ライフサイエンスコーパス: adept

1 In this study, we present ADEPT, a dynamic error detection method, based on the qu

2 ro antibody-directed enzyme prodrug therapy (ADEPT), abrogated the cytotoxicity of a combination of A

3 erefore, we have named these protein domains ADEPTs (Additional Domains for Eukaryotic Protein Target

4 gs demonstrate the utility of MOSAIC and the ADEPT algorithm, and offer a new tool that can improve t

5 dely used in suicide gene therapy (GDEPT and ADEPT) applications as a activating enzyme for nitroarom

6 tor proposed for use in conjunction with the ADEPT approach.

7 y, the N-terminal third of BLAP75 is just as adept as the full-length protein in the promotion of dHJ

8 In nature, desaturases and acetylenases are adept at achieving this essential oxidative functionaliz

9 This virus is adept at altering its surface proteins, the proteins tha

10 Children who are adept at any one of the three academic 'R's (reading, wr

11 vitro [8], we show that Abl and Arg are more adept at binding and phosphorylating cortactin.

12 Many species that are adept at biofilm formation have the capacity to produce

13 ings (Chrysopidae), where immatures are also adept at camouflage [1-4].

14 Oral treponemes are uniquely adept at capitalizing on the environmental conditions th

15 SOS polymerases are adept at copying a variety of lesions, but the relative

16 Microorganisms are adept at degrading chemically resistant aromatic compoun

17 Though quantum mechanics has proved adept at describing the microscopic world, quantum super

18 Auditory systems are adept at detecting and segregating competing sound sourc

19 ch may be a widespread strategy for microbes adept at dissipating reducing equivalents via anaerobic

20 Humans are adept at distinguishing between stimuli that are very si

21 eae, which causes gonorrhea, is particularly adept at driving HIV-1 expression, but the molecular det

22 will differ as tumors evolve to become more adept at each of these characteristics.

23 t DNA polymerases, but POLN was particularly adept at efficient and accurate translesion synthesis pa

24 Brucella spp. are adept at establishing a chronic infection in mammals.

25 Cancer cells are adept at evading cell death, but the underlying mechanis

26 cally adapted to human infection and appears adept at evading normal human antiviral responses, yet i

27 Viruses are adept at evolving or co-opting genomic elements that all

28 n of different bases reveal that AAG is most adept at excising the deaminated lesion hypoxanthine (k(

29 us and Cenozoic, leptosporangiate ferns were adept at exploiting newly created niches in angiosperm-d

30 The results reveal that monkeys are adept at exploiting perceptual cues to locate a food rew

31 Humans are very adept at extracting the "gist" of a scene in a fraction

32 The small intestine is void of aquaporins adept at facilitating vectorial water transport, and yet

33 hibit behavioral responses, and (c) are more adept at flexibly switching behavioral patterns.

34 ortunistic human pathogen that is especially adept at forming surface-associated biofilms.

35 incapable of tRNA mismethionylation are less adept at growth in the presence of antibiotics and stres

36 h as computed tomography, although perfectly adept at identifying and quantifying advanced calcificat

37 lack of chemical specificity, they are less adept at identifying unique chemical activity on those s

38 We show that WORMHOLE is particularly adept at improving LDO prediction performance between di

39 of Y-family DNA polymerase that is naturally adept at incorporating ribonucleotides by virtue of a le

40 onsistent with our analysis, LCs were highly adept at inducing primary CTL responses.

41 We are remarkably adept at inferring the consequences of our actions, yet

42 CD8(+) CTLs are adept at killing virally infected cells and cancer cells

43 e that soft-bodied (coleoid) cephalopods are adept at learning and remembering features of their envi

44 Numerous studies have shown that people are adept at learning novel object dynamics, linking applied

45 violates Occam's razor, insofar as (i) it is adept at ligating 3'-monophosphate and 5'-OH ends; (ii)

46 rporation products formed by DNA polymerases adept at making small frameshift mutations in vivo.

47 g this machinery, they are also particularly adept at manipulating cellular translation control pathw

48 uce hippocampal states that are more or less adept at map formation.

49 ligand-gated cation channels, they are most adept at mediating slow neuromodulatory functions that a

50 One class of polymer that is particularly adept at mimicking the globular structure of enzymes are

51 reliance on social support or becoming more adept at mobilising resources to meet social needs.

52 The LSMs prove adept at modelling the progress of evolution as a functi

53 dence that variola proteins are particularly adept at overcoming human immunity, and the decreased fu

54 Some tumors were more adept at overcoming the additional endothelial cell laye

55 Humans are highly adept at processing speech.

56 In contrast, living organisms are remarkably adept at producing molecules and molecular assemblies wi

57 Primates are remarkably adept at ranking each other within social hierarchies, a

58 The nervous system is particularly adept at rapidly adapting to change, and this in fact ma

59 countries, public health systems have become adept at rapidly identifying the etiology and impact of

60 ine and 6-O-methylguanosine caps, but is not adept at removing a deoxyguanosine cap.

61 This expands BrCa subpopulations adept at resisting therapy and reinitiating tumor growth

62 sposition outcome in some superfamilies, are adept at restructuring chromosomes and may have been ins

63 Artificial neural networks are remarkably adept at sensory processing, sequence learning and reinf

64 , we demonstrate that hHR23a is surprisingly adept at sequestering the ubiquitin moieties of a polyub

65 is anticipated that as surgeons become more adept at such procedures, maximally invasive procedures

66 lasma gondii enjoys a wide host range and is adept at surviving in both naive and activated macrophag

67 Influenza viruses are remarkably adept at surviving in the human population over a long t

68 Humans are adept at switching between goal-directed behaviors quick

69 With magnesium, DinB2 is adept at synthesizing A:oxo-dG or C:oxo-dG pairs.

70 NK cells are especially adept at this activity, as they direct lytic granules to

71 This pathogen is adept at transporting and metabolizing a wide variety of

72 tiation, and point to pathogens particularly adept at triggering apoptosis that might preferentially

73 Humans are adept at understanding speech despite the fact that our

74 Humans are remarkably adept at understanding speech, even when it is contamina

75 Clinicians must become more adept at understanding the molecular genetics of corneal

76 binds D-loop structures and is particularly adept at unwinding these structures.

77 Humans are adept at using facial similarity to recognize likely kin

78 dge in other minds and by being particularly adept at using situational support to build explanations

79 Here we show that hPolkappa is very adept at using template-primer misalignment as a novel m

80 of Y-family DNA polymerase that is naturally adept at utilizing rNTPs or dNTPs as substrates.

81 99 beta-lactamase (P99betaL), a component of ADEPT cancer therapies, revealed that the population pos

82 We show that ADEPT detects previously unreported conductance states t

83 l gyrus, which differed from those with more adept foot motor skill who activated both the precentral

84 e public-private health sector partnerships, adept fund mobilizer, and advocate of the 'let's get it

85 ndicate that the preferred hand was the most adept hand.

86 Antibody-directed enzyme prodrug therapy (ADEPT) has the potential of greatly enhancing antitumor

87 The outcome is that ADEPT improves upon prior efforts in identifying true er

88 Because adenovirus is adept in binding to the respiratory epithelium, we teste

89 h, which combines an e-Nose and an e-Tongue, adept in generating combined aroma and taste profiles.

90 s in action selection: Participants are more adept in invoking an appropriate aiming strategy when pr

91 id-infrared free-electron lasers have proven adept in surgical applications.

92 the associated outcome correlations and were adept in using that information to dynamically adjust th

93 Although dendritic cells (DCs) are adept initiators of CD4(+) T cell responses, their funda

94 ADEPT is the only tool to date that dynamically assesses

95 ency of hCPA1-268G was tested in an in vitro ADEPT model.

96 protein-protein interactions (PPIs) requires adept molecular design and synthesis strategies as well

97 For would-be Hermetic adepts of the Renaissance and Baroque, the ancient art o

98 as antibody-directed enzyme prodrug therapy (ADEPT) or gene-directed enzyme prodrug therapy (GDEPT).

99 ined at baseline to determine the residents' ADEPT score (range, 1.0-32.5; higher scores indicate wor

100 as a continuous measure, the ability of the ADEPT score to identify nursing home residents with adva

101 At baseline, the residents' mean (SD) ADEPT score was 10.1 (3.1) points and 65 residents (10.7

102 The AUROC for the ADEPT score's prediction of 6-month mortality as a conti

103 Using a cutoff of 13.5 on the ADEPT score, which also had specificity of 0.89, the AUR

104 enges that require mechanisms for prompt and adept sensing of and responses to stress if the bacteria

105 and type 2-low asthmatic groups, but in the ADEPT study population CCL26 expression was optimal.

106 se Endotyping for Personalized Therapeutics (ADEPT) study profiled patients with mild, moderate, and

107 Whether early hominins were adept tree climbers is unclear.

108 ese data strongly support the feasibility of ADEPT using a mutated human enzyme with a single amino a

109 nce of HIVSGD-derived BKPyV oral tropism and adept viral replication in human salivary gland cells co

110 Two key algorithms are implemented: ADEPT, which uses a physical model of the nanopore syste

111 in antibody-directed enzyme prodrug therapy (ADEPT) with beta-galactosidase for enzyme-specific activ