o-dependent inhibition of adenylyl cyclase.

5 ly rectifying potassium channels, as well as adenylyl cyclase.

6 the beta(3a)-AR, caveolin-1, Galpha(s), and adenylyl cyclase.

7 r-mediated Galpha(i)-dependent inhibition of adenylyl cyclase.

8 trimer leads to reduced A(2A)R activation of adenylyl cyclase.

9 to biological agents involving activation of adenylyl cyclase.

10 AMP response requires mechanisms upstream of adenylyl cyclase.

11 ecifically, we hypothesize that AMP inhibits adenylyl cyclase.

12 s measure pH via bicarbonate-sensing soluble adenylyl cyclase.

13 pha subunit of heterotrimeric G proteins and adenylyl cyclases.

14 ransgenic mice lacking calmodulin-stimulated adenylyl cyclases.

15 was restricted to the transmembrane class of adenylyl cyclases.

16 ins, e.g. in histidine kinases and bacterial adenylyl cyclases.

17 ng (SOcAMPS) and activating Ca(2+) regulated adenylyl cyclases.

18 is mediated by calcium/calmodulin-stimulated adenylyl cyclases.

19 ck gene Npas2, and the clock-controlled gene adenylyl cyclase 1 (Adcy1) in a subset of retinal gangli

20 alpha7 nAChR, CFTR, and adenylyl cyclase-1 are physically and functionally assoc

21 The enzyme that synthesizes cAMP, adenylyl cyclase 3 (AC3), is coexpressed in olfactory se

22 lase LSD1 and the OR-dependent expression of adenylyl cyclase 3 (Adcy3) as requirements for initiatio

23 ATF5 induces the transcription of adenylyl cyclase 3 (Adcy3), which relieves the UPR.

24 ated basal ciliary cAMP level is a result of adenylyl cyclase 5 and 6 activity that depends on ciliar

25 Activity of both adenylyl cyclase 5 and extracellular signal-regulated ki

26 cells contains a protein complex comprising adenylyl cyclase 5/6 (AC5/6), A-kinase anchoring protein

27 tion of this signaling complex is disrupted, adenylyl cyclase 5/6 no longer associates with caveolin

28 ofiles of the corresponding mutated enzymes, adenylyl cyclase-5 and retinal guanylyl cyclase-1.

29 tan and pasireotide, which indirectly reduce adenylyl cyclase 6 (AC6) activity, have hence proven eff

30 bone cell mechanotransduction that involves adenylyl cyclase 6 (AC6) and cAMP.

31 udy tested the hypothesis that activation of adenylyl cyclase 6 (AC6) expression in cardiac myocytes

32 Previously we demonstrated that adenylyl cyclase 6 (AC6), a membrane-bound enzyme enrich

33 roximal tubule-derived, PC1-knock-out cells, adenylyl cyclase 6 and 3 (AC6 and -3) are both expressed

34 t the hypothesis that pressure stress of the adenylyl cyclase 6-deleted (AC6-KO) heart would result i

35 The Ca(2+)-dependent adenylyl cyclase 8 (AC8, expressed by large cholangiocyt

36 d for chemoattractant-mediated activation of adenylyl cyclase 9 (AC9), which converts ATP into cAMP a

37 ocess mediated through the activation of the adenylyl cyclase 9 (AC9).

38 Synthesis of cAMP receptor and adenylyl cyclase A (ACA) is inhibited, and activation of

39 gnaling cascade leading to the activation of adenylyl cyclase A (ACA), the synthesis and secretion of

40 Trafficking of vesicles containing adenylyl cyclase A to the rear of the cell and secretion

41 D2 receptor (D2R) to inhibit G(i/o)-mediated adenylyl cyclase, a recent study has shown that many APD

42 occur in mice lacking calmodulin-stimulated adenylyl cyclases, a mouse strain that learns but cannot

43 Adenylyl cyclase (AC) activity relies on multiple effect

44 2 receptors that are linked to activation of adenylyl cyclase (AC) and an increase in cyclic adenosin

45 le cells, prostaglandin E2 (PGE2) stimulates adenylyl cyclase (AC) and attenuates the increase in int

46 I-induced SA requires continuing activity of adenylyl cyclase (AC) and cAMP-dependent protein kinase

47 ed by equilibrium between receptor-activated adenylyl cyclase (AC) and phosphodiesterase (PDE).

48 eptors via D4 receptors (D4R), which inhibit adenylyl cyclase (AC) and reduce PKA activity.

49 Here, adenylyl cyclase (AC) and the alpha-subunit of the AC-st

50 vation of which occluded acute inhibition of adenylyl cyclase (AC) by agonists to delta-opioid (DOR),

51 ominantly through Gs-mediated stimulation of adenylyl cyclase (AC) by testing the effect of ACEI and

52 Adenylyl cyclase (AC) converts ATP into cyclic AMP (cAMP

53 There are abundant adenylyl cyclase (AC) coupled GPCRs for these neuromodul

54 cAMP analogues and stimulation of adenylyl cyclase (AC) directly or through G-protein-coup

55 g heterotrimeric Gi/Go proteins resulting in adenylyl cyclase (AC) inhibition.

56 Several adenylyl cyclase (AC) isoforms could mediate cAMP accumu

57 We have previously identified a subset of adenylyl cyclase (AC) isoforms that interact with Yotiao

58 acts not only with PKA but also with various adenylyl cyclase (AC) isoforms.

59 PTH activates adenylyl cyclase (AC) through PTH 1 receptors and stimul

60 Adenylyl cyclase (AC) toxin is an essential toxin that a

61 n mammalian cells, an intramitochondrial CO2-adenylyl cyclase (AC)-cyclic AMP (cAMP)-protein kinase A

62 ncrease was blocked by G15, linking GPR30 to adenylyl cyclase (AC).

63 0 facilitates a complex containing TPRV1 and adenylyl cyclase (AC).

64 anion exchanger 2 (Cl(-) /HCO3 (-) AE2), and adenylyl cyclase (AC)8 (proteins regulating large biliar

65 Regulation of multiple adenylyl cyclases (AC) provides unique inputs to mediate

66 d corals have both transmembrane and soluble adenylyl cyclases (AC).

67 iological pacing using the Ca(2+)-stimulated adenylyl cyclase AC1 gene expressed alone or in combinat

68 coupling of odorant receptors to the type 3 adenylyl cyclase (AC3) in olfactory cilia.

69 udy in humans has recently implicated type 3 adenylyl cyclase (AC3; ADCY3) in MDD.

70 wed that AKAP79/150 clusters PKA with type 5 adenylyl cyclase (AC5) to assemble a negative feedback l

71 reasons that remain unclear, whether type 5 adenylyl cyclase (AC5), 1 of 2 major AC isoforms in hear

72 Intriguingly, type III adenylyl cyclase (ACIII), a key protein in olfactory sig

73 We found that SSTR3 and type III adenylyl cyclase (ACIII), proteins normally enriched in

74 olf), and the downstream effector enzyme, an adenylyl cyclase (ACIII).

75 s, cAMP is synthesized by nine transmembrane adenylyl cyclases (ACs) and one soluble AC (sAC).

76 atids and detailed studies of trypanosomatid adenylyl cyclases (ACs) and phosphodiesterases (PDEs) si

77 Adenylyl cyclases (ACs) belonging to three nonhomologous

78 Ca(2+)-stimulated adenylyl cyclases (ACs) have recently been shown to play

79 ited cAMP levels after direct stimulation of adenylyl cyclases (ACs) with forskolin (FSK), as determi

80 eptors are responsible for the activation of adenylyl cyclases (ACs), which increase intracellular cy

81 ock-out mice (DKO) lacking both type 1 and 8 adenylyl cyclases (ACs).

82 ered by the presence of at least 15 distinct adenylyl cyclases (ACs).

83 cAMP is synthesized by one of 10 homologous adenylyl cyclases (ACs): nine transmembrane enzymes and

84 luding neuropilin 1, neuropilin 2, slit2 and adenylyl cyclase-activating peptide in both MN9D cells a

85 ges, the kinetics of chemoattractant-induced adenylyl cyclase activation and actin polymerization are

86 AMP-induced positive feedback loop following adenylyl cyclase activation and B56delta phosphorylation

87 although salmeterol shows weak efficacy for adenylyl cyclase activation and G protein-coupled recept

88 rts demonstrating that signaling by PGE2 and adenylyl cyclase activation are associated with macropha

89 CB1b blockade by JD-5037 results in stronger adenylyl cyclase activation compared to rimonabant and i

90 cate that morphine tolerance is dependent on adenylyl cyclase activation.

91 btype is required to couple this receptor to adenylyl cyclase activation.

92 h hormonal stimulation of cAMP generation by adenylyl cyclases (activation phase) and cAMP hydrolysis

93 al mu-opioid signaling through inhibition of adenylyl cyclase, activation of MAPK and G protein-gated

94 f PGI2 on stress fibres were mimicked by the adenylyl cyclase activator forskolin and prevented by in

95 Furthermore, treatment with the adenylyl cyclase activator forskolin diminishes cytosoli

96 The adenylyl cyclase activator forskolin facilitates synapti

97 Repeated microinjections of morphine or the adenylyl cyclase activator NKH477 into the vlPAG decreas

98 iacylglycerol analog), but not forskolin (an adenylyl cyclase activator) or elevated extracellular ca

99 ntractile agonist acetylcholine (ACh) or the adenylyl cyclase activator, forskolin (FSK), a dilatory

100 inhibitors, two calpain inhibitors, and one adenylyl cyclase activator, forskolin.

101 thermore, we demonstrated that forskolin, an adenylyl cyclase activator, significantly increased the

102 ive against MEK2 cleavage by lethal toxin or adenylyl cyclase activity by edema toxin in human kidney

103 cyclase, partly due to reduced inhibition of adenylyl cyclase activity by pertussis toxin-sensitive G

104 cellular cAMP consistent with an increase in adenylyl cyclase activity for both mutants relative to w

105 to the field, CB1b is a potent regulator of adenylyl cyclase activity in peripheral metabolic tissue

106 DOR-KOR heteromer agonist 6'-GNTI inhibited adenylyl cyclase activity in vitro as well as PGE(2)-sti

107 BlaC had adenylyl cyclase activity that was negligible in the dar

108 Adenylyl cyclase activity was blunted in sarcolemmal mem

109 1/2 phosphorylation, but only PAR1 inhibited adenylyl cyclase activity, and pertussis toxin blocked P

110 tissues may be, in part, caused by enhanced adenylyl cyclase activity, but inhibition of cAMP degrad

111 two compounds are equipotent for inhibiting adenylyl cyclase activity, these results suggest that Co

112 etaAR desensitization as measured by cardiac adenylyl cyclase activity.

113 tant pertussis toxin-sensitive inhibition of adenylyl cyclase activity.

114 hibit prostaglandin E(2) (PGE(2))-stimulated adenylyl cyclase activity.

115 tretch-induced GRK2 activation, and restored adenylyl cyclase activity.

116 However, only PAR1 inhibited adenylyl cyclase activity.

117 cAMP levels through effects on transmembrane adenylyl cyclase activity.

118 Furthermore, bPAC replaces endogenous adenylyl cyclase activity.

119 mitochondrial ROS and subsequent increase of adenylyl cyclase activity.

120 istration is associated with upregulation of adenylyl cyclase activity.

121 ntify that, in Fmr1 knockout neurons, type 1 adenylyl cyclase (Adcy1) mRNA translation is enhanced, l

122 Although the HCO3(-)-dependent soluble adenylyl cyclase Adcy10 plays a role in motility, less i

123 CD34(+) cell culture model, we show that the adenylyl cyclase agonist forskolin inhibits megakaryocyt

124 l because PGE2 could be substituted with the adenylyl cyclase agonist forskolin, and CCR8 expression

125 This cascade includes soluble adenylyl cyclase, an atypical bicarbonate-stimulated ade

126 both the stimulatory G protein (Gs) for the adenylyl cyclase and arrestin pathways, synthetic ligand

127 ugh Galphas G-proteins and via activation of adenylyl cyclase and cAMP-dependent protein kinase, but

128 pertussis toxin blocked PAR1 effects on both adenylyl cyclase and ERK1/2 signaling.

129 in) agonists to inhibit forskolin-stimulated adenylyl cyclase and increase mitogen-activated protein

130 In addition, we report that CRY1 binds to adenylyl cyclase and limits cAMP production.

131 Furthermore, the diurnal oscillation of adenylyl cyclase and MAPK activities in the hippocampus

132 Recently, we discovered that adenylyl cyclase and MAPK activities undergo a circadian

133 ined hippocampus-dependent memory as well as adenylyl cyclase and MAPK activities.

134 dynamic regulation of betaAR complexes with adenylyl cyclase and phosphodiesterase enzymes and the i

135 AR(2) causes Galphas-dependent activation of adenylyl cyclase and PKA, which activates TRPV4 and sens

136 Adenylyl cyclase and PKA-mediated elastase-induced activ

137 is induced by neuronal activity via soluble adenylyl cyclase and protein kinase A (PKA) signaling.

138 that express a mutated PTH1R that activates adenylyl cyclase and protein kinase A (PKA) via Gsalpha

139 Pre-LTP also involves adenylyl cyclase and protein kinase A and is expressed v

140 and stimulated neuronal hyperexcitability by adenylyl cyclase and protein kinase A-dependent mechanis

141 PGE2 via EP2 receptors activated macrophage adenylyl cyclase and protein kinase A.

142 obutamine, reflecting its better coupling to adenylyl cyclase and the reliance of dopamine on dopamin

143 termined by the balance of cAMP synthesis by adenylyl cyclases and degradation by phosphodiesterases

144 inase A isoform (PKAI) signaling pathway, as adenylyl-cyclase and PKAI inhibition prevented adenosine

145 sion in YY1(T372R) tumors included ADCY1 (an adenylyl cyclase) and CACNA2D2 (a Ca(2+) channel); both

146 ependence of the enzymes that generate cAMP (adenylyl cyclase) and degrade it (phosphodiesterase).

147 e CatSper1 (Ca(2+) channel), Adcy10 (soluble adenylyl cyclase) and Slo3 (K(+) channel) KO mice.

148 gulated cyclic nucleotide phosphodiesterase, adenylyl cyclase, and E. coli transcription factor FhlA

149 olfaction, coupling D1 and A2a receptors to adenylyl cyclase, and histone H3 phosphorylation.

150 cyclase, an atypical bicarbonate-stimulated adenylyl cyclase, and is mediated by protein kinase A an

151 phs stimulated by forskolin, an activator of adenylyl cyclases, and by membrane-permeable cAMP analog

152 minal GAF (cGMP-specific phosphodiesterases, adenylyl cyclases, and FhlA) domain and two EAL motifs w

153 TRPV4 currents in Xenopus laevis oocytes by adenylyl cyclase- and protein kinase A (PKA)-dependent m

154 on one of its cognate receptor, TAS2R43, and adenylyl cyclase; and (ii) reduced by homoeriodictyol (H

155 ue, Inda et al. show that different forms of adenylyl cyclase are activated at the plasma membrane ve

156 Adenylyl cyclases are widely distributed across all king

157 ctions was recently shown to include soluble adenylyl cyclase as a local source of the second messeng

158 validation of 3 predicted relevant proteins, adenylyl cyclase-associated protein 1 (CAP1), SHC-transf

159 CAP (adenylyl cyclase-associated protein) was first identifie

160 These 2 receptors have opposing actions on adenylyl cyclase because of differential G-protein coupl

161 We make an argument for adenylyl cyclases being central to the formation and mai

162 enic mouse model expressing a photoactivated adenylyl cyclase (bPAC) in sperm.

163 tal terminal segments enhanced activation of adenylyl cyclase by 50-75% and diminished activation of

164 mal cAMP resulting from direct activation of adenylyl cyclase by forskolin (15,689 +/- 7038% of contr

165 /- myocytes fail to respond to activation of adenylyl cyclase by forskolin, and the localized express

166 ensable, but Ras1 is found to associate with adenylyl cyclase Cac1 through the conserved Ras associat

167 A transmembrane adenylyl cyclase cAMP-dependent protein kinase cascade m

168 mediate cAMP-induced stimulation of chimeric adenylyl cyclases, cAMP binding did not stimulate the PD

169 o reduced activity of the downstream cascade adenylyl cyclase-cAMP-PKA-cAMP response element-binding

170 a(2+)](i), through activation of a G protein/adenylyl cyclase/cAMP/Epac-1/IP(3) pathway.

171 ypes, the liganded PTHR1 activates Galpha(S)/adenylyl cyclase/cAMP/PKA (cAMP/PKA) and Galpha(q/11)/ph

172 component protective antigen (PA) and of the adenylyl cyclase catalytic moiety, edema factor (EF).

173 These results show that the upregulation of adenylyl cyclase caused by repeated vlPAG morphine admin

174 AC1, a Ca(2+)/calmodulin-stimulated adenylyl cyclase, colocalized with CFTR in the cell apic

175 hese studies was to test the hypothesis that adenylyl cyclase contributes to opioid tolerance by modu

176 choline, dopamine, and adenosine signals via adenylyl-cyclase coupled GPCRs in shaping the dopamine-d

177 pase C-coupled D1R agonist (but not a D2R or adenylyl cyclase-coupled D1R agonist) decreased the pers

178 e cytosolic portion of the membrane-integral adenylyl cyclase Cya from Mycobacterium intracellulare i

179 ified an S-helix of about 25 residues in the adenylyl cyclase CyaG from Arthrospira maxima.

180 Moreover, the adenylyl cyclase Cyr1 activity is present in mitochondri

181 The failure of cells lacking adenylyl cyclase (cyr1Delta) to form hyphae has suggeste

182 -293 cells, ostensibly through inhibition of adenylyl cyclase, decreases intracellular levels of cAMP

183 mutations that disrupt Ca(2+)/CaM-dependent adenylyl cyclase, demonstrating a convergence of K(+) ch

184 ated betaAR couple to Gs protein, leading to adenylyl cyclase-dependent increases in secondary-messen

185 blocked STa/GCC-dependent, but not forskolin/adenylyl cyclase-dependent, cystic fibrosis transmembran

186 The two-metal catalysis by the adenylyl cyclase domain of the anthrax edema factor toxi

187 rotein, followed by subsequent activation of adenylyl cyclase, elevation of cyclic AMP levels, and pr

188 is abolished in a strain lacking MT1302, an adenylyl cyclase encoding gene.

189 R in a sequential manner, such as G protein, adenylyl cyclase, Epac-1 protein, and inositol 1,4,5-tri

190 rusion connecting the cGMP phosphodiesterase/adenylyl cyclase/FhlA (GAF) and phytochrome-specific (PH

191 for the photosensing cGMP phosphodiesterase/adenylyl cyclase/FhlA (GAF) domain from Thermosynechococ

192 ore buried within the cGMP phosphodiesterase/adenylyl cyclase/FhlA (GAF) domain, and a well-ordered h

193 es of the 23-kDa GAF (cGMP phosphodiesterase/adenylyl cyclase/FhlA) domain fragment of phytochrome fr

194 ivation of Gs, the stimulatory G protein for adenylyl cyclase, has long been a model system for GPCR

195 terol showed weak efficacy for activation of adenylyl cyclase; however, its efficacy in the complex d

196 y a mechanism involving Ca(2+) activation of adenylyl cyclase I (AC1) and cAMP/PKA signaling.

197 h muscle actin, vimentin, alpha-actinin, and adenylyl cyclase II.

198 Feedback inhibition of adenylyl cyclase III (ACIII) via Ca(2+)-induced phosphor

199 This study used immunohistochemistry for adenylyl cyclase III (ACIII), a marker of primary cilia,

200 tivation of odorant receptors (ORs) leads to adenylyl cyclase III activation, cAMP increase, and open

201 whereas the presence of the effector enzyme adenylyl cyclase III remained largely unaltered.

202 vergence are perturbed in mice deficient for adenylyl cyclase III, which is downstream from the OR an

203 localization of ciliary proteins ARL13B and adenylyl cyclase III.

204 domembrane-associated trimeric G protein and adenylyl cyclase immediately after endocytosis.

205 e of UDP-glucose for promoting inhibition of adenylyl cyclase in C6 glioma cells stably expressing th

206 on activation of NMDA and AMPA receptors and adenylyl cyclase in D1 receptor-expressing cells.

207 r instance, expression of the Rutabaga (Rut) adenylyl cyclase in gamma neurons is sufficient to resto

208 nase activities attenuate the stimulation of adenylyl cyclase in response to catecholamines.

209 blaC gene encoding a putative photoactivated adenylyl cyclase in the Beggiatoa sp. PS genome.

210 forms a local signaling system with soluble adenylyl cyclase in the matrix, which regulates the acti

211 ructure of Gs, the stimulatory G protein for adenylyl cyclase, in complex with the alpha2 adrenergic

212 t (expected to activate matrix-bound soluble adenylyl cyclase) increased intramitochondrial cAMP, but

213 RPV1 via activation of TRPA1, which involves adenylyl cyclase, increased cAMP, subsequent translocati

214 ex, implicating enhanced Galpha(i)-dependent adenylyl cyclase inhibition as a possible causative fact

215 n of G proteins with all Galphai/o subunits, adenylyl cyclase inhibition, and beta arrestin recruitme

216 otein activation, beta-arrestin recruitment, adenylyl cyclase inhibition, and extracellular signal-re

217 activated G-protein-dependent calcium flux, adenylyl cyclase inhibition, and the rapid activation of

218 was attenuated by PAR2 or TRPV4 deletion and adenylyl cyclase inhibition.

219 ocked by the CFTR inhibitor CFTR_inh172, the adenylyl cyclase inhibitor MDL 12330A, and the protein k

220 Conversely, microinjection of the adenylyl cyclase inhibitor SQ22536 reversed both the dev

221 multiple G protein alpha subunits, including adenylyl cyclase-inhibitory (Galpha(i)) subunits and tho

222 receptor (with G-protein alpha subunits and adenylyl cyclase) internalization.

223 cause it is not clear whether G proteins and adenylyl cyclase internalize with receptors, we tested w

224 Edema factor (EF), a potent adenylyl cyclase, is one of the toxin components.

225 rosclerosis triggers a de novo expression of adenylyl cyclase isoform 8 (AC8), associated with the pr

226 than Galpha(s short) and directly activates adenylyl cyclase isoforms 3, 5, and 6 with less efficacy

227 or more of the nine different transmembrane adenylyl cyclase isoforms that generate the cAMP signal

228 t Plin5 is phosphorylated, and activation of adenylyl cyclase leads to phosphorylation of Plin5, sugg

229 sticity was dependent on the Rutabaga type I adenylyl cyclase, linking cAMP-dependent plasticity to b

230 that for the structurally related membranous adenylyl cyclases (mACs) 1, 2, 5 and the purified mAC ca

231 ent on the SCN-controlled oscillation of the adenylyl cyclase/MAPK pathway in the hippocampus.

232 f betaARs as well as Gi inhibition of type 1 adenylyl cyclase may underlie the experimental observati

233 brane-permeable 8Br-cAMP under inhibition of adenylyl cyclase-mediated cAMP production by MDL 12330A.

234 otifs first identified in histidine kinases, adenylyl cyclases, methyl-accepting chemotaxis proteins,

235 egion; a cytoplasmic HAMP (histidine kinase, adenylyl cyclases, methyl-accepting chemotaxis proteins,

236 er-Arnt-Sim) and poly-HAMP (histidine kinase-adenylyl cyclase-methyl-accepting chemotaxis protein-pho

237 ough the activation of phospholipase Cbeta-, adenylyl cyclase-, mitogen-activated protein kinase-, an

238 s of ADCY5-the first definitive link between adenylyl cyclase mutation and human disease.

239 G protein, Gs (the stimulatory G protein for adenylyl cyclase) on formation of a complex with agonist

240 Inhibition of adenylyl cyclase or PKA activity blocked p65 and CREB ph

241 roperties toward the beta(1)AR in either the adenylyl cyclase or the mitogen-activated protein kinase

242 rmone- and G protein-regulated transmembrane adenylyl cyclases or via the widely expressed and struct

243 We hypothesized that a photoactivatable adenylyl cyclase (PAC) can be employed to modulate cAMP

244 tant residues for the enhanced activation of adenylyl cyclase, partly due to reduced inhibition of ad

245 T6) receptor constitutively activates the Gs/adenylyl cyclase pathway in various cell types, includin

246 The inhibitory effects of agonists on the adenylyl cyclase pathway were investigated.

247 with either IBMX or forskolin, activates the adenylyl cyclase pathway, and the effect of VIP and fors

248 gents, alone or in combination, modulate the adenylyl cyclase pathway, the accumulation of intracellu

249 uction of cAMP (G protein-coupled receptors, adenylyl cyclases, phosphodiesterases (PDEs)), and recep

250 ein, AKAP5 (also called AKAP150/79), targets adenylyl cyclase, PKA, and calcineurin to a caveolin 3-a

251 dor receptors couple to G-protein activating adenylyl cyclase, producing cAMP.

252 AMP signaling are suggested by low levels of adenylyl cyclase protein in Deltaric8 mutants and suppre

253 ccurs through Ca(2+) entry and activation of adenylyl cyclases, protein kinase A, and PKC.

254 First, Rutabaga adenylyl cyclase (Rut-AC), a putative molecular coincide

255 raction between Nf1 and the rutabaga-encoded adenylyl cyclase (Rut-AC).

256 in NMJ growth and plasticity, including the adenylyl cyclase Rutabaga, the Ig-CAM Fasciclin II, the

257 work we used a HAMP containing mycobacterial adenylyl cyclase, Rv3645, as a reporter enzyme in which

258 cAMP sources, involving the atypical soluble adenylyl cyclase (sAC) in addition to transmembrane aden

259 Soluble adenylyl cyclase (sAC) is a novel source of cAMP subject

260 addition, the cAMP-producing enzyme soluble adenylyl cyclase (sAC) is expressed in pigment cells, an

261 , we show that bicarbonate-sensitive soluble adenylyl cyclase (sAC) is highly expressed in the ciliar

262 study, significant overexpression of soluble adenylyl cyclase (sAC), an alternative source of cAMP, w

263 increased expression and activity of soluble adenylyl cyclase (sAC), an evolutionarily conserved bica

264 brane adenylyl cyclases (tmACs), and soluble adenylyl cyclase (sAC).

265 ly and biochemically distinct enzyme soluble adenylyl cyclase (sAC).

266 TASK, ROMK), and the bicarbonate-stimulated adenylyl cyclase (sAC).

267 d the expression and function of the soluble adenylyl cyclase (sAC, ADCY10) in CNS retinal ganglion c

268 mimics the action of the endogenous soluble adenylyl cyclase (SACY) that is required for motility an

269 miR-212-enhanced Raf1 activity, resulting in adenylyl cyclase sensitization and increased expression

270 nonical negative interaction at the level of adenylyl cyclase signaling, to a strong recruitment of b

271 reabsorption in the collecting duct through adenylyl cyclase-stimulated cyclic AMP, which exists as

272 Results of experiments with the adenylyl cyclase stimulator forskolin and with the PKA i

273 nction of the encoded protein, Galphaolf, an adenylyl-cyclase-stimulatory G-protein highly enriched i

274 In neurons, two families of adenylyl cyclases synthesize cAMP, transmembrane adenyly

275 s the enzyme to a specific, light-stimulated adenylyl cyclase that catalyzes the formation of cAMP fr

276 l of c-di-AMP is modulated by activity of di-adenylyl cyclase that produces c-di-AMP and phosphodiest

277 Adenylyl cyclases, the enzymatic source of cAMP producti

278 In striatal neurons, D(1)R activates adenylyl-cyclase through Galpha(olf), a protein upregula

279 Transmembrane adenylyl cyclases (tmACs) are another possible source of

280 ylyl cyclases synthesize cAMP, transmembrane adenylyl cyclases (tmACs), and soluble adenylyl cyclase

281 l cyclase (sAC) in addition to transmembrane adenylyl cyclases (tmACs).

282 CD99 signals through soluble adenylyl cyclase to activate PKA to trigger ongoing targ

283 oups converge on the same signaling cascade--adenylyl cyclase to cAMP to protein kinase A--but with o

284 Stimulation of adenylyl cyclase to form cAMP induces hyphal morphogenes

285 FSI axon terminals and negatively couple to adenylyl cyclase to induce a long-term depression of GAB

286 ntly decreases the colonization abilities of adenylyl cyclase toxin-producing bacteria, such as ETEC.

287 ght and also indicate that cAMP generated by adenylyl cyclase type 1 is required for phosphorylation

288 In mice missing the gene for adenylyl cyclase type 1, levels of phosphorylated GRK1 w

289 N-methyl-D-aspartate receptor activation of adenylyl cyclase type 1.

290 lous DM(high)-VL(low) expression gradient of adenylyl cyclase type 3 appears, which coincides with al

291 via onset of the stimulus-transducing enzyme adenylyl cyclase type 3.

292 Adenylyl cyclase type 5 knockout (AC5KO) mice have incre

293 bited by STIM1 inhibitors or by silencing of adenylyl cyclase type 6 (AC6).

294 Adenylyl cyclase type 9 (AC9) is found tightly associate

295 To assess this, we studied mice deficient in adenylyl cyclase type VI specifically in the principal c

296 nctions to inhibit the production of cAMP by adenylyl cyclase upon Hh stimulation, thus maximizing si

297 In summary, these data suggest that adenylyl cyclase VI mediates vasopressin-stimulated ENaC

298 expression of the membrane-bound isoforms of adenylyl cyclase, while immunostaining revealed one, AC6

299 xperiments revealed that acute activation of adenylyl cyclase with forskolin increased the frequency

300 In HF, activation of adenylyl cyclase with forskolin rescued the Ca2+ transie