ライフサイエンスコーパス: adult T-cell leukemia

1 type 1 (HTLV-1) is the etiological agent of adult T cell leukemia.

2 oncogenic retrovirus etiologically causal of adult T cell leukemia.

3 play an important role in the development of adult T cell leukemia.

4 ymphotropic virus type-I (HTLV-I)-associated adult T cell leukemia.

5 evelopment of the virally associated disease adult T cell leukemia.

6 cytokine-dependent T lymphocytes and causes adult T cell leukemia.

7 in all subjects, including the patient with adult T cell leukemia.

8 related retroviruses with the former causing adult T cell leukemia.

9 myelopathy/tropical spastic paraparesis and adult T cell leukemia.

10 type I (HTLV-1) is the etiological agent of adult T-cell leukemia.

11 l responses in the majority of patients with adult T-cell leukemia.

12 s type 1 (HTLV-1) is the etiologic agent for adult T-cell leukemia.

13 oncogenic retrovirus etiologically causal of adult T-cell leukemia.

14 type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia.

15 unctions of Tax to promote HTLV-I-associated adult T-cell leukemia.

16 us type 1 (HTLV-1) is the causative agent of adult T-cell leukemia.

17 formation contributing to the development of adult T-cell leukemia.

18 lopment of an acute T-cell malignancy termed adult T-cell leukemia.

19 human T cells, clinically manifested as the adult T-cell leukemia.

20 s type 1 (HTLV-1) is the etiologic agent for adult T-cell leukemia.

21 ocytes, which can lead to the development of adult T-cell leukemia.

22 oncovirus that is clinically associated with adult T-cell leukemia.

23 oncogenic retrovirus that is associated with adult T-cell leukemia.

24 rmation events leading to the development of adult T-cell leukemia.

25 us type 1 (HTLV-1) is the causative agent of adult T-cell leukemia.

26 cer in humans and is etiologically linked to adult T-cell leukemia.

27 to T-cell transformation and development of adult T-cell leukemia.

28 emia virus type-1 is the causative agent for adult T-cell leukemia.

29 ic agent of the aggressive and fatal disease adult T-cell leukemia.

30 type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia.

31 marily infects CD4+ T lymphocytes and causes adult T-cell leukemia.

32 the virus may play a role in the etiology of adult T-cell leukemia.

33 In one patient with adult T cell leukemia, a specific clone bearing Vbeta7 w

34 ell transformation by Tax and development of adult T-cell leukemia after HTLV-1 infection.

35 virus (HTLV-I) is etiologically linked with adult T cell leukemia, an aggressive and usually fatal e

36 us type I (HTLV-I) is the etiologic agent of adult T-cell leukemia, an acute and often fatal T-cell m

37 us type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia, an aggressive CD4(+) malignancy.

38 nd sustained diseases, such as autoimmunity, adult T cell leukemia and HIV-1.

39 nopathogenesis related to the progression of adult T cell leukemia and HTLV-1-associated myelopathy/t

40 us type I (HTLV-I) is the etiologic agent of adult T cell leukemia and HTLV-I-associated myelopathy/t

41 us type I (HTLV-I) is the etiologic agent of adult T cell leukemia and HTLV-I-associated myelopathy/t

42 IL-15 in HTLV-I-associated diseases such as adult T cell leukemia and HTLV-I-associated myopathy/tro

43 ell leukemia virus (HTLV) is associated with adult T cell leukemia and neurological disorders (TSP/HA

44 hotropic virus type 1 (HTLV-1) mainly causes adult T cell leukemia and predominantly immortalizes/tra

45 oncogenic retrovirus that is responsible for adult T-cell leukemia and a neurological disease, HTLV-I

46 pic virus type I (HTLV-I) is associated with adult T-cell leukemia and a slowly progressive disease o

47 us type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia and HTLV-1-associated myelopathy.

48 ll leukemia virus type 1 (HTLV-1) results in adult T-cell leukemia and HTLV-1-associated myelopathy/t

49 us type 1 (HTLV-1) is the causative agent of adult T-cell leukemia and HTLV-1-associated myelopathy/t

50 kemia virus type 1 (HTLV-1) infection causes adult T-cell leukemia and is associated with a variety o

51 us type I (HTLV-1) is the etiologic agent of adult T-cell leukemia and lymphoma and HTLV-1-associated

52 us-specific host immune response, and causes adult T-cell leukemia and lymphoma in approximately 2% o

53 us type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia and lymphoma, an aggressive clonal

54 HTLV-1 is the etiologic agent of adult T-cell leukemia and lymphoma, an aggressive clonal

55 (HTLV-1), an etiological factor that causes adult T-cell leukemia and lymphoma, has a crucial role i

56 cogenic retrovirus associated primarily with adult T-cell leukemia and neurological disease.

57 ropic virus type 1 (HTLV-1) infection causes adult T-cell leukemia and several lymphocyte-mediated in

58 ll leukemia virus type 1 (HTLV-1)-associated adult T-cell leukemia and T-cell lymphoma (ATL) are aggr

59 s type I (HTLV-I) is the etiologic agent for adult T-cell leukemia and the neurological disorder trop

60 type I (HTLV-I) is the etiological agent for adult T-cell leukemia and tropical spastic paraparesis/H

61 iated with several serious diseases, such as adult T-cell leukemia and tropical spastic paraparesis/m

62 s etiologically linked to the development of adult T-cell leukemia and various human neuropathies.

63 irus (HTLV) type 1, the etiological agent of adult T-cell leukemia, are remarkably resistant to conve

64 ax plays an integral role in the etiology of adult T cell leukemia, as expression of Tax in T lymphoc

65 y by HBZ is important for the development of adult T-cell leukemia associated with HTLV-1 infection.

66 umber of pathologic abnormalities, including adult T cell leukemia (ATL) and HTLV-1-associated myelop

67 Adult T cell leukemia (ATL) is a serious form of cancer

68 cked spontaneous proliferation of smoldering adult T cell leukemia (ATL) T cells.

69 uses a fatal hematopoietic malignancy termed adult T cell leukemia (ATL).

70 HTLV-1 is associated with adult T-cell leukemia (ATL) and a variety of immune-medi

71 us type I (HTLV-1) is the etiologic agent of adult T-cell leukemia (ATL) and HTLV-1 associated myelop

72 type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia (ATL) and HTLV-1-associated myelop

73 pic virus type 1 (HTLV-1) is associated with adult T-cell leukemia (ATL) and HTLV-1-associated myelop

74 us type 1 (HTLV-1) is the causative agent of adult T-cell leukemia (ATL) and HTLV-1-associated myelop

75 Adult T-cell leukemia (ATL) and human T-cell lymphotropi

76 c virus-1 (HTLV-I) is the etiologic agent of adult T-cell leukemia (ATL) and the neurological disorde

77 the group that first identified a cluster of adult T-cell leukemia (ATL) cases in Japan, provided con

78 of interleukin-10 (IL-10), in patients with adult T-cell leukemia (ATL) caused by human T-cell leuke

79 Adult T-cell leukemia (ATL) cells contain integrated hum

80 athway is also activated in freshly isolated adult T-cell leukemia (ATL) cells that often lack detect

81 (HTLV-1)-transformed lymphocyte cell lines, adult T-cell leukemia (ATL) cells, and in other hematolo

82 In most adult T-cell leukemia (ATL) cells, Tax oncoprotein expre

83 Adult T-cell leukemia (ATL) consists of an overabundance

84 Adult T-cell leukemia (ATL) develops in a small proporti

85 Adult T-cell leukemia (ATL) develops in a small proporti

86 Adult T-cell leukemia (ATL) develops in a small proporti

87 Adult T-cell leukemia (ATL) develops in a small proporti

88 antibodies, which recognize CD25, for human adult T-cell leukemia (ATL) in a murine model.

89 Adult T-cell leukemia (ATL) is a fatal malignancy caused

90 Adult T-cell leukemia (ATL) is a highly chemoresistant a

91 Adult T-cell leukemia (ATL) is an aggressive hematologic

92 Adult T-cell leukemia (ATL) is an aggressive lymphoproli

93 Adult T-cell leukemia (ATL) is an aggressive malignancy

94 Adult T-cell leukemia (ATL) is an aggressive T-cell mali

95 Adult T-cell leukemia (ATL) is caused by human T-cell ly

96 The etiologic agent of adult T-cell leukemia (ATL) is human T cell lymphotropic

97 irus type-I (HTLV-I), the etiologic agent of adult T-cell leukemia (ATL) transforms human T cells bot

98 Adult T-cell leukemia (ATL), a heterogeneous disease, ca

99 us type I (HTLV-I) is the etiologic agent of adult T-cell leukemia (ATL), a rapidly progressing, clon

100 roteins are implicated in the development of adult T-cell leukemia (ATL), a T-cell malignancy caused

101 mia virus type 1 (HTLV-I) is associated with adult T-cell leukemia (ATL), an aggressive lymphoprolife

102 us type-I (HTLV-I) is the etiologic agent of adult T-cell leukemia (ATL), an aggressive lymphoprolife

103 irus type I (HTLV-I), the etiologic agent of adult T-cell leukemia (ATL), and is indispensable for ma

104 irus type-I (HTLV-I), the etiologic agent of adult T-cell leukemia (ATL), is estimated to affect 10-2

105 rved on chromosome 6q in acute/lymphoma-type adult T-cell leukemia (ATL), suggesting a putative tumor

106 emia virus type 1 (HTLV-1) that recapitulate adult T-cell leukemia (ATL)-like leukemic symptoms and d

107 s type I (HTLV-I) is the causative agent for adult T-cell leukemia (ATL).

108 us considered to be the etiological agent of adult T-cell leukemia (ATL).

109 virus type I (HTLV-I) are characteristics of adult T-cell leukemia (ATL).

110 ople worldwide and is the causative agent of adult T-cell leukemia (ATL).

111 can cause a rare form of leukemia designated adult T-cell leukemia (ATL).

112 irus that induces a fatal T-cell malignancy, adult T-cell leukemia (ATL).

113 type 1 (HTLV-I) is the etiological agent of adult T-cell leukemia (ATL).

114 oncogenic retrovirus etiologically causal of adult T-cell leukemia (ATL).

115 uman retrovirus and the etiological agent of Adult T-cell Leukemia (ATLL).

116 genes have been found in only one-fourth of adult T-cell leukemia cases.

117 Consistently, human adult T cell leukemia cells that acquire elevated APC(Cd

118 planation for the highly aneuploid nature of adult T-cell leukemia cells.

119 7 amino acids and is 59% homologous to human adult T cell leukemia-derived factor/TRX, originally des

120 The cellular redox factors Ref-1 and adult T-cell leukemia-derived factor stimulated the DNA

121 en linked to a spectrum of diverse diseases: adult T cell leukemia, encephalomyelopathy, and predispo

122 us type 1 (HTLV-1), the etiological agent of adult T-cell leukemia, encodes unique regulatory and acc

123 irus (HTLV) type 1, the etiological agent of adult T-cell leukemia, expresses the viral oncoprotein T

124 hematopoietic stem cell transplantation for adult T-cell leukemia in Japan.

125 e altered properties of cell growth found in adult T cell leukemia induced by HTLV-I.

126 an T cell leukemia virus 1 (HTLV-1)-mediated adult T cell leukemia is associated with the ability of

127 Because adult T-cell leukemia is a highly virulent cancer that i

128 Adult T-cell leukemia is caused by human T-cell leukemia

129 of Blood, Nagai et al provide evidence that adult T-cell leukemia is hierarchically organized and su

130 -cell leukemia virus type 1 (HTLV-1)-induced adult T-cell leukemia is linked to the expression of the

131 rus type 1 (HTLV-1), a virus associated with adult T-cell leukemia, is significantly lower than that

132 nsformation of T cells during the genesis of adult T-cell leukemia, it is important to understand the

133 Because adult T cell leukemia like many other human cancers is a

134 Thus, IL-15 synthesis by the adult T-cell leukemia line HuT- 102 involves an increase

135 mphotrophic virus type I (HTLV-I)-associated adult T-cell leukemia line HuT-102 produces a cytokine d

136 he findings are similar to those in evolving adult T cell leukemia lymphoma and may represent a prely

137 lishes a lifelong infection and is linked to adult T-cell leukemia lymphoma (ATLL).

138 tor (HBZ) could be used for immunotherapy in adult T-cell leukemia-lymphoma (ATL) patients.

139 obal modification of host gene expression in adult T-cell leukemia-lymphoma (ATL).

140 nd at position 88 in HTLV-1 strains from all adult T-cell leukemia-lymphoma (ATLL) cases and healthy

141 promoters in HTLV-1-infected cell lines and adult T-cell leukemia-lymphoma cells.

142 ell and natural killer cell lymphoma and for adult T-cell leukemia-lymphoma.

143 ll leukemia virus type 1 (HTLV-1)-associated adult T cell leukemia/lymphoma (ATL) cells as a model sy

144 Adult T cell leukemia/lymphoma (ATL) is an aggressive ca

145 Adult T cell leukemia/lymphoma (ATLL) is an aggressive m

146 In adult T cell leukemia/lymphoma (ATLL), the FoxP3(+) popu

147 f an aggressive hematologic neoplasia termed adult T cell leukemia/lymphoma (ATLL).

148 a/lymphotropic virus type I (HTLV-I) induces adult T cell leukemia/lymphoma (ATLL).

149 irus type 1 (HTLV-1) is a causative agent of adult T cell leukemia/lymphoma and a variety of inflamma

150 CI, 1.1-7.1) infection, although no case of adult T cell leukemia/lymphoma was diagnosed.

151 in the circulation, as seen in patients with adult T cell leukemia/lymphoma.

152 y/tropical spastic paraparesis (HAM/TSP) and adult T cell leukemia/lymphoma.

153 us type 1 (HTLV-1) is the causative agent of adult T cell leukemia/lymphoma.

154 s type 1 (HTLV-1) is the etiologic agent for adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associat

155 ophic virus (HTLV) type I has been linked to adult T-cell leukemia/lymphoma (ATL) and HTLV-I associat

156 T-cell lymphotropic virus type I (HTLV-I) in adult T-cell leukemia/lymphoma (ATL) and HTLV-I associat

157 ropic virus type 1 (HTLV-1) infection causes adult T-cell leukemia/lymphoma (ATL) and is associated w

158 ociated with the lymphoproliferative disease adult T-cell leukemia/lymphoma (ATL) and the neurodegene

159 In adult T-cell leukemia/lymphoma (ATL) cell lines and pati

160 Adult T-cell leukemia/lymphoma (ATL) is an aggressive an

161 Adult T-cell leukemia/lymphoma (ATL) is an aggressive ma

162 Adult T-cell leukemia/lymphoma (ATL) is etiologically li

163 The majority of patients with adult T-cell leukemia/lymphoma (ATL) resulting from huma

164 uman T-cell leukemia virus type 1-associated adult T-cell leukemia/lymphoma (ATL) typically has survi

165 leukemia virus type 1 (HTLV-1) will develop adult T-cell leukemia/lymphoma (ATL), a disease frequent

166 x transactivator initiates transformation in adult T-cell leukemia/lymphoma (ATL), a highly aggressiv

167 us type 1 (HTLV-1) is the causative agent of adult T-cell leukemia/lymphoma (ATL), a malignancy of CD

168 al knowledge about viral and host factors in adult T-cell leukemia/lymphoma (ATL).

169 in a lymphoproliferative disorder resembling adult T-cell leukemia/lymphoma (ATL).

170 1 (HTLV-1) is etiologically associated with adult T-cell leukemia/lymphoma (ATL).

171 ) results in a variety of diseases including adult T-cell leukemia/lymphoma (ATL).

172 Sixty-four patients with adult T-cell leukemia/lymphoma (ATL; 18 patients with in

173 cytic leukemia (3), hairy cell leukemia (1), adult T-cell leukemia/lymphoma (ATLL) (1), marginal zone

174 CL-NOS), anaplastic large-cell lymphoma, and adult T-cell leukemia/lymphoma (ATLL) and a lower incide

175 ll lymphotropic virus type 1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATLL) and a variety of l

176 member A (RHOA) hotspot mutations among the adult T-cell leukemia/lymphoma (ATLL) category have oppo

177 Adult T-cell leukemia/lymphoma (ATLL) is an incurable di

178 the cytogenetic and clinical significance of adult T-cell leukemia/lymphoma (ATLL) is still unclear.

179 In IL-2-dependent cells and adult T-cell leukemia/lymphoma (ATLL) patient samples, h

180 hotropic virus type-1 (HTLV-1) that initiate adult T-cell leukemia/lymphoma (ATLL) remain unclear, in

181 ) to primary T cells in vitro and in ex vivo adult T-cell leukemia/lymphoma (ATLL) samples, but not a

182 We recently reported the first case of adult T-cell leukemia/lymphoma (ATLL) that responded rap

183 +) and CD8(+) T cells, yet this virus causes adult T-cell leukemia/lymphoma (ATLL) that typically has

184 in the CD4+ leukemic cells of patients with adult T-cell leukemia/lymphoma (ATLL), the viral transac

185 us type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma (ATLL).

186 Type I (HTLV-I) is the etiological agent of Adult T-cell Leukemia/Lymphoma (ATLL).

187 us type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma (ATLL).

188 munoblastic type (18.5%), NKTCL (10.4%), and adult T-cell leukemia/lymphoma (ATLL; 9.6%).

189 -negative anaplastic large cell lymphoma, 14 adult T-cell leukemia/lymphoma and 44 extranodal NK/T-ce

190 ll lymphotropic virus type 1 (HTLV-1) causes adult T-cell leukemia/lymphoma and exhibits high genetic

191 us type 1 (HTLV-1) is the causative agent of adult T-cell leukemia/lymphoma and HTLV-1-associated mye

192 T-lymphotropic virus type 1 (HTLV-1) causes adult T-cell leukemia/lymphoma and is associated with a

193 us type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma and is associated with a

194 human retrovirus identified and causes both adult T-cell leukemia/lymphoma and tropical spastic para

195 that causes two distinct pathologies termed adult T-cell leukemia/lymphoma and tropical spastic para

196 ukemia virus type 1 (HTLV-1) is the cause of adult T-cell leukemia/lymphoma as well as tropical spast

197 ow well recognized as a potential factor for adult T-cell leukemia/lymphoma development.

198 Adult T-cell leukemia/lymphoma has a homogeneous molecul

199 Adult T-cell leukemia/lymphoma is a fatal malignancy eti

200 so studied: MT4 (derived from a patient with adult T-cell leukemia/lymphoma) and Jurkat (derived from

201 mia virus type I is the etiological agent of adult T-cell leukemia/lymphoma, an aggressive and fatal

202 type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia/lymphoma, and it encodes a number

203 T-cell lymphoma, cutaneous T-cell lymphoma, adult T-cell leukemia/lymphoma, and other peripheral T-c

204 clude malignant infiltrates in patients with adult T-cell leukemia/lymphoma, retinal degeneration, ne

205 e each had diffuse large B-cell lymphoma and adult T-cell leukemia/lymphoma.

206 ity in patients with hairy cell leukemia and adult T-cell leukemia/lymphoma.

207 kemia virus type I is the etiologic agent of adult T-cell leukemia/lymphoma.

208 quently seen in patients with HTLV-I-induced adult T-cell leukemia/lymphoma.

209 presents a major risk for the development of adult T-cell leukemia/lymphoma.

210 ) anaplastic large-cell lymphoma (ALCL), and adult T-cell leukemia/lymphoma.

211 T-cell proliferation, which in turn leads to adult T-cell leukemia/lymphoma.

212 reproduced many elements of HTLV-associated adult T-cell leukemia/lymphoma.

213 , CD4+ cutaneous T-cell lymphomas (6 cases), adult T-cell leukemia/lymphomas (3 cases), T-cell chroni

214 tient), Hodgkin's disease (one patient), and adult T-cell leukemia (one patient).

215 emain asymptomatic, but a proportion develop adult T cell leukemia or inflammatory disease.

216 solated from patients with HTLV-I-associated adult T-cell leukemia or with progeria.

217 mary peripheral blood mononuclear cells from adult T-cell leukemia patients.

218 In our murine model of adult T-cell leukemia, PS-341 used alone did not yield p

219 are causative agents for cervical cancer and adult T-cell leukemia, respectively.

220 Nine patients with adult T-cell leukemia were treated.

221 Adult T-cell leukemia, which can result from infection w

222 HTLV-1 mainly causes adult T cell leukemia, while HTLV-2 is not associated wi

223 mbined immunodeficient murine model of human adult T-cell leukemia with an anti-Tac antibody-streptav

224 -2 receptor alpha (IL-2Ralpha) using a human adult T-cell leukemia xenograft model.