ライフサイエンスコーパス: adrenoreceptor

1 th adjacent structural domains in the beta 2 adrenoreceptor.

2 azosin activated EphA2 independent of alpha1-adrenoreceptor.

3 enough to activate low-threshold inhibitory adrenoreceptors.

4 scending inputs and the activation of beta 1-adrenoreceptors.

5 ar glutamatergic neurons that express alpha1-adrenoreceptors.

6 signal transduction pathway linked to alpha1-adrenoreceptors.

7 phrine to investigate signal transduction of adrenoreceptors.

8 ted with an up-regulation in alpha1-vascular adrenoreceptors.

9 ion, desensitization, and uncoupling of beta-adrenoreceptors.

10 ding vasodilatation through activating alpha-adrenoreceptors.

11 puts to these neurons via presynaptic alpha2-adrenoreceptors.

12 arkers of polymorphisms of candidate alpha2A adrenoreceptor, 5-HT transporter, and GNbeta3 genes and

13 tory period of up to 48 h in culture, alpha1-adrenoreceptor activation by phenylephrine or noradrenal

14 mediate the natriuretic response to alpha(2)-adrenoreceptor activation in vivo.

15 the prior history of hypoxia and that alpha2 adrenoreceptor activation plays a role in its underlying

16 were mimicked by either alpha 1- or alpha 2-adrenoreceptor activation, reversibly decreasing motor b

17 licular cells in response to NE-induced beta-adrenoreceptor activation.

18 ed during enforced HSC mobilization or beta3 adrenoreceptor activation.

19 ger is regulated by isoproterenol via a beta-adrenoreceptor/adenylate-cyclase/cAMPdependent signaling

20 d to activation of muscle postsynaptic beta2-adrenoreceptor (ADRB2), cAMP production, and import of t

21 rotein-coupled receptors (GPCRs): the beta-2 adrenoreceptor (ADRB2), the adenosine A(2A) receptor (AA

22 bone microarchitecture and the expression of adrenoreceptors, aggrecans, matrix metalloproteinases (M

23 r agonist midodrine (5 to 10 mg), the alpha2-adrenoreceptor agonist clonidine (0.1 mg), and I.V. sali

24 CSH enhanced the alpha2-adrenoreceptor agonist clonidine-mediated inhibition (3

25 human monocytes, epinephrine and the beta(2) adrenoreceptor agonist fenoterol potently inhibited LPS-

26 A new beta-3 adrenoreceptor agonist has demonstrated significant impr

27 e studied the effects of placebo, the alpha1-adrenoreceptor agonist midodrine (5 to 10 mg), the alpha

28 e opposite was the case either for an alpha2-adrenoreceptor agonist or for inhibition of catecholamin

29 The alpha-adrenoreceptor agonist phenylephrine increased arterial

30 NHE1 phosphorylation induced by the alpha(1)-adrenoreceptor agonist phenylephrine, without affecting

31 - 5%, n = 4; p < 0.05) but attenuated alpha1-adrenoreceptor agonist phenylephrine-mediated inhibition

32 Additionally, isoproterenol, a beta adrenoreceptor agonist suppressed LPS-induced TNF-alpha

33 Ractopamine (RAC) is a beta-adrenoreceptor agonist that enhances growth but increase

34 Dexmedetomidine is a selective alpha2 adrenoreceptor agonist that has been described as a usef

35 e (PE, 0.025 to 0.8 mug kg min) and an alpha-adrenoreceptor agonist, BHT-933 (1.0 to 10 mug kg min) d

36 Infusions of the beta-adrenoreceptor agonist, clenbuterol, into the BLA immedi

37 When infused into the CA1, the beta-adrenoreceptor agonist, isoproterenol, the D1/D5 dopamin

38 d during intra-arterial infusion of an alpha-adrenoreceptor agonist, phenylephrine (PE, 0.025 to 0.8

39 729 to act at FFA2 receptors to inhibit beta-adrenoreceptor agonist-promoted lipolysis in primary mou

40 tor antagonists (LAMA) and long-acting beta2-adrenoreceptor agonists (LABA), are the mainstay of phar

41 Microinfusion of alpha2 adrenoreceptor agonists and antagonists into amygdala ha

42 report showing that microinfusion of alpha 2 adrenoreceptor agonists and antagonists into the vicinit

43 be stimulated 19-61% above baseline by beta-adrenoreceptor agonists and cGI-phosphodiesterase inhibi

44 These cells were incubated with beta-adrenoreceptor agonists and/or antagonists and assayed f

45 nt and selective sulfonamide derived beta(2)-adrenoreceptor agonists are described that exhibit poten

46 protocols: (1) wide dose ranges of the alpha-adrenoreceptor agonists phenylephrine (PE, alpha(1) sele

47 Both alpha(1)- and alpha(2)-adrenoreceptor agonists produce comparable vasoconstrict

48 beta2 -Adrenoreceptor agonists that act via cAMP can reduce ute

49 enoreceptor antagonism and mimicked by beta2-adrenoreceptor agonists.

50 5-HT(1A) receptor and alpha(1)-adrenoreceptor (alpha(1)-AR) binding sites recognized by

51 sue transglutaminase (TGII)-mediated alpha1B-adrenoreceptor (alpha(1B)AR) signaling.

52 al CGRP expression via activation of alpha 2-adrenoreceptors (alpha 2-AR) on DRG neurons.

53 Stimulation of alpha1-adrenoreceptors (alpha1-AR) acutely alters ion channel b

54 ve randomized controlled trial of the alpha1-adrenoreceptor (alpha1AR) antagonist prazosin for combat

55 is attenuated during advanced age via alpha-adrenoreceptor (alphaAR) activation, but it is unknown w

56 on and is attenuated during ageing via alpha-adrenoreceptor (alphaAR) stimulation, but it is unknown

57 ng results from cryocooled crystals of beta2-adrenoreceptor and an RNA polymerase II complex indicate

58 Galpha(sS)-N280 interacted with the beta(2)-adrenoreceptor and exhibited high-affinity XTPase activi

59 ta receptors) mediated chemotaxis; the beta2-adrenoreceptor and the M3-muscarinic receptor, which cou

60 in two other serpentine receptors, the beta2-adrenoreceptor and the parathyroid hormone receptor; occ

61 eased and inverted complement of beta1/beta2-adrenoreceptors and absence of RyR2, which may explain t

62 n pattern, show partial overlap with alpha 2 adrenoreceptors and are heavily represented in sensory p

63 M prazosin) or alpha2- (0.1 microM RX821002) adrenoreceptors and fully restored with both antagonists

64 blocked by pharmacologic antagonists of beta-adrenoreceptors and the myelopoietic growth factor GM-CS

65 This effect was blocked by beta2-adrenoreceptor antagonism and mimicked by beta2-adrenore

66 inished by prior hypoxic episodes and alpha2-adrenoreceptor antagonism.

67 Clinically used as an alpha1-adrenoreceptor antagonist (Cardura(R)) for treating hype

68 lasma ACTH after microinjecting the alpha(1)-adrenoreceptor antagonist benoxathian into the BSTL.

69 i.c.v. infusion of the alpha1-adrenoreceptor antagonist benoxathian, at up to 5.3 micr

70 The alpha1-adrenoreceptor antagonist doxazosin induces apoptosis in

71 he ability of the quinazoline-based alpha(1)-adrenoreceptor antagonist doxazosin to suppress prostate

72 Administration of the beta-adrenoreceptor antagonist esmolol (1 mg kg(-1)) also att

73 The alpha-adrenoreceptor antagonist phentolamine abolished NE inhi

74 This increase was inhibited by the alpha(1)-adrenoreceptor antagonist prazosin (1 microM) and blocke

75 k randomized controlled trial of the alpha-1 adrenoreceptor antagonist prazosin for combat trauma nig

76 The alpha2-adrenoreceptor antagonist yohimbine abolished CSH-induce

77 When infused into the BLA, the beta-adrenoreceptor antagonist, timolol, the D1/D5 dopamine r

78 evation was prevented by propranolol, a beta-adrenoreceptor antagonist.

79 ; these effects were abolished by an alpha2A-adrenoreceptor antagonist.

80 Moreover, these adrenoreceptor antagonists alone were sufficient to mark

81 alpha1 and alpha2 adrenoreceptor antagonists included in the medium of cor

82 Saline vehicle, alpha2- and beta-adrenoreceptor antagonists or agonists were injected loc

83 lin or dibutyryl-cAMP) and abrogated by beta-adrenoreceptor antagonists or the PKA inhibitor rp-cAMP,

84 lol and carvedilol are third-generation beta-adrenoreceptor antagonists, which unlike classic beta-bl

85 yperalgesia (PPH), can be blocked with alpha-adrenoreceptor antagonists.

86 to perivascular nerve stimulation (PNS) and adrenoreceptor (AR) activation during blood flow control

87 through the selective activation of alpha-2 adrenoreceptors (AR).

88 Since alpha(2c)-adrenoreceptors are expressed primarily in the brain, we

89 HEK 293 cells, while co-expressed alpha(2C)-adrenoreceptors are found mainly in an intracellular com

90 pharmacological tests indicate that alpha 1-adrenoreceptors are involved in the permissive role of N

91 alpha-Adrenoreceptors are present in the ventricular (VZ) and

92 Antagonists of beta-adrenoreceptors are safe and well tolerated in patients

93 Our data indicate that RARs, like beta2-adrenoreceptors, are sensitive to inverse agonists and t

94 Both beta(1)- and beta(2)-adrenoreceptor (ARs) subtypes induce cAMP accumulation,

95 i-LC dendritic zone, as determined by alpha2-adrenoreceptors (ARs) and norepinephrine transporter bin

96 Acute pharmacological blockade of alpha1 adrenoreceptors (ARs) attenuates the locomotor response

97 Activation of vascular adrenoreceptors (ARs) governs the magnitude and distribu

98 assessed by immunoblotting using the beta(2)-adrenoreceptor as a standard.

99 Furthermore, inhibition of alpha2A-adrenoreceptor attenuated degenerative remodelling in th

100 enhances CFC and that antagonism of the beta-adrenoreceptors attenuates this effect.

101 In PC12 cells the expressed alpha(2C)-adrenoreceptors become concentrated in neurite outgrowth

102 In contrast to beta(1)-adrenoreceptor (beta(1)-AR) signaling, beta(2)-AR stimul

103 gically relevant system in which the beta(2)-adrenoreceptor (beta(2)AR) couples to G(s), and Sf9 inse

104 icient PDZ-directed recycling of the beta(2)-adrenoreceptor (beta(2)AR) from early endosomes.

105 The G protein-coupled beta(2)-adrenoreceptor (beta(2)AR) signals through the heterotri

106 Obesity is associated with blunted beta-adrenoreceptor (beta-AR)-mediated lipolysis and lipid ox

107 The three known subtypes of beta-adrenoreceptors (beta(1)-AR, beta(2)-AR, and beta(3)-AR)

108 Desensitization of the beta-adrenoreceptors (beta-AR) may contribute to a post-exerc

109 that the activation of the Gs-coupled beta1-adrenoreceptor (beta1-AR) by the catecholamines isoprena

110 rolled well in most patients by inhaled beta-adrenoreceptor (beta2 AR) agonists and steroids.

111 othelial HMEC-1 cells by counteracting beta2-adrenoreceptor (beta2ADR) activity using pharmacological

112 bined use of glucocorticosteroids and beta-2-adrenoreceptor (beta2AR) agonists in the treatment of ch

113 bronchodilators in asthma therapy are beta2-adrenoreceptor (beta2AR) agonists, but their chronic use

114 The beta2-adrenoreceptor (beta2AR) couples to the G-protein Gs to

115 The beta2 adrenoreceptor (beta2AR) is a prototypical G protein-cou

116 ene expression, we discovered that the beta2-adrenoreceptor (beta2AR) is a regulator of the alpha-syn

117 mRNA and increases the density of alpha(1B)-adrenoreceptor binding in the hypothalamus.

118 H(4) + 10 mM ascorbate, and (4) 5 mM BH(4) + adrenoreceptor blockade (5 mM yohimbine + 1 mM propranol

119 cholamine levels, and the effect of alpha(1)-adrenoreceptor blockade (phentolamine) on supine SBP.

120 DeltaCVC(base); P < 0.001), however, adding adrenoreceptor blockade abolished VC in aged skin indica

121 Use of beta-adrenoreceptor blockade in the treatment of heart failur

122 Local adrenoreceptor blockade increased FBF and FVC at rest an

123 This study tested the hypothesis that beta1-adrenoreceptor blockade modulates the angiotensin II (An

124 foot was used to monitor the degree of alpha-adrenoreceptor blockade produced by phentolamine.

125 ns and during combined local alpha- and beta-adrenoreceptor blockade via intra-arterial infusions of

126 ified sites of vascular dysfunction in OZRs (adrenoreceptor blockade with phentolamine, antioxidant t

127 These effects were abolished by either beta-adrenoreceptor blockade with propranolol or adrenalectom

128 duals ingested either a placebo or an alpha1-adrenoreceptor blocker (prazosin; 0.05 mg kg(-1)).

129 n cyan fluorescent protein-labeled alpha(2A)-adrenoreceptors (C-alpha2ARs) and G proteins in cells us

130 We find that beta2 adrenoreceptors constitutively associate with each other

131 lasts, a significant proportion of alpha(2C)-adrenoreceptor detected by immunocytochemistry co-locali

132 esting diameter but this inhibition of alpha-adrenoreceptors enabled ROV to spread along the anastomo

133 alpha2a (alpha(2A))- and alpha2c (alpha(2C))-adrenoreceptors expressed in the same cell line.

134 ed by perivascular SNS fibers acting on beta-adrenoreceptors expressed on nonhematopoietic cells and

135 Increased alpha2A-adrenoreceptor expression was observed in condylar carti

136 ith liraglutide demonstrated decreased beta1-adrenoreceptor expression.

137 ta-arrestin-1 (ARRB1), activated via beta(2)-adrenoreceptors, facilitates AKT-mediated activation of

138 ctivity in cell membranes expressing alpha2A adrenoreceptor-Galphao1 wild-type (wt) or C351I mutant f

139 ce with a targeted disruption of the beta(3)-adrenoreceptor gene (beta(3)-AR KO) were treated with ve

140 thesis that constitutive activation of alpha-adrenoreceptors governs blood flow distribution within i

141 A dynamic orthostatic hypovolemia and alpha1-adrenoreceptor hypersensitivity have been demonstrated i

142 A crystal structure of the beta2-adrenoreceptor in complex with a covalent noradrenaline

143 at the resulting mutants bind to the beta(2)-adrenoreceptor in vitro in a phosphorylation-independent

144 This study tested whether activation of adrenoreceptors in chondrocytes has roles in degenerativ

145 cle of OM through subtle activation of alpha-adrenoreceptors in microvascular resistance networks.

146 ave investigated the possible role of alpha1-adrenoreceptors in regulating the germination of progeni

147 dicate that constitutive activation of alpha-adrenoreceptors in skeletal muscle can restrict the spre

148 n greater density of alpha(1)- than alpha(2)-adrenoreceptors in the mouse nucleus.

149 nist propranolol, suggesting a role for beta-adrenoreceptors in this response.

150 for AGS in GEPR-9s and that NMDA and alpha1 adrenoreceptors in this site may play important roles in

151 red the intracellular targeting of alpha(2C)-adrenoreceptors in two neuroendocrine cell lines with th

152 nt cells with moderate potency via an alpha1-adrenoreceptor-independent mechanism.

153 enylephrine) or alpha2- (1 microM UK 14,304) adrenoreceptors inhibited conduction partially and their

154 Thus, the activation of alpha1- and alpha2-adrenoreceptors inhibits conducted vasodilatation throug

155 Conversely, activation of alpha2A-adrenoreceptor intensified aforementioned degenerative c

156 restingly, the persistent activation of beta-adrenoreceptors is likely one of the upstream repressors

157 ression of a C-terminal fragment of the beta-adrenoreceptor kinase, which sequesters free betagamma,

158 istent with the D3 receptor adopting a beta1-adrenoreceptor-like quaternary arrangement.

159 Thus, blockade of beta-adrenoreceptors may provide a new avenue to inhibit VEGF

160 e present study was to test whether alpha(2)-adrenoreceptor-mediated vasoconstriction was more sensit

161 The results indicated that alpha-adrenoreceptor modulation of the mGluR-mediated inhibiti

162 stradiol treatment in vivo induces alpha(1b)-adrenoreceptor mRNA and increases the density of alpha(1

163 ublished crystal structures of dimeric beta1-adrenoreceptor, mu-opioid, and CXCR4 receptors.

164 the role of the complete ECS of the alpha1B-adrenoreceptor on norepinephrine (NE) potency, affinity,

165 ses chronic pain through inhibitory alpha(2)-adrenoreceptors on afferent nociceptors and stimulatory

166 conducted vasodilatation by activating alpha-adrenoreceptors on feed arteries through noradrenaline r

167 germinal cells, and the expression of alpha1-adrenoreceptors on their surface could act to determine

168 Blockade of alpha2-adrenoreceptors or catecholamine-generating enzymes grea

169 Activated beta(2)-adrenoreceptors promote Gs-protein-dependent activation

170 The beta2-adrenoreceptors regulate VEGF expression in ChECs and RP

171 The results suggest that alpha-adrenoreceptor regulation of the mGluR-mediated inhibiti

172 However, after 14 d of cocaine, alpha-adrenoreceptor regulation of the mGluR-mediated inhibiti

173 alpha(2A)-Adrenoreceptors reside primarily in the plasma membrane

174 d TPC2 comprise an important element in beta-adrenoreceptor signal transduction in cardiac myocytes.

175 A component of beta-adrenoreceptor signaling in the heart involves NAADP and

176 The effect of beta-adrenoreceptor signaling on expression of vascular endot

177 tor rp-cAMP, indicating transduction via the adrenoreceptor signaling pathway.

178 In Mz-ChA-1 cells, alpha(2)-adrenoreceptor stimulation causes up-regulation of cAMP,

179 play a critical role in the response to beta-adrenoreceptor stimulation occurring during acute exerci

180 r CD38, which contributes to effects of beta-adrenoreceptor stimulation to increase both Ca(2+) trans

181 st stimuli, although constriction to alpha1 -adrenoreceptor stimulation was elevated.

182 ytes from WT mice, but these effects of beta-adrenoreceptor stimulation were reduced in myocytes from

183 endency for arrhythmias following acute beta-adrenoreceptor stimulation.

184 alpha-Adrenoreceptor supersensitivity in many tissues has been

185 ly mediated by an axon reflex and that alpha-adrenoreceptor supersensitivity occurs in the presynapti

186 stress hormone adrenaline stimulates beta(2)-adrenoreceptors that are expressed throughout the body,

187 ein alpha-subunit (Gsalpha) couples the beta-adrenoreceptor to adenylyl cyclase and the intracellular

188 d AtT20 cells efficiently targeted alpha(2C)-adrenoreceptors to the plasma membrane.

189 , Leu-311, Asn-312) in TMD VII of the beta 2 adrenoreceptors were mutated to the amino acids found in

190 H in normal human subjects by blocking alpha-adrenoreceptors with intravenous phentolamine.

191 With no effect in YM, blockade of alpha-adrenoreceptors with phentolamine (1 mum) restored ROV i