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1 acyl-enzyme intermediate so that the mutant adopts a conformation analogous to that of the acyl-enzy
2 ), together with its 2',3'-cyclic phosphate, adopts a conformation close to and approximately perpend
3 (2+) and SNAP25 to bind the plasma membrane, adopting a conformation compatible to interact with the
5 icating that calcium binding results in LapG adopting a conformation competent for interaction with t
6 m66, the N-terminal region of the gp41 MPER adopts a conformation comprising a helix, followed by an
7 the structural features of the receptor that adopt a conformation different from that observed in the
8 at at acidic pH, the PhoQ periplasmic domain adopts a conformation different from that in the presenc
10 ear magnetic resonance (NMR) spectroscopy to adopt a conformation distinct from that seen in crystals
12 esting that Glu-plasminogen on cell surfaces adopts a conformation distinct from that in solution.
13 itivity and inhibition by luminal Ca(2+) and adopts a conformation distinct from the activated state
14 nd shape of the template anions, dynamically adopting a conformation either where all four azaphospha
15 II suppressor mutations induce Switch II to adopt a conformation favorable for nucleotide binding an
17 s controlled by the ability of the latter to adopt a conformation in which carbonyl groups are almost
18 e form of the ribozyme-substrate complex can adopt a conformation in which helices 2 and 3 are coaxia
19 ificant proportion of HIV-1 MA molecules may adopt a conformation in which myristic acid is hidden an
20 her TF family members and (2) the N-lobe can adopt a conformation in which the cleft closes when iron
21 The compounds with an axial phenyl commonly adopt a conformation in which the plane of the aromatic
22 , and it showed that the ouabain derivatives adopt a conformation in which the sugar extends out of t
23 MR data (1) demonstrate that Abeta(1)(-)(40) adopts a conformation in amyloid fibrils with two in-reg
25 ntrast, the PKB-selective inhibitor A-443654 adopts a conformation in PKB and PKA-PKB that differs fr
26 ation also implies that the acetylenic chain adopts a conformation in which a significant interaction
27 w that 1) newly synthesized protein kinase C adopts a conformation in which its pseudosubstrate seque
28 summary, newly synthesized protein kinase C adopts a conformation in which its pseudosubstrate seque
29 STAT2, whereby the semiphosphorylated dimers adopted a conformation incapable of importin-alpha bindi
30 uctural studies indicate that the C1 complex adopts a conformation incompatible with intramolecular a
31 luble mutants refolded from inclusion bodies adopted a conformation inherent to the wild-type N(t)-FD
32 suggesting that the anchor-minus ectodomain adopts a conformation largely similar to the postfusion
34 itands are conformationally flexible, always adopting a conformation locating the phenyl substituents
36 eaded through the RNA exit channel, where it adopts a conformation mimicking that of a single strand
37 sts that the protease binding loop of ecotin adopts a conformation mimicking that of the cleaved stra
38 , in contrast to the free protein, Y35G BPTI adopts a conformation nearly identical with that of the
40 e FMN is reduced to the semiquinone form and adopts a conformation ("O-up") in which O 58 hydrogen bo
42 s their membrane affinity and causes them to adopt a conformation on membranes that is similar to the
43 consisting in part of Asp168-Phe169-Gly170, adopts a conformation permitting lipophilic and hydrogen
44 ent behavior of His-143 in which the residue adopts a conformation proximal to the site of catalytic
46 oligomerization, and the resulting oligomers adopt a conformation representing a state of reduced act
47 lutaraldehyde-fixed rat brain sec6/8 complex adopts a conformation resembling the letter "T" or "Y".
48 ckbone flexibility of the switch loop, which adopted a conformation restricting the pathway toward th
49 eing partially inserted into beta-sheet A to adopt a conformation similar to an intermediate on the p
50 the asymmetric unit that are bound to FliM16 adopt a conformation similar to BeF3- -activated wild-ty
51 e stabilize the integrin-bound conformation, adopt a conformation similar to earlier-evolving family
52 cellular ends of helices 3 and 6 together to adopt a conformation similar to that found in inactive r
53 e coat protein has an enhanced propensity to adopt a conformation similar to that found in the native
54 axial phenyl group at C(5) of 1,3-dioxane to adopt a conformation similar to that in axial phenylcycl
55 side chains, with two methylene groups, can adopt a conformation similar to that of Pro side chains,
56 uses sigma(32) to initiate transcription can adopt a conformation similar to that of sigma(70)-contai
57 re prediction suggest that Cdh23 ectodomains adopt a conformation similar to the classic cadherins.
58 gly (although not as well as the wild type), adopted a conformation similar to that of the wild type.
60 P-70 reveals that the inactive kinase domain adopts a conformation similar to that of cyclin-dependen
62 ral analysis showed that SUV3-83, at pH 5.0, adopts a conformation similar to that of SUV3-70, sugges
63 dynamics simulations, the fCS repeating unit adopts a conformation similar to that of the Le(x) blood
64 tion, we find that the EGFRK activation loop adopts a conformation similar to that of the phosphoryla
66 ral change that affects a mobile loop, which adopts a conformation similar to that seen in complexes
67 NA ASL indicate that the threonyl side chain adopts a conformation similar to that seen in the soluti
68 the Sec4-GDP crystals, the switch II region adopts a conformation similar to that seen in the struct
69 thered Rad4 flips out normal nucleotides and adopts a conformation similar to that seen with damaged
71 ructure of an AM-8138.COX-2 complex, AM-8138 adopts a conformation similar to the unproductive confor
72 the guanine at the N7 position permits it to adopt a conformation such that the Hoogsteen face of the
73 analysis showed that the GCAP1-I143NT mutant adopted a conformation susceptible to proteolysis, and t
74 usual overall architecture that allows it to adopt a conformation that appears to facilitate pairwise
75 tic activity of Sos by forcing the domain to adopt a conformation that destabilizes the autoinhibitor
76 non-denaturing gels) that TR-T(4) complexes adopt a conformation that differs from TR-T(3) complexes
77 on K252 and allowing tubulin heterodimers to adopt a conformation that disfavors tubulin incorporatio
78 on enables the monomethyllysyl side chain to adopt a conformation that is catalytically competent for
80 is that the A and B rings of aminoglycosides adopt a conformation that is recognized not only by the
81 ng to greater flexibility and the ability to adopt a conformation that minimizes steric clashing and
82 , the omega-aminoalkyl side chains prefer to adopt a conformation that points them toward the 3'-base
85 3-580) in the zymogen serine protease domain adopt a conformation that would be predicted to sterical
86 eover, as the temperature was lowered, Tyr31 adopted a conformation that more effectively blocked the
87 g revealed that the CYP17 inhibitor-bound AR adopted a conformation that resembled the unliganded AR
88 tive site cavity, is partially disordered or adopts a conformation that allows access to the cavity.
91 es indicate that the (S)-nucleotide backbone adopts a conformation that has little impact on the over
93 t in many cases, the inhibitor-bound protein adopts a conformation that is distinct from its unbound
95 DNA contacts in the DNA-bound structure, it adopts a conformation that is incompatible with DNA bind
96 5'-imidotriphosphate-bound form, this mutant adopts a conformation that is intermediate between the G
97 on during activated catalysis, whereas K335Q adopts a conformation that is resistant to trypsin cleav
98 ructure, the characteristic UCU bulge of TAR adopts a conformation that is stabilized by three divale
99 rystallographic analysis: The remodeled loop adopts a conformation that is within 1-A Calpha RMSD of
100 Upon lysine binding, the lysC riboswitch adopts a conformation that not only inhibits translation
102 ed in other alanine racemase structures, PLP adopts a conformation that significantly distorts the pl
103 In the NADP(+)-free structure, the loop adopts a conformation that sterically hinders NADP(H) bi
104 in revealed that the (1248)SFYYS(1252) motif adopts a conformation tightly packed against the kinase
107 ex with ATP reveals that the gamma-phosphate adopts a conformation unique among Fic domains that seem
108 Mutants missing this buried 30-51 disulfide adopt a conformation very similar to that of the native
109 the modeling of a NifEN-bound "FeMoco" that adopts a conformation very similar to that of the MoFe p
110 stance where a bithiophene has been shown to adopt a conformation where the sulfur atoms are complete
111 reveal this region to be dynamic and able to adopt a conformation where U-1 is stacked with G33.
112 ranes lacking cholesterol and anionic lipids adopts a conformation where agonist binding is uncoupled
113 stal structures showed that the dppms ligand adopts a conformation which creates a sterically crowded
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