ライフサイエンスコーパス: adult human

1 to be restricted to liver and kidney in the adult human.

2 vidence that new lung growth can occur in an adult human.

3 lmonds in the growing pig as a model for the adult human.

4 act (stomach and small intestine) of healthy adult humans.

5 l to understanding why regeneration fails in adult humans.

6 Its normal habitat is the nasopharynx of adult humans.

7 tations to behavioral responses to threat in adult humans.

8 gulating embryonic globin gene expression in adult humans.

9 y the same anatomic regions as active BAT in adult humans.

10 se (18FDG) have shown the presence of BAT in adult humans.

11 18-30 years old) and older (60-67 years old) adult humans.

12 -specific manner in the prefrontal cortex of adult humans.

13 fat mass and higher lean mass in animals and adult humans.

14 mice with immune systems closer to those of adult humans.

15 fants and hibernating mammals-also exists in adult humans.

16 urbance, sleep duration, and inflammation in adult humans.

17 le size of 50 or more patients; studies with adult humans 18 years or older; and studies published in

18 rtex and the contraction force of 17 healthy adult humans (7 females, 10 males).

19 In adult humans, 700 new neurons are added in each hippocam

20 Improved endurance exercise performance in adult humans after sprint interval training (SIT) has be

21 id burden and WMH in clinically normal older adult humans aged 65-86 (N = 168) and examined each biom

22 is evidence for hippocampal neurogenesis in adult humans, although whether its extent is sufficient

23 We trained a group of adult human amblyopes on a crowded letter identification

24 ision drawing task and fMRI to investigate 8 adult human amputees with chronic (mean 33 years) unilat

25 higher than SCN10A transcript levels in both adult human and mouse heart tissue.

26 f pyramidal neurons in acute brain slices of adult human and mouse temporal cortex and probed the dyn

27 This study aimed to investigate whether adult humans and a distantly related habitually tool-usi

28 However, adult humans and animals that have evolved at altitude s

29 enic energy dissipation has been revealed in adult humans and has high clinical importance.

30 cortices varies several fold across healthy adult humans and is genetically heritable.

31 tic beta-cell proliferation is infrequent in adult humans and is not increased in type 2 diabetes des

32 owed that brown adipose tissue is present in adult humans and may be exploited for its anti-obesity a

33 al perceptual learning paradigms, we trained adult humans and mice in an immersive audio game that ch

34 ted feedback is compelling but restricted to adult humans and nonhuman animals.

35 uary 1, 2010, and June 1, 2015, inclusive of adult humans, and reported in the English language only.

36 tissue combust fuels for heat production in adult humans, and so constitute an appealing target for

37 l brain activity alteration in healthy young adult human APOE-epsilon4 carriers.

38 tudies of social learning have revealed that adult humans are "over-imitators" who frequently reprodu

39 previously identified brown fat deposits in adult humans are composed of beige adipocytes.

40 bolism in brown fat really is increased when adult humans are exposed to cold.

41 NIRS is not strictly limited, NIN signals in adult humans are strongly biased towards the outermost 1

42 ument a bias in head-turning to the right in adult humans, as tested in the act of kissing.

43 Using adult human astrocytes and motor neurons, Re et al. (201

44 results suggest that CCL2 binding to primary adult human astrocytes is CCR2-independent and is likely

45 In a group of older adult humans at the earliest stages of cognitive decline

46 Here, we found that adult human atrial epicardial cells were highly adipogen

47 hown that in response to mild cold exposure, adult human BAT consumes more glucose per gram than any

48 dipocytes from stromal vascular fractions of adult human BAT from two individuals and globally analyz

49 erging questions, with a special emphasis on adult human BAT.

50 ored energy and its demonstrated presence in adult humans, BAT holds great promise for the treatment

51 sized that targeting p57Kip2 could stimulate adult human beta cell replication.

52 herapeutic approach to beta cell deficiency, adult human beta cells have proven recalcitrant to such

53 hat can induce regeneration and expansion of adult human beta cells in vivo or ex vivo.

54 lated insulin secretion by both juvenile and adult human beta cells.

55 goal of diabetes research, yet induction of adult human beta-cell replication has proven frustrating

56 at conclusions on the lack of replication of adult human beta-cells are incorrect and suggest that ad

57 authentic replication with the expansion of adult human beta-cells could be demonstrated.

58 Some report that adult human beta-cells do not replicate, but we postulat

59 Surprisingly, adult human beta-cells express little or no PRLR.

60 ss failed to confer proliferative ability on adult human beta-cells in response to PRL.

61 Induction of proliferation in adult human beta-cells is challenging.

62 an beta-cells are incorrect and suggest that adult human beta-cells replicate at a low but quantitati

63 We have devised an adult human bone marrow MSC (hMSC) delivery formula by i

64 It was previously demonstrated that adult human bone marrow-derived mesenchymal stem/stromal

65 ngle cell RNA sequencing on the study of the adult human brain and constitutes a first step toward a

66 Zika virus (ZIKV) infects fetal and adult human brain and is associated with serious neurolo

67 e we address this issue by using post-mortem adult human brain and spinal cord samples originating fr

68 Six tau isoforms are present in the adult human brain and they differ by the presence of 3(3

69 found in a yeast two-hybrid screen using an adult human brain cDNA library.

70 esonance imaging and network analysis in the adult human brain has identified a set of highly connect

71 A significant feature of the adult human brain is its ability to selectively process

72 with all cell types in both adult mouse and adult human brain tissue.

73 ow numbers of neurons and glial cells in the adult human brain were reported and we examine the reaso

74 The comprehensive relations between healthy adult human brain white matter (WM) microstructure and g

75 ne expression and splicing are widespread in adult human brain, being detectable in all major brain r

76 ant population of GlyRs in the postnatal and adult human brain, brainstem and spinal cord.

77 d analysis of a transcriptional atlas of the adult human brain, comprising extensive histological ana

78 ough tau isoforms are balanced in the normal adult human brain, imbalances in 3R:4R ratio have been t

79 In the adult human brain, two tau isoforms are found in equal a

80 Using microglia isolated from the adult human brain, we demonstrate that myelin phagocytos

81 o glial progenitor cells derived from normal adult human brain, we found that the F2R gene encoding P

82 that TERT protein persists in neurons of the adult human brain, where it may have a protective role a

83 In vitro studies were conducted using adult human brain-derived oligodendrocytes challenged by

84 such responses using dissociated cultures of adult human brain-derived oligodendrocytes.

85 that it might have a protective function in adult human brain.

86 n sulfate proteoglycan in the developing and adult human brain.

87 ronounced differences between the foetal and adult human brain.

88 au and 4R-tau, which is equally expressed in adult human brain.

89 rate a unique pattern of neurogenesis in the adult human brain.

90 ed in oligodendrocytes and astrocytes in the adult human brain.

91 atter and of multiple sclerosis lesions from adult human brain.

92 NPs based upon an eQTL data set derived from adult human brain.

93 nctionality was identified for 4 loci in the adult human brain.

94 genes are expressed in the developmental and adult human brain.

95 purify astrocytes from fetal, juvenile, and adult human brains and to maintain these cells in serum-

96 Adult human brains retain the capacity to undergo tissue

97 ene expression data sets from developing and adult human brains revealed that BCL11A expression patte

98 he study of adult mouse, adult zebrafish and adult human brains, and it may find many other applicati

99 dataset from 150 neuropathologically normal adult human brains, our method identifies eQTLs that wer

100 underpinning complex cognitive functions in adult human brains.

101 esolution in visual and temporal cortices of adult human brains.

102 ls with epidermal progenitor activity within adult human breast tissues.

103 To understand the nature of adult human brown adipocytes at single cell resolution,

104 ent understanding of processing of threat by adult humans by revealing the characteristics of behavio

105 assessment of osteoblast recruitment during adult human cancellous bone remodeling is lacking.

106 z scores (HAZs) and stunting at age 24 mo to adult human capital, marriage, fertility, health, and ec

107 progenitor cell [FhCPC]) and adult failing (adult human cardiac progenitor cell [AhCPC]) hearts, as

108 Prolonged mechanical unloading induces adult human cardiomyocyte proliferation, possibly throug

109 diomyocytes resemble, but are not identical, adult human cardiomyocytes and provide a new platform fo

110 ntractility of isolated healthy and ischemic adult human cardiomyocytes would be minimally sensitive

111 decisions and transitions from embryonic to adult human cell types during development are poorly und

112 e demonstrates the applicability of SCNT for adult human cells and supports further investigation of

113 human, being more prominent in the stenosed adult human central canal.

114 MAPT, generates six protein isoforms in the adult human central nervous system (CNS).

115 A immunoreactivity was detected in fetal and adult human cerebral cortex.

116 neuronal marker immunotagging of nuclei from adult human cerebral cortex; 2) fluorescence-activated n

117 meterized based on representative indoor and adult human characteristics, the model is applied here t

118 ed transcriptome sequencing of 16 regions of adult human, chimpanzee, and macaque brains.

119 caudate nucleus, and hippocampus of multiple adult humans, chimpanzees, and rhesus monkeys.

120 mpared with chondrocytes isolated from young adult humans, chondrocytes from older adults exhibited h

121 g to include six tau isoforms as seen in the adult human CNS.

122 Adult human cognition is supported by systems of brain r

123 have demonstrated that the skin of a normal adult human contains 10-20 billion resident memory T cel

124 y expressed in the limbal stem cell niche of adult human cornea, we assume that CHRDL1 plays a key ro

125 Adult human corneal endothelial cells are G1-arrested, e

126 e reconstructed >500 dendritic segments from adult human cortex obtained from autopsies.

127 Thus, adult human cortical microcircuits relay information at

128 R to investigate changes in transcription in adult human cortical slices exposed to sublethal doses o

129 olomics findings in a longitudinal cohort of adult human dengue patients across different infection s

130 lly, P12 bound PDGF-BB (KD=200 nM), enhanced adult human dermal fibroblast (AHDF) survival under seru

131 rived growth factor BB (PDGF-BB) and promote adult human dermal fibroblast (AHDF) survival under stre

132 rticularly in the areas of BAT physiology in adult humans, developmental lineages of brown adipose ce

133 FACS-sorted adult human ductal cells clonally expanded as spheres in

134 We show that in healthy adult human ears, deeper tissue penetration of SWIR ligh

135 e report a novel method for the isolation of adult human epithelial stem cells (hEpiSCs) from the epi

136 ides a molecular basis for observations that adult human epithelium can be transdifferentiated on the

137 d the chromosomal architectures of fetal and adult human erythroblasts and found that, globally, chro

138 o the fetal gamma-globin promoter in primary adult human erythroblasts increases gamma-globin promote

139 B expression regulates HbF levels and causes adult human erythroblasts to differentiate with a more f

140 to a reversion of gamma-globin silencing in adult human erythroblasts.

141 The bony pelvis of adult humans exhibits marked sexual dimorphism, which is

142 owever, TNC immunolocalization in the JCT of adult human eyes suggests that certain areas of the TM a

143 Adult humans fail to regenerate their hearts following i

144 rapid, highly reproducible method to convert adult human fibroblasts from living ALS patients to indu

145 dedifferentiation and lineage conversion of adult human fibroblasts into functional endothelial cell

146 ngle VEE-RF RNA transfection into newborn or adult human fibroblasts resulted in efficient generation

147 is to establish conditions for conversion of adult human fibroblasts to a cardiac phenotype.

148 ed cardiac marker expression in neonatal and adult human fibroblasts.

149 as used to investigate the BCR repertoire of adult humans following immunization and to test the hypo

150 (n = 7) and SPECT/CT (n = 74) scans done in adult humans for parathyroid imaging were reviewed for u

151 dopamine synthesis capacity in healthy older adult humans free of amyloid pathology, relative to youn

152 Adult humans frequently engage in the reciprocal exchang

153 We show here that cells can be isolated from adult human gingival tissue that can be expanded in vitr

154 t between the nasopharynx and bloodstream of adult humans: glucose is absent from the nasopharynx, wh

155 Even though the existence of BAT in adult humans has been widely appreciated, its cellular o

156 Adult humans have brown fat, but the amounts and activit

157 is paralleled only by the confirmation that adult humans have heat-dissipating brown adipose tissue,

158 on the minimal regenerative potential of the adult human heart and the limited availability of human

159 mphasizing the regeneration potential of the adult human heart and the mechanisms involved.

160 The adult human heart does not regenerate significant amount

161 Mitochondrial DNA (mtDNA) in adult human heart is characterized by complex molecular

162 or cardiomyocyte regeneration in the healthy adult human heart is fundamentally relevant for both myo

163 The adult human heart is unable to regenerate after various

164 rstanding the maturation and pathogenesis of adult human heart muscle cells, and this concept may be

165 The heart from a 6-day old neonate and an adult human heart served as controls.

166 cting enhancers active in the developing and adult human heart, an organ whose impairment is a predom

167 essed and confined to the nuclei of diseased adult human hearts but is restricted to the cytoplasm of

168 The low regenerative capacity of adult human hearts has thus far limited the available th

169 presses adult beta-globin gene expression in adult human hematopoietic precursor cells, but the under

170 Here we report that in adult human hematopoietic stem and progenitor cells (HSP

171 investigate here explicit O(2) diffusion in adult human hemoglobin (HbA) as a case study employing t

172 y, because this amino acid is not present in adult human hemoglobin.

173 In most adult humans, hepatitis B is a self-limiting disease lea

174 y, here we report the expression of ABCG2 in adult human hepatocellular carcinoma (HCC) in both in vi

175 Eighty adult human (Homo sapiens) participants were presented w

176 Here we studied in healthy adult humans how two different types of context (large o

177 in which 5-hmC regulates differentiation of adult human intestine and 5-hmC alterations contribute t

178 a-cell formation and coproduced with MAFA in adult human islet beta-cells, bound MLL3 and MLL4 comple

179 ndent hPSC lines, human fetal pancreata, and adult human islets points to two major conclusions: (i)

180 the cells, in vitro differentiated cells and adult human islets were compared by global proteomic ana

181 ced in culture and released from quiescence, adult human kidney epithelial cells (hKEpCs), uniformly

182 steine (NAC) reduces the incidence of DGF in adult human kidney transplant recipients.

183 ive principal cells of the distal nephron of adult human kidney.

184 Laboratory mice--like newborn, but not adult, humans--lack effector-differentiated and mucosall

185 ymphocytic leukemia (CLL) is the most common adult human leukemia.

186 ion in cognitive test performance across the adult human life span.

187 ing) beyond their acoustic (surface) form in adult human listeners.

188 ree-dimensional liver buds against fetal and adult human liver single-cell RNA sequencing data, and f

189 pithelial cell phenotypes preexist in normal adult human livers, which might provide an alternative e

190 vitro and in vivo grown HLOs with fetal and adult human lung tissue, we found that in vivo transplan

191 s that were remarkably similar to the native adult human lung.

192 ndicate the existence of beige adipocytes in adult humans, making this cell type an attractive therap

193 lations predict that 370 MBq of (51)Mn in an adult human male would yield an effective dose equivalen

194 STRO1(+) mesenchymal stem/stromal cells from adult human marrow and mesenchymal cells spontaneously a

195 Adult human mesenchymal stem cells show structural rearr

196 5) neonatal rat cardiomyocytes and 7% or 28% adult human MSCs (hMSCs) in diffuse or clustered distrib

197 We explored POMK expression in fetal and adult human muscle and identified widespread expression

198 nistic insights into both Wnt signalling and adult human myogenic progenitor differentiation.

199 A sample of nonclinical adult humans (N = 518) performed three cognitive tasks (

200 We conclude that in adult human neocortex spine positions are mostly random.

201 timing-dependent synaptic plasticity in the adult human neocortex.

202 Compared with older children and adults, human neonates have reduced and delayed CD4(+) T

203 ntiation potential of stem/progenitor cells, adult human neural progenitor cells ("AHNPs") isolated f

204 here are no disease-modifying treatments for adult human neurodegenerative diseases.

205 Both AS3MT(d2d3) and BORCS7 are expressed in adult human neurons and astrocytes, and they are upregul

206 h expression has not been reported in normal adult human neurons.

207 cal and carbon-14 dating approaches, that in adult humans new neurons integrate in the striatum, whic

208 bolism and excreted in the urine of mice and adult human non-smokers as carnosine-propanols.

209 Here we report the conversion of adult human nonendocrine pancreatic tissue into endocrin

210 viously identified NP and NC marker genes in adult human NP cells from a range of ages and degenerate

211 HSV infection of adult humans occasionally results in life-threatening he

212 dies of the mechanisms underlying subsequent adult human oligodendrocyte cell death.

213 in mouse and increases both adult mouse and adult human oligodendrocyte progenitor cell (OPC) differ

214 Under basal conditions, adult human OLs were less metabolically active than thei

215 Using fMRI, we scanned 36 healthy young adult humans on a novel two-back task requiring working

216 tudy compares the relative susceptibility of adult human OPCs and mature OLs to injury in actively de

217 epair, plus demonstration of its activity on adult human OPCs, leads us to propose dual PDE7-GSK3 inh

218 also report anti-Foxo3 immunofluorescence in adult human outer hair cells.

219 Adult human pancreatic beta cells are refractory to curr

220 21 facilitates cell cycle entry of quiescent adult human pancreatic beta cells.

221 onation, expansion and conversion of primary adult human pancreatic ductal cells into progeny resembl

222 In vitro expansion of beta-cells from adult human pancreatic islets would overcome donor beta-

223 f Oldowan tool-making skills along chains of adult human participants (N=184) using five different tr

224 On every trial, adult human participants attended to one of three simult

225 Following from previous work indicating that adult human participants can exhibit cumulative learning

226 zing electrical brain responses from healthy adult human participants while they performed a time est

227 halographic (MEG) data were recorded from 13 adult human participants with ASD and 16 controls during

228 We recorded magnetoencephalography from 20 adult human participants with ASD and 20 matched control

229 Testing adult human participants with high-density EEG, we show

230 y (RSFC) analyses, with data from 33 healthy adult human participants, we demonstrate that (1) the VW

231 3T MRI scanner in 16 autistic and 17 control adult human participants.

232 We find that these principles also obtain in adult human perception.

233 ns that are representative of those found in adult human plasma.

234 Over 90% of the adult human population is chronically infected with the

235 Because a large proportion of the adult human population possesses Ras mutations in tissue

236 That adult humans possess brown fat is now accepted - but is

237 In this study, comparison of neonatal versus adult human progenitors has identified a blockade in the

238 Werner syndrome (WS) is the canonical adult human progeroid ('premature aging') syndrome.

239 The study of congenitally deaf adult humans provides an opportunity to examine neuroana

240 e closely reflected the immune signatures of adult humans rather than neonates, altered resistance to

241 set of lincRNAs in terminally differentiated adult human retinal neurons based on their sequence cons

242 B-crystallin (alphaB) is exported out of the adult human retinal pigment epithelial cells (ARPE19) pa

243 K4a expression, leading to RGC senescence in adult human retinas.

244 Here we show that a subpopulation of adult human RPE cells can be activated in vitro to a sel

245 Furthermore, adult human salivary glands damaged by irradiation also

246 xisting culture techniques to prepare viable adult human sensory neurons for functional studies.

247 In adult humans, short-term monocular deprivation strongly

248 stem/progenitor cells (MDSPCs) isolated from adult human skeletal muscle (hMDSPCs) can adopt neuronal

249 n fetal skeletal muscle and compared them to adult human skeletal muscle and rabbit psoas muscle.

250 d reports on the kinetics of either fetal or adult human skeletal muscle myofibrils.

251 ogenesis during development, but its role in adult human skeletal muscle remains unknown.

252 are differentially expressed in fetal versus adult human skeletal muscle tissue.

253 Adult human skin biopsies were obtained from volunteers

254 Adult human skin fibroblasts were exposed for 18 h to th

255 B1 accumulation, whereas in newborn mice and adult human skin, we report LC3 puncta coincident with m

256 Epigenetic reprogramming of adult human somatic cells to alternative fates, such as

257 We found that the infant and adult human spinal cord contains ependymal cell types th

258 Four of the loci were also associated with adult human stature, but these remained associated with

259 nin-expressing interneurons are added to the adult human striatum at a substantial rate.

260 eads between conventional pigs (growing) and adult human subjects (with the metabolic syndrome).

261 ed using the English language that described adult human subjects who received a heart, lung, kidney,

262 In a sample of 160 adult human subjects with a broad IQ range, we investiga

263 We now report that, in male and female adult human subjects, encoding and later consolidation o

264 tion in cerebral and extracerebral tissue of adult human subjects, where the top layer (layer 1) repr

265 but capacity-limited) mechanisms in healthy adult human subjects.

266 if they evaluated vital signs monitoring in adult human subjects.

267 uivocally the existence of functional BAT in adult humans, suggesting that many humans retain some fu

268 microvessels from four cryopreserved normal adult human sural nerves referenced to the Genome Refere

269 ermined the energy utilization properties of adult human surgically derived OLs cultured under either

270 It is unknown whether adult human synapses are more efficient in transferring

271 e the immune system, and the availability of adult human synovial fibroblasts are likely to provide n

272 differentiation status and ECM production in adult human tendons and ligaments.

273 ed genes, species which can also be found in adult human testis.

274 B cells comprise a much smaller fraction in adult humans than mice.

275 In adult humans the prefrontal cortex possesses wider minic

276 tive functions of the upper tract of healthy adult humans: the TIM-1.

277 Lindquist et al.'s meta-analysis focuses on adult humans; the authors' emotion model might be streng

278 xia decreases insulin sensitivity in healthy adult humans; the mechanism is unclear, but increased ac

279 with evidence for cardiomyocyte turnover in adult humans, this suggests that cardiomyocyte prolifera

280 uted in the juxtacanalicular (JCT) region of adult human TM, predominantly in the basement membrane u

281 and the 1-CoPK model was parametrized for an adult human to calculate HLB from HLT.

282 avioral training enables monaurally-deprived adult humans to exploit both of these adaptive processes

283 rategies for activating BAT thermogenesis in adult humans to increase whole-body energy expenditure.

284 ch kinetics approaching reported values from adult human trabeculae.

285 We scanned 391 healthy adult human twins and their siblings (mean age: 23.6 +/-

286 or-posterior axis using neuroimaging data of adult human twins.

287 nhibition triggers homeostatic plasticity in adult human V1 after a brief period of abnormal visual e

288 Compared with adult human ventricular cardiomyocytes, T-tubules in T3+

289 data in a predictive in silico model of the adult human ventricular myocyte.

290 oit the intrinsic residual plasticity of the adult human visual cortex.

291 We found that the adult human visual system is tuned to these contingencie

292 isolated anatomically defined neck fat from adult human volunteers and compared its gene expression,

293 infused as an intravenous bolus in 7 healthy adult human volunteers at </=2 mg/kg to provide circulat

294 of 400 mg and 600 mg administered in healthy adult human volunteers.

295 GABA concentration in V1 of adult humans was measured using ultra-high-field 7T magn

296 ounts for up to 70% of bone marrow volume in adult humans, we examined the adipocyte-leukemia cell in

297 In healthy adults humans, we investigated the impact of effortful,

298 we examined the distribution of netrin-1 in adult human white matter and multiple sclerosis lesions.

299 s were recorded from 20 right-handed healthy adult humans who listened to five different recorded sto

300 ZIKV is considered a transient infection in adult humans without marked long-term effects, there may