ライフサイエンスコーパス: adiposity

1 ce, decreased fasting insulin, and decreased adiposity.

2 rain consumption and reduced body weight and adiposity.

3 ween polyunsaturated fatty acids (PUFAs) and adiposity.

4 elation between temporal eating patterns and adiposity.

5 terol levels and improvements in measures of adiposity.

6 stances (PFASs) is associated with childhood adiposity.

7 vidual-level safety was associated with more adiposity.

8 sex-specific BMI percentiles, as measures of adiposity.

9 ociated with bone loss and enhanced visceral adiposity.

10 blood pressure, and obesity, mainly central adiposity.

11 maternal BMI resulting in greater offspring adiposity.

12 ased indexes are poor surrogates for newborn adiposity.

13 animals that display hypophagia and reduced adiposity.

14 intolerance without accompanying changes in adiposity.

15 in addition to reduced body weight and total adiposity.

16 focused on unravelling the underpinnings of adiposity.

17 reports suggest a positive association with adiposity.

18 lammation typically associated with visceral adiposity.

19 trations for children at different levels of adiposity.

20 ) blunted food intake, body weight gain, and adiposity.

21 d hamsters, which is associated with reduced adiposity.

22 and childhood were inversely associated with adiposity.

23 , resulting in reductions in body weight and adiposity.

24 ce fetal outcomes including birth weight and adiposity.

25 ed from HFD-induced weight gain and elevated adiposity.

26 ould include measures of central and general adiposity.

27 the population regardless of their degree of adiposity.

28 with GHS-R in the regulation of bone marrow adiposity.

29 ist circumference was used as the measure of adiposity.

30 on when taking into account the variation in adiposity.

31 e may contribute to developmental origins of adiposity.

32 Meanwhile, it also inhibited bone marrow adiposity.

33 y, and AMY1 copies have been associated with adiposity.

34 olice-recorded crime was not associated with adiposity.

35 absent when compared to those with increased adiposity.

36 dation, fetal insulin resistance, and excess adiposity.

37 in osteopenia coupled with increased marrow adiposity.

38 ing in significantly reduced weight gain and adiposity.

39 due to volume overload and variable visceral adiposity.

40 d a lower SI at age 18 years, independent of adiposity.

41 ations were not associated with excess child adiposity.

42 ritol compared with participants with stable adiposity.

43 sure control and the development of visceral adiposity.

44 mpact of adjacent genetic variation on human adiposity.

45 energy expenditure, respiratory quotient, or adiposity.

46 umference to height (WHTR) ratio for central adiposity; 4) age; 5) smoking; 6) glucose tolerance; and

47 is polymorphism best predicted body mass and adiposity, a dominant model was most predictive of NAcc

48 crease vascular risk in all individuals with adiposity above normal range.

49 Early adiposity accretion from birth to 9 years and late linea

50 1) studied the association of SGA birth with adiposity, adjusting for baseline covariates only, and 2

51 % of individuals carrying the most favorable adiposity alleles had higher BMIs (0.120 kg/m(2) [95% CI

52 . 50%; P = 3E-14), but in men, the favorable adiposity alleles were associated with higher waist circ

53 copies are associated with 2-year changes in adiposity among 692 overweight and obese individuals who

54 natural sources, and subsequent measures of adiposity among girls enrolled in the Breast Cancer and

55 ntly associated with poorer diet quality and adiposity among women, after adjustment for covariates a

56 ease-associated weight loss), having central adiposity and a BMI corresponding to normal weight or ov

57 Metabolic pathways that contribute to adiposity and ageing are activated by the mammalian targ

58 as an mTORC1-S6K1 target that contributes to adiposity and ageing.

59 The reduced adiposity and antisteatotic effects observed in ZFP36L1-

60 feeding-fasting transition but also promotes adiposity and associated metabolic disorders in fat-fed

61 ChEAT) at age 11.5 y and in whom we measured adiposity and blood pressure at ages 6.5, 11.5, and 16 y

62 alter the genetic susceptibility to overall adiposity and body fat distribution.

63 played a significant decrease in the gain of adiposity and body weight as well as an improvement in g

64 petite stimulation and a drive to accumulate adiposity and body weight.

65 of a breastfeeding promotion intervention on adiposity and BP at age 16 years and on longitudinal gro

66 upported the findings linking methylation to adiposity and cardiometabolic disease.

67 dea that dietary fat per se promotes ectopic adiposity and cardiometabolic syndrome in humans.

68 we recruited 88 healthy adults with varying adiposity and chronic stress exposure.

69 that early-life exposure to BPA may increase adiposity and circulating lipid levels in rodents.

70 ht in WT and KIKO, in part, due to increased adiposity and daytime carbohydrate utilization in WT and

71 s revealing new insights in the link between adiposity and disease risk.

72 Moderate improvements in adiposity and fitness with ILI did not mitigate the adve

73 Synergy between adiposity and genotype promoted the full spectrum of NAF

74 -protein diets are associated with decreased adiposity and greater HDL cholesterol than lower protein

75 which may confound associations between own adiposity and HIF3A methylation.

76 was independently associated with decreased adiposity and increased skeletal muscle compared with th

77 ating obese mice with NAT3 or AAT3 decreases adiposity and increases lean mass.

78 se our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk,

79 ons of insulin metabolism stemming from high adiposity and lipogenic diets.

80 Maternal obesity programmed increased adiposity and liver triglycerides, with decreased glucos

81 sely, chronic stress-exposed men had greater adiposity and lower cardiovascular responses to acute st

82 olic pathways that correspond with increased adiposity and lower fat-free mass in early infancy.

83 ially affect the ability to reverse visceral adiposity and metabolic syndrome.

84 The role of TRPC1 in adiposity and obesity-associated metabolic diseases has

85 socio-demographic and diet-related factors, adiposity and other diseases.

86 Developmentally, high neo-natal adiposity and preferential distribution of resources to

87 ulin levels independently of weight gain and adiposity and prevented hepatic lipid accumulation.

88 These changes were accompanied by increased adiposity and reduced glucose production and glucose tol

89 nd no evidence of strong interaction between adiposity and sequence variants influencing other adipos

90 and lean mass index (LMI) were surrogates of adiposity and skeletal muscle, respectively.

91 irectional, prospective associations between adiposity and sleep duration (covariates included demogr

92 Cross-sectional analyses of adiposity and sleep duration in younger adults suggest t

93 genetic support for a link between childhood adiposity and T1D risk.

94 ementation with fermentable fiber suppresses adiposity and the associated parameters of metabolic syn

95 level, decreased investment in muscularity, adiposity and the digestive tract allow for a larger bra

96 e relationship between general and abdominal adiposity and the risk of heart failure.

97 rivers, while consolidating the link between adiposity and the sympathetic nervous system.

98 ve of a causal association between abdominal adiposity and these outcomes.

99 ntified robust associations between maternal adiposity and variations in newborn blood DNA methylatio

100 sidential density had a protective effect on adiposity and was associated with lower BMI (beta -0.22

101 a result of its leptin-dependent effects on adiposity and, to a lesser extent, the promotion of adip

102 sociations between PFAS and birth weight and adiposity, and between PFAS and maternal glucose and lip

103 n through increased energy intake, increased adiposity, and dyslipidemia.

104 etary BCAAs will promote weight loss, reduce adiposity, and improve blood glucose control in diet-ind

105 hts into the biologic pathways influenced by adiposity, and may enable development of new strategies

106 was to examine the associations between GS, adiposity, and mortality.The UK Biobank study is an ongo

107 measures of valvular/vascular calcification, adiposity, and muscle attenuation.

108 robiome in a manner that contributes to host adiposity, and reflect upon the remarkable advances and

109 obesity regimens, CR decreased body weight, adiposity, and serum metabolic hormones as expected and

110 Both interventions reduced adiposity, and showed a modest improvement in glucose to

111 yperglycemia, glucose intolerance, increased adiposity, and steatosis, with large lipid droplets in t

112 5-hydroxyvitamin D (25(OH)D) concentration), adiposity, and telomere length are not well established.

113 Our analyses accounted for age, sex, adiposity, and the use of psychoactive medications.

114 lar mortality.Lower grip strength and excess adiposity are both independent predictors of higher mort

115 olic and inflammatory consequences of excess adiposity are critical drivers of non-AIDS events in thi

116 dy was to evaluate how different measures of adiposity are related to both arterial inflammation and

117 This is the first report of neonatal adiposity as a predictor of AD at 6 and 12 months of age

118 e we propose a cell-autonomous mechanism for adiposity as a result of persistent cell surface glucose

119 k-out female mice exhibited mild obesity and adiposity as described previously, as well as a signific

120 The genetics of general adiposity, as measured by body mass index, and that of a

121 g for body mass index, we found that central adiposity, as measured by waist circumference, was assoc

122 ssociations between exposure to p,p'-DDE and adiposity assessed by body mass index (BMI) z-score.

123 deficient mice display progressive increased adiposity associated with adipocyte hypertrophy.

124 ly, the microbe significantly attenuated the adiposity associated with the model and altered the seru

125 sity and sequence variants influencing other adiposity-associated traits.

126 or BMI reversed (i.e., to positive) the SGA-adiposity association.

127 at each visit, test differences in phthalate-adiposity associations across visits, and model trajecto

128 wo statistical methods to estimate phthalate-adiposity associations at each visit, test differences i

129 ss in uMSC-adipocytes were related to higher adiposity at 5 months of age.

130 To examine the relationship between child adiposity at 8 y of age and repeated urinary biomarkers

131 l long-term consequences of lower weight and adiposity at birth associated with prenatal PFAS exposur

132 Adiposity at birth was approximately 10% lower in the hi

133 PFAS concentrations and offspring weight and adiposity at birth, and secondarily to estimate associat

134 These results indicate that adiposity augments genetic risk of NAFLD at multiple loc

135 henotype [incident central adiposity, stable adiposity, baseline hemoglobin A1c (HbA1c) > 5.05%, HbA1

136 units per km(2) was positively related with adiposity, being associated with higher BMI (beta 0.19 k

137 l prepregnancy adiposity may influence child adiposity beyond the transmitted genetic effects, which,

138 eighborhood crime and safety with changes in adiposity (body mass index (BMI) and waist circumference

139 for body mass index [WHRadjBMI]) and general adiposity (body mass index [BMI]) with cardiometabolic d

140 atterns, nutrient intakes, diet quality, and adiposity (body mass index, waist circumference, weight

141 e, recorded intake of potatoes, and measured adiposity (body weight, body mass index, or waist circum

142 e attenuation, and U-shaped association with adiposity) but similar patterns in men and women.

143 8 y of age were associated with higher child adiposity, but earlier childhood concentrations were not

144 -life phthalate exposure may influence child adiposity, but prior studies have not determined if ther

145 that EDCs can predispose individuals toward adiposity by affecting developmental processes, little i

146 ck adipose tissue in EPA and DHA and reduced adiposity by promoting more, but smaller, adipocytes.

147 detailed measurements of global and regional adiposity (by magnetic resonance imaging and dual-energy

148 oxygen consumption, percentage of body fat (adiposity) by dual-energy x-ray absorptiometry, moderate

149 ncentrations included older child age, lower adiposity, carpeting or a rug in the child's bedroom, hi

150 Neighborhood-level safety likely influences adiposity change and subsequent cardiovascular risk in m

151 ic regression models with BMI used to define adiposity, compared with metabolically healthy/normal we

152 Visceral adiposity confers significant risk for developing metabo

153 age-accelerated muscle atrophy and increased adiposity, consistent with sarcopenic obesity.

154 ply rising global prevalence of obesity, how adiposity contributes to transformation (stage a non-tum

155 acteristics, including increased bone marrow adiposity, decreased bone mass, and impaired MSC self-re

156 , coronary, and valvular calcification); (2) adiposity (defined by pericardial, visceral, hepatic, an

157 uring pregnancy and newborn birth weight and adiposity demand fuller characterization.

158 tes and monoethyl phthalate (MEP) with child adiposity depended on the timing of exposure.

159 besity-related phenotypes, including central adiposity, diabetes mellitus, insulin resistance, and ci

160 er amylase activity may have greater loss of adiposity during low-calorie diet interventions.

161 It has been suggested that greater maternal adiposity during pregnancy affects lifelong risk of offs

162 erences were most apparent for biomarkers of adiposity, endothelial dysfunction, inflammatory cell re

163 ng the renin-angiotensin-aldosterone system, adiposity, energy expenditure, and pancreatic cell activ

164 In LD hamsters with increased adiposity, FGF21 lowered body weight as a result of both

165 es of physical activity facilities and lower adiposity for adults in mid-life.

166 hat were generated by divergent selection on adiposity for over 60 generations.

167 with 0.9 +/- 0.2, respectively;P= 0.04), but adiposity from birth to 12 mo of age and growth trajecto

168 In contrast, genes associated with abdominal adiposity function in adipose tissue.

169 ated that DeltaBMIZ was the optimal proxy of adiposity gain (P < 0.0001, pairwise difference).Weight-

170 Participants with incident central adiposity gain had statistically significantly higher bl

171 mic markers associated with incident central adiposity gain were investigated in young adults.

172 When assessing adiposity gain, DeltaBMIZ is the best indicator of fat a

173 s not appear to be explained by differential adiposity gains in infancy.

174 In observational studies, abdominal adiposity has been associated with type 2 diabetes and c

175 Both general and central adiposity have causal effects on CHD and type 2 diabetes

176 a key protein regulating energy balance and adiposity, have been related to obesity and glucose meta

177 (LD) photoperiods that increase appetite and adiposity, however these effects are attenuated in short

178 iation was observed for triclosan and girls' adiposity; however, it was due to effect modification by

179 iet, manifested in increased body weight and adiposity, impaired glucose tolerance, and elevated insu

180 a clinical condition characterized by excess adiposity, impaired glycaemic control, dyslipidaemia and

181 showed decreased body weight, reduced total adiposity, improved insulin sensitivity, enhanced energy

182 We assessed overall and central adiposity in 1,006 children in early childhood (median,

183 French fries were positively associated with adiposity in 3 of 3 studies.

184 rient intakes, diet quality, and measures of adiposity in a representative sample of Australian adult

185 Intriguingly, reduced adiposity in Ad-FLD mice was associated with increased o

186 sulting in BAT atrophy and increased overall adiposity in adult mice.

187 In this cohort, birth size and adiposity in adulthood interact to predict events of car

188 inical consequences, and treatment of excess adiposity in adults with treated HIV infection.

189 exposure has been associated with increased adiposity in animal models, mediated through the gut mic

190 previously identified CpG sites at HIF3A and adiposity in approximately 1,000 mother-offspring pairs

191 ed a comparable reduction in body weight and adiposity in both genotypes because of a negative effect

192 age (SGA) birth is associated with increased adiposity in childhood and adulthood have been based on

193 lymorphisms (SNPs) associated with childhood adiposity in children aged 2-10 years.

194 (22:6 n-3) has been associated with reduced adiposity in children, suggesting the possibility to pro

195 tral infusion of UGN reduces weight gain and adiposity in diet-induced obese mice.

196 al exposure to perfluoroalkyl substances and adiposity in early and mid-childhood.

197 ociations of prenatal exposure to PFASs with adiposity in early and mid-childhood.

198 Increased adiposity in hip OA patients is associated with altered

199 s between FTO variants and PA on measures of adiposity in Latinos.

200 ing found no differences in wheel running or adiposity in male or female offspring, suggesting that c

201 alleviated diet-induced body-weight gain and adiposity in mice.

202 ith both measures of EE and both measures of adiposity in Pima Indians, where the G allele (frequency

203 s between exposure to p,p'-DDT and increased adiposity in rodents.

204 d evidence in support of a role of childhood adiposity in T1D (odds ratio in Egger regression, 2.76,

205 trength and often accompanies an increase in adiposity in the elderly.We examined the association of

206 cal activity facilities were associated with adiposity in UK adults.

207 n the ability of MR to reduce body weight or adiposity, increase energy intake and expenditure, incre

208 The adiposity-increasing allele (C) of the MC4R variant rs65

209 on as reflected by increased body weight and adiposity index in adult male offspring that is parallel

210 on as reflected by increased body weight and adiposity index in adult male offspring that is parallel

211 To assess the merits of each adiposity index, 3 criteria were used: stability with ag

212 Body weight, food intake, adiposity index, fasting insulin, triglycerides and chol

213 uced obese Wistar rats significantly reduces adiposity index, whole body weight, glucose, triacylglyc

214 Blood levels of leptin and adiposity indexes (body mass index and waist circumferen

215 S6K1-deficient mice normalized body mass and adiposity, indicating that EPRS phosphorylation mediates

216 We regressed adiposity indicators of body-mass index (BMI; kg/m(2)),

217 (2006-2010) included measurements of GS and adiposity indicators, including body mass index (BMI; in

218 consistent associations with blood pressure, adiposity, insulin resistance, and blood lipids.

219 The degree of adiposity, insulin resistance, and dyslipidemia in KW mi

220 -grade inflammation, thereby contributing to adiposity, insulin resistance, and other predisease stat

221 ly reduced food intake and totally prevented adiposity, insulin resistance, and steatosis.

222 results suggest that dietary soy ameliorates adiposity, insulin sensitivity, adipose tissue inflammat

223 any patients with OA are obese and increased adiposity is associated with chronic inflammation, we in

224 adults, our findings suggested that greater adiposity is associated with decreases in sleep duration

225 er, it is unknown whether maternal pregnancy adiposity is associated with long-term risk of adverse m

226 ion in younger adults suggest that increased adiposity is associated with shorter sleep.

227 higher mortality risk associated with excess adiposity is attenuated, although not completely attenua

228 Gene expression associated with general adiposity is enriched in the nervous system.

229 attenuated effects in the animal model where adiposity is reduced naturally independent of photoperio

230 The accumulation of visceral adiposity is strongly associated with systemic inflammat

231 , whether this association is independent of adiposity is uncertain.The purpose of this study was to

232 that body mass index (BMI; a key measure of adiposity) is associated with widespread changes in DNA

233 ith inflammatory response, fetal growth, and adiposity later in life.

234 be due to reversed causation with increased adiposity leading to suboptimal concentrations of circul

235 This association was stronger for increasing adiposity levels (leptin by body mass index interaction,

236 -based anthropometric indexes as proxies for adiposity, little is known regarding the extent to which

237 y prespecified secondary outcomes, including adiposity, liver function tests, incidence of conjugated

238 elderly is accompanied by increased visceral adiposity, lower exercise capacity, failure to maintain

239 ed at baseline and months 3 and 6.Changes in adiposity markers were greater in participants who were

240 Central adiposity may have a stronger effect on stroke risk.

241 Maternal prepregnancy adiposity may influence child adiposity beyond the trans

242 orly understood, recent studies suggest that adiposity may influence DNA methylation, a key regulator

243 to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-

244 Given that adiposity, measured by BMI, is associated with widesprea

245 /height (m)2) measured concurrently with the adiposity measurement.

246 le groups) were related to changes in girls' adiposity measurements from ages 7 through 15 years.

247 PFASs was associated with small increases in adiposity measurements in mid-childhood, but only among

248 ain most of the associations seen with other adiposity measures and metabolic factors.

249 These data suggest that adiposity measures are associated with PA and FTO varian

250 We profile six adiposity measures in 3666 twins and estimate their heri

251 ween genetic risk for obesity and phenotypic adiposity measures is exacerbated by adverse sleeping ch

252 The implications of different adiposity measures on cardiovascular disease etiology re

253 ll associations for boys and early-childhood adiposity measures.

254 eetened beverages, in relation to changes in adiposity measures.

255 ulation, observed effect of baseline central adiposity on future periodontitis progression is conditi

256 Future estimates of the burden of adiposity on health should include measures of central a

257 we found support for an effect of childhood adiposity on T1D risk (odds ratio 1.32, 95% CI 1.06-1.64

258 of this study was to determine the effect of adiposity on the architecture and composition of hip OA

259 Triclosan was positively associated with adiposity only among overweight girls.

260 the LD state are a consequence of increased adiposity or of the central photoperiodic state.

261 lyzing the association between SGA birth and adiposity outcomes (skinfold thicknesses and bioelectric

262 ative associations between SGA birth and all adiposity outcomes.

263 use human energy metabolism evolved to favor adiposity over leanness, the availability of palatable,

264 additional factors in producing variation in adiposity patterns between species and across human cont

265 ed maternal grandfathers exhibited increased adiposity, plasma leptin and luteinising hormone to test

266 For women, abdominal adiposity, rather than overall body size, was associated

267 in part from failing to account for central adiposity, rather than reflecting a protective physiolog

268 ylation are predominantly the consequence of adiposity, rather than the cause.

269 asis and impaired insulin secretion increase adiposity, reduce skeletal muscle mass, and cause system

270 e link between DNA methylation, obesity, and adiposity-related diseases in the general population rem

271 onship between DNA methylation, obesity, and adiposity-related diseases.

272 Adiposity-related inflammation is associated with a redu

273 ctor 1 [SREBF1]), demonstrated links to BMI, adiposity-related traits, and coronary artery disease.

274 The fitted restricted cubic spline adiposity-residential density dose-response curve identi

275 Here we show that adiposity significantly amplifies the effect of three se

276 ls was pooled by phenotype [incident central adiposity, stable adiposity, baseline hemoglobin A1c (Hb

277 ained by the metabolic syndrome and visceral adiposity, suggesting a possible specific contribution o

278 able effects on both whole-body and regional adiposity that could facilitate health span in humans.

279 However, in LD animals with reduced adiposity, the effect of FGF21 on body weight, caloric i

280 cific phenols during childhood may influence adiposity through adolescence.

281 Although the mechanisms linking adiposity to associated clinical conditions are poorly u

282 , MI, diabetes, lipids, glycaemic traits and adiposity to obtain unconfounded estimates, with body ma

283 aytime sleepiness and increased measures for adiposity traits (body mass index (BMI): rg = 0.20, P =

284 GWAS) for BMI, waist-to-hip ratio, and other adiposity traits have identified more than 300 single-nu

285 0 genetic regions now are known to influence adiposity traits.

286 tary behavior, with effects on BMI and other adiposity traits.

287 -pattern score was inversely associated with adiposity, triglycerides, liver enzymes, C-reactive prot

288 plays an important role in the regulation of adiposity via autophagy and apoptosis and that TRPC1 inh

289 and contrast causal associations of central adiposity (waist-to-hip ratio adjusted for body mass ind

290 Total adiposity was an independent risk factor for endometrial

291 Midlife adiposity was derived from BMI data at 50 years of age.

292 p to 11.6% of the effect of PFAS on neonatal adiposity was mediated by maternal glucose concentration

293 Greater body size (overall and abdominal adiposity) was positively associated with colorectal can

294 asure of genetic predisposition to abdominal adiposity, was constructed with 48 single-nucleotide pol

295 Associations with lipids, diabetes and adiposity were assessed using the Global Lipids Genetics

296 MI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI

297 and survival, confirm a novel form of excess adiposity with paradoxical suppression of leptin express

298 increased significantly body weight (BW) and adiposity, with additive effects after sequential exposu

299 ipoprotein and total cholesterol levels, and adiposity, with evidence of a dose-response effect, with

300 energy balance and metabolism, and decreased adiposity, with the effects of lactoferrin being partly

301 ody mass index (BMI), a measure of abdominal adiposity, with type 2 diabetes and CHD through the pote