ライフサイエンスコーパス: adult neurogenesis

1 or investigating the behavioral functions of adult neurogenesis.

2 chanism of transcriptional dosage control in adult neurogenesis.

3 at the immune system is a key contributor to adult neurogenesis.

4 each species analyzed when used to quantify adult neurogenesis.

5 and the epigenetic mechanisms that maintain adult neurogenesis.

6 rinus canaria), a species well-known for its adult neurogenesis.

7 cRNA)--plays a pivotal role in embryonic and adult neurogenesis.

8 ew neurons every day, through the process of adult neurogenesis.

9 dy was to elucidate the function of FXR1P in adult neurogenesis.

10 and glia during persistent or injury-induced adult neurogenesis.

11 g plays a critical role in developmental and adult neurogenesis.

12 rt of BDNF, a crucial factor for hippocampal adult neurogenesis.

13 aling mechanism underlying prolactin-induced adult neurogenesis.

14 tly identify lncRNAs with potential roles in adult neurogenesis.

15 memory, hippocampal synaptic plasticity, and adult neurogenesis.

16 one of the most important brain regions for adult neurogenesis.

17 e dentate gyrus, and suffer from deficits in adult neurogenesis.

18 fferentiate into neurons in a process called adult neurogenesis.

19 e important in large mammals with respect to adult neurogenesis.

20 point to this pathway as a key regulator of adult neurogenesis.

21 ugs, including antidepressants, can modulate adult neurogenesis.

22 TNF-alpha negatively regulates embryonic and adult neurogenesis.

23 cell-intrinsic molecular pathway regulating adult neurogenesis.

24 M1 expression in neural stem cells regulates adult neurogenesis.

25 have identified IGF2 as a novel regulator of adult neurogenesis.

26 stress and glucocorticoids strongly inhibit adult neurogenesis.

27 ation by the neurotransmitter GABA regulates adult neurogenesis.

28 ry and inflammation are potent regulators of adult neurogenesis.

29 ng is associated with suppressed hippocampal adult neurogenesis.

30 and progenitor cells (aNSCs) and its role in adult neurogenesis.

31 suggesting unique functions not shared with adult neurogenesis.

32 d to males without pups and observed reduced adult neurogenesis.

33 neural stem cells during development enables adult neurogenesis.

34 , D-aspartate may function as a modulator of adult neurogenesis.

35 s vary in their sensitivity to the arrest of adult neurogenesis.

36 regulation contributes to the modulation of adult neurogenesis.

37 regulates multiple aspects of embryonic and adult neurogenesis.

38 ly regulating critical genes in aNSCs during adult neurogenesis.

39 ivo expression of active RIT1 driving robust adult neurogenesis.

40 actory acuity, memory, and restored impaired adult neurogenesis.

41 y surrounding the functional implications of adult neurogenesis.

42 we report biological functions for miR-19 in adult neurogenesis.

43 important functions in learning, memory, and adult neurogenesis.

44 ic marker 5-bromo-2'-deoxyuridine to analyze adult neurogenesis.

45 beling will contribute to expand research on adult neurogenesis.

46 greatly accelerate in vivo investigations of adult neurogenesis.

47 ny in the adult brain, and thereby increases adult neurogenesis.

48 How plastic is adult neurogenesis?

49 Adult neurogenesis, a developmental process of generatin

50 Adult neurogenesis, a particular form of plasticity in t

51 Adult neurogenesis, a process of generating functional n

52 Adult neurogenesis, a specific form of brain plasticity

53 In these regions, adult neurogenesis adds another dimension of plasticity

54 These data demonstrate a functional role for adult neurogenesis after brain injury and offer compelli

55 The role of microRNAs (miRNAs) in mediating adult neurogenesis after stroke has not been extensively

56 gs show, for the first time, that inhibiting adult neurogenesis alters the circuitry of projection ne

57 entricular zone (SVZ) is a principal site of adult neurogenesis and appears to participate in the bra

58 evelopmental alcohol exposure on hippocampal adult neurogenesis and contextual fear conditioning.

59 At present, the links between adult neurogenesis and depression seem stronger than tho

60 the antidepressant fluoxetine restores both adult neurogenesis and depressive states, and improves m

61 study, we investigated the role of Norbin in adult neurogenesis and depressive-like behaviors using N

62 nt implications for environmental control of adult neurogenesis and harvesting NSCs for replacement t

63 erse roles in regulating specific aspects of adult neurogenesis and highlight the implications of suc

64 y reveals the molecular continuum underlying adult neurogenesis and illustrates how Waterfall can be

65 okine levels in vivo in young mice decreased adult neurogenesis and impaired learning and memory.

66 he tumor suppressor gene Pten is involved in adult neurogenesis and is mutated in a subset of autism

67 cial implications for the brain functions of adult neurogenesis and long-term memory.

68 , findings that advance our understanding of adult neurogenesis and may have future regenerative medi

69 iscovery five decades ago, investigations of adult neurogenesis and neural stem cells have led to an

70 We investigated adult neurogenesis and neuritic development of newly for

71 We find that adult neurogenesis and neuronal migration are not unusua

72 work controlling neuronal differentiation in adult neurogenesis and neuronal reprogramming of somatic

73 ndicate a profound role for alpha7-nAChRs in adult neurogenesis and predict that alpha7-nAChR loss wi

74 RK5 as a novel signaling molecule regulating adult neurogenesis and provide strong evidence that adul

75 theory that depression results from impaired adult neurogenesis and restoration of adult neurogenesis

76 vestigate the relationship between decreased adult neurogenesis and stress-induced changes in hippoca

77 AR from the mouse brain triggers deficits in adult neurogenesis and synapse homeostasis that lead to

78 on also prompted the recovery of hippocampal adult neurogenesis and synaptic plasticity and restored

79 stigated how alpha-synuclein levels modulate adult neurogenesis and the development of dendritic arbo

80 the transcriptional control of neurogenesis, adult neurogenesis and the epigenetic regulation of gene

81 owever, the link between the role of PTEN in adult neurogenesis and the etiology of autism has not be

82 nto how epigenetic regulation contributes to adult neurogenesis and the potential impact of its dysre

83 m is a sensory neuroepithelium that supports adult neurogenesis and tissue regeneration following inj

84 addition, we propose unique roles for DCL in adult neurogenesis and we suggest high levels of neurona

85 ings suggest a physiological role for PS1 in adult neurogenesis, and a potential target for the manip

86 eptic seizures potently modulate hippocampal adult neurogenesis, and adult-born dentate granule cells

87 role of primary cilia in neuronal signaling, adult neurogenesis, and brain tumor formation.

88 ptor signaling in type B stem cells inhibits adult neurogenesis, and further suggest that the regulat

89 Changes in behavioral phenotype, hippocampal adult neurogenesis, and gene expression were evaluated i

90 in the hippocampus could be used to augment adult neurogenesis, and may therefore represent a novel

91 ories: A Critical Look at the Dentate Gyrus, Adult Neurogenesis, and Pattern Separation," in this iss

92 ptor (OR) expression, synaptic organization, adult neurogenesis, and the contribution of cortical rep

93 and CD44 play important roles in regulating adult neurogenesis, and we provide evidence that HA cont

94 a hippocampal fissure; 2) nonperiventricular adult neurogenesis; and 3) prolonged ontogeny, involving

95 ain has been overturned; however, endogenous adult neurogenesis appears to be insufficient for brain

96 ling mechanisms underlying prolactin-induced adult neurogenesis are completely unknown.

97 cific metabolic programs and their impact on adult neurogenesis are largely unknown.

98 Postnatal and adult neurogenesis are region- and modality-specific, bu

99 ursor cell (NPC) survival, and thus maintain adult neurogenesis, are not well defined.

100 Adult neurogenesis arises from neural stem cells within

101 pocampal plasticity and memory and implicate adult neurogenesis as a promising therapeutic target to

102 ction is central to the hypothesized role of adult neurogenesis as a substrate for learning and memor

103 Adult neurogenesis at the ventricle has been most extens

104 t to capture rare dynamic processes, such as adult neurogenesis, because isolation of rare neurons fr

105 Remarkably, the effect of ablating adult neurogenesis before acute seizures is long lasting

106 Here we show that the ablation of adult neurogenesis before pilocarpine-induced acute seiz

107 family cytokines are important regulators of adult neurogenesis, but their involvement in the regulat

108 nal telomeres are required for embryonic and adult neurogenesis, but their uncapping has surprisingly

109 the hippocampal subgranular zone-the site of adult neurogenesis--but was restricted to maturing, rath

110 Accordingly, hunger and satiety regulate adult neurogenesis by modulating the activity of this hy

111 This suppression of adult neurogenesis by the carbon monoxide poisoning was

112 Understanding the circadian regulation of adult neurogenesis can help optimize the timing of thera

113 Here, we review studies of postnatal and adult neurogenesis, challenging the notion that fixed ge

114 action may result in less or no reduction in adult neurogenesis compared with classic opiates.

115 The restoration of adult neurogenesis completely rescued the synaptic plast

116 ons to influence pattern separation and that adult neurogenesis constitutes an adaptive mechanism to

117 Adult neurogenesis continually produces a small populati

118 How does adult neurogenesis contribute to memory?

119 as been made in recent years to decipher how adult neurogenesis contributes to brain functions.

120 In the present review, we evaluate how adult neurogenesis contributes to the repair and regener

121 uding the hippocampus, where it might impair adult neurogenesis, contributing to nonmotor symptoms.

122 ession was high in brain areas implicated in adult neurogenesis, DCX-expressing neurons were also abu

123 out (KO) mouse model exhibits behavioral and adult neurogenesis deficits consistent with human illnes

124 hether these correlations reflect changes in adult neurogenesis, detail the conceptual and technical

125 Combining stress and inhibition of adult neurogenesis did not have additive effects on the

126 During caregiving, suppressed adult neurogenesis does not appear to be related to chan

127 support a direct role for the importance of adult neurogenesis during abstinence in compulsive-like

128 isruption of ERK signaling, or inhibition of adult neurogenesis, each blocks the ketamine-induced beh

129 Neural activity enhances adult neurogenesis, enabling experience to influence the

130 progress and aided by new technologies, the adult neurogenesis field is poised to leap forward in th

131 In contrast, complete inhibition of adult neurogenesis for 4 weeks led to volume reduction o

132 ion, including the possibility of harnessing adult neurogenesis for brain repair.

133 to validate in vivo neuroimaging measures of adult neurogenesis for future investigations.

134 ss possible future directions for harnessing adult neurogenesis for therapeutic use.

135 his local niche, regulate multiple stages of adult neurogenesis, from neural progenitor proliferation

136 ent with a function of TGF-beta signaling in adult neurogenesis, genetic deletion of the TGF-beta rec

137 Although adult neurogenesis has been conserved in higher vertebra

138 Whereas adult neurogenesis has been extensively studied in the d

139 can impair this process, and alterations in adult neurogenesis have been described in human autopsy

140 Many genes regulating adult neurogenesis have been identified and are known to

141 Alterations in adult neurogenesis have been noted in the brain of HIV-i

142 rpoises), in which DG size, convolution, and adult neurogenesis have undergone evolutionary regressio

143 lays important epigenetic roles in mammalian adult neurogenesis; however, the precise molecular mecha

144 wever, it remains unknown whether increasing adult neurogenesis improves hippocampal plasticity and b

145 rotein as a popular indirect tool to monitor adult neurogenesis in a variety of species.

146 nous alpha-synuclein, and we found increased adult neurogenesis in alpha/beta-synuclein knock-out mic

147 n the systemic milieu can inhibit or promote adult neurogenesis in an age-dependent fashion in mice.

148 adult brain, secretes signals that regulate adult neurogenesis in an age-dependent manner.

149 ude that dogs are a valuable animal model of adult neurogenesis in comparative and preclinical studie

150 In conclusion, as in mammalian brains, adult neurogenesis in crustacean brains is fueled by neu

151 f the HPA axis and support a direct role for adult neurogenesis in depressive illness.

152 Restoring adult neurogenesis in disrupted rats using oxytocin and

153 Here we show that the absence of adult neurogenesis in Drosophila results from the elimin

154 e, we investigated its role in postnatal and adult neurogenesis in GD3-synthase knock-out (GD3S-KO) a

155 Research focusing on plasticity has shown adult neurogenesis in hippocampal subfields.

156 we are able to detect and measure levels of adult neurogenesis in living human brains-a formidable c

157 Notably, OSNs are continually replenished by adult neurogenesis in mammals, including humans, so OSN

158 Although an influence of adult neurogenesis in mediating some of the effects of a

159 t the importance of studying the features of adult neurogenesis in models other than rodents, especia

160 behavioral alterations and rescued abnormal adult neurogenesis in mutant DISC1 mice.

161 mber of new neurons by limited inhibition of adult neurogenesis in naive transgenic GFAP-thymidine ki

162 evertheless, many questions remain regarding adult neurogenesis in other brain regions and particular

163 d others have recently reported constitutive adult neurogenesis in other brain structures, including

164 s for alpha-synuclein-mediated disruption of adult neurogenesis in Parkinson disease.

165 ta suggest a critical role for ERK5-mediated adult neurogenesis in pattern separation, a form of dent

166 set of transcription factors known to govern adult neurogenesis in response to active RIT1 expression

167 vity exerts its impacts on multiple steps of adult neurogenesis in rodents and culminates in the sele

168 ular mechanisms underlying developmental and adult neurogenesis in rodents and primates.

169 hy of CA3 pyramidal cells and suppression of adult neurogenesis in rodents.

170 es questions about the role of sprouting and adult neurogenesis in sustaining seizure-like activity.

171 hese findings are the first to indicate that adult neurogenesis in the baboon hippocampal DG may be f

172 g their activity, required for understanding adult neurogenesis in the context of network remodeling,

173 Adult neurogenesis in the dentate gyrus (DG) is strongly

174 As both astrocytes and DISC1 influence adult neurogenesis in the dentate gyrus (DG) of the hipp

175 In AD, adult neurogenesis in the dentate gyrus (DG) of the hipp

176 fluoxetine (FLX) on behavior, olfaction, and adult neurogenesis in the dentate gyrus (DG), olfactory

177 aque monkeys to determine the time course of adult neurogenesis in the dentate gyrus of the hippocamp

178 s the effect of neonatal alcohol exposure on adult neurogenesis in the dentate gyrus of the hippocamp

179 (HDACi) AR-42, ameliorates the deficiency of adult neurogenesis in the granule cell layer of the dent

180 of the Wnt/beta-catenin pathway and restored adult neurogenesis in the hippocampal dentate gyrus (DG)

181 tem cells that form the reservoir supporting adult neurogenesis in the hippocampal dentate gyrus and

182 Adult neurogenesis in the hippocampal subgranular zone (

183 al plasticity in the central nervous system, adult neurogenesis in the hippocampus alters network fun

184 recent evidence suggests that alterations in adult neurogenesis in the hippocampus might play a role.

185 To investigate this issue, we examined adult neurogenesis in the hippocampus of California mous

186 Adult neurogenesis in the hippocampus subgranular zone i

187 ies have investigated the cellular origin of adult neurogenesis in the hippocampus, yielding divergen

188 tentially adaptive way, possibly by reducing adult neurogenesis in the hippocampus.

189 ry of working memory capacity via suboptimal adult neurogenesis in the hippocampus.

190 questions related to almost every aspect of adult neurogenesis in the mammalian brain.

191 Here, we show that inhibition of adult neurogenesis in the mouse dentate gyrus decreases

192 y stream (RMS) is required for postnatal and adult neurogenesis in the olfactory bulbs (OB).

193 Adult neurogenesis in the olfactory epithelium is often

194 recent progress on the molecular control of adult neurogenesis in the SGZ and SVZ, focusing on the r

195 tor (BDNF) has been implicated in regulating adult neurogenesis in the subgranular zone (SGZ) of the

196 Prolactin-stimulated adult neurogenesis in the subventricular zone (SVZ) and

197 the importance of Igf2 imprinting for murine adult neurogenesis in the subventricular zone (SVZ) and

198 Although evidence suggest that adult neurogenesis in these two regions is subjected to

199 of new neurons added to HVC, suggesting that adult neurogenesis in this context may contribute to beh

200 ey role in the correct development of DG and adult neurogenesis in this region.

201 rmacogenetic methods to conditionally ablate adult neurogenesis in transgenic mice, we find that the

202 and the harmine metabolite harmol, stimulate adult neurogenesis in vitro.

203 owerful model to identify genes required for adult neurogenesis in vivo.

204 n of neuronal differentiation and attenuates adult neurogenesis in vivo.

205 junction with behavioral tests, we evaluated adult neurogenesis, including neural progenitor prolifer

206 atory factors involved in distinct stages of adult neurogenesis, including proliferation and lineage

207 Together, these properties of adult neurogenesis indicate that this process could be h

208 ious interpretation of these results is that adult neurogenesis indirectly regulates hippocampal info

209 Adult neurogenesis is a key feature of the mammalian olf

210 Adult neurogenesis is actively studied in part because o

211 achinery is present in adult rats, even when adult neurogenesis is blocked.

212 Adult neurogenesis is coupled to angiogenesis in neuroge

213 eurogenesis and provide strong evidence that adult neurogenesis is critical for several forms of hipp

214 Early studies found that adult neurogenesis is impaired in models of depression a

215 Taken together, our results suggest that adult neurogenesis is involved in the delayed long-lasti

216 e of epigenetic regulators in the control of adult neurogenesis is largely undefined.

217 , the relationship between these factors and adult neurogenesis is less well understood.

218 Adult neurogenesis is maintained by self-renewable neura

219 Adult neurogenesis is modulated by a balance of extrinsi

220 osis of the apoptotic cells generated during adult neurogenesis is normally driven by both TAM recept

221 y considering a general model proposing that adult neurogenesis is not a cell-replacement mechanism,

222 ell-tolerated, oral medications that enhance adult neurogenesis is of great clinical interest.

223 The findings suggest that adult neurogenesis is required to maintain hippocampal v

224 d behavior; however, we find that increasing adult neurogenesis is sufficient to reduce anxiety and d

225 A major question in studying adult neurogenesis is the source and identity of molecul

226 Adult neurogenesis is thought to provide neural plastici

227 This new vertebrate model of adult neurogenesis is thus advancing our knowledge of th

228 ) number during development, but its role in adult neurogenesis is unclear.

229 This process, named adult neurogenesis, is involved in important cognitive f

230 ocampal dentate gyrus, a region with ongoing adult neurogenesis, is sensitive to MAGUK loss in mature

231 paired adult neurogenesis and restoration of adult neurogenesis leads to recovery.

232 edictable restraint stress and inhibition of adult neurogenesis led to atrophy of pyramidal cell apic

233 earch has focused on the DG for its roles in adult neurogenesis, little is known regarding how this k

234 lization, and demonstrates that juvenile and adult neurogenesis make different contributions to socia

235 tion of bromodeoxyuridine and two additional adult neurogenesis markers, Ki-67 and doublecortin, in t

236 Although there is evidence suggesting that adult neurogenesis may contribute to hippocampus-depende

237 These data suggest that defective adult neurogenesis may contribute to the learning impair

238 r integrity, neurotoxicity and inhibition of adult neurogenesis may underlie alcohol-mediated cogniti

239 Thus, during adult neurogenesis, microglia regulate the elimination (

240 To examine whether adult neurogenesis might contribute to regeneration afte

241 o neuronal plasticity, and induce changes in adult neurogenesis, neuritic maintenance, synaptic trans

242 During embryonic and adult neurogenesis, neuronal stem cells follow a highly

243 We propose that adult neurogenesis not only replenishes the population o

244 bulb we show that fundamental aspects of the adult neurogenesis observed in the olfactory bulb--the p

245 Adult neurogenesis occurs in mammals and provides a mech

246 Adult neurogenesis occurs in specific locations in the b

247 Adult neurogenesis occurs in the dentate gyrus of the hi

248 Adult neurogenesis occurs throughout life in the mammali

249 hippocampus, one of the brain regions where adult neurogenesis occurs, in development of autism is n

250 nance and proliferation during postnatal and adult neurogenesis of the subgranular zone.

251 inning to shed light on the flexibility that adult neurogenesis offers to mature circuits and the pot

252 We discuss the impact of aging and adult neurogenesis on pattern separation, and also highl

253 However, their potential roles in adult neurogenesis or central nervous system (CNS) funct

254 Adult neurogenesis persists in the rodent dentate gyrus

255 Adult neurogenesis persists throughout life in restricte

256 Thus, adult neurogenesis plays a central role in the adaptive

257 spatial learning and memory, suggesting that adult neurogenesis plays an important role in hippocampu

258 We investigated the role that adult neurogenesis plays in the seasonal reconstruction

259 We investigated the role that adult neurogenesis plays in the seasonal reconstruction

260 These results suggest that adult neurogenesis produces a population of functionally

261 Inhibition of adult neurogenesis produces some behavioral impairments

262 Before training, X-ray ablation of adult neurogenesis-reduced dentate responses to perforan

263 Adult neurogenesis remains controversial in the cerebral

264 endent regulation of the sequential steps of adult neurogenesis remains largely unknown.

265 Wnt/Planar cell polarity (PCP) signaling in adult neurogenesis remains unknown.

266 Adult neurogenesis represents a unique form of plasticit

267 A central goal of adult neurogenesis research is to characterize the cellu

268 on, olfactory deafferentation did not reduce adult neurogenesis, showing that activated microglial ce

269 r transgenic or radiation methods to inhibit adult neurogenesis specifically, we find that glucocorti

270 Adult neurogenesis supports performance in many hippocam

271 ally in NSCs display a transient increase in adult neurogenesis that leads to a loss in the neurogeni

272 Adult neurogenesis, the formation of new neurons in the

273 Interestingly, a major site of adult neurogenesis, the hippocampus, is important in the

274 Among the multiple steps of adult neurogenesis, the integration and survival of adul

275 ral changes span from synaptic plasticity to adult neurogenesis, the latter being highly reduced in l

276 he complex relationship between Type-1 NSCs, adult neurogenesis, the neurogenic niche, and environmen

277 Adult neurogenesis, the process of generating mature neu

278 Adult neurogenesis, the process of generating mature neu

279 Several lines of evidence suggest that adult neurogenesis, the production of new neurons in adu

280 APP controls adult neurogenesis through a non cell-autonomous mechani

281 The contribution of adult neurogenesis to memory is indirect, by regulating

282 This article reviews the data relating adult neurogenesis to mental illness and discusses where

283 ts short lifespan and shows the high rate of adult neurogenesis typical of anamniotes.

284 cute carbon monoxide poisoning by preserving adult neurogenesis via an increase in hippocampal brain-

285 The circadian system may regulate adult neurogenesis via intracellular molecular clock mec

286 sting activity-dependent mechanism governing adult neurogenesis via the acute release of tonic inhibi

287 Adult neurogenesis was arrested in mice using low-dose,

288 Adult neurogenesis was initially studied with the tritia

289 sensitivity to hypoxia/anoxia, and decreased adult neurogenesis was observed in the dentate gyrus.

290 tant DISC1-associated behaviors and abnormal adult neurogenesis were also examined.

291 These deficits in adult neurogenesis were rescued with administration of p

292 Drugs of abuse dynamically regulate adult neurogenesis, which appears important for some typ

293 And, conversely, studies in animals lacking adult neurogenesis, which are likely to have more limite

294 uppressed, respectively, unlike mice lacking adult neurogenesis, which did not change.

295 ons in the dentate gyrus during neonatal and adult neurogenesis, which include errors in axonal targe

296 CL as a novel marker for specific aspects of adult neurogenesis, which partly overlap with DCX.

297 We show that BLA lesions suppress adult neurogenesis, while lesions of the central nucleus

298 ing covered diverse aspects of embryonic and adult neurogenesis with a focus on novel technologies, i

299 otion raised an interesting question whether adult neurogenesis within specific subregions of the hip

300 In adult neurogenesis young neurons connect to the existing