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1 e existence of a Wnt/beta-catenin-responsive adult stem cell.
2 ring gastrulation and the differentiation of adult stem cells.
3 nes in induced pluripotent stem cells and in adult stem cells.
4 ing cell cycle progression in populations of adult stem cells.
5 ant, accessible, and replenishable source of adult stem cells.
6 ulation and fulfilling criteria of unipotent adult stem cells.
7 al gene and by promoting genome stability in adult stem cells.
8 control at the H19-Igf2 locus in maintaining adult stem cells.
9 attractive model for studying regulation of adult stem cells.
10 gets also regulate changes between fetal and adult stem cells.
11 -catenin signaling is a central regulator of adult stem cells.
12 vidence demonstrating this effect in healthy adult stem cells.
13 euronal lineage specification of multipotent adult stem cells.
14 e to validate a novel strategy for selecting adult stem cells.
15 to control differentiation in embryonic and adult stem cells.
16 pathways thought to play important roles in adult stem cells.
17 se regulating the self-renewal capability of adult stem cells.
18 t transcriptional regulator in embryonic and adult stem cells.
19 (CNS) that produces new myelin sheaths from adult stem cells.
20 aden and refine concepts of the phenotype of adult stem cells.
21 of newly differentiated cells from resident adult stem cells.
22 eled by a population of highly proliferative adult stem cells.
23 -beta superfamily functions in embryonic and adult stem cells.
24 t and in the self-renewal and maintenance of adult stem cells.
25 and functional properties of tissue specific adult stem cells.
26 neration depends on the timely activation of adult stem cells.
27 idence supporting a role for Hh signaling in adult stem cells.
28 the embryo by mobilization of precursors or adult stem cells.
29 ewly differentiated cells cease to form from adult stem cells.
30 vior normally associated with more classical adult stem cells.
31 establish a paradigm for the development of adult stem cells.
32 mmitment cell-fate decision in embryonic and adult stem cells.
33 ce is essential for long-term maintenance of adult stem cells.
34 affects the regenerative potentials of human adult stem cells.
35 the specific effects of p53 loss in colonic adult stem cells.
36 to adults, Lin-28 persists in populations of adult stem cells.
37 l differentiation of embryonic stem (ES) and adult stem cells.
38 f epigenetic gene silencing in embryonic and adult stem cells.
39 scape for myocardial regeneration powered by adult stem cells 4 years ago.(1) The intervening years s
43 recent advances in our understanding of why adult stem cells age and how this aging impacts diseases
45 n of comprehensive profiling technologies to adult stem cell and progenitor populations has been chal
47 We found that CRCs share characteristics of adult stem cells and exhibit up-regulated expression of
48 protein CD133 as a marker of organ-specific adult stem cells and in some cancers as a bona fide CSC
49 ceptors in maintenance of stemness of normal adult stem cells and in support of cancer development.
52 yl oxidase that is enriched in embryonic and adult stem cells and plays an essential prosurvival role
53 ies to remuscularize the injured heart using adult stem cells and pluripotent stem cells, cellular re
54 very of crypt base columnar cells as LGR5(+) adult stem cells and summarizes subsequent progress, pro
55 s an important role in lineage commitment of adult stem cells and that it could be used for clinical
56 ates with significant alterations in somatic/adult stem cells and therapies to counteract these might
57 cardiac stem cell regenerative therapy using adult stem cells and to highlight the merits and limitat
59 nd oxidative stress during the maturation of adult stem cells, and during the reprogramming of somati
60 lf-renewal and pluripotency of embryonic and adult stem cells, and merging 3D printing with bioconjug
63 her mature hepatocytes or a subpopulation of adult stem cells are capable of full recovery in severe
77 pathway plays a fundamental role in multiple adult stem cells, as well as in orchestrating proper mam
78 l accumulation of genetic mutations in human adult stem cells (ASCs) during life is associated with v
80 are an abundant, heterogeneous population of adult stem cells (ASCs) that facilitate the maintenance
81 tissue homeostasis is generally mediated by adult stem cells (ASCs), tissue-specific stem cells resp
83 te the potential of a system for delivery of adult stem cells at any time after primary percutaneous
85 represent an excellent model system to study adult stem cell behavior; however, the earliest stages o
90 muscle stem cells cautions against inferring adult stem-cell biology from embryonic studies, and has
91 self-renewal and differentiation of various adult stem cells, but its role in cell fate determinatio
92 ability in cells derived from pluripotent or adult stem cells, but surprisingly, transdifferentiated
93 d segregation correlate with self-renewal of adult stem cells, but the capacity of CPCs for asymmetri
94 rged as important regulators of invertebrate adult stem cells, but their activities remain poorly app
95 f multiple organs as well as the survival of adult stem cells by activation of canonical Wnt signalin
96 cer stem cells are distinguished from normal adult stem cells by their stemness without tissue homeos
98 flatworms are attributed to a population of adult stem cells called neoblasts that proliferate and d
104 e we show, for the first time, that Sox10(+) adult stem cells contribute to both encapsulation and mi
105 The accumulation of somatic mutations in adult stem cells contributes to the decline of tissue fu
106 Here we tested whether the induction of adult stem cells could repair chemoradiation-induced tis
109 port high-resolution DNA methylation maps of adult stem cell differentiation in mouse, focusing on 19
110 l-time label-free quantitative monitoring of adult stem cell differentiation with impedance sensing.
112 mechanism through which Lin-28 controls the adult stem cell division patterns that underlie tissue h
114 ssociated with changes in DNA methylation in adult stem cells during lifetime are still largely unkno
115 ion and/or proliferation of adult intestinal adult stem cells during postembryonic development in ver
117 on of the function of human islets and human adult stem cell, embryonic stem cell, or induced pluripo
118 rd injury and provide specific evidence that adult stem cells exert positive immunomodulatory and neu
122 ere length; embryonic stem cells and certain adult stem cells express mTert, but whether cells in the
123 difiers and pioneer transcription factors in adult stem cell fate decisions and plasticity, which ens
125 gy opens new possibilities of using cultured adult stem cells for drug development, disease modeling,
126 resting or injured pancreas do not behave as adult stem cells for insulin-producing beta (beta)-cells
127 an abundant and easily accessible source of adult stem cells for use in such regenerative approaches
129 igated the autocrine effect of PGE2 on human adult stem cells from cord blood or adipose tissue, and
137 ed R-spondin proteins (RSPOs1-4) function as adult stem cell growth factors by potentiating Wnt signa
143 ic mechanisms that control the activation of adult stem cells holds the promise of tissue and organ r
144 findings provide an insight in regulation of adult stem cells homeostasis by two major pathways with
150 d receptor 5 (LGR5) is a bona fide marker of adult stem cells in several epithelial tissues, most not
153 a Wnt target gene and a bona fide marker of adult stem cells in the gastrointestinal tract and hair
154 We report the presence of nestin-expressing adult stem cells in the perilumenal region of the mature
156 se findings demonstrate the critical role of adult stem cells in tissue remodeling and unravel the co
157 ids opens up avenues for the manipulation of adult stem cells in vitro, which could facilitate the st
159 ion of cells with several characteristics of adult stem cells, including the retention of proliferati
160 ses of ionizing radiation (IR) as a model of adult stem cell injury and identified a regeneration def
161 ability to isolate, expand and differentiate adult stem cells into a chondrogenic lineage is an impor
162 ed the transdifferentiation process of human adult stem cells into retinal ganglion-like cells and re
164 demonstrate that in vivo differentiation of adult stem cells is associated with small but informativ
165 The proliferation and differentiation of adult stem cells is balanced to ensure adequate generati
166 anding the regulation of chromatin states in adult stem cells is likely to have important implication
179 limited proliferation and differentiation-to adult stem cell lines, which can generate a far more lim
185 g pathway controls embryonic development and adult stem cell maintenance through the regulation of tr
186 gnalling pathway is crucial for development, adult stem cell maintenance, cell migration and axon gui
188 e we report that Lgr5, a recently discovered adult stem cell marker, is exclusively expressed in GBCs
189 n certain vertebrate classes, MG function as adult stem cells, mediating retinal regeneration in resp
190 suggested that a rare cell type, such as an adult stem cell, might be the cell of origin for iPS cel
194 Planarian flatworms contain a population of adult stem cells (neoblasts) that proliferate and genera
200 cent findings, we propose that several other adult stem cell niches, including those in the blood, in
204 echanisms by which external signals regulate adult stem cell numbers, stem cell maintenance, and stem
207 rom pluripotent stem cells and germ cells to adult stem cells of the lung, liver, muscle, bone and ma
208 go whole-body regeneration using pluripotent adult stem cells of the neoblast population, can reversi
209 mild up-regulation of Bmi1 expression in the adult stem cells of the skeletal muscle leads to a remar
213 xpression profiling of pluripotent planarian adult stem cells (pASCs), Onal et al present evidence fo
215 gnaling during the asymmetric division of an adult stem cell population and in other BMP signaling co
216 cular Biology of the Cell describing a novel adult stem cell population isolated from adipose tissue-
221 SC has gone on to be one of the most popular adult stem cell populations currently being used in the
225 x anatomy of the epidermis contains multiple adult stem cell populations, but the extent to which the
226 c tissues often maintain their expression in adult stem cell populations, but whether their function
231 s an allogeneic bone marrow-derived adherent adult stem cell product that has shown efficacy in precl
232 n with or without autologous adipose-derived adult stem cell recellularization within the corneal str
234 iated with telomere biology, senescence, and adult stem-cell regulation, have since gained support fr
244 poorly understood how tissues maintained by adult stem cells respond to chronic changes in metabolis
247 f skeletal muscle depends on a population of adult stem cells (satellite cells) that remain quiescent
249 cquire different cell fates are critical for adult stem cell (SC) potential, yet are poorly understoo
254 ed for the DNA damage-mediated disruption of adult stem cell self-renewal and lineage differentiation
257 evidence from both pluripotent embryonic and adult stem cell studies suggests that this balance is pa
258 assays for whether a cell is derived from an adult stem cell, such as the melanocyte stem cell (MSC),
261 possibly because the best studied vertebrate adult stem cell systems are not readily amenable to in v
262 ecently and developed culture conditions for adult stem cells that allow the long-term expansion of a
263 the entire lifetime by small populations of adult stem cells that are believed to reside in the bott
265 tion, individual memory T cells can serve as adult stem cells that provide robust regeneration of an
266 re the most thoroughly characterized type of adult stem cell, the intricate molecular machinery that
267 myocardial regenerative medicine mediated by adult stem cell therapy has gathered momentum fueled by
268 be useful to increase circulating levels of adult stem cells, thereby exerting beneficial effects on
269 ancer development as well as the survival of adult stem cells through potentiation of Wnt signaling.
270 the pluri- and multipotency of embryonic and adult stem cells, thus the germline and stem cells must
271 tenin, is crucially involved in development, adult stem cell tissue maintenance, and a host of diseas
274 constructs containing either human fetal or adult stem cells to enhance functional repair of nude ra
275 ic development that eventually establish the adult stem cells to maintain the specific features and f
276 ad Box O (FoxO) transcription factors act in adult stem cells to preserve their regenerative potentia
277 recently shown to be expressed in mammalian adult stem cells to support self-renewal of neural and l
278 Next, we explored the ability of engineered adult stem cells to track metastatic deposits in this mo
279 cells, axonal growth cones and many types of adult stem cells, to specific areas distant from their o
280 Insights gained from clinical trials of adult stem cells, together with fundamental scientific a
281 ification for the use of RIC regimens in all adult stem cell transplant candidates with acute leukemi
282 tients underwent PET/CT 30 days after either adult stem cell transplantation (allogeneic cell transpl
283 e SpORF2 mRNA alone in human fibroblasts and adult stem cells triggers a senescence-like phenotype, w
286 in applications to Ewing's sarcoma and human adult stem cells using publicly available and custom gen
287 ls can be derived either from pluripotent or adult stem cells via differentiation or by transdifferen
289 y regulate renewal versus differentiation of adult stem cells, we evaluated Wnt signal transduction i
293 issue maintenance and regeneration depend on adult stem cells, which are characterized by their abili
294 on mechanisms of regeneration has focused on adult stem cells, which give rise to new tissue necessar
295 f stem cell biology, including embryonic and adult stem cells, will allow the scientific community to
296 nchymal stem cells (MSCs) are a prototypical adult stem cell with capacity for self-renewal and diffe
298 iferative embryonic stem cells and quiescent adult stem cells, with a focus on hematopoietic and musc
299 iferation, differentiation, and migration of adult stem cells within the tissues in which they exist.
300 ity may allow derivation of patient-specific adult stem cells without genetic manipulation and holds
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