ライフサイエンスコーパス: adozelesin

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1 with that of the highly cytotoxic CPI agent adozelesin.

2 de higher than those of its parent CPI agent adozelesin.

3 ted similar covalent sequence specificity to adozelesin 3 and the racemic seco-CBI-TMI 4 for binding

4 that damage DNA, we examined the effects of adozelesin, a DNA-alkylating antitumor agent that has a

5 sor of the orc2-1-specific lethal effects of adozelesin, a DNA-alkylating drug.

6 The S phase checkpoint response triggered by adozelesin acts by inactivating RPA in some function ess

7 Here we determined how adozelesin affects chromosomal DNA replication at a mole

8 Further, adozelesin also induced "apparent" chi fragment formatio

9 Adozelesin also induced a cellular response that require

10 tent inhibitor of DNA unwinding, followed by adozelesin and hedamycin.

11 Therefore, whereas adozelesin and other anti-cancer therapeutics trigger co

12 One of the adducts, formed with adozelesin and the d(ATTAAT)(2) sequence, also demonstra

13 Bizelesin and adozelesin are DNA-reactive antitumor drugs that alkylat

14 e cyclopropylpyrroloindole anti-cancer drug, adozelesin, binds to and alkylates DNA.

15 m infected cells when they were treated with adozelesin, but not when the cells were also treated wit

16 trigger common DNA damage response markers, adozelesin causes DNA replication arrest through a uniqu

17 elesin-modified template DNAs suggested that adozelesin-DNA adducts inhibit DNA replication at the le

18 Adozelesin, ecteinascidin 743 (Et743) and hedamycin each

19 adozelesin motif, actual lesions induced by adozelesin exceeded by severalfold lesions by bizelesin

20 Mge1p also suppressed the lethal effects of adozelesin in parallel with the suppression of adozelesi

21 ent in the same chromosome were activated by adozelesin in rad53 and mec1 mutant cells.

22 treatment but was not due to the presence of adozelesin in the in vitro assay.

23 ozelesin in parallel with the suppression of adozelesin-induced alterations in protein-DNA interactio

24 Mutations in these genes did not abrogate adozelesin-induced inhibition of origin activity and for

25 Adozelesin inhibited initiation of S. cerevisiae DNA rep

26 -dimensional gel electrophoresis showed that adozelesin inhibited the activity of a replication origi

27 Adozelesin inhibition of nascent chain elongation is fir

28 Adozelesin is a member of a family of extraordinarily cy

29 The antitumor drug adozelesin is a potent cytotoxic DNA-damaging agent.

30 The proteasome-dependent pathway induced by adozelesin is conserved in the budding yeast Saccharomyc

31 Whereas adozelesin is likely to affect similar regions as bizele

32 Unwinding of adozelesin-modified DNA was accompanied by the appearanc

33 vious studies employing purified enzymes and adozelesin-modified template DNAs suggested that adozele

34 stent with the more frequent, less localized adozelesin motif, actual lesions induced by adozelesin e

35 hibition of the active replication origin by adozelesin, normally silent origins present in the same

36 ed concentrations of drug relative to either adozelesin or Et743.

37 cell death induced by the DNA-damaging drug adozelesin, or by a separate caspase-dependent pathway i

38 Treatment of human cells with low levels of adozelesin results in potent inhibition of both cellular

39 kely to affect similar regions as bizelesin, adozelesin's more promiscuous binding probably compromis

40 Extracts were prepared from adozelesin-treated cells and shown to be deficient in th

41 eplication could be rescued in extracts from adozelesin-treated cells by the addition of exogenous RP

42 DNA replication intermediates recovered from adozelesin-treated SV40 virus-infected cells.

43 Adozelesin treatment inhibits SV40 DNA replication at co

44 Adozelesin treatment of cells was shown to result in the

45 on of the RPA-cdc2 complex), indicating that adozelesin treatment triggers cellular DNA damage respon

46 of SV40 replication intermediates induced by adozelesin treatment was a consequence of maturation of

47 n was dependent on both the concentration of adozelesin used and the time of treatment but was not du

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