ライフサイエンスコーパス: administer orally

1 adjuvant for regional analgesia but not when administered orally.

2 (900 mg once per day) or 8 weeks of placebo administered orally.

3 ydrolysed by endogenous proteases and may be administered orally.

4 op live, attenuated HAV vaccines that can be administered orally.

5 tment with succimer, a lead chelator that is administered orally.

6 d mucosal and systemic lymphoid tissues when administered orally.

7 kg), a glycogen phosphorylase inhibitor, was administered orally.

8 sessed the desired detrusor selectivity when administered orally.

9 otulinum neurotoxin serotype A is toxic when administered orally.

10 ophilic drugs are often poorly absorbed when administered orally.

11 rom this class of TFMKs were not active when administered orally.

12 and intestinal antibody responses than VLPs administered orally.

13 triene formation with an ED50 = 7 mg/kg when administered orally.

14 and the spontaneously hypertensive rat when administered orally.

15 y in the Plasmodium berghei mouse model when administered orally.

16 st in developing small molecules that can be administered orally.

17 rge volumes of enteric contrast material are administered orally.

18 wed a markedly reduced gastric toxicity when administered orally.

19 Drugs were administered orally.

20 can CNS penetration, 200 mg/kg gefitinib was administered orally 1 hour before 4 mg/kg topotecan i.v.

21 Rapamycin administered orally (1 mg/kg per d for 7 d) significantl

22 l occurred when 2 x 10(6) corneal cells were administered orally 10 days before orthotopic corneal tr

23 (relaxation group), and 0.5-mg of alprazolam administered orally 15 minutes before CNB (medication gr

24 Two days later, 400 mg of ketoconazole was administered orally 2 hr before to the morning dose.

25 Biotin was administered orally (2.1, 8.2, or 81.9 micromol) or intr

26 sion of the NGF receptor-IR elements, C3 was administered orally (25 mg/kg, once a day), by gavage, 7

27 Latrepirdine (20 mg) vs matching placebo administered orally 3 times daily for 26 weeks.

28 yelodysplastic syndromes (MDS), MGCD0103 was administered orally 3 times weekly without interruption.

29 TMZ was administered orally 30 minutes after completion of each

30 tivity on bladder smooth muscle in vivo when administered orally (31, ED(50) = 3 mg/kg) in a rodent m

31 d in diabetic subjects only when glucose was administered orally (37.8 +/- 14.9 vs 68.3 +/- 22.8 nmol

32 Treatment was administered orally 5 d/wk for 3 months.

33 ZD6169 (5 mg/kg), administered orally 5 h prior to stimulation, significan

34 PN401 was administered orally 8 hours after 5-FU administration, t

35 Acyclovir or a matched placebo was administered orally, 800 mg five times daily, for 21 day

36 Treatments were administered orally, 801 mg or 399 mg three times a day.

37 A-988315 (20 or 60 mg/kg) or water was administered orally 90 min before retention testing, fol

38 domized to receive 8 weeks of valganciclovir administered orally (900 mg once per day) or 8 weeks of

39 However, when administered orally, A-784168, with good CNS penetration

40 None of the 3 isoflavonoid compounds administered orally affected liver alcohol dehydrogenase

41 Contrast media were administered orally and by means of an enema.

42 ent lack of cardiovascular side effects when administered orally and high affinity (K(i) of 36 nM for

43 Zinc stable isotopes were administered orally and intravenously.

44 ncipal adverse event observed when 2-CdA was administered orally and IV.

45 tive high-affinity FXR inhibitor that can be administered orally and prevents, or reverses, high-fat

46 HPV-16 and HPV-18 VLPs are immunogenic when administered orally and that oral coadministration of th

47 e characteristics of clinical use (low doses administered orally and titrated for therapeutic effects

48 other genotypes may also be immunogenic when administered orally and whether mucosal adjuvants can be

49 rine lymphoid tumors (even when the drug was administered orally) and against human breast and bladde

50 ing 48Ca administered intravenously and 46Ca administered orally, and measuring 48Ca, 46Ca, and 42Ca

51 acute exacerbation of COPD low-dose steroids administered orally are not associated with worse outcom

52 mor activity in murine xenograft models when administered orally as a lipid-based formulation or impl

53 eated with azithromycin at a dosage of 2.0 g administered orally as a single dose with cure rates for

54 in the rat, dog, and cynomolgus monkey when administered orally as a solution formulation.

55 (13)C-glycerol tripalmitin was administered orally as an independent measure of CM TAG

56 Of these 16 new anilides administered orally as one 6 mg/kg dose combined with 18

57 VP-16 was administered orally as repeated 21-day courses at 50 mg/

58 Immunosuppressants were administered orally as single daily doses.

59 of human tumor xenografts in nude mice when administered orally as single-agent therapy.

60 in humans is three to five times higher when administered orally as the prodrug.

61 hritis in rats with established disease when administered orally at 0.3 and 3 mg/kg twice daily.

62 RAD was administered orally at 0.5 mg/kg per day for days 0 to 1

63 Everolimus was administered orally at 10 mg daily and letrozole was adm

64 Administered orally at 10 mg/kg the level of reversal wa

65 ced blood pressure by more than 45 mmHg when administered orally at 10 mg/kg to the spontaneously hyp

66 n thyroparathyroidectomized (TPTX) rats when administered orally at 10 mg/kg.

67 %, comparable to the effect of carbamazepine administered orally at 100 mg/kg.

68 were randomly assigned to receive ivacaftor administered orally at 150 mg (n = 26) or placebo (n = 2

69 ered orally at 10 mg daily and letrozole was administered orally at 2.5 mg daily.

70 Sildenafil (n = 79) or a placebo (n = 81) administered orally at 20 mg, 3 times daily for 12 weeks

71 Sildenafil (n = 113) or placebo (n = 103) administered orally at 20 mg, 3 times daily for 12 weeks

72 and 42 induced tumor growth inhibition when administered orally at 200 mg/kg/day.

73 Lenalidomide was administered orally at 25 mg on days 1 through 21 of a 2

74 ppressing >/= 99.8% parasitemia in mice when administered orally at 25 mg/kg, b.i.d., for 4 days.

75 Marimastat was administered orally at 25, 50, or 100 mg twice daily to

76 ethyl-2H3]methionine and [2H2]cysteine) were administered orally at 30-min intervals for 8 h.

77 Sorafenib was administered orally at 400 mg twice daily on a continuou

78 Alisertib was administered orally at 50 mg twice daily for 7 days in 2

79 Prednisone or a matched placebo was administered orally at 60 mg/d for the first 7 days, 30

80 Everolimus was administered orally at a daily dose of 2.1, 3, 5, or 6.5

81 Patients received artesunate, administered orally at a daily dose of either 2 mg per k

82 stay of at least 3 days to receive apixaban, administered orally at a dose of 2.5 mg twice daily for

83 When administered orally at a single 10(4) (CFU) dose, SC602

84 betic rat model for approximately 17 h, when administered orally at a single dose of 2 mg/kg/day.

85 In nonclinical studies, fidaxomicin was administered orally at approximately 1 g/kg/d to dogs fo

86 zed to receive placebo or 274 mg of ADS-5102 administered orally at bedtime for up to 25 weeks.

87 r human or nonhuman primate populations, was administered orally at doses ranging from 10(6) to 10(10

88 Drug was administered orally at escalating doses as a solution (2

89 Quizartinib was administered orally at escalating doses of 12 to 450 mg/

90 PT2385 was administered orally at twice-per-day doses of 100 to 1,8

91 ubcutaneously) and FTY720 (0.3 mg/kg per day administered orally), both administered on day -2 throug

92 virulence attenuation when the strains were administered orally but not when they were administered

93 urium fis mutant is attenuated 100-fold when administered orally, but has wild-type virulence when ad

94 olytic actions with a low bleeding risk when administered orally, but its benefit for preventing recu

95 In groups PROB and LIP/PROB, the PROB was administered orally by addition to the drinking water of

96 ce a day, or imatinib 400 mg once a day, all administered orally, by use of a computer-generated rand

97 he intravenous formulation of irinotecan was administered orally daily for 5 days for 2 consecutive w

98 Temozolomide was administered orally daily for 5 days, with subsequent co

99 Vorinostat was administered orally daily starting at 180 mg/m(2)/d with

100 Erlotinib was administered orally daily to groups of at least three as

101 m(2) on days 1 to 3 and etoposide 40 mg/m(2) administered orally days 1 through 14.

102 5bb administered orally demonstrated a biphasic effect on th

103 kg), a glycogen phosphorylase inhibitor, was administered orally, either alone to create mild hypogly

104 Thereafter, 80 mg/kg hydroxyurea was administered orally every 3 days.

105 Pravastatin and nicotinamide were administered orally every day for 14 days, starting on t

106 hionine aminopeptidase type 2 inhibitor, was administered orally every other day at 1, 5, or 10 mg/kg

107 Pterosin A, administered orally for 4 weeks, effectively improved hy

108 variectomy-induced bone loss in the rat when administered orally for 6 months at 10 mg/kg/d and was p

109 Citicoline (500 mg/day) was administered orally for 6 weeks, and patients were follo

110 maximum tolerated dose (MTD) of capecitabine administered orally for 7 days followed by a 7-day rest

111 PSC 833 was administered orally for 7 days, beginning 72 hours befor

112 AQX-1125 (450 mg daily) or placebo was administered orally for 7 days.

113 n the present phase 1 study, capravirine was administered orally for up to 28 days to 55 HIV-1-infect

114 elial cells from relevant donor strains were administered orally from day -14 to day -4 on a daily ba

115 any potential neuroprotective agent must be administered orally, have a safe profile and poses a bro

116 Both treatments were administered orally in 10 ml (increasing to 20 ml, accor

117 Alisertib was administered orally in 21-day cycles at the recommended

118 C3 was administered orally in 5, 10, and 25 mg/kg/day concentra

119 onventional antimicrobial therapy, which was administered orally in 96 percent.

120 In addition, we propose that the vaccine be administered orally in a 2-dose schedule, with the first

121 hion via subcutaneous implant, whereas P was administered orally in a cyclic fashion.

122 owth regression at well tolerated doses when administered orally in a human BT474 human breast cancer

123 4m and its efficacy and GI tolerability when administered orally in a rat adjuvant arthritis model.

124 ofile and demonstrated maximal efficacy when administered orally in a rat adjuvant arthritis model.

125 ole 6d demonstrated impressive efficacy when administered orally in a rat model of arthritis and in a

126 c disease, a range of doses (0.4-100 mg) was administered orally in a single dose before challenge.

127 e tablets were dissolved into a solution and administered orally in a single dose.

128 d possesses antiinflammatory properties when administered orally in an in vivo murine inflammation mo

129 icin and paclitaxel in xenograft models when administered orally in combination therapy.

130 When suboptimal doses were administered orally in combination to wild-type mice, IF

131 Conclusions-Heparin, administered orally in combination with the delivery age

132 limus (18 mg/day and 5 mg/day, respectively) administered orally in continuous 28-day cycles until di

133 MA 800 mg/d was administered orally in divided doses.

134 WAY-202196 or control (vehicle) was administered orally in doses ranging from 1.5 to 50 mg/k

135 Here, we find that EGCG administered orally in drinking water (50 mg/kg) similar

136 SM16 was administered orally in formulated chow.

137 Dasatinib (15 to 240 mg per day) was administered orally in four-week treatment cycles, once

138 veral compounds that exhibited efficacy when administered orally in murine pyelonephritis and pneumon

139 When administered orally in murine xenograft models, CX-4945

140 escalations in the dose of PLX3397 that was administered orally in patients with solid tumors (dose-

141 treated with escalating doses of clopidogrel administered orally in solution until either a clinicall

142 nonreplicating rNV VLPs are immunogenic when administered orally in the absence of any delivery syste

143 Nicotine was administered orally in the drinking water to achieve ser

144 Finally, an NOS-2 inhibitor, aminoguanidine, administered orally in the drinking water, was tested fo

145 Arimoclomol was administered orally, in drinking water, from symptom ons

146 VLPs administered orally induced serum antibody and intestina

147 Oseltamivir (GS4104), which can be administered orally, is the prodrug of GS4071, a potent

148 a favorable risk-to-benefit ratio when it is administered orally long-term to patients with the pruri

149 When administered orally, LY333531 ameliorated the glomerular

150 When administered orally, mastic oil inhibited the growth of

151 cobalamin deficiency, 2 mg of cyanocobalamin administered orally on a daily basis was as effective as

152 dose for disease-directed studies of OSI-774 administered orally on a daily, continuous, uninterrupte

153 ydrogenase, allows fluorouracil (5-FU) to be administered orally on a schedule that simulates continu

154 Melphalan and prednisone were administered orally on days 1 to 4; carfilzomib was IV a

155 CHOP intravenously on day 1 (with prednisone administered orally on days 1 to 5) or VR-CAP (R-CHOP re

156 Dexamethasone 40 mg daily was administered orally on days 1, 8, 15, and 22 of each cyc

157 ither olaparib (200 mg capsules twice daily, administered orally on days 1-10 of each 21-day cycle) p

158 Therapy was administered orally on the first 5 days of a 28-day cycl

159 Temodar was administered orally once a day for five consecutive days

160 LGD1069 administered orally once daily at doses that ranged from

161 COL-3 was administered orally once daily at one of two doses (grou

162 of five dose cohorts of lapatinib (GW572016) administered orally once daily continuously.

163 Darapladib 160 mg or placebo monotherapy was administered orally once daily for 3 months, and patient

164 pidermal growth factor receptor (EGFR), when administered orally once daily on an intermittent-dose s

165 Sunitinib (25, 37.5, or 50 mg) was administered orally once daily on three dosing schedules

166 Erlotinib was administered orally once daily to cohorts of three to si

167 COL-3 administered orally once daily to patients with AIDS-rel

168 COL-3 was administered orally once daily, and doses were escalated

169 ing mortality using doses of 5 to 1.25 mg/kg administered orally once daily, even when treatments wer

170 cancer with 125 mg of motesanib diphosphate, administered orally once daily.

171 Pazopanib 800 mg was administered orally once daily.

172 (Ocean Spray, Lakeville-Middleboro, MA) and administered orally once per day for 5 days every 3 week

173 Valganciclovir administered orally once per day is well tolerated and s

174 th extracranial solid tumors is 12 mg/m(2)/d administered orally, once daily, continuously.

175 LCL161 was administered orally, once weekly, on a 21-day cycle to a

176 tion of diatrizoate meglumine and sodium was administered orally or by means of a nasogastric tube as

177 es weeks of antibiotic therapy, which can be administered orally or intravenously via a peripherally

178 Mouse studies indicate that caffeine, administered orally or topically, promotes apoptosis of

179 ither eukaryotic cells or model animals when administered orally or topically.

180 xotoxin A (SPEA) did not cause symptoms when administered orally or vaginally.

181 All-trans retinoic acid administered orally (oral ATRA) may not regularly lead t

182 tients underwent active AMPT (five 1-g doses administered orally over 28 hours) and placebo (diphenhy

183 Vitamin C at a dose of 1.25 g administered orally produced mean (+/-sd) peak plasma co

184 wn that this novel formulation of AmB can be administered orally, resulting in 99% inhibition of para

185 ant number (N = 34) of these macrocycles are administered orally, revealing that oral bioavailability

186 BALB/c mice administered orally serovar Typhimurium chi4550 expressi

187 low bioavailability of bisphosphonates when administered orally, subsequent studies tested the mice

188 terone metabolites 1 and 2 are inactive when administered orally, suggesting that 3 beta-substitution

189 Eltrombopag is a TPO nonpeptide mimetic administered orally that activates the TPO receptor by b

190 We found that when administered orally, the control virus was far more viru

191 ere also markedly altered; for example, when administered orally, the maximum plasma concentration fo

192 When administered orally, these new carboxyphenyltrioxanes ar

193 Dipyridamole 75 mg was administered orally three times daily during the FU admi

194 ears or older were treated with mocetinostat administered orally three times per week, in 28-day cycl

195 -escalation phase (n = 47), panobinostat was administered orally thrice weekly every week in combinat

196 isted of FOLFOX-4 with gefitinib at 500 mg/d administered orally throughout the 14-day cycle.

197 STI571 was administered orally to 83 patients with CML in the chron

198 9-cis-Retinal was administered orally to a subset of Rpe65(-/-) mice, and

199 Moreover, AV513 administered orally to AAV-FVIII dogs and treatment-naiv

200 ective when applied topically to the skin or administered orally to affect the colon but are not effe

201 der filling, 30 mL of corn oil emulsion were administered orally to all patients followed by dynamic

202 nuated compared to the wild-type parent when administered orally to BALB/c mice and were less invasiv

203 groups severely attenuated the mutants when administered orally to BALB/c mice, but the mutants colo

204 virulence in the msbB mutant background when administered orally to BALB/c mice.

205 sed constitutively in Lactococcus lactis and administered orally to C57 BL/6 mice.

206 ated rotavirus vaccines lacked efficacy when administered orally to calves and pigs in the field, pre

207 clinical trials of monopreparations of CoQ10 administered orally to cancer patients were included.

208 Gefitinib (150, 300, 400, or 500 mg/m2) was administered orally to cohorts of three to six patients

209 ability to inhibit plasma ACE activity when administered orally to conscious normotensive rats.

210 kg), a glycogen phosphorylase inhibitor, was administered orally to decrease glucose output in each o

211 Rather, when administered orally to fasted mice, glucose was directed

212 Injected or administered orally to fasted or normally fed mice at th

213 Vector strains were administered orally to germfree mice that were subsequen

214 de synthesized from D-amino acids (D-4F) was administered orally to LDL receptor-null mice on a Weste

215 (3.2 mg/kg/day) and CsA (10 mg/kg/day), when administered orally to Lewis rats for 10 days (day 0-9),

216 ility was established whereby compounds were administered orally to mice and plasma levels were measu

217 TM preferentially concentrates in liver when administered orally to mice and potently inhibits hepati

218 VNI displays promising pharmacokinetics and administered orally to mice at 25 mg/kg for 30 days cure

219 ly 4F synthesized from D-amino acids (D-4F), administered orally to mice did not raise HDL-cholestero

220 , to assess its efficacy in vivo, BTKB66 was administered orally to mice for 7 days before subjecting

221 The compounds were administered orally to mice with acute T. cruzi infectio

222 50) values of 0.14 mg/kg and 0.08 mg/kg when administered orally to mice with acute toxoplasmosis.

223 Antigens were administered orally to mice, and antigen-specific genera

224 When administered orally to mice, these compounds exhibited p

225 ild-type Salmonella serovar Typhimurium when administered orally to mice, while the PmrA-regulated ge

226 mately 5-fold increased 50% lethal dose when administered orally to mice.

227 ARRY-063 was administered orally to ovalbumin (OVA) sensitized and ch

228 toxicity and good antimalarial activity when administered orally to P. berghei -infected mice.

229 Lorlatinib was administered orally to patients at doses ranging from 10

230 emic and hypotriglyceridaemic responses when administered orally to rat and dog.

231 ive P2X3 and P2X2/3 receptor antagonist, was administered orally to rats and found to produce highly

232 d that also contained two chlorine atoms was administered orally to rats, and samples of bile, urine,

233 or growth delay at well tolerated doses when administered orally to SCID mice implanted with PTEN-def

234 doses of egg white or ovomucoid as OIT were administered orally to sensitized mice.

235 Elacridar and cold erlotinib were administered orally to wild-type (WT) and Abcb1a/b;Abcg2

236 opotecan in combination with ABT-888 (10 mg) administered orally twice a day (BID) were evaluated.

237 ce a day on days 1 to 28 and abexinostat was administered orally twice a day on days 1 to 5, 8 to 12,

238 Patients and Methods MK-8242 was administered orally twice a day on days 1 to 7 in 21-day

239 lacebo, tofacitinib at 1, 3, 5, 10, or 15 mg administered orally twice a day, or adalimumab at 40 mg

240 ratio, to four regimens: 5 mg of tofacitinib administered orally twice daily (132 patients); 10 mg of

241 Lonafarnib was administered orally twice daily at dose levels of 70, 90

242 Lapatinib was administered orally twice daily at escalating doses star

243 ctive) and appropriate placebo solution were administered orally twice daily for 12 months, and child

244 ylcysteine 1200 mg or matching placebo) were administered orally twice daily for 2 doses before and 2

245 levels of 50, 65, 85, and 110 mg/m(2)/dose, administered orally twice daily for 28 days, with course

246 Imatinib mesylate administered orally twice daily for AIDS-related KS resu

247 ecitabine (825, 1,000, or 1,250 mg/m(2)) was administered orally twice daily on days 1 to 14 every 3

248 ) or control (capecitabine 1000 mg/m(2) self-administered orally twice daily on days 1-14 on each 21-

249 ase 2 open-label study, 400 mg nilotinib was administered orally twice daily to 280 patients with Phi

250 ML120B was administered orally twice daily, either prophylactically

251 ays to receive either 100 mg of minocycline, administered orally twice daily, or placebo.

252 AZD1775 was administered orally twice per day over 2.5 days per week

253 Ibrutinib at a daily dose of 420 mg was administered orally until disease progression or the dev

254 tment followed by 2 weeks without treatment) administered orally until disease progression or unaccep

255 Allogeneic dendritic cells (DC) were administered orally using a protocol that is known to re

256 tenuated recombinant Listeria monocytogenes, administered orally utilizing its natural route of infec

257 fficacy of azithromycin at a dosage of 2.0 g administered orally was equivalent to that of benzathine

258 opiridol had a similar activity in vivo when administered orally, we examined neointimal formation in

259 , and antiviral effects of ganciclovir (Gcv) administered orally were evaluated in 36 children infect

260 70Zn and dysprosium were administered orally with all meals for 5 consecutive day

261 Axitinib or placebo were administered orally with food at a starting dose of 5 mg

262 taste-masked preparation of SNAC 2.25 g was administered orally with heparin 30000 to 150000 IU.

263 eogenic gene expression in the liver of mice administered orally with metformin.

264 Temozolomide was administered orally within 60 minutes of the end of the

265 In mice, these VLPs are immunogenic when administered orally without adjuvant, and they elicit se

266 Such a hybrid vaccine, administered orally, would stimulate immune responses bo