ライフサイエンスコーパス: adjuvanticity

1 novel and effective approach to improve its adjuvanticity.

2 and size as critical factors affecting their adjuvanticity.

3 mma-Syk-Card9 pathway for APC activation and adjuvanticity.

4 ation is a critical determinant for Th1/Th17 adjuvanticity.

5 that stress is involved in the mechanism of adjuvanticity.

6 nd conversely that stress agents will elicit adjuvanticity.

7 plored the underlying basis for this form of adjuvanticity.

8 ice revealed a GM1-independent pathway of LT adjuvanticity.

9 y be a superior method for measuring mucosal adjuvanticity.

10 uirements for cytokine-mediated pathways for adjuvanticity.

11 ent mouse model, and oral immunogenicity and adjuvanticity.

12 N-gamma to antigen could further enhance its adjuvanticity, a chimeric protein involving IFN-gamma an

13 that appears to be important for its mucosal adjuvanticity and immunogenicity.

14 ponses, including B-lymphocyte mitogenicity, adjuvanticity and macrophage activation.

15 i-B7.2 Ab in vivo inhibited both the mucosal adjuvanticity and the immunogenicity of CT.

16 nicity, reduced allergenicity, and intrinsic adjuvanticity and thus represent promising vaccines for

17 greatly dampened both CT immunogenicity and adjuvanticity, and the differential CT responses in IgA(

18 toxic properties of CT can be separated from adjuvanticity, and the mCTs induce Ab responses via a Th

19 Although there was a difference in adjuvanticity between AS03 and MF59 at a lower dose (3.7

20 n and, moreover, suggest novel mechanisms of adjuvanticity by non-toxic derivatives of type II entero

21 immunity and indicates that antigenicity and adjuvanticity can be decoded by distinct innate immune r

22 mark of stress, as well as inflammasomes and adjuvanticity, commensurate with those of alum, which ma

23 We found that flu adjuvanticity correlates with the upregulation of proinf

24 on of caspase 1, production of IL-1beta, and adjuvanticity, demonstrated by enhancing OVA-specific se

25 nses, indicating partial independence of TDB adjuvanticity from inflammasome activation.

26 Discovery of CT adjuvanticity has prompted the generation of CT chimeras

27 endogenous danger signals has been linked to adjuvanticity; however, the role of extracellular ATP du

28 ANTES and CpG ODN had capacities for mucosal adjuvanticity, i.e., for enhancing serum and vaginal ant

29 fy DC-derived IL-2 as a key mediator of alum adjuvanticity in vivo and the Src-Syk pathway as a poten

30 To identify the determinants of Th1/Th17 adjuvanticity, in vivo tracking experiments using fluore

31 to examine the hypothesis that alum-mediated adjuvanticity is a function of stress and conversely tha

32 A pivotal role for pDCs in the adjuvanticity is ascertained by significant abrogation o

33 Thus, LPS adjuvanticity is based on MyD88 promoting T cell surviva

34 s, but whether these are responsible for the adjuvanticity is controversial.

35 is ill-known, and a better understanding of adjuvanticity is needed to develop improved adjuvants ba

36 immunization; therefore, unlike toxicity, LT adjuvanticity is not dependent on the AB5 holotoxin stru

37 ant, our results suggest a mechanism for the adjuvanticity of Alum.

38 lls and antigen-presenting cells, the strong adjuvanticity of CFA could be attributed, at least in pa

39 Although the mechanism of adjuvanticity of CT is not completely understood, it is

40 relationship of these effects to the mucosal adjuvanticity of CT.

41 D11c (encoded by Itgax) was required for the adjuvanticity of CT.

42 be approved for human use, we evaluated the adjuvanticity of Escherichia coli heat-labile toxin (LT)

43 We studied the adjuvanticity of GPI-anchored CCL28 co-incorporated with

44 proteins prompted the investigation into the adjuvanticity of Invaplex.

45 In addition, we found that the adjuvanticity of LPS to induce T-cell activation is comp

46 that the toxicity, immunogenicity, and oral adjuvanticity of LT are dependent upon binding of the B

47 bunit to further understand the toxicity and adjuvanticity of LT.

48 eceptor through a mAb, we confirmed that the adjuvanticity of MF59 and Pam3CSK4 to a trivalent influe

49 The B cell adjuvanticity of MF59 appears to be mediated by the pote

50 In this study, we further evaluated the adjuvanticity of rOv-ASP-1 and explored its mechanism of

51 The adjuvanticity of the CpG ODN was secondary to their dire

52 nthesis and establishment of the stand-alone adjuvanticity of the examined synthetic adjuvant (2b) op

53 urface pegylation on the biodistribution and adjuvanticity of the formulations, in a bid to further m

54 binding in the toxicity, immunogenicity, and adjuvanticity of the heat-labile enterotoxin of Escheric

55 These results demonstrate the adjuvanticity of the NP adjuvant in inducing persistent

56 relating the biodistribution pattern and the adjuvanticity of the strong CD8(+) T-cell inducing lipos

57 r their potential involvement in MPL-induced adjuvanticity or in its ability to protect against sepsi

58 ty of cancer cells mostly by affecting their adjuvanticity rather than their antigenicity.

59 presentation, although the mechanisms of its adjuvanticity remain poorly understood.

60 ne use in humans, although the basis for its adjuvanticity remains poorly understood.

61 ne use in humans, although the basis for its adjuvanticity remains poorly understood.

62 PEI adjuvanticity required release of host double-stranded D

63 However, CT adjuvanticity required type-I IFN sensitivity, participa

64 In this article, we show that alum adjuvanticity requires IL-2 specifically released by DCs

65 ts without systemic exposure can afford good adjuvanticity, suggesting peripheral innate activation (

66 To identify innate immune correlates of adjuvanticity to influenza subunit vaccine, we investiga

67 een proposed that IFN type I is required for adjuvanticity to influenza vaccines, we found that MF59

68 Furthermore, PTX co-adjuvanticity was Bhlhe40 dependent.

69 When mucosal adjuvanticity was examined, both dmCTs induced enhanced

70 Even though significant mucosal adjuvanticity was seen with both mCT E112K and nCT, neur

71 role of edema toxin (EdTx) components in its adjuvanticity, we examined how a PA mutant lacking the a

72 in molecules, which were developed to retain adjuvanticity without the toxicity associated with the n