ライフサイエンスコーパス: adherens junction

1 otein responsible for actin stability at the adherens junction.

2 ures, but in contrast, it did not affect the adherens junction.

3 lity and decreased actin accumulation at the adherens junction.

4 local E-cadherin dilution at the ingressing adherens junction.

5 ilizes TRAF2 and reduces E-cadherin-mediated adherens junctions.

6 PDZ-binding membrane proteins to epithelial adherens junctions.

7 asal surface and impairs apical polarity and adherens junctions.

8 which is known to regulate the stability of adherens junctions.

9 ractile cytoskeletal network's attachment to adherens junctions.

10 trol, consistent with formation of defective adherens junctions.

11 role of alpha-catenin-actin interactions in adherens junctions.

12 and VE-Cadherin, two components of tight and adherens junctions.

13 tin stress fibres and decreased formation of adherens junctions.

14 the corresponding endothelial and epithelial adherens junctions.

15 mics after the proteolytic disruption of the adherens junctions.

16 tween the contractile actomyosin network and adherens junctions.

17 between cells through E-cadherin-containing adherens junctions.

18 actomyosin network associated with disrupted adherens junctions.

19 adhesive function provided by desmosomes and adherens junctions.

20 Mer executes its function by stabilizing adherens junctions.

21 rtical actin filaments, Kindlin-2 stabilizes adherens junctions.

22 0-catenin functions by recruiting Shroom3 to adherens junctions.

23 dillo repeat protein ARVCF is a component of adherens junctions.

24 olymerization with concomitant disruption of adherens junctions.

25 regulates BBB permeability by destabilizing adherens junctions.

26 e defective in tension-induced engagement of adherens junctions.

27 e dense projection and after 1 s adjacent to adherens junctions.

28 of the apical complex proteins and disrupted adherens junctions.

29 g partners beta-catenin and alpha-catenin at adherens junctions.

30 r Lyn-dependent stabilization of endothelial adherens junctions.

31 main protein, which functions to restabilize adherens junctions.

32 at a rate consistent with residence times in adherens junctions.

33 the Na(+)/K(+)-ATPase, which also resides in adherens junctions.

34 dimeric partner of beta-catenin at cell:cell adherens junctions.

35 ectin are distinct transmembrane proteins of adherens junctions.

36 tin cytoskeleton, which stabilizes tight and adherens junctions.

37 abilization of VE-cadherin and maturation of adherens junctions.

38 on E-cadherin, the key membrane component of adherens junctions.

39 Talin is not present in adherens junctions.

40 ther correlated with the retention of normal adherens junctions.

41 marily regulated by a protein complex called adherens junctions.

42 at is a key component of tight junctions and adherens junctions.

43 -cadherin as well as other components in the adherens junctions.

44 iously unrecognized component of endothelial adherens junctions.

45 -cadherin, resulting in impaired activity of adherens junctions.

46 function, beta-catenin also plays a role at adherens junctions.

47 impregnations analogous to animal tight and adherens junctions.

48 on of cell junction scaffold afadin from the adherens junctions.

49 structural rearrangement of alpha-catenin in adherens junctions [10] and vinculin's molecular clutch

50 ascular endothelial (VE)-cadherin, the major adherens junction adhesion molecule in endothelial cells

51 nates tissue polarization of tension-bearing adherens junction (AJ) and F-actin organization to allow

52 Linkage between the adherens junction (AJ) and the actin cytoskeleton is req

53 De novo formation of an adherens junction (AJ) between single epithelial cells r

54 ckdown cultured cells, staining of canonical adherens junction (AJ) components, beta-catenin and E-ca

55 p120-catenin (p120) modulates adherens junction (AJ) dynamics by controlling the stabi

56 ces of genes encoding proteins that regulate adherens junction (AJ) integrity and determined that vas

57 to basolateral surfaces and interacted with adherens junction (AJ) protein beta-catenin.

58 associated with significant upregulation of adherens junction (AJ) protein E-cadherin and tight junc

59 activation also enhanced interaction between adherens junction (AJ) proteins VE-cadherin and p120-cat

60 e cluster is also required for regulation of adherens junction (AJ) stability and dynamics.

61 alization (ES), a testis-specific actin-rich adherens junction (AJ) type, Rai14 was shown to be one o

62 KEY POINTS: N-cadherin formed punctate adherens junctions (AJ) along the borders between vascul

63 N-cadherin formed punctate adherens junctions (AJ) along the borders between VSMCs.

64 - and gamma-catenin and actin, components of adherens junctions (AJ).

65 Adherens junctions (AJs) and cell polarity complexes are

66 Adherens junctions (AJs) and focal adhesion (FA) complex

67 This process involves the fine regulation of adherens junctions (AJs) and of adhesive E-Cadherin (E-C

68 Once adherens junctions (AJs) are formed between polarized ep

69 Stable adherens junctions (AJs) are required for formation of r

70 Adherens junctions (AJs) are the major intercellular jun

71 We identify adherens junctions (AJs) as a key target of endocytosis

72 Compromise in adherens junctions (AJs) is associated with several chro

73 Stability of endothelial cell (EC) adherens junctions (AJs) is central for prevention of ti

74 Modification of adherens junctions (AJs) is clearly required for budding

75 TPase Rac1 in stabilizing mature endothelial adherens junctions (AJs) is not well understood.

76 ssed whether altered activity of endothelial adherens junctions (AJs) might contribute to this dysfun

77 dynamic changes in the length of individual adherens junctions (AJs) provide epithelia with the flui

78 During morphogenesis, adherens junctions (AJs) remodel to allow changes in cel

79 plus end-binding protein CLASP2 localizes to adherens junctions (AJs) via direct interaction with p12

80 f E-cadherin, an obligatory component of the adherens junctions (AJs), at the wound edge.

81 es Par3/Baz, provoking its relocalization to adherens junctions (AJs).

82 regulating the stability of endothelial cell adherens junctions (AJs).

83 le into large macromolecular complexes named adherens junctions (AJs).

84 a manipulation expected to help destabilize adherens junctions (AJs).

85 at alphaN-catenin, the neural subtype of the adherens junction alpha-catenin protein, regulates crani

86 erturbed pathways in gastric cancer included adherens junction and focal adhesion, in which RHOA and

87 of MZ Crb is necessary to maintain an intact adherens junction and MZ.

88 method harnessing the biology of endothelial adherens junction and opens a new avenue for drug delive

89 ilitated by afadin, a protein connecting the adherens junction and the actin cytoskeleton.

90 /Y949F) leads to VEGFA-resistant endothelial adherens junctions and a block in molecular extravasatio

91 a-catenin, leading to destabilization of the adherens junctions and a subsequent increase in cytoplas

92 ng 15q11.2 microdeletion exhibit deficits in adherens junctions and apical polarity.

93 h alpha-catenin and that its localization to adherens junctions and association with alpha-catenin ar

94 alize polarity proteins such as DLG-1 within adherens junctions and at the apical surface, thereby ge

95 Bazooka then helps to position both adherens junctions and atypical protein kinase C (aPKC).

96 ssential for polarity establishment, as both adherens junctions and Bazooka are mispositioned in thei

97 Here, we investigate how adherens junctions and bicellular and tricellular tight

98 ion, molecular assembly and stability of the adherens junctions and cell-cell aggregation, which was

99 molecules are cadherins: type 1 cadherins in adherens junctions and desmosomal cadherins in desmosome

100 cribed structural protein functioning at the adherens junctions and desmosomes, was shown to be eithe

101 eveal a role for PCP signaling in regulating adherens junctions and directed cell rearrangements duri

102 signaling pathways regulating plasticity of adherens junctions and endothelial permeability.

103 complex activates RAC1 to drive assembly of adherens junctions and establish barrier function.

104 aintenance of the apical protein complex and adherens junctions and for stratification and proper mig

105 icated in the disruption of endothelial cell adherens junctions and in the diapedesis of metastatic c

106 Src inhibition increased VE-cadherin at adherens junctions and increased endothelial dilatation

107 show that Rho GTPase recruits Rho-kinase to adherens junctions and is required for Rho-kinase planar

108 disassembly from traditional cadherin-based adherens junctions and its 360 degrees distribution arou

109 se to promote the transport of E-cadherin to adherens junctions and myotactin to hemidesmosomes.

110 sphorylation resulting in the disassembly of adherens junctions and opening of the paracellular pathw

111 gulate the vinculin-assisted linkage between adherens junctions and the actin cytoskeleton.

112 oglobin (gamma-catenin) that maintained both adherens junctions and the activation of Wnt target gene

113 a-catenin levels increased simultaneously at adherens junctions and the centrosome, and a membrane-ce

114 meability is mainly caused by disruptions in adherens junctions and tight junction proteins.

115 The crosstalk between adherens junctions and tight junctions in maintaining ba

116 ta-catenin functions in cell adhesion at the adherens junctions and Wnt-induced nuclear signaling.

117 rate that IGPR-1 is localized to endothelial adherens junctions and, through trans-homophilic dimeriz

118 -containing proteins known to regulate tight/adherens junctions and/or transmembrane adhesions, inclu

119 unctions while actin maintains microtubules, adherens-junctions and apical end-foot dimensions.

120 p, which is used to restore the integrity of adherens junctions, and a negative feedback loop, which

121 ribution of p120 catenin and E-cadherin from adherens junctions, and also increased endogenous TNF-al

122 signalling mechanism that drives assembly of adherens junctions, and confirm these findings in mouse

123 ures such as tight junctions, cadherin-based adherens junctions, and desmosomes.

124 osphorylation of VE-cadherin, disassembly of adherens junctions, and EC barrier failure.

125 Intercalated discs composed of desmosomes, adherens junctions, and gap junctions provide the struct

126 ia peripheral actin cables and discontinuous adherens junctions, and lead migrating clusters near the

127 proteases often co-localize with epithelial adherens junctions, and nonepithelial-derived proteases

128 the cytoplasm and the nucleus, formation of adherens junctions, and reduced cell motility.

129 c domain of N-cadherin, a major component of adherens junctions, and SK1 can interact with the extrac

130 which are connected through tight junctions, adherens junctions, and stabilizing basement membrane st

131 that connect the contractile networks to the adherens junctions, and thus mechanically connect neighb

132 t calcium-independent hyperadhesion, whereas adherens junctions appear to lack such ordered arrays, a

133 herin clusters that constitute an individual adherens junction are united by the same actin-filament

134 Both tight junctions and adherens junctions are disrupted when Anillin is knocked

135 Desmosomes and adherens junctions are intercellular adhesive structures

136 Adherens junctions are not static structures; they are c

137 actin-based cytoskeleton and its associated adherens junctions are well-established contributors to

138 in at their entire shared interface, both at adherens junctions as well as along basolateral interfac

139 Adherens junctions, as detected by cadherin-GFP expressi

140 eveal Pkp3 as a coordinator of desmosome and adherens junction assembly and maturation through its fu

141 The pathways driving desmosome and adherens junction assembly are temporally and spatially

142 They also suggest that early events of adherens junction assembly involve interactions between

143 tracellular binding events in the process of adherens junction assembly.

144 man umbilical endothelial cells by promoting adherens junction assembly.

145 dependent of Src and likely occur through an adherens junction associated complex.

146 We find that Vinculin is recruited to the adherens junction at the cleavage furrow, and that inhib

147 on (apical ES; a testis-specific, actin-rich adherens junction at the Sertoli cell-spermatid interfac

148 3 hemichannels are efficiently trafficked to adherens junctions at intercalated discs.

149 ay an expanded apical domain, aggregation of adherens junctions at the cell membrane, and microtubule

150 In metazoan adherens junctions, beta-catenin links the cytoplasmic t

151 ac1-dependent manner, thus preserving stable adherens junctions between adjacent cells.

152 n receptors and is located to both tight and adherens junctions between epithelial cells where it can

153 Adherens junctions between RGCs are disrupted in the mut

154 adherin, and the aberrant interaction of its adherens junction binding partner, p120-catenin (p120ctn

155 versed the degradation of tight junction and adherens junction both in vivo and in vitro.

156 Furthermore, Mgc regulates adherens junction but not tight junction structure, and

157 stimulated c-Src and FAK translocation to EC adherens junctions, but FAK inhibition does not alter c-

158 and controlled tissue reorganization disrupt adherens junctions by cleaving the extracellular binding

159 egulates tension acting on VE-cadherin-based adherens junctions, cell migration, and barrier formatio

160 interactions between ZIKA-NS2A and multiple adherens junction complex (AJ) components.

161 unction complex proteins, we also quantified adherens junction complex assembly dynamics during epith

162 icle, we validate and quantify multi-protein adherens junction complex assembly in situ using light m

163 otein pairs, we quantified various stages of adherens junction complex assembly, the multiprotein com

164 n live cells expressing fluorescently tagged adherens junction complex proteins, we also quantified a

165 ively, we identified novel components of the adherens junction complex, and we introduce a novel mole

166 ges in expression of proteins central to the adherens junction complex.

167 n to the cell-cell contact zone, assembly of adherens junction complexes, acto-myosin tension-mediate

168 ll adhesion defects and revealed loss of the adherens junction component E-cadherin at lateral membra

169 Our findings suggest that defects in adherens junctions components in mice massively affects

170 a syndecan-TRPC4 complex controls adhesion, adherens junction composition, and early differentiation

171 so discovered that IL2 induces disruption of adherens junctions, concomitant with cytoskeletal reorga

172 Restoring the activity of adherens junctions could be of therapeutic benefit in va

173 species impairs Ca(2+)-mediated formation of adherens junctions, critical to maintaining mechanical i

174 , alpha-pv-deficient ECs show reduced stable adherens junctions, decreased monolayer formation, and i

175 nd metastasis by promoting the disruption of adherens junctions, dedifferentiation, and an epithelial

176 atenin at cell-cell junctions, disruption of adherens junctions destabilizes cadherin-catenin complex

177 egulating endothelial cell contractility and adherens junction disassembly leading to endothelial bar

178 Adherens junction disassembly within premigratory neural

179 t to modulate cytoskeletal contractility and adherens junctions disassembly during extravasation and

180 rocess, also known as delamination, involves adherens-junction disassembly and acto-myosin-mediated a

181 istamine causes the rapid formation of focal adherens junctions, disrupting the endothelial barrier b

182 Fmnl3 localizes to adherens junctions downstream of Src and Cdc42 and its d

183 though Snail is essential for disassembly of adherens junctions during epithelial-mesenchymal transit

184 ls that protect the integrity of endothelial adherens junctions during the inflammatory response, thu

185 n endocytosis and recycling to contribute to adherens junction dynamics without resulting in junction

186 NAs encoding tight junction protein ZO-1 and adherens junction E-cadherin, resulting in the dysfuncti

187 d NOCA-1 are recruited to hemidesmosomes and adherens junctions early in elongation.

188 Pacsin2 concentrates at focal adherens junctions (FAJs) that are experiencing unbalanc

189 VE-cadherin adhesions, defined here as focal adherens junctions (FAJs).

190 Both these proteins are essential for adherens junction formation and maintenance.

191 e are 5 known S1P receptors, and S1P induces adherens junction formation between endothelial cells th

192 2 signaling in an in vitro BBB model altered adherens junction formation via activation of Rho/ROCK,

193 is sufficient to prevent stable cell-to-cell adherens junction formation, up-regulate matrix metallop

194 erface, we show that it is not essential for adherens junction formation.

195 nomers inhibit angiogenesis by blocking this adherens junction formation.

196 nomer form on endothelial tip cells prior to adherens junction formation.

197 excessive endothelial proliferation and poor adherens junction formation.

198 adin, a nectin adaptor protein implicated in adherens junction formation.

199 Inhibition of VE-cadherin clustering at adherens junctions (function-blocking antibody; FBA) red

200 che interactions are mediated by heterotypic adherens junctions (hAJs) involving cancer-derived E-cad

201 functions, as a structural component of the adherens junction in cell adhesion and as the T-cell fac

202 al cells and sustains the remodelling of the adherens junction in response to mechanical forces.

203 plasmic specialization (ES) is an actin-rich adherens junction in the seminiferous epithelium of adul

204 ral analysis shows actin accumulation at the adherens junction in TOCA-1-knockout cells but unaltered

205 e analysis shows that PDZD11 is localized at adherens junctions in a PLEKHA7-dependent manner, becaus

206 lial-mesenchymal transitions (EMTs), loss of adherens junctions in Drosophila melanogaster gastrula i

207 and the clustering of E-cadherin into basal adherens junctions in early cellularisation.

208 In addition, ROS disassembles adherens junctions in epithelial cells via posttranslati

209 .05), a cytoskeletal protein associated with adherens junctions in FF pups suggested impaired gut str

210 conclude that Myo1c stabilizes E-cadherin at adherens junctions in polarized epithelial cells and tha

211 nt with Oct4/POUV phenotypes observed in the adherens junctions in Xenopus ectoderm, mouse embryonic,

212 y we sought to identify how contractility at adherens junctions influences apoptotic cell extrusion.

213 2 and VE-cadherin phosphorylation, preserved adherens junction integrity and VEGFR2.VE-cadherin compl

214 rb juxtamembrane domain was not required for adherens junction integrity, it was necessary for MZ loc

215 t cell contractility is required to maintain adherens junction integrity.

216 Thus, the adherens junction is not a uniform structure but a mosai

217 ction structure, and the ability to regulate adherens junctions is dependent on GAP activity and sign

218 ctive oxygen species-mediated disassembly of adherens junctions is pivotal for the acute epidermal da

219 The activity of this complex at adherens junctions is thereby essential for normal epith

220 e to the regulation of cell-cell tension and adherens junctions is unknown.

221 n pancreatic beta-cells Kirrel2 localizes to adherens junctions, is regulated by multiple post-transl

222 ial cadherin (VE-cadherin), a constituent of adherens junctions, leads to dissociation of its stabili

223 It consists of short stretches of adherens junction-like contacts inserted between interme

224 Src or cause appropriate dissolution of the adherens junctions made up of the proteins vascular endo

225 ires two major events: local dissociation of adherens junctions manifested as gaps in vascular endoth

226 thelial glycocalyx layer (EGL) and tight and adherens junction markers with plasma leakage.

227 acto-myosin tension-mediated anchoring, and adherens junction maturation following de novo cell-cell

228 d EGFR activation and promoted disruption of adherens junctions, migratory and invasive properties in

229 We demonstrated reduced adherens junction molecule (CD31 and VE-cadherin) expres

230 Here we report on the roles of adherens junction molecule modulation of survivin and th

231 how that alphaE-catenin recruits vinculin to adherens junctions more effectively than alphaN-catenin,

232 presses the expression of a key component of adherens junctions, N-cadherin, and promotes the detachm

233 VE-cadherin) is an adhesive protein found in adherens junctions of endothelial cells.

234 e developed, for the first time, detects the adherens junctions of epithelial cells in 3D, without th

235 symbol CTNND1) is an important component of adherens junctions of epithelial cells; however, its fun

236 nd that 18 CCARPs link to core components of adherens junctions or desmosomes.

237 epletion disrupted apical-basal polarity and adherens junction organization in mesoderm cells, sugges

238 helicase, is required for cell polarity and adherens junction organization in the Drosophila melanog

239 When released from the adherens junction, p120ctn promotes cell migration throu

240 RhoA signaling at adherens junctions plays a key role in this process by c

241 VE-cadherin clustering at adherens junctions promotes protective endothelial funct

242 pericyte cell survival; N-cadherin, the key adherens junction protein between endothelium and pericy

243 At the molecular level, transcription of the adherens junction protein E-cadherin is upregulated, lea

244 ultured cells and enhanced expression of the adherens junction protein E-cadherin.

245 spreads to epithelia expressing nectin-4, an adherens junction protein expressed preferentially in th

246 ic activation molecule (SLAM; CD150) and the adherens junction protein nectin-4 (poliovirus receptor-

247 e discovery that measles virus (MV) uses the adherens junction protein nectin-4 as its epithelial rec

248 The adherens junction protein P-cadherin appears loosely dis

249 The adherens junction protein p120-catenin (p120ctn) shuttle

250 n of astrocytic gap junction and endothelial adherens junction protein using immunostaining and Weste

251 Src-related tyrosine phosphorylation of the adherens junction protein vascular endothelial cadherin

252 junction protein occludin (p < 0.05) and the adherens junction protein VE-cadherin (p < 0.05).

253 eins, reduction in expression of endothelial adherens junction protein, and reduced microvascular rea

254 ithelial cells, we demonstrated that loss of adherens junction protein, epithelial cadherin, and the

255 clustering of the main endothelial-specific adherens junction protein, VEC (vascular endothelial cad

256 cells and decreased production of tight- and adherens-junction protein, resulting in leakage of serum

257 at dorsal and ventral cell boundaries, where adherens junction proteins accumulate.

258 Here we show that the adherens junction proteins afadin and CDH2 are critical

259 n which it shows partial colocalization with adherens junction proteins and apical proteins.

260 PGN+poly(I:C) treatment disturbed adherens junction proteins and increased apoptotic cell

261 d organization of actin denticle precursors, adherens junction proteins and microtubules in the epide

262 r photobleaching (FRAP), we demonstrate that adherens junction proteins are stabilized at the cleavag

263 ein that co-localizes and interacts with the adherens junction proteins E-cadherin and beta-catenin i

264 Although we observed reduced expression of adherens junction proteins E-cadherin, beta-catenin, and

265 and reflect a loss in expression of the key adherens junction proteins epithelial (E)- and neural (N

266 By contrast, adherens junction proteins fail to accumulate to the wil

267 n did not affect the expression of tight and adherens junction proteins such as ZO-1, claudin, and JA

268 The colocalization of KCNQ1 with adherens junction proteins was lost with increasing EMT

269 tracellular domains of the E- and N-cadherin adherens junction proteins, that both E- and N-cadherin

270 e, which may be related to the relocation of adherens junction proteins.

271 The PVM/Ms modulate expression of tight- and adherens-junction proteins in the endothelial barrier of

272 he apical zonula adherens (ZA) of epithelial adherens junctions recruit the core components of the RN

273 Apical complex proteins and adherens junctions regulate the different modes of divis

274 s been extensively studied in the context of adherens junction reinforcement to stabilize adhesive ce

275 catenin complex to the actin cytoskeleton at adherens junctions remain unclear.

276 pply during early stages of ciliogenesis and adherens junction remodeling.

277 n of an E-cadherin/Rap1 complex required for adherens junction sealing.

278 othelial cells and pericytes, which disrupts adherens junction structure and function, and this was s

279 lular tight junctions (tTJs) and tricellular adherens junctions (tAJs) have been identified.

280 podocytes at the slit diaphragm, a modified adherens junction that comprises the protein filtration

281 protein associated with the E-cadherin-based adherens junction that regulates cell-cell adhesion.

282 role of APC2 and F-actin in maintaining the adherens junctions that anchor GSCs to the niche.

283 al tissue architecture is maintained through adherens junctions that are created through extracellula

284 ons between epithelial cells are mediated by adherens junctions that are dynamically regulated during

285 ng the composition and function of tight and adherens junctions that define paracellular transport pr

286 Although apical localization of the adherens junctions, the Par complex, the Crumbs complex

287 tic field to temporarily disrupt endothelial adherens junctions through internalized iron oxide nanop

288 zed role for DUSP23 in regulating E-cadherin adherens junctions through promoting the dephosphorylati

289 l (hPSC)-derived BMECs, particularly through adherens junction, tight junction, and multidrug resista

290 rity requires coordination between cell-cell adherens junctions, tight junctions (TJ), and the periju

291 helial cells transmit contractile force with adherens junctions to mediate morphological changes like

292 tight junctions (Claudins and ZO proteins), adherens junctions (VE-cadherin, alpha-Actinin), and the

293 In collecting lymphatics, adherens junctions were disrupted, and the vessels leake

294 ocalize to apical intestinal epithelial cell adherens junctions, where they are critical for junction

295 Ageing impairs the activity of adherens junctions, which contributes to endothelial dil

296 hol exposure leads to reduction in tight and adherens junctions, which in turn leads to increases in

297 These microtubules maintain adherens-junctions while actin maintains microtubules, a

298 at the Cdt induced substantial remodeling of adherens junctions, with a potential impact on the barri

299 ion, aligned with the apical actin cable and adherens-junctions within chick and mouse neuroepithelia

300 Adherens junctions (zonula adherens) are essential for m