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1 ed active site residues essential for ligase adenylylation.
2 onounced lag phase in the progress of target adenylylation.
3 trogen-excess conditions due to excessive GS adenylylation.
4 397 to Phe, Ala, or Ser was found to prevent adenylylation.
5 induce changes previously thought to require adenylylation.
6 he hydroxyl group to AMP in a process termed adenylylation.
7 y is inversely proportional to the extent of adenylylation.
8 eleased after formation, and then rebind for adenylylation.
9 racteristics similar to the form obtained by adenylylation.
10 d associated with the phosphocholination and adenylylation activities of the enzymes AnkX and DrrA/Si
11 ylylated by the UTase/UR and to activate the adenylylation activity of ATase.
12  the NRII phosphatase activity and the ATase adenylylation activity.
13 volves three distinct chemical steps: enzyme adenylylation, adenylyl transfer to DNA, and nick sealin
14  of a post-translational modification termed adenylylation/AMPylation in regulating signal transducti
15 ates the activity of glutamine synthetase by adenylylation and deadenylylation in response to signals
16 ranferase (ATase, EC 2.7.7.49) catalyzes the adenylylation and deadenylylation of glutamine synthetas
17                                          The adenylylation and deadenylylation of GS are catalyzed by
18  glutamine synthetase (GS) by catalyzing the adenylylation and deadenylylation of GS in response to s
19  Escherichia coli is regulated by the cyclic adenylylation and deadenylylation of Tyr-397 in each of
20 lysis revealed distinct requirements for the adenylylation and end-sealing reactions catalyzed by Lig
21          P. horikoshii ligase catalyzes auto-adenylylation and nick sealing in the presence of a diva
22 onal effects on the isolated steps of ligase adenylylation and phosphodiester bond formation.
23 of mutational effects on the isolated ligase adenylylation and phosphodiester formation reactions rev
24 -285 and Phe-286 in the catalysis of the DNA adenylylation and phosphodiester synthesis reactions.
25                             The rates of DNA adenylylation and phosphodiester synthesis respond diffe
26   Examples of modification by N-acetylation, adenylylation and proteolytic processing were characteri
27 ling-defective mutants were active in ligase adenylylation and sealing a preadenylylated nick, thereb
28 y the antibiotic, including phosphorylation, adenylylation, and acetylation.
29 example of a PII protein that is modified by adenylylation, and demonstrates that this reaction is pe
30  ligation pathway (ligase adenylylation, DNA adenylylation, and phosphodiester synthesis).
31  the deadenylylation of GS was to inhibit GS adenylylation, and this was due to the allosteric regula
32 f the nick 3' nucleoside for catalysis of 5' adenylylation; and (ii) EcoLigA's potential to embed mut
33 characterized the kinetics of DrrA-catalyzed adenylylation as well as SidD-catalyzed deadenylylation
34                   Co-immunoprecipitation and adenylylation assays demonstrated that this associated f
35                Interestingly, in contrast to adenylylation by DrrA, AnkX can covalently modify inacti
36 lytic activity due to covalent modification (adenylylation by GS adenylyltransferase).
37  which effectively inhibits catalysis in the adenylylation cycle (cycle II).
38                            The order for the adenylylation cycle was ATP(in), FMN(in), pyrophosphate(
39 ponent steps of the ligation pathway (ligase adenylylation, DNA adenylylation, and phosphodiester syn
40 in light of available structural data on the adenylylation domains of ATP- and NAD-dependent ligases.
41                                We found that adenylylation enhances BiP's ATPase activity, which is r
42                                         This adenylylation event inactivates Rho GTPases by preventin
43 domains of IbpA catalyze a unique reversible adenylylation event that uses ATP to add an adenosine mo
44           The mechanistic insights to lysine adenylylation gained from the NgrRnl structures are like
45 coli glutamine synthetase (GS) by reversible adenylylation has provided one of the classical paradigm
46                                  AMPylation (adenylylation) has been recognized as an important post-
47 e the first functional data for Fic-mediated adenylylation in mammalian signaling.
48  of proteins that undergo phosphorylation or adenylylation in signal transduction cascades might be s
49 and suggests the intriguing possibility that adenylylation in the pathogenic versus non-pathogenic my
50 ting conditions, whereas there was little GS adenylylation in wild-type strains.
51 scherichia coli and is subject to reversible adenylylation (inactivation) by a bifunctional GS adenyl
52 tions and a rapid decrease of GS activity by adenylylation is needed.
53  suppressed overall nick ligation and ligase adenylylation, it did not compromise sealing at a preade
54 tacts at the nick and with ATP during ligase adenylylation; (iv) the role of Phe-44 in forming the pr
55 s (k(step3) = 25 s(-1)) exceeds that for DNA adenylylation (k(step2) = 2.4 s(-1)) and that Mg(2+) bin
56                            The IbpA-mediated adenylylation occurs on a functionally critical tyrosine
57  report that Escherichia coli RtcA catalyzes adenylylation of 5'-phosphate ends of DNA or RNA strands
58                                   Subsequent adenylylation of enzyme prevents rebinding to the adenyl
59                            It was shown that adenylylation of FMN is reversible; FAD and pyrophosphat
60 re potent than GlnK in the activation of the adenylylation of glutamine synthetase by ATase.
61 phosphatase activity of NRII, and stimulated adenylylation of GS by ATase.
62                                          The adenylylation of GS plays no significant role in nif exp
63  autoinhibition and thus allowing subsequent adenylylation of its target, the DNA gyrase subunit GyrB
64 enylylated ( approximately 30%), whereas the adenylylation of M. bovis BCG GS does not change.
65                                  The site of adenylylation of MTb GS by the E. coli ATase is Tyr-406,
66 g these is DrrA/SidM, which catalyzes stable adenylylation of Rab1b, a regulator of endoplasmatic ret
67 sence of [alpha-(32)P]ATP, which resulted in adenylylation of Rho GTPases and cytoskeletal disruption
68                   Nick sensing also requires adenylylation of Rnl2.
69        In some bacteria, GS is regulated via adenylylation of some or all of the subunits within the
70                Equilibrium constants for the adenylylation of T4 DNA ligase have been measured at 10
71 rates the second step of the ligase pathway (adenylylation of the 5'-PO4 strand) by a factor of 1000,
72 er, but dispensable for nick recognition and adenylylation of the 5'-PO4 strand.
73  protein, and the reversible modification as adenylylation of the conserved tyro-sine 51 residue that
74 ride linkage in ATP significantly facilitate adenylylation of the enzyme.
75 D) cofactor biosynthesis, which catalyze the adenylylation of the nicotinic acid mononucleotide (NaMN
76 mechanism based on the loop motions in which adenylylation of the Tyr397 loop reverses the effect of
77 Tase is Tyr-406, as indicated by the lack of adenylylation of the Y406F mutant, and, as expected, is
78 of Tyr-326 together with either nitration or adenylylation of Tyr-397 leads to inactivation of the en
79              It was further established that adenylylation of Tyr-397 precludes its nitration by pero
80           We have established the effects of adenylylation on Rab1 interactions and properties in a q
81  by cyclic AMP (FIC)-domain enzymes catalyze adenylylation or other posttranslational modifications o
82 rovide important structural insight into the adenylylation reaction mechanism catalyzed by Fic domain
83 amide mononucleotide (NMN) occurs before the adenylylation reaction, which converts this alternative
84 stinctive catalytic mechanisms of the lysine adenylylation reaction.
85 tion induced by cAMP) domain, catalyzes this adenylylation reaction.
86 sting that the 3' de-guanylylation and 5' de-adenylylation reactions follow the same pathway of nucle
87 bolished by mutation of the predicted lysine adenylylation site (Lys-165) in the C-terminal domain an
88 lutarate concentration, the regulation of GS adenylylation state by glutamine was sharper and occurre
89             We examined the regulation of GS adenylylation state in a reconstituted system containing
90 se (ATase, the glnE product) to regulate the adenylylation state of glutamine synthetase (GS).
91 s reconstituted bicyclic cascade system, the adenylylation state of GS was regulated reciprocally by
92        We also compared the regulation of GS adenylylation state to the regulation of phosphorylation
93  a substrate for E. coli ATase, but only low adenylylation states are accessible.
94                       This parallels the low adenylylation states observed for GS from mycobacteria a
95                             Whereas the RtcA adenylylation step is metal-catalyzed, the subsequent st
96 7 carboxylate, exclusively during the ligase adenylylation step.
97 fs I, IV, and V and suffices for both enzyme adenylylation (step 1 of the ligation pathway) and phosp
98 tional effects on the isolated steps of Rnl1 adenylylation (step 1) and phosphodiester bond formation
99 3'OH/5'PO(4) nicks in duplex RNAs via ligase adenylylation (step 1), AMP transfer to the nick 5'PO(4)
100 eps of the ligation pathway including ligase-adenylylation (step 1), RNA adenylylation (step 2) and p
101 including ligase-adenylylation (step 1), RNA adenylylation (step 2) and phosphodiester bond synthesis
102  3'-OH nucleoside in the catalysis of DNA 5'-adenylylation (step 2) and phosphodiester synthesis (ste
103 dysfunctional by virtue of defects in ligase adenylylation: T163A, H167A, G168A, K186A, E230A, F281A
104                                  Enzyme self-adenylylation was confirmed to also occur on a fast time
105                                     Abortive adenylylation was suppressed at low ATP concentrations (

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