ライフサイエンスコーパス: adrenomedullin

1 m a receptor for additional peptides such as adrenomedullin.

2 these effects, "uncovering" an inhibition by adrenomedullin.

3 ed, one of which was found to be the peptide adrenomedullin.

4 eptide, calcitonin gene-related peptide, and adrenomedullin.

5 d by small hairpin RNA-mediated knockdown of adrenomedullin.

6 ating the ability of the cells to respond to adrenomedullin.

7 ptor is involved in the autocrine actions of adrenomedullin.

8 s, CGRP, adrenomedullin (AM), and intermedin/adrenomedullin 2 (AM2), is well known to result in a Gal

9 Intermedin/Adrenomedullin-2 (IMD), a newly described peptide with s

10 Previous studies show that adrenomedullin, a cerebrovasodilator, prevented sex depe

11 ammatory response, we focused our studies on adrenomedullin, a peptide produced in response to bacter

12 Adrenomedullin, a potent vasoactive peptide, is actively

13 Adrenomedullin, a recently identified potent vasodilator

14 Patients with a MR-pro-adrenomedullin above this cutoff level had an odds ratio

15 These data indicate that adrenomedullin acting via ADMR increases the aggressiven

16 eceptor expression had functional effects on adrenomedullin activity, with increasing secretin recept

17 JMJD1A regulates the expression of adrenomedullin (ADM) and growth and differentiation fact

18 hypoxia (pO(2) 20 torr, 8 h), we identified adrenomedullin (ADM) as a prominent hypoxia-inducible fa

19 PC cells identified Sonic-hedgehog (SHH) and Adrenomedullin (ADM) as two differentially-expressed gen

20 or a single nucleotide polymorphism near the adrenomedullin (ADM) gene (rs6484218), with the best-fit

21 Therefore, we evaluated whether modulating adrenomedullin (Adm) gene dosage within tumor cells affe

22 The angiogenic peptide adrenomedullin (ADM) has been implicated as a mediator o

23 Adrenomedullin (ADM) is a circulating vasoactive peptide

24 The angiogenic factor adrenomedullin (ADM) is a hypoxia regulated gene.

25 Adrenomedullin (ADM) is a newly discovered endogenous va

26 Adrenomedullin (ADM) is elevated in heart failure (HF) a

27 The 52 amino acid peptide hormone adrenomedullin (ADM) plays a major role in the developme

28 Here, we report that adrenomedullin (ADM) significantly contributes to the ca

29 Production of adrenomedullin (ADM), a vasodilator peptide, increases i

30 nin, calcitonin gene-related peptide (CGRP), adrenomedullin (ADM), and amylin belong to a unique grou

31 monstrating that the dosage and signaling of adrenomedullin (Adm, gene; AM, protein)-a mitogenic pept

32 s endothelin-1, endothelin receptor A and B, adrenomedullin, adrenomedullin receptor, and vasopressin

33 ursor of atrial natriuretic peptide B and of adrenomedullin also increased approximately twofold.

34 The vasoactive hormone adrenomedullin (AM) and its binding protein (AMBP-1) are

35 Adrenomedullin (AM) and its receptor complexes, calciton

36 Two potent hypotensive peptides, adrenomedullin (AM) and proadrenomedullin N-terminal 20

37 expression of the pregnancy-related peptide adrenomedullin (AM) by fetal trophoblast cells is necess

38 Previous studies showed that adrenomedullin (AM) could be a promising agent for molec

39 milar to those of the recently characterized adrenomedullin (AM) gene KO despite the presence of elev

40 ecent study indicates that administration of adrenomedullin (AM) in combination with AM-binding prote

41 Adrenomedullin (AM) is a multifunctional peptide vasodil

42 Adrenomedullin (AM) is a multifunctional peptide vasodil

43 Adrenomedullin (AM) is a newly discovered hypotensive pe

44 Adrenomedullin (AM) is a peptide hormone with numerous e

45 Adrenomedullin (AM) is a potent lymphangiogenic factor t

46 Adrenomedullin (AM) is a potent vasodilator peptide in p

47 Adrenomedullin (AM) is an important regulatory peptide i

48 Adrenomedullin (AM) is peptide encoded, together with pr

49 calcitonin gene-related peptide (CGRP), and adrenomedullin (AM) peptides.

50 We have previously demonstrated that adrenomedullin (AM) plays a critical role as an autocrin

51 Although adrenomedullin (AM) previously has been identified in hu

52 n gene-related peptide (CGRP) receptor or an adrenomedullin (AM) receptor.

53 s calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) that have diverse functions in the c

54 ve shown that gene transfer of human and rat adrenomedullin (AM) up-regulates IL-13Ralpha2 in a human

55 cently shown that vascular responsiveness to adrenomedullin (AM), a newly discovered vasodilator pept

56 Adrenomedullin (AM), a potent hypotensive peptide, is pr

57 Plasma levels of adrenomedullin (AM), a potent vasorelaxant, are increase

58 g of one of the three peptide ligands, CGRP, adrenomedullin (AM), and intermedin/adrenomedullin 2 (AM

59 The anti-inflammatory peptide, adrenomedullin (AM), and its cognate receptor are expres

60 tional receptor for the vasodilatory ligand, adrenomedullin (AM), is comprised of RAMP2 or RAMP3 and

61 escribed peptide with structural homology to adrenomedullin (AM), is present in brain and pituitary g

62 ng protein 2 (RAMP2) comprise a receptor for adrenomedullin (AM).

63 e have recently shown that administration of adrenomedullin (AM, a potent vasodilator peptide) and ad

64 Calcitonin gene-related peptide, adrenomedullin, amylin, atrial natriuretic peptide, and

65 nary studies indicate that administration of adrenomedullin and adrenomedullin binding protein-1 in c

66 the signaling of the two potent vasodilators adrenomedullin and calcitonin gene-related peptide, we t

67 Adrenomedullin and conditioned media from pancreatic cel

68 -induced increases in the vasoactive peptide adrenomedullin and infiltration of iNOS-positive leukocy

69 up-regulated the expression of vasodilators adrenomedullin and suppressed the expression of vasocons

70 h higher urinary atrial natriuretic peptide, adrenomedullin, and cGMP excretions than with ACEI+D.

71 iuretic peptide, B-type natriuretic peptide, adrenomedullin, and homocysteine concentrations to arter

72 Plasma natriuretic peptide, adrenomedullin, and homocysteine levels are associated w

73 ic toxicity of this molecular class, leptin, adrenomedullin, and the compounds associated with increa

74 ective effect of regulatory peptides such as adrenomedullin, and the influence of H. pylori on the ju

75 e proangiogenic HIF targets, including PlGF, adrenomedullin, angiogenin, and PAI-1.

76 Treatment of the cell cultures with an adrenomedullin antagonist inhibited basal levels of prol

77 Calcitonin-gene-related peptide (CGRP) and adrenomedullin are related peptides with distinct pharma

78 The current study investigated adrenomedullin as a potential autocrine regulator of pan

79 Using microarray analysis, we identified adrenomedullin as a potential mediator of diabetes in pa

80 ffect of B. burgdorferi on the expression of adrenomedullin as well as the ability of adrenomedullin

81 ypoxia-exposed cardiac fibroblasts expressed adrenomedullin at 4-fold increased levels, as determined

82 while macrophages in the endometrium express adrenomedullin at a low level, endometrial macrophages o

83 llaries, whereas Ace1 and AT1 inhibitors and adrenomedullin attenuated vasoobliteration in OIR, indic

84 ullin (AM, a potent vasodilator peptide) and adrenomedullin binding protein-1 (AMBP-1) prevented the

85 te that administration of adrenomedullin and adrenomedullin binding protein-1 in combination (AM/AMBP

86 established that keratinocytes do not store adrenomedullin but secrete it constitutively.

87 dometrial induction of the angiogenic factor adrenomedullin by tamoxifen is part of the mechanism by

88 Since CGRP and adrenomedullin can both signal through CRLR, which has b

89 in, medium chain acyl-CoA dehydrogenase, and adrenomedullin correlate equally well with the degree of

90 r a set of biomarkers (procalcitonin, MR-pro-adrenomedullin, CT-pro-endothelin-1, CT-pro-arginine vas

91 The association of natriuretic peptides, adrenomedullin, endothelin, and galectin-3 with new-onse

92 d a significant decrease in the secretion of adrenomedullin, endothelin-1, and CD105; molecules that

93 Because adrenomedullin exhibits low metabolic stability, enhance

94 Mean plasma levels of adrenomedullin (femtomoles per liter) were higher in pat

95 free at least one target, the proangiogenic adrenomedullin, from repression, enhancing vascular grow

96 These data demonstrate that the adrenomedullin gene is developmentally regulated in vent

97 These results support a physiologic role for adrenomedullin gene products in the central regulation o

98 g the technique of differential display, the adrenomedullin gene was observed to be differentially ex

99 N-terminal peptide (PAMP), by the Adm gene (adrenomedullin gene).

100 ivo and in vivo angiogenesis models that the adrenomedullin gene-related peptide, proadrenomedullin N

101 rminal 20 peptide (PAMP), are encoded by the adrenomedullin gene.

102 and downstream targets of HIF (endothelin-1, adrenomedullin, haem oxygenase 1, and vascular endotheli

103 and N-terminal probrain natriuretic peptide: adrenomedullin (hazard ratio per log increase 2.53), ago

104 ptional up-regulation of CRLR and its ligand adrenomedullin in endothelial cells could lead to a pote

105 Conversely, overexpression of adrenomedullin in mice with pancreatic cancer led to glu

106 We measured plasma levels of adrenomedullin in patients with pancreatic cancer, patie

107 ri significantly increased the expression of adrenomedullin in RAW264.7 macrophages through MyD88-, p

108 these tissues; however, the concentration of adrenomedullin in saliva was insufficient to suggest a s

109 The concentration of adrenomedullin in the synovial fluid of untreated Lyme a

110 dings suggest a paracrine/autocrine role for adrenomedullin in these tissues; however, the concentrat

111 g of ADMR in pancreatic cancer cells blocked adrenomedullin-induced growth and invasion, indicating t

112 The AC stimulatory agonist adrenomedullin inhibited collagen synthesis in CF that o

113 Pancreatic cancer cell lines also secreted adrenomedullin into the culture medium as determined by

114 Adrenomedullin is a 52 amino acid peptide that shows a r

115 MR-pro-adrenomedullin is a good predictor of mortality (c-stati

116 Adrenomedullin is a multifunctional peptide produced by

117 We have shown that adrenomedullin is a novel growth factor for endothelial

118 Adrenomedullin is a recently discovered hypotensive pept

119 Adrenomedullin is able to act through at least two diffe

120 is study was designed to investigate whether adrenomedullin is present in human saliva and in salivar

121 Adrenomedullin is up-regulated in patients with pancreat

122 Furthermore, increasing adrenomedullin levels by gene transfer to Panc-1 cells i

123 at can be reversed upon genetic depletion of adrenomedullin ligand.

124 This raises the possibility that adrenomedullin may serve a different functions in oral m

125 In elective cardiac surgery, MR-pro-adrenomedullin measured between 6 and 18 hours after adm

126 ch as vascular endothelial growth factor and adrenomedullin mediate a comparable effect at nanomolar

127 hat express antisense RCP RNA, and CGRP- and adrenomedullin-mediated signal transduction were greatly

128 Adrenomedullin-mediated signaling was disrupted when P32

129 Levels of adrenomedullin messenger RNA and protein were increased

130 issues (controls) to determine expression of adrenomedullin messenger RNA and protein, respectively.

131 ess the prognostic impact of midregional pro-adrenomedullin (MR-proADM) after an acute myocardial inf

132 and the prognostic value of mid-regional pro-adrenomedullin (MR-proADM) in patients with AHF.

133 l provasopressin (copeptin), midregional pro-adrenomedullin (MR-proADM), and midregional pro-atrial n

134 iuretic peptide (MR-proANP), midregional pro-adrenomedullin (MR-proADM), C-terminal pro-endothelin-1

135 Adrenomedullin mRNA levels were significantly (P < 0.05)

136 in a significant, time-dependent increase in adrenomedullin mRNA levels.

137 reaction analysis revealed that the level of adrenomedullin mRNA was significantly higher in adult ve

138 brain, heart, kidney, liver, and lung, with adrenomedullin, MT-1, and VEGF being prominently induced

139 e in production of the pulmonary vasodilator adrenomedullin of almost 70% (P </= 0.05).

140 We studied the effects of adrenomedullin on insulin secretion by beta cell lines a

141 f women receiving tamoxifen strongly express adrenomedullin (P=0.008).

142 e expression of TGF-beta target genes (e.g., adrenomedullin, pentraxin 3, KN motif and ankyrin repeat

143 pithelium may contribute the majority of the adrenomedullin peptide found in saliva.

144 l. demonstrate that loss of signaling by the adrenomedullin peptide results in embryonic edema and de

145 ing attention to procalcitonin (PCT) and pro-adrenomedullin (proADM).

146 t there are differences in the regulation of adrenomedullin production between oral and skin keratino

147 ibes the effects of a range of substances on adrenomedullin production from cultures of oral and skin

148 peptides thrombin and endothelin-1 increase adrenomedullin production, particularly from skin kerati

149 s binding sites were identified in the mouse adrenomedullin promoter at -1095 and -770 nucleotides fr

150 ily mediated by HIF-1 consensus sites in the adrenomedullin promoter.

151 scriptase-PCR as follows: VEGF, EPO, GLUT-1, adrenomedullin, propyl 4-hydroxylase alpha, MT-1, MKP-1,

152 ct through at least two different receptors, adrenomedullin receptor (ADMR) and calcitonin receptor-l

153 n 5 (cdh5; VE-cadherin), aquaporin 8 (aqp8), adrenomedullin receptor (admr), complement receptor C1qR

154 on, we now propose that a functional CGRP or adrenomedullin receptor consists of at least three prote

155 Adrenomedullin receptor mRNA was constitutively expresse

156 endothelin receptor A and B, adrenomedullin, adrenomedullin receptor, and vasopressin receptor 1a.

157 can function as either a CGRP receptor or an adrenomedullin receptor, depending on which members of a

158 se with the pharmacological properties of an adrenomedullin receptor.

159 gene-related peptide (CGRP) receptor and an adrenomedullin receptor.

160 receptor-like receptor to yield a functional adrenomedullin receptor.

161 For example, adrenomedullin receptors are comprised of RAMP2 or RAMP3

162 Specific adrenomedullin receptors were found in cell lines from t

163 rted receptors are core-glycosylated and are adrenomedullin receptors.

164 d interferon-gamma are potent suppressors of adrenomedullin secretion from both cell types, as are fo

165 lipopolysaccharide, significantly stimulate adrenomedullin secretion from oral but not skin keratino

166 ome recognized as integral components of the adrenomedullin signaling system.

167 transfer to Panc-1 cells increased, whereas adrenomedullin small hairpin RNA silencing in MPanc96 ce

168 Adrenomedullin suppression in T(H) 2-related inflammatio

169 id glands contained higher concentrations of adrenomedullin than did the circulation, but lower conce

170 Furthermore, the addition of exogenous adrenomedullin to B. burgdorferi-stimulated RAW264.7 mac

171 of adrenomedullin as well as the ability of adrenomedullin to dampen host inflammatory responses to

172 egulated in ventricular cardiomyocytes, that adrenomedullin transcription can be induced by hypoxia,

173 Exogenous adrenomedullin treatment of Panc-1, BxPC3, and MPanc96 c

174 pression of other angiogenic factors such as adrenomedullin, vascular endothelial growth factor, basi

175 In men, adrenomedullin was associated with mean arterial pressur

176 es revealed that the 5'-flanking sequence of adrenomedullin was capable of mediating a hypoxia-induci

177 Adrenomedullin was localized in the neoplastic epitheliu

178 Adrenomedullin was up-regulated in pancreatic cancer cel

179 Levels of adrenomedullin were higher in patients with pancreatic c

180 eas decreases in PAP in response to CGRP and adrenomedullin were not changed and decreases in PAP in

181 at saliva may contain high concentrations of adrenomedullin, which has antimicrobial activity in vitr

182 t B. burgdorferi increases the production of adrenomedullin, which in turn negatively regulates the B

183 t resulted in a sustained increase in plasma adrenomedullin, with higher urinary atrial natriuretic p