ライフサイエンスコーパス: adult-onset

1 ing criteria for persistence, and adolescent/adult-onset.

2 2q11.2, a rate higher than that reported for adult onset (0.3-1%) (P<0.001) or autism spectrum disord

3 The association of adult-onset ACC with inherited cancer predisposition syn

4 In late (adult)-onset acid maltase deficiency (glycogen storage d

5 There was no evidence for adult-onset ADHD independent of a complex psychiatric hi

6 Importantly, we demonstrate that adult-onset administration of the drug trametinib, a hig

7 RNA-dependent pathways may have an impact on adult-onset, age-associated events by silencing developm

8 ense or in-frame mutation is associated with adult onset and slow progression.

9 t clinical exome sequencing in patients with adult-onset and sporadic presentations of ataxia is a hi

10 pic organization in three patients (two with adult-onset, and one with congenital pathology) consisti

11 ly enriched gene signatures in patients with adult-onset as compared with childhood-onset severe asth

12 preventive measure for reducing the risk of adult-onset asthma among those with asthmatic heredity.

13 en, there was a positive association between adult-onset asthma and childhood physical abuse and weak

14 ent case-control study of clinically defined adult-onset asthma and randomly drawn control subjects (

15 To identify underlying mechanisms of adult-onset asthma and to capture predictors of disease

16 The majority of patients with severe adult-onset asthma are nonatopic and have persistent eos

17 One in 6 patients with adult-onset asthma experiences remission within the firs

18 This suggests that severe adult-onset asthma has a distinct underlying mechanism c

19 Some patients with adult-onset asthma have severe disease, whereas others h

20 A proportion of patients with adult-onset asthma have severe disease.

21 n BMI and physical activity with the risk of adult-onset asthma in 76,470 asthma-free women from the

22 ergens distinguish subjects with and without adult-onset asthma in Finland.

23 ildhood and adolescence and the incidence of adult-onset asthma in the Black Women's Health Study.

24 vity may have a modest impact on the risk of adult-onset asthma in this population of US women.

25 Adult-onset asthma is an important but relatively unders

26 Adult-onset asthma is associated with abnormal proximal

27 te whether disease severity in patients with adult-onset asthma is associated with specific phenotypi

28 ctive or passive smoking to the incidence of adult-onset asthma is inconsistent with both positive an

29 rrently unknown whether patients with severe adult-onset asthma represent a distinct clinical phenoty

30 members with childhood-onset and adolescent/adult-onset asthma was not different from leukocyte telo

31 high exacerbation rate, patients with severe adult-onset asthma were more often nonatopic (52% vs 34%

32 Patients with adult-onset asthma were predominately female (61%) and n

33 One hundred seventy-six patients with adult-onset asthma were recruited from 1 academic and 3

34 redity have a considerably increased risk of adult-onset asthma when exposed to SHS.

35 hip between perceived stress and the risk of adult-onset asthma, allergic rhinitis, atopic dermatitis

36 p, active smoking increased the incidence of adult-onset asthma, and passive smoke exposure increased

37 respiratory disease (AERD) is manifested by adult-onset asthma, nasal polyposis, chronic rhinosinusi

38 Amongst patients with adult-onset asthma, three subphenotypes can be identifie

39 have a beneficial effect on the incidence of adult-onset asthma.

40 depression as a marker of risk for incident adult-onset asthma.

41 f patients were identified three clusters of adult-onset asthma.

42 Our outcome measure was new adult-onset asthma.

43 rmation on the effect of early-life abuse on adult-onset asthma.

44 alysis was performed to identify clusters of adult-onset asthma.

45 y predictors of persistence and remission of adult-onset asthma.

46 62 adult-onset asthmatic patients who had prolonged coughs

47 To date adult-onset asthmatic patients who lack a clear stridor

48 Schnitzler syndrome is an adult-onset autoinflammatory disease characterized by ur

49 cipants from a 3-generation family with pure adult-onset autosomal dominant HSP of unknown genetic or

50 g syndrome, whereas LMNB1 duplication causes adult-onset autosomal dominant leukodystrophy (ADLD).

51 man lamin B1 (LMNB1) gene has been linked to adult-onset autosomal dominant leukodystrophy, and mouse

52 Adult-onset autosomal-dominant leukodystrophy (ADLD) is

53 n of the LMNB1 gene encoding lamin B1 causes adult-onset autosomal-dominant leukodystrophy (ADLD) sta

54 Several heterozygous SLC25A4 mutations cause adult-onset autosomal-dominant progressive external opht

55 ) is a neurodegenerative disease that causes adult-onset blindness.

56 Fly mir-34 expression exhibits adult-onset, brain-enriched and age-modulated characteri

57 ology and pathophysiologic features of human adult-onset branching enzyme deficiency.

58 Primary dystonia is usually of adult onset, can be familial, and frequently involves th

59 f CVD risk in 36,232 >/= 2-year survivors of adult-onset cancer compared with matched (age, sex, and

60 Follow-up of adult-onset cancer survivors given cisplatin should incl

61 en comprehensively evaluated in survivors of adult-onset cancer.

62 with subsequent exposures in relationship to adult-onset cancers.

63 oring of cardiac dysfunction in survivors of adult-onset cancers.

64 c expression of NSML-associated SHP2 induced adult-onset cardiac hypertrophy.

65 th that correlates positively with increased adult-onset cardiovascular, metabolic and behavioural di

66 of clinical features that include mainly for adult-onset cases cognitive decline, seizures, parkinson

67 Both adult-onset cases had direct damage to early visual cort

68 85 pediatric- and 117 adult-onset CD patients were tested for the three main N

69 tations, linked in two different families to adult-onset cerebellar ataxia, and a de novo truncation

70 grees of mixed European ancestry with mainly adult-onset cervical and segmental dystonia.

71 Screening in subjects with adult-onset cervical dystonia identified 2 additional CI

72 and CIZ1 appear not to be a common cause of adult-onset cervical dystonia.

73 Adult-onset CFLD lacks sufficient characterization and d

74 Adult-onset CFLD may be more prevalent than previously d

75 Adult-onset CI included approximately 1 in 6 adults who

76 analyzed contribution to observed background adult-onset CML incidence acceleration with age, and wou

77 d an inducible Cre gene construct to produce adult-onset CNTFRalpha disruption in facial MNs without

78 the adult mouse facial nerve crush model and adult-onset conditional disruption of the CNTF receptor

79 egenerative diseases ranging from well-known adult onset conditions such as Alzheimer and Parkinson d

80 jority thought that incidental results about adult-onset conditions (62%) and carrier status (62%) sh

81 ng (WES) for the diagnosis and management of adult-onset constitutional disorders has not been adequa

82 We identified a family suffering from adult onset, cortical myoclonus without associated seizu

83 dity and health-care costs in paediatric and adult onset Crohn's disease.

84 , behaviour and treatment of pediatric- than adult-onset Crohn's disease (CD).

85 from patients with pediatric IBD (n = 45) or adult-onset Crohn's disease (n = 20) and healthy individ

86 ised of 29(29%) pediatric-onset and 72 (71%) adult-onset CVS patients.

87 sponse to standard therapy in pediatric- and adult-onset CVS were mostly similar.

88 studies until now investigated the effect of adult-onset damage on fear conditioning, the current stu

89 ned in hearing cats, and cats with early- or adult-onset deafness.

90 gous mice of both sexes (Atoh1(lacZ/+)) have adult-onset deafness.

91 Ub(G76V)-GFP-Syb2 mice developed progressive adult-onset degeneration of motor nerve terminals, where

92 Amyotrophic lateral sclerosis (ALS) is an adult-onset degeneration of motor neurons that is common

93 he central nervous system (CNS), causing the adult-onset degenerative disease amyotrophic lateral scl

94 omal dominant leukodystrophy (ADLD), a fatal adult onset demyelinating disease.

95 B1 (LMNB1) gene underlie autosomal dominant adult-onset demyelinating leukodystrophy (ADLD), a rare

96 alent asthma is not associated with incident adult-onset depression.

97 between low birth weight (LBW; <2.5 kg) and adult-onset diabetes in 12,525 participants from the Bra

98 the disease stages, thus eliciting early- or adult-onset diabetes syndromes, reminiscent of type 1 an

99 linical phenotypes that include neonatal and adult-onset diabetes using CRISPR (clustered regularly i

100 tations, ranging from pancreatic agenesis to adult-onset diabetes with subclinical or no exocrine ins

101 mutations have also recently been linked to adult-onset diabetes, with subclinical or no exocrine in

102 IR are two physiologically distinct forms of adult-onset diabetes.

103 ndow for therapeutic intervention to prevent adult-onset diabetes.

104 iated with dominantly inherited nonsyndromic adult-onset diabetes.

105 screening was performed in 220 probands with adult-onset dilated cardiomyopathy.

106 obal Id3 ablation (Id cDKOs), which develops adult-onset dilated cardiomyopathy.

107 epigenetic transgenerational inheritance of adult onset disease and associated DNA methylation epimu

108 epigenetic transgenerational inheritance of adult onset disease and sperm epimutations.

109 epigenetic transgenerational inheritance of adult onset disease in subsequent generations (F1-F3) fo

110 nadal sex determination and the incidence of adult onset disease was evaluated in F1 and F3 generatio

111 epigenetic transgenerational inheritance of adult onset disease.

112 yotrophic lateral sclerosis (ALS) is a fatal adult-onset disease characterized by upper and lower mot

113 olism has a critical role in establishing an adult-onset disease model using patient-specific iPSCs.

114 ey disease (ADPKD) is a common, progressive, adult-onset disease that is an important cause of end-st

115 CARD9 deficiency caused by p.Y91H results in adult-onset disease with variable penetrance and express

116 -onset Crohn disease is more aggressive than adult-onset disease, has high rates of resistance to exi

117 pically more severe than infantile-onset and adult-onset disease, long-term morbidity has not been as

118 While this pathogenesis model accounts for adult-onset disease, the molecular basis of congenital D

119 at of infantile-onset (ie, <6 years old) and adult-onset disease, with genetic cause characterised by

120 ts were independently associated with severe adult-onset disease.

121 reening programs and reduce the incidence of adult onset diseases via genetic risk identification and

122 may also be involved in in the prevention of adult onset diseases.

123 Adult-onset diseases can be associated with in utero eve

124 d mortality and a greater risk of developing adult-onset diseases in later life, understanding the ro

125 pregnancy influence the risk of many chronic adult-onset diseases in the offspring.

126 The development of adult-onset diseases is influenced by perinatal exposure

127 are serious caveats to their use in modeling adult-onset diseases such as cardiomyopathies and Alzhei

128 normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these as

129 cause or increase the risk for childhood and adult-onset diseases, finding genes that influence how p

130 Some adult-onset disorders may be linked to dysregulated embr

131 We have previously found that adult onset disruption of CNTFRalpha in facial MNs of "f

132 and, although most are also misregulated in adult-onset DM1, dysregulation is significantly more sev

133 In this study, we analyzed consequences of adult-onset DR (24 h to 1 yr) on hematopoietic stem cell

134 Using an adult-onset Drosophila model of Abeta (amyloid beta) tox

135 Both models recreate the progressive adult-onset dysfunction and degeneration of a neuronal n

136 dystonia pathogenesis.SIGNIFICANCE STATEMENT Adult-onset dystonia DYT25 is caused by dominant loss-of

137 company the motor manifestations of isolated adult-onset focal dystonias.

138 Few genes have been implicated in the adult-onset form of this disease.

139 0) and complex inheritance evident in common adult-onset forms of disease.

140 ing from severe childhood variants to milder adult-onset forms, were collected in 17 neuromuscular re

141 h age-related macular degeneration (AMD) and adult-onset foveomacular vitelliform dystrophy (AOFVD) w

142 fundus flavimaculatus than those reported in adult-onset foveomacular vitelliform dystrophy.

143 Thus, mutations in PAX2 may contribute to adult-onset FSGS in the absence of overt extrarenal mani

144 s, in addition to other suggested actionable adult-onset genetic conditions, opportunistic screening

145 Adult-onset genetic leukoencephalopathies and leukodystr

146 The number of identified causes of adult-onset genetic leukoencephalopathies has recently i

147 MRI scans may help indicate the diagnosis of adult-onset genetic leukoencephalopathies.

148 ent GWAS completed for three types of common adult-onset glaucoma have identified novel loci for POAG

149 elopmental irregularities that manifested as adult-onset glomerulosclerosis and proteinuria.

150 were separated into infantile, childhood and adult-onset groups.

151 nown regarding CVD in long-term survivors of adult-onset (>/= 40 years) cancer.

152 A cohort of 200 patients with adult-onset (>18 year) asthma (age 54 (26-75) year) was

153 enome-wide significant locus associated with adult-onset (>27 years) MDD (rs7647854, odds ratio: 1.16

154 enile onset hearing loss (89 Hz) relative to adult onset hearing loss (64 Hz).

155 lacking the transcription factor Foxo3 have adult onset hearing loss with the hallmark characteristi

156 Whether NKX2-5 mutations have a role in adult-onset heart disease is unknown.

157 erived cardiomyocytes (iPSC-CMs) to model an adult-onset heart disease remains challenging owing to t

158 during cardiac development leads to CHD and adult-onset heart hypertrophy.

159 Therefore, an adult-onset, hepatocyte-specific, GH receptor (GHR) knoc

160 ophy, also known as Kennedy's disease, is an adult-onset hereditary neurodegenerative disorder caused

161 deficiency manifesting a complicated form of adult-onset hereditary spastic paraparesis partially res

162 during the heroin-seeking test, whereas the adult-onset heroin self-administration group showed two

163 ulates hallmark symptoms of MODY1, including adult-onset hyperglycemia, glucose intolerance and impai

164 Compared with patients with pediatric or adult-onset IBD, elderly patients used fewer biologics a

165 tic targets for patients with very early and adult-onset IBD.

166 etic factors associated very early onset and adult-onset IBD.

167 l presentation of specific gene defects (eg, adult-onset idiopathic T-cell lymphopenia and early-onse

168 urons, as well as a neuron subtype-specific, adult-onset increase in olfactory bulb neuron population

169 More significantly, adult-onset inducible expression of TAK1DeltaN protected

170 Adult-onset inherited myopathies with similar pathologic

171 The exception is FKRP mutations, in which adult onset is a common presentation.

172 SF1R mutations account for 10% of idiopathic adult onset leukodystrophies and that genetic testing fo

173 atients from the UK, Greece and Ireland with adult onset leukodystrophy of unknown cause.

174 euroaxonal spheroids (HDLS) is a hereditary, adult onset leukodystrophy which is characterised by the

175 pigmented glia (ALSP) is a frequent cause of adult-onset leukodystrophy known to be caused by autosom

176 roposed to improve the diagnostic process of adult-onset leukoencephalopathies.

177 The term "adult-onset leukoencephalopathy with axonal spheroids an

178 Importance: Adult-onset leukoencephalopathy with axonal spheroids an

179 Adult-onset leukoencephalopathy with axonal spheroids, a

180 o improved diagnostic rates in patients with adult-onset leukoencephalopathy.

181 ural abnormalities and intellectual delay to adult-onset limb-girdle muscular dystrophies without men

182 s, Walker-Warburg syndrome, to mild forms of adult-onset limb-girdle muscular dystrophy.

183 ) with impaired neurotransmitter release and adult-onset locomotor dysfunction.

184 ared genetic risk exists between earlier and adult-onset MDD with commonly comorbid disorders of schi

185 r to schizophrenia and bipolar disorder than adult-onset MDD.

186 provides a refined estimate of the burden of adult onset, medically actionable incidental findings ex

187 SH) in distinguishing PNs from childhood and adult-onset melanoma arising in CMN.

188 g for HMB45 was seen in 3 of 6 patients with adult-onset melanoma.

189 ISH aberration compared with 4 patients with adult-onset melanoma.

190 ll patients) but negative in 4 patients with adult-onset melanoma.

191 from childhood-onset melanoma as opposed to adult-onset melanoma.

192 n these regions) are at risk of stunting and adult-onset metabolic conditions.

193 metabolome accompany heritable IUGR, precede adult-onset MetS, and are partially amenable to dietary

194 a neonatal-onset, very severe disease to an adult-onset, milder form.

195 To develop an adult-onset model of BRAF-mutant ATC, we generated a thy

196 hic lateral sclerosis (ALS), the most common adult-onset motor neuron (MN) disease.

197 ral sclerosis (ALS), the most common form of adult-onset motor neuron disease and the third most comm

198 Thus, adult-onset motor neuron disease does not require aggreg

199 progression were compared with patients with adult-onset MS (AOMS).

200 atus at birth may be associated with risk of adult onset multiple sclerosis, but this link has not be

201 muscular atrophy (SBMA) is characterized by adult-onset muscle weakness and lower motor neuron degen

202 trophy type 1 (DM1), the most common form of adult-onset muscular dystrophy, is caused by an expanded

203 ophy type 1 (DM1) is the most common form of adult-onset muscular dystrophy, which is characterised b

204 atabase of fMRI vision maps in patients with adult-onset (n=25) and congenital (n=2) pathology of the

205 A recent study of a sibling pair with adult onset NCL and retinal degeneration showed linkage

206 overexpression of rab7 CMT2B mutants, causes adult-onset neurodegeneration in a Drosophila model.

207 pted "RNA-only" repeats in Drosophila caused adult-onset neurodegeneration.

208 ic lateral sclerosis (ALS) is a progressive, adult onset neurodegenerative disease that is always fat

209 Huntington's disease (HD) is a progressive, adult-onset neurodegenerative disease caused by a polygl

210 use amyotrophic lateral sclerosis is a fatal adult-onset neurodegenerative disease produced by mutati

211 pinal and bulbar muscular atrophy (SBMA), an adult-onset neurodegenerative disease that affects males

212 Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease that leads invaria

213 yotrophic lateral sclerosis is a progressive adult-onset neurodegenerative disease that primarily aff

214 ike 2 (HDL2) and Huntington disease (HD) are adult-onset neurodegenerative diseases characterized by

215 ociated tremor/ataxia syndrome (FXTAS) is an adult-onset neurodegenerative disorder caused by CGG tri

216 ateral sclerosis (ALS), a progressive, fatal adult-onset neurodegenerative disorder characterized by

217 hic lateral sclerosis (ALS) is a devastating adult-onset neurodegenerative disorder with a poor progn

218 Multiple system atrophy is a fatal sporadic adult-onset neurodegenerative disorder with no symptomat

219 otrophic lateral sclerosis (ALS) is a fatal, adult-onset neurological disease characterized by a prog

220 he pathogenesis of several developmental and adult-onset neurological disorders that affect the hippo

221 ogued genome-wide association study hits for adult-onset neurological disorders.

222 This locus for this form of adult onset neuronal ceroid lipofuscinosis was designate

223 Adult onset neuronal lipofuscinosis (ANCL) is a human ne

224 Autosomal-dominant adult-onset neuronal ceroid lipofuscinosis (ANCL) is cau

225 pha proteins may underlie the development of adult-onset neuronal ceroid lipofuscinosis in affected f

226 fied to cause the neurodegenerative disorder adult-onset neuronal ceroid lipofuscinosis.

227 families have relatively mild, childhood- to adult-onset NM with slowly progressive muscle weakness.

228 post-neonatal mortality, growth failure, and adult-onset non-communicable diseases.

229 growth restriction (IUGR) is associated with adult-onset obesity, insulin resistance, and type 2 diab

230 ctivity as low as 5-20% leads to juvenile or adult onset of a disorder that primarily affects the cen

231 have used Nscl-2 mutant mice suffering from adult onset of obesity and hypogonadotropic hypogonadism

232 cline in cognitive function, as well as with adult onset of psychosis and anxiety.

233 tients with ataxia present sporadically with adult onset of symptoms and the contribution of genetic

234 rvational study in which adult patients with adult-onset of asthma (defined as starting at age >/=18

235 n is a gene linked directly to juvenile- and adult-onset open angle glaucoma.

236 explain many of its key aspects, such as its adult onset or its specificity for the corticospinal tra

237 m brain samples from individuals with either adult-onset or juvenile-onset HD.

238 ermination, the F1 and F3 generation progeny adult onset ovarian disease was assessed.

239 spasticity (XPDS) presents either as typical adult onset Parkinson's disease or earlier onset spastic

240 iants were identified in family members with adult-onset parkinsonism.

241 associated with refractory celiac disease in adult onset patients.

242 ts were most pronounced in first episode and adult-onset patients (>21 years).

243 ent in the pediatric-onset group compared to adult-onset patients (0% vs. 23%, p = 0.004).

244 ompared with their healthy siblings and with adult-onset patients (AOS), carry significantly more rar

245 ompared with their healthy siblings and with adult-onset patients (AOS), carry significantly more rar

246 into classic infantile, childhood-onset, and adult-onset patients.

247 opmentally impaired myelination, whereas the adult-onset phenotype reflects axonal degeneration witho

248 cent trauma (AT) is a common risk factor for adult-onset posttraumatic stress disorder (PTSD).

249 Adult onset primary torsion dystonia (AOPTD) is a poorly

250 ariants from previously published studies in adult-onset primary CNS tumors and replicated these in s

251 revalence and phenomenology in patients with adult-onset primary dystonia is limited.

252 inical correlates of tremor in patients with adult-onset primary dystonia.

253 tremor is a common feature of patients with adult-onset primary dystonia.

254 consecutive patients with different types of adult-onset primary dystonia.

255 the MYOCILIN gene may lead to juvenile- and adult-onset primary open-angle glaucoma.

256 INTERPRETATION: Mutations in CIZ1 may cause adult onset, primary cervical dystonia, possibly by prec

257 as 18% and varied from 8.3% in those with an adult onset progressive disorder to 40% in those with a

258 FUS protein at physiological levels and have adult onset progressive motor neuron loss and denervatio

259 aging, age-related motor deficits as well as adult onset, progressive and cell-type-specific, dopamin

260 nt identification of a dominantly inherited, adult-onset, progressive dementia associated with inacti

261 isease should be considered in patients with adult-onset proximal or distal myopathy and early respir

262 eurodegenerative diseases, epilepsy or other adult-onset psychiatric diseases.

263 whether these associations pertain to other adult-onset psychiatric disorders and whether these peri

264 d; original data on incidence of non-organic adult-onset psychosis or one or more factor(s) pertainin

265 defects have been associated with familial, adult-onset pulmonary fibrosis, these cases demonstrate

266 lar to those observed in RA, suggesting that adult-onset RA and childhood-onset RA share common genet

267 To test the hypothesis that adult-onset RA-associated variants are also associated w

268 adic amyotrophic lateral sclerosis (ALS), an adult-onset, rapidly progressing neurodegenerative disea

269 Adult-onset receptor disruption in SVZ NSP cells with a

270 GBE1 mutations can cause an early adult-onset relapsing-remitting form of polyglucosan bod

271 the importance of stress in the etiology of adult-onset respiratory and dermatologic allergic disord

272 ere we describe five families affected by an adult-onset retinal dystrophy with early macular involve

273 rare CNVs that had well-documented risk for adult onset schizophrenia (AOS), autism, epilepsy and/or

274 ood-onset schizophrenia, and the more common adult-onset schizophrenia.

275 ldhood-onset Alpers-Huttenlocher syndrome to adult-onset sensory ataxic neuropathy dysarthria and oph

276 Adult-onset severe asthma is characterized by highly sym

277 Adult-onset severe asthma is characterized by inflammato

278 innate lymphoid cells were more enriched in adult-onset severe asthma, whereas signatures associated

279 ht to identify gene profiles associated with adult-onset severe asthma.

280 epresent useful targets for the treatment of adult-onset severe asthma.

281 th induced lung injury were less enriched in adult-onset severe asthma.

282 pendent populations: childhood-onset SLE and adult-onset SLE.

283 nsidered when patients show a combination of adult-onset spastic ataxia and a thin corpus callosum.

284 ockout (MCM-Speg(fl/fl)) model revealed that adult-onset SPEG deficiency results in heart failure (HF

285 2 patients with Schnitzler syndrome, 12 with adult-onset Still's disease, 7 with cryopyrin-associated

286 All of the most common forms of adult-onset strabismus increased with age, especially af

287 r period, constituting 15.7% of all forms of adult-onset strabismus observed in this population.

288 The incidence of adult-onset strabismus overall and its 4 most common for

289 The lifetime risk of being diagnosed with adult-onset strabismus was 4.0% in women and 3.9% in men

290 early-life stress, (2) in adulthood to model adult-onset stress, or (3) across the entire postnatal l

291 Adult-onset stressors exert opposing effects on hippocam

292 the age-associated effects of miR-34 require adult-onset translational repression of Eip74EF, an esse

293 pools, with loss of function predisposing to adult-onset tumorigenesis.

294 pools, with loss of function predisposing to adult-onset tumorigenesis.Oncogene advance online public

295 duals, including one family with exclusively adult-onset upper motor neuron features, consistent with

296 ngenital anomalies that may be causative for adult-onset vascular instability.

297 chopathy) differs from that of patients with adult-onset ventromedial prefrontal cortex lesions--the

298 These genes should be screened in adult-onset vitelliform dystrophy with (1) moderate visu

299 set analyses were performed for childhood vs adult-onset vitiligo and alopecia totalis or alopecia un

300 nclude limb-girdle muscular dystrophies with adult onset with or without intellectual disability, or