ライフサイエンスコーパス: adrenal insufficiency

1 on the type of lymphoma and/ or presence of adrenal insufficiency.

2 differ significantly (P > 0.5) for secondary adrenal insufficiency.

3 ticularly in the identification of secondary adrenal insufficiency.

4 seful therapeutic strategy for patients with adrenal insufficiency.

5 ul diagnostic threshold for the diagnosis of adrenal insufficiency.

6 0.30 to 0.60) for the diagnosis of secondary adrenal insufficiency.

7 evaluation of suspected primary or secondary adrenal insufficiency.

8 -language papers related to the diagnosis of adrenal insufficiency.

9 reshold of <18 microg/dL, 7% (two of 28) had adrenal insufficiency.

10 adrenal insufficiency but harms mice without adrenal insufficiency.

11 entration <18 microg/dL, 21% (six of 28) had adrenal insufficiency.

12 nsufficiency, 50% (14 of 28) of patients had adrenal insufficiency.

13 ause different criteria are used to diagnose adrenal insufficiency.

14 y variable assessed that was associated with adrenal insufficiency.

15 at varies with the criteria used to diagnose adrenal insufficiency.

16 ed high-dose fluconazole appeared to develop adrenal insufficiency.

17 he critical illness and relative or absolute adrenal insufficiency.

18 ported to cause complete XY sex reversal and adrenal insufficiency.

19 nd impaired quality of life in patients with adrenal insufficiency.

20 ophysitis with documented hypothyroidism and adrenal insufficiency.

21 here were no cases of clinically symptomatic adrenal insufficiency.

22 to 60% of severe septic patients experience adrenal insufficiency.

23 current infections, autoimmune features, and adrenal insufficiency.

24 ogen production, in addition to treatment of adrenal insufficiency.

25 aC likely contributes to the hyponatremia of adrenal insufficiency.

26 e administered to overcome etomidate-related adrenal insufficiency.

27 ia and uniformly revealed hypotension due to adrenal insufficiency.

28 sufficiency, and 69 (88%) had either form of adrenal insufficiency.

29 lation test to diagnose absolute or relative adrenal insufficiency.

30 atory criteria for the diagnosis of relative adrenal insufficiency.

31 ill patients who are in refractory shock and adrenal insufficiency.

32 d-free immunosuppression were diagnosed with adrenal insufficiency.

33 y failure, hypotension) was used to diagnose adrenal insufficiency.

34 og) cosyntropin was considered diagnostic of adrenal insufficiency.

35 (250-microg cosyntropin test), and secondary adrenal insufficiency (1-microg cosyntropin test), respe

36 ncy (250-microg cosyntropin test), secondary adrenal insufficiency (250-microg cosyntropin test), and

37 for summary ROC curves in tests for primary adrenal insufficiency (250-microg cosyntropin test), sec

38 hildren with suspected or proven "absolute"' adrenal insufficiency (2C).

39 ds only in children with suspected or proven adrenal insufficiency (2C); and a recommendation against

40 corticotropin testing, 44 (56%) had absolute adrenal insufficiency, 39 (50%) had relative adrenal ins

41 e sole diagnostic threshold for diagnosis of adrenal insufficiency, 50% (14 of 28) of patients had ad

42 In patients with cirrhosis, adrenal insufficiency (AI) is reported during sepsis and

43 lude uncommon manifestations like autoimmune adrenal insufficiency (AI), hypoparathyroidism, and chro

44 endent severe sepsis appear to have relative adrenal insufficiency and benefit from replacement gluco

45 only prescribed HDS to prevent perioperative adrenal insufficiency and cardiovascular collapse.

46 ufficiency but harms septic patients without adrenal insufficiency and encourage further efforts to t

47 e needed to define the risk of postoperative adrenal insufficiency and establish standardized practic

48 an nuclear receptors SF1 and DAX1 each cause adrenal insufficiency and gonadal dysgenesis in humans,

49 Our results suggest a basis for adrenal insufficiency and hypogonadotropic hypogonadism

50 enita, an X-linked disorder characterized by adrenal insufficiency and hypogonadotropic hypogonadism.

51 Therefore, the recognition of adrenal insufficiency and interventions to improve adren

52 Relative adrenal insufficiency and its clinical implications have

53 e raised in medical teams and patients about adrenal insufficiency and management of adrenal crisis t

54 ntubation is associated with higher rates of adrenal insufficiency and mortality in patients with sep

55 genetic syndrome of growth retardation with adrenal insufficiency and selective NK deficiency.

56 In addition, the associations between adrenal insufficiency and the CD4 count, human cytomegal

57 the current diagnostic approach to detecting adrenal insufficiency and the clinical consequences in c

58 adrenal insufficiency, 39 (50%) had relative adrenal insufficiency, and 69 (88%) had either form of a

59 with autosomal recessive growth retardation, adrenal insufficiency, and a selective NK cell deficienc

60 ts in a classic triad of hypoparathyroidism, adrenal insufficiency, and candidiasis.

61 er of very-long-chain fatty acid metabolism, adrenal insufficiency, and cerebral demyelination.

62 th hormone deficiency, primary hypogonadism, adrenal insufficiency, and hypothyroidism.

63 The lack of an adrenal insufficiency animal model and our poor understa

64 enger receptor BI mice as the first relative adrenal insufficiency animal model, we found that cortic

65 Current treatment options for adrenal insufficiency are limited to corticosteroid repl

66 in critically ill neonates and children with adrenal insufficiency are required to determine if these

67 Four of the nine patients had secondary adrenal insufficiency as determined by a normal aldoster

68 y be more promising in the prevention of the adrenal insufficiency associated with prolonged sepsis.

69 It is important to recognize patients with adrenal insufficiency, because this disorder may be fata

70 corticosteroid treatment benefits mice with adrenal insufficiency but harms mice without adrenal ins

71 erapy for a subgroup of septic patients with adrenal insufficiency but harms septic patients without

72 taneous candidiasis, hypoparathyroidism, and adrenal insufficiency, but patients also develop intesti

73 test performs well in patients with primary adrenal insufficiency, but the lower sensitivity in pati

74 f GC exposure to prevent perioperative acute adrenal insufficiency, but this practice is not well sup

75 t of patients met the diagnostic criteria of adrenal insufficiency by the low-dose test and 8% by the

76 The exception is adrenal insufficiency caused by glucocorticosteroids whi

77 Adrenal insufficiency, common in critically ill patients

78 sol was 10.0 +/- 4.8 microg/dL in those with adrenal insufficiency compared with 35.6 +/- 21.2 microg

79 Adrenal insufficiency continues to be a challenge for pa

80 Adrenal insufficiency contributes to morbidity in critic

81 linked disorder that typically presents with adrenal insufficiency during infancy.

82 CTH or cortisol-secreting tumours, secondary adrenal insufficiency ensues because of the prior suppre

83 nd serve as hormone substitution in cases of adrenal insufficiency explain their effectiveness in sta

84 nterferes with steroidogenesis and can cause adrenal insufficiency, fluconazole in standard doses is

85 ificantly greater than the AUC for secondary adrenal insufficiency for the high-dose cosyntropin test

86 s systemic inflammation and rescue mice with adrenal insufficiency from polymicrobial peritonitis.

87 I, which classically manifests as a triad of adrenal insufficiency, hypoparathyroidism, and chronic m

88 of dehydroepiandrosterone supplementation in adrenal insufficiency, hypopituitarism, osteoporosis, sy

89 lts of newly revised diagnostic criteria for adrenal insufficiency (i.e., stress cortisol concentrati

90 milies with SRNS and facultative ichthyosis, adrenal insufficiency, immunodeficiency, and neurologica

91 ility that high-dose fluconazole might cause adrenal insufficiency in already compromised critically

92 this study was to estimate the frequency of adrenal insufficiency in children with IBD that were at

93 The incidence of adrenal insufficiency in critically ill HIV-infected pat

94 There is a high incidence of adrenal insufficiency in critically ill HIV-infected pat

95 Adrenal insufficiency in critically ill patients is best

96 iscusses the current therapeutic approach to adrenal insufficiency in critically ill patients.

97 To help clarify the incidence of adrenal insufficiency in HIV-infected critically ill pat

98 icoids, by adrenalectomy in animal models or adrenal insufficiency in humans, has shown that endogeno

99 riteria for, and the prevalence of, relative adrenal insufficiency in patients with acute lung injury

100 nd defined clinical outcomes associated with adrenal insufficiency in preterm infants.

101 The frequency of secondary adrenal insufficiency in sepsis remains open to debate a

102 have a critical role in the manifestation of adrenal insufficiency in this model, through regulation

103 In addition, it examines the diagnosis of adrenal insufficiency in this population and provides an

104 The diagnosis of adrenal insufficiency in this population is challenging

105 itive than the high-dose test for diagnosing adrenal insufficiency in this population.

106 ay be helpful in identifying glucocorticoid (adrenal) insufficiency in patients with sepsis.

107 Adrenal insufficiency incidence was significantly higher

108 ls with adrenolectomized mice mimic clinical adrenal insufficiency, increase the susceptibility to se

109 Adrenal insufficiency is caused by either primary adrena

110 Adrenal insufficiency is common in patients with septic

111 Adrenal insufficiency is common in septic patients with

112 Primary adrenal insufficiency is life threatening and can presen

113 t therapy, health-related quality of life in adrenal insufficiency is more severely impaired than pre

114 ry, the incidence of postural hypotension or adrenal insufficiency is similar among those receiving h

115 eroid if the patient is on vasopressor or if adrenal insufficiency is suspected; and e) monitor for l

116 toxemia (LPS injection), we demonstrate that adrenal insufficiency is triggered early in the disease.

117 te that the patients' growth retardation and adrenal insufficiency likely reflect the ubiquitous but

118 -related serious adverse events (pemphigoid, adrenal insufficiency, liver disorder).

119 Thus, in adrenal insufficiency, loss of glucocorticoid feedback b

120 Adrenal insufficiency may be common in adults and childr

121 In such patients, adrenal insufficiency must be treated with hydrocortison

122 sisting of ulcerative/Crohn's colitis (n=6), adrenal insufficiency (n=5), hematological disorders (n=

123 lower sensitivity in patients with secondary adrenal insufficiency necessitates use of tests involvin

124 ocus and called ALADIN (alacrima, achalasia, adrenal insufficiency neurologic disorder).

125 We found that in the presence of fetal adrenal insufficiency, normal fetal lung development is

126 Reports of adrenal insufficiency occur but are rare and are confine

127 Although studies have indicated that adrenal insufficiency occurs after severe trauma and hem

128 Adrenal insufficiency occurs most in patients taking the

129 HPA axis activation and the role of relative adrenal insufficiency on the outcome of patients with ac

130 neumonitis (two [5%] and one [3%] patients), adrenal insufficiency (one [3%] and two [5%] patients),

131 For secondary adrenal insufficiency, only studies that stratified part

132 TH tests, patients were classified as having adrenal insufficiency or as normal.

133 This improvement may be due to treatment of adrenal insufficiency or from direct cardiovascular effe

134 Postoperative adrenal insufficiency or steroid dependency developed in

135 wer than 5 persons with primary or secondary adrenal insufficiency or with fewer than 10 persons as n

136 testing was the only variable predictive of adrenal insufficiency (p < .0001).

137 Under conditions of prolonged stress or adrenal insufficiency, persistent ACTH-induced changes i

138 ation increased the likelihood of developing adrenal insufficiency (pooled relative risk 1.33; 95% co

139 understanding of the pathogenesis caused by adrenal insufficiency present significant barriers to ad

140 The prevalence of relative adrenal insufficiency (RAI) in critically ill cirrhosis

141 Relative adrenal insufficiency (RAI) was demonstrated in patients

142 Thus, long-term management of patients with adrenal insufficiency remains a challenge, requiring an

143 -dependent sepsis and may indicate "relative adrenal insufficiency." Replacement glucocorticoid/miner

144 psis using genetic or surgical initiation of adrenal insufficiency resulted in increased mortality, b

145 Here we show that SF-1 +/- mice exhibit adrenal insufficiency resulting from profound defects in

146 he adrenal glands may be responsible for the adrenal insufficiency seen in patients with hemorrhagic

147 M4 and have shown that it is associated with adrenal insufficiency, short stature, and NK cell defici

148 Here, we have described a primary adrenal insufficiency syndrome and steroid-resistant nep

149 rty-five (72%) patients met our criteria for adrenal insufficiency (the hepatoadrenal syndrome).

150 ed corticosteroid insufficiency is caused by adrenal insufficiency together with tissue corticosteroi

151 In vasopressor-dependent patients without adrenal insufficiency, treatment with hydrocortisone did

152 In vasopressor-dependent patients with adrenal insufficiency, treatment with hydrocortisone was

153 Of the four patients with secondary adrenal insufficiency, two had a history of amenorrhea a

154 had immune-related SAEs, including two with adrenal insufficiency, two with pneumonitis, and one wit

155 One patient with known adrenal insufficiency underwent conservative ablation an

156 The incidence of adrenal insufficiency was 21% (six of 28) with a cortiso

157 We hypothesized that absolute and relative adrenal insufficiency was common in children with system

158 Adrenal insufficiency was determined using a cosyntropin

159 The incidence of absolute and relative adrenal insufficiency was determined using several defin

160 primary end point, whereas the prevalence of adrenal insufficiency was our secondary end point.

161 Absolute and relative adrenal insufficiency was prevalent in this cohort of ch

162 The area under the curve for primary adrenal insufficiency was significantly greater than the

163 with a complex progressive gait disorder and adrenal insufficiency, was referred for ophthalmic evalu

164 and 100% mortality in the three cases where adrenal insufficiency went unrecognized.

165 irus antigenemia, and other risk factors for adrenal insufficiency were determined.

166 he diagnostic criteria for etomidate-related adrenal insufficiency were fulfilled in 41 of 45 (91%) a

167 However, 61% of patients met the criteria of adrenal insufficiency when we used a baseline cortisol c

168 ction may underlie some forms of subclinical adrenal insufficiency, which become life threatening dur

169 The most serious potential adverse effect is adrenal insufficiency, which can be life threatening.

170 ed patients should undergo an evaluation for adrenal insufficiency with the stress cortisol concentra

171 iod or early childhood with virilization and adrenal insufficiency, with or without salt loss; the mi