ライフサイエンスコーパス: adult mice

1 cose clearance and exercise capacity in lean adult mice.

2 s the incidence of multi-oocyte follicles in adult mice.

3 lterations in spatial learning and memory in adult mice.

4 xpression specifically in the hippocampus of adult mice.

5 es also abolished colonization resistance in adult mice.

6 ally in the alveolar type II (ATII) cells of adult mice.

7 ark early cells of the osteoblast lineage in adult mice.

8 cyte polarity, but these defects improved in adult mice.

9 ormal function of pancreatic acinar cells in adult mice.

10 step-by-step development in otherwise normal adult mice.

11 cally with observed PT-promoted pathology in adult mice.

12 mic pathology, and death in neonatal but not adult mice.

13 on mediated-kidney specific gene transfer in adult mice.

14 the olfactory and vomeronasal epithelium in adult mice.

15 ck LIP of CD8(+) T cells in neonatal but not adult mice.

16 from aged mice were comparable to levels in adult mice.

17 ent and disruption of glucose homeostasis in adult mice.

18 ty and central nervous system homeostasis in adult mice.

19 T atrophy and increased overall adiposity in adult mice.

20 es (LNPs), was administered intravenously in adult mice.

21 shown to be necessary for mEV71 virulence in adult mice.

22 intact skeletal muscle fibres obtained from adult mice.

23 tact long skeletal muscle fibre bundles from adult mice.

24 gait alterations in Chn1KO/KO and Epha4KO/KO adult mice.

25 r collateral-CA1 synapses in acute slices of adult mice.

26 n restoring the decreased RANKL/OPG ratio in adult mice.

27 uces hypertension and cardiac hypertrophy in adult mice.

28 PCs have collaterals in young, juvenile, and adult mice.

29 B integrity under pathological conditions in adult mice.

30 ll subfields of the hippocampus in young and adult mice.

31 n, blood glucose homeostasis and survival in adult mice.

32 o2(+) vagal sensory neurons causes apnoea in adult mice.

33 bnormal neuronal morphology and behaviors in adult mice.

34 odestly increases bone density parameters of adult mice.

35 he extensor digitorum longus (EDL) muscle of adult mice.

36 erinatal DDT exposure causes hypertension in adult mice.

37 the proper function of endothelial cells in adult mice.

38 uced in different neuropathic pain models in adult mice.

39 neonatal pups and airway hyper-reactivity in adult mice.

40 ment of Sox2 for maintenance of the DESCs in adult mice.

41 after experimental traumatic brain injury in adult mice.

42 ulting in increased beta-cell replication in adult mice.

43 creasing seizure susceptibility in young and adult mice.

44 r2, or both in smooth muscle cells (SMCs) of adult mice.

45 lectrophysiological recordings in DGGCs from adult mice.

46 the forebrain and to inducibly ablate it in adult mice.

47 0.11 and 0.77 +/- 0.08 ms, respectively) in adult mice.

48 also orchestrate other complex behaviors in adult mice.

49 RNAs) within the medial prefrontal cortex of adult mice.

50 born mice and severe neurological defects in adult mice.

51 thality but strong immune responses in young adult mice.

52 ellite cells inhibits muscle regeneration in adult mice.

53 ells, we have conditionally ablated Ctla4 in adult mice.

54 ecific, conditional ablation of microglia in adult mice.

55 pecifically ablate FOXA1/2 in mDA neurons of adult mice.

56 l (RES) induces beige adipocyte formation in adult mice.

57 for glucose-stimulated insulin secretion in adult mice.

58 ations from socially interacting, individual adult mice.

59 llowing manipulation of visual experience in adult mice.

60 lysis with RNA sequencing of MEC tissue from adult mice.

61 DA neurons and impact on feeding behavior in adult mice.

62 roglia dynamics through the intact skulls of adult mice.

63 vascular malformations to vascular tumors in adult mice.

64 lens degeneration becomes apparent in young adult mice.

65 tially rescue DMM-induced OA-like defects in adult mice.

66 rmore, IL-3 increases the serum OPG level in adult mice.

67 memory impairment and neurodegeneration, in adult mice.

68 ed cold-induced beige adipocyte formation in adult mice.

69 e to eliminate FMRP only in the PFC alone of adult mice.

70 ling stimulates neurogenesis in unchallenged adult mice.

71 Vectors were IVT injected into the eyes of adult mice.

72 in life, on the metabolism of cholesterol in adult mice.

73 delete the histone demethylase LSD1/KDM1A in adult mice.

74 f this marker in the olfactory epithelium of adult mice.

75 lite cells inhibits myofiber regeneration in adult mice.

76 f remodeling circadian behavioral rhythms in adult mice.

77 ent and is essential during remyelination in adult mice.

78 contributes to its tissue increase in hph-1 adult mice.

79 and synaptic functions in n-3 PUFA-deficient adult mice.

80 expendable for maintaining BRB integrity in adult mice.

81 a activity causes adipose tissue fibrosis in adult mice.

82 onal and cognitive behaviors in malnourished adult mice.

83 astrocytic processes at CA3-CA1 synapses of adult mice (1) differ from those in astrocytic somata an

84 In adolescent (but not adult) mice, a low dose of cocaine reduced p-eIF2alpha i

85 Although colonization of adult mice acutely reduces bone mass, in long-term colon

86 on of agrin promotes cardiac regeneration in adult mice after myocardial infarction, although the deg

87 n adult neurons, and that it is increased in adult mice after nerve injury.

88 d delivery of CRISPR/Cas9 to the pancreas of adult mice, allowing simultaneous editing of multiple ge

89 nvestigated how manipulating neurogenesis in adult mice alters excitatory synaptic transmission to ma

90 injected an AAV8-F9 vector into neonatal and adult mice and achieved on-target integration into appro

91 bacter rodentium colitis (CC) was induced in adult mice and colonic neurons were quantified.

92 pes were observed in induced RASA1-deficient adult mice and embryos expressing a catalytically inacti

93 litis promotes rapid enteric neurogenesis in adult mice and humans through differentiation of Sox2- a

94 dual neurons in the auditory cortex of awake adult mice and is associated with long-term improvement

95 We found that mECMs isolated from adult mice and rats were sufficient to redirect testicul

96 (NGIs) in the dorsal hippocampus (dNGIs) of adult mice and regulate both the dNGIs survival and spat

97 ot analysis on heart lysates from Snrk cmcKO adult mice and SNRK knockdown cardiomyocytes showed incr

98 This includes local and systemic delivery to adult mice and systemic delivery to neonatal mice.

99 expressed in epithelial cells of the lung in adult mice and that it is induced during pneumonia.

100 nced global DNA methylation patterns in both adult mice and their offspring and engendered behavioral

101 led markers in a 1-mm thick brain slice from adult mice, and 14 days were required for detecting anti

102 tissue culture cells, after gene transfer to adult mice, and ex vivo in cell-free conditions, indicat

103 sed retrograde tracing of sensory neurons in adult mice, and may help to better understand the molecu

104 al for normal vocal behavior in juvenile and adult mice, and that Foxp2 mutant mice may provide a tra

105 ated with the degree of anxiety displayed in adult mice, and that this correlation was disrupted in M

106 thirds of all myeloid cells and platelets in adult mice, and this contribution could be accelerated b

107 al excitatory synaptic input following MD in adult mice, and this disinhibition induces a "lower PV n

108 well as the locomotor abilities observed in adult mice are independent of Gal-1.

109 ds enabling kidney-specific gene transfer in adult mice are needed to develop new therapies for kidne

110 ow that oral administration of DHA to normal adult mice as lysophosphatidylcholine (LPC) (40 mg DHA/k

111 of the KCTD16 proteins in the hippocampus of adult mice associate with KCTD12.

112 In adult mice, attenuation of hippocampal ACSS2 expression

113 subventricular and the subgranular zones of adult mice brains, all compounds stimulated neural stem

114 all phenotypes displayed by Trpm6-deficient adult mice, but also may extend the lifespan of wildtype

115 pletion of CD4(+) T cells in PhtD-vaccinated adult mice, but not PCV13-vaccinated mice, caused a loss

116 e-body distribution of (52)Mn(2+) in healthy adult mice by dynamic and static PET imaging.

117 restingly, IL-3 restores RANKL expression in adult mice by enhancing bone-specific RANKL and decreasi

118 ) balance during prenatal development and in adult mice by the ion channel TRPM6.

119 s in mature hepatocytes in vivo, we injected adult mice carrying floxed Dicer1 alleles with an adenoa

120 On the other hand, adult mice carrying the schizophrenia-linked R1117X muta

121 of OGT from alphaCaMKII-positive neurons in adult mice caused obesity from overeating.

122 Acute deletion of mTORC1 in adult mice caused severe thymic involution.

123 ced ablation of Piezo2 in sensory neurons of adult mice causes decreased neuronal responses to lung i

124 oplastin deficiency or Nptn gene ablation in adult mice causes substantial electrophysiologic deficit

125 We find that adult mice deficient in microglial Mer and Axl exhibit a

126 tent appearance of proneural glioblastoma in adult mice deleted additionally for the tumor suppressor

127 These F2 generation adult mice developed a cardiac phenotype similar to hype

128 -deficient mice, activated oocytes of mature adult mice developed slower and largely failed to reach

129 of GABAB receptors from dopamine neurons in adult mice did not affect general or morphine-induced lo

130 ditional knockout (CKO) in the endothelia of adult mice did not affect homeostatic BBB integrity, but

131 opoiesis in the liver, and Vegfc deletion in adult mice did not cause anemia.

132 Induction of cKO in adult mice did not produce obvious abnormalities in rena

133 We conclude that, in adult mice, disrupting adenosine signaling in the thalam

134 In metabolic studies, HAT-L4-deficient adult mice drank water more frequently than wild-type co

135 an additional source of Mphi populations in adult mice during steady state and inflammation.

136 lergen exposure in neonatal mice, but not in adult mice, elevated the level and activity of cholinerg

137 viors were quantified based on time spent by adult mice engaging in social behaviors toward a juvenil

138 Cav-1 overexpression in adult mice enhanced dendritic arborization within the ap

139 Surprisingly, NAG neurons from lean adult mice exhibit a reduction in the GABAergic synapses

140 nimals are fertile and develop normally, and adult mice exhibit no overt tissue abnormalities.

141 hizophrenia and 62 healthy subjects and from adult mice exposed prenatally to maternal immune activat

142 perresponsiveness in vivo among juvenile and adult mice exposed to neonatal hyperoxia.

143 wed increased 5-lipoxygenase levels, whereas adult mice expressed more group 10 secretory phospholipa

144 In transgenic adult mice expressing channelrhodopsin (ChR2) in Dbx1(+)

145 In transgenic adult mice expressing ChR2 in SST(+) neurons, photorespo

146 Newborn and adult mice fecal material was screened for 6-pyruvoyltet

147 In adult mice fed normal chow, skeletal muscle expression o

148 Primary macrophages were isolated from adult mice fed standard chow, control diets, or DHA supp

149 In adult mice, FLARE also gave light- and motor-activity-de

150 ion and myelination in vitro, for 2 weeks in adult mice following social isolation.

151 at NuMA-MT interactions are also required in adult mice for hair follicle morphogenesis and spindle o

152 clonally amplify the genomes of neurons from adult mice for whole-genome sequencing.

153 ub glomeruli in unmanipulated (gonad-intact) adult mice from both sexes, and found that in females od

154 gene (Ati-CB1-KO) was sufficient to protect adult mice from diet-induced obesity and associated meta

155 d this receptor from vascular endothelium of adult mice, generating CXCR7(DeltaEND/DeltaEND) animals.

156 In adult mice, global inducible (Lrp1(flox/flox);CAG-CreER)

157 In adult mice, greater numbers of ectopic K8+ cells were cr

158 eta-arrestin-2 gene, barr2, in beta-cells of adult mice greatly impairs insulin release and glucose t

159 hondrocyte function and in OA development in adult mice has not been fully defined.

160 atic nerve crush and Neto2(-/-) neurons from adult mice have stunted neurite outgrowth.

161 ed despite normal immune cell development in adult mice homozygous for two different Etaa1 mutations:

162 hown not to be required for hearing in young adult mice, IHCs from Cx30 knock-out mice exhibited a co

163 hown not to be required for hearing in young adult mice, IHCs from Cx30 knockout mice exhibited a com

164 In adult mice, IL-1alpha deletion is accompanied by increas

165 at in the lymphoid and nonlymphoid organs of adult mice, ILCs are tissue-resident cells that were mai

166 Neonatal, but not adult, mice immunized with this alpha-1,3-glucan-bearing

167 whether the loss of sodium taste activity in adult mice impacts the maintenance of how taste nerves p

168 lter the development of pathological pain in adult mice in any chronic pain model evaluated.

169 poietic stem and progenitor cells (HSPCs) in adult mice in situ and found that LT-HSCs recovered from

170 terminal fields in adult control mice and in adult mice in which the alpha-subunit of the epithelial

171 response to lipopolysaccharide challenge in adult mice in which the EC expressed TRPM2 is conditiona

172 certa bidirectionally regulate sleep time in adult mice, in part through hypocretin-dependent mechani

173 p25/p35 ratio in the cortex of preCGG young adult mice indicate abnormal Cdk5 regulation.

174 However, its systemic inactivation in adult mice induces T-cell acute lymphoblastic lymphoma (

175 e susceptible to C. rodentium infection than adult mice; infants infected with 50-fold fewer bacteria

176 pertoire of the CTL response in neonatal and adult mice infected with influenza type A virus.

177 ne allele of Dkk1 in Osx-expressing cells in adult mice inhibited the recovery of BM stem and progeni

178 on of reversibility of several phenotypes in adult mice is encouraging, and brings hope that with nov

179 nases 1 and 2 (ERK1/2) in preexisting OLs of adult mice is sufficient to drive increased myelin thick

180 hat while combined Akt1 and Akt3 deletion in adult mice is tolerated, combined Akt1 and Akt2 deletion

181 1 is required for the growth and survival of adult mice is unclear.

182 ot recapitulated by a high-fat diet in young adult mice, it is significantly prevented by long-term c

183 Adult mice lacking beta-arrestin 1 selectively in hepato

184 Although adult mice lacking Ifi27l2a were more vulnerable to leth

185 l three viruses were lethal in the brains of adult mice lacking the interferon receptor, suggesting t

186 f large numbers of cells in those regions in adult mice lacking the pro-death Bax gene.

187 Trpm6 inactivation in adult mice leads to a shortened lifespan, growth deficit

188 show that peripheral sciatic nerve lesion in adult mice leads to elevated levels of Tet3 and 5-hydrox

189 uthors provide evidence that loss of LSD1 in adult mice leads to paralysis and neurodegeneration in t

190 eport that forebrain-specific loss of OGT in adult mice leads to progressive neurodegeneration, inclu

191 ss of Tsc1 within nestin-expressing cells in adult mice leads to the formation of kidney cysts, renal

192 Loss of MOZ in adult mice leads to the rapid loss of HSCs as defined by

193 n of GABA synthesis in AgRP neurons in young adult mice led to a dramatic loss of body weight due to

194 isera or CD4(+) T cells from PhtD-vaccinated adult mice led to a nonsignificant reduction in NP colon

195 The broad loss of Tmem30a in adult mice led to a reduced scotopic photoresponse, misl

196 However, expression of these genes in adult mice led to different tumor phenotypes.

197 how that re-expression of the Shank3 gene in adult mice led to improvements in synaptic protein compo

198 Deletion of Pax6 in beta cells of adult mice led to lethal hyperglycemia and ketosis that

199 Systemic knockdown of Fxn in adult mice led to multiple phenotypes paralleling those

200 tive deletion of Traf6 in satellite cells of adult mice led to profound muscle regeneration defects a

201 Cdh9/Dbx1 double-positive preBotC neurons in adult mice left breathing intact but increased calm beha

202 In adult mice, lung-localized, tissue-resident memory T cel

203 In adult mice, lymphopenia-induced proliferation (LIP) lead

204 In adult mice, monocular enucleation (ME) results in an imm

205 In normal adult mice, most mature B cells are enriched for Nod1 up

206 the deletion of Th in hematopoietic cells of adult mice neither alters energy expenditure upon cold e

207 odification of primary visual cortex (V1) in adult mice: ocular dominance (OD) plasticity resulting f

208 ait, motor coordination, or grip strength in adult mice of both sexes.

209 Using classical conditioning in adult mice of either sex, we show that orientation discr

210 e cortical region, primary visual cortex, in adult mice on the basis of single-cell RNA sequencing.

211 OA targets are frequently performed on young adult mice only.

212 e, corpus callosum, and spinal cord of young adult mice or rats.

213 ifically led to LTP of the paired pathway in adult mice (P75).

214 In adult mice, pDC depletion predisposed to severe bronchio

215 Adult mice perinatally exposed to DDT exhibited chronica

216 In adult mice, plasma OT was also increased in a RAGE-depen

217 selective knockout of Tet1 in NAc neurons of adult mice produced antidepressant-like effects in sever

218 of necdin in the substantia nigra in vivo of adult mice protects dopaminergic neurons against degener

219 mbing fibre collateral excitation is weak in adult mice, raising the question of whether the primary

220 Blockade of NTRK2 activity in adult mice recapitulate the age-like pattern in the expr

221 Adult mice received acute head only irradiation (9 Gy) a

222 NS)-Pten heterozygous (HT) and wildtype (WT) adult mice received either intraperitoneal injections of

223 Suppressing KCNH2-3.1 expression in adult mice rescues both the behavioral and physiological

224 ecific requirement for this ATR activator in adult mice restricted to rapidly dividing effector T cel

225 ditional Ssb1/Ssb2 double knockout (cDKO) in adult mice resulted in acute lethality due to bone marro

226 AND Long-term global Vegfr3 gene deletion in adult mice resulted in increased fibrinogen deposition i

227 report that disruption of the Rasa1 gene in adult mice resulted in loss of LV endothelial cells (LEC

228 cing OGT knock-out in the sensory neurons of adult mice results in a similar decrease in nerve fiber

229 xclusively in the pancreatic acinar cells of adult mice results in decreased overall pancreatic weigh

230 ices and its knockdown in the hippocampus of adult mice results in enhanced fear memory.

231 ed protein beta-arrestin 2 in hepatocytes of adult mice results in greatly increased hepatic GCGR sig

232 trate that Gsalpha deficiency in JG cells of adult mice results in kidney injury, and suggest that JG

233 sly that inactivation of WT1 in podocytes of adult mice results in proteinuria, foot process effaceme

234 Abrupt deletion of ADAR1 in adult mice revealed that both of these functions were re

235 When Zeb2 is deleted in adult mice, Schwann cells readily dedifferentiate follow

236 haematopoietic repopulation of myeloablated adult mice similarly to bone marrow cells.

237 ferences in thymic selection in young versus adult mice skew the TCR repertoire, and the relatively h

238 kin-specific deletion of both YAP and TAZ in adult mice slows proliferation of basal layer cells, lea

239 In both aged and young adult mice, stroke induces NgR1 ligands and down-regulat

240 Consequently, the G3YR adult mice suffered severe renal failure.

241 dly reduced when dystroglycan was ablated in adult mice, suggesting a role for dystroglycan in both f

242 model of symptomatic SMA in adolescents and adult mice that is induced pharmacologically from a more

243 we show in 2- to 3-week-old young neurons of adult mice, that brief-burst activity in glutamatergic f

244 In adult mice, the efficacy of PhtD vaccination was compare

245 Surprisingly, in adult mice, the LVs showed regression after VEGF-C or VE

246 In adult mice, the thalamic and cortical inputs representin

247 lls (CD31-) present in marrow from uninjured adult mice, thereby limiting the specificity of these ma

248 Pyramidotomies were performed in adult mice to deprive the left side of the spinal cord o

249 we used chronic calcium imaging in behaving adult mice to examine the activity of individual excitat

250 ith a histone deacetylase inhibitor, enables adult mice to generate neurons from MG after retinal inj

251 rences in the responses of both neonatal and adult mice to the trophic and cystic life cycle stages o

252 the behavioral phenotype of Magel2-deficient adult mice, to characterize the central oxytocin (OT) sy

253 Blockade of GR in adult mice treated with FGF2 precluded the therapeutic e

254 In adult mice, TRPM6 is required in the intestine to mainta

255 II vestibular hair cells undergo turnover in adult mice under normal conditions.

256 ial Hus1 impairment has been accomplished in adult mice using hypomorphic (Hus1(neo)) and null (Hus1(

257 tely knocked down in select brain regions of adult mice using shRNAs.

258 ent and reduction of striatal GDNF levels in adult mice via AAV-Cre delivery.

259 Deletion of ARL13b in adult mice via tamoxifen-induced Cre/loxP recombination

260 erent synapses, while sparing hair cells, in adult mice virtually eliminated the auditory brainstem r

261 RRM deletion in adult mice was triggered by injecting raloxifene (cRbm20

262 -loxP-mediated conditional gene targeting in adult mice was used.

263 l of TLS formation in the salivary glands of adult mice we demonstrate that the expansion of the lymp

264 However, in adult mice we identified a progenitor within bone marrow

265 000 nuclei isolated from cortical tissues of adult mice, we demonstrate that sNucDrop-seq not only ac

266 Using adult mice, we evaluate the effect of alcoholic steatohe

267 Here, in both juvenile and adult mice, we show that either PTEN and SOCS3 co-deleti

268 ockout in olfactory epithelial stem cells in adult mice, we show that lamin B1 deficient neurons exhi

269 y targeted loss-of-function manipulations in adult mice, we show that preventing astrocyte scar forma

270 mice with the cecal contents of neonatal and adult mice, we show that the neonatal microbiota is unab

271 epatocyte-specific deletion of Smoothened in adult mice, we showed that hepatocellular inhibition of

272 Adult mice were exposed to reaerosolized nPM for 5, 20,

273 Adult mice were exposed to repeated immobilization stres

274 Adolescent or adult mice were exposed to subchronic cocaine, then beha

275 Homozygous ETAA1-deficient adult mice were otherwise normal, healthy, and fertile,

276 PolySia levels on NCAM in adult mice were reduced significantly upon administratio

277 Adult mice were treated with an angiotensin converting e

278 Adult mice were treated with vehicle or tamoxifen and eu

279 CTL response when compared with 7-d-old and adult mice, whereas secondary CTL responses were normal.

280 Here, we demonstrate that adult mice which underwent chronic social defeat stress

281 to establish persistence in immunocompetent adult mice, which prevented its use for some in vivo exp

282 specific ablation of Nptn gene expression in adult mice, which shows that neuroplastins are indispens

283 tory subunit MYPT1 in ileal smooth muscle in adult mice with (1) smooth muscle-specific deletion of M

284 Daily gavage of conventional C3H/HeN adult mice with 10(9) commensal E coli induced visceral

285 Adult mice with a history of subchronic cocaine exposure

286 e inferior colliculus and auditory cortex in adult mice with a near-complete loss of auditory nerve a

287 esses viral propagation when administered to adult mice with active ZIKV infection, highlighting its

288 In contused adult mice with conditional ablation of Nrg1, we found a

289 We performed studies in adult mice with conditional disruption of Klf5 (Klf5(fl/

290 bacterial Cre recombinase via canalostomy in adult mice with floxed connexin 26 (Cx26) alleles promot

291 Adult mice with genetic or pharmacological reduction in

292 In fact, synaptic SCs of these adult mice with NRG1-III overexpression exhibited behavi

293 was performed in the portal trunk of C57BL6 adult mice with polyester microspheres, to ensure a bila

294 Therefore, based on aneuploidy, these adult mice with reduced life span and accelerated proger

295 ion-was impaired in both adolescent mice and adult mice with reduced p-eIF2alpha mediated translation

296 Like adolescents, adult mice with reduced p-eIF2alpha-mediated translation

297 ursors into dorsal horn circuitry in intact, adult mice with short- (5-6 weeks) or long-term (4-6 mon

298 usion and healing were evaluated in C57BL/6J adult mice with streptozotocin-induced diabetes.

299 at enables conditional deletion of CTLA-4 in adult mice, with some surprising new conclusions.

300 of normal MeCP2 levels in MECP2 duplication adult mice would rescue their phenotype.