ライフサイエンスコーパス: advanced age

1 ed genes, the majority being associated with advanced age.

2 ate and litter size compared with WT mice at advanced age.

3 isease in different arterial territories and advanced age.

4 ation, a task that is negatively affected by advanced age.

5 rate adherence seemed to fade away with more advanced age.

6 in the prevalence of PAD, CAS, and AAA with advanced age.

7 critical determinants of health status with advanced age.

8 uch as fetal alcohol exposure, seizures, and advanced age.

9 arly adulthood on, and atrophy aggravated in advanced age.

10 cts of AD pathologic changes on cognition in advanced age.

11 hic pulmonary fibrosis [IPF]) increases with advanced age.

12 ned significance in Cox models that included advanced age.

13 ation remains unresolved, in particular with advanced age.

14 adulthood, and including a mild phenotype in advanced age.

15 ults with predisposing chronic conditions or advanced age.

16 in lower muscle protein synthesis rates with advanced age.

17 anges in high-level perceptual processing in advanced age.

18 inclusions increased in number and size with advanced age.

19 ll proliferation was severely decreased with advanced age.

20 ht and developed tumors in various organs at advanced age.

21 reduction of SI change correlated with only advanced age.

22 nd results in elevation of blood pressure at advanced age.

23 for developing carcinoma of the prostate is advanced age.

24 Increasingly, adults are living to an advanced age.

25 ial Alzheimer disease (AD) risk factor after advanced age.

26 nd in population-based cohorts of similar or advanced age.

27 or risk of amyloidosis prior to the onset of advanced age.

28 and was attenuated throughout networks with advanced age.

29 terneurons may be particularly vulnerable in advanced age.

30 of how their functional role is affected by advanced age.

31 ith a history of severe immunosuppression or advanced age.

32 , whereas others remain asymptomatic despite advanced age.

33 in Old, confirming signalling integrity with advanced age.

34 pport consideration of this approach despite advanced age.

35 probably will have more effective impact at advanced ages.

36 nduced cardiac hypertrophy at both young and advanced ages.

37 cantly decreased pathological progression at advanced ages.

38 and causes only mild cardiomyopathy even at advanced ages.

39 re detected in Ppt1-deficient flies, even at advanced ages.

40 mmon markers of neurodegeneration present in advanced aging.

41 ly harboring elevated amyloid burden, and in advanced aging.

42 eport that this maintenance is not random in advanced aging.

43 cal record were poor surgical targets (24%), advanced age (16%), and renal insufficiency (16%).

44 At more advanced ages (16-19 months), cognitive deficits progres

45 n p73 KO mice from early embryonic life into advanced age (25 months).

46 development at both early (age 10 weeks) and advanced (age 28 weeks) stages of atherosclerosis in mic

47 vels after active or passive immunization in advanced aged 3xTg-AD mice that contain both amyloid pla

48 gative life events, a higher literacy level, advanced age, a higher educational level, and more time

49 le infection (CDI) are identified, including advanced age, a prolonged hospital stay, and use of acid

50 including 21 within MC who were excluded for advanced age, acquired comorbidities, or refusal and 30

51 Advanced age, acute respiratory failure, and sepsis were

52 -deshydrogenase level (P = .0006) and a more advanced age adjusted international prognostic index (P

53 Whether or not advanced age affects the ability of PRC principal cells

54 ution to cardiac fibrosis, which occurs with advanced age, after acute injury (e.g., myocardial infar

55 Advanced age alone does not appear to be a contraindicat

56 thermore, mice that received treatment at an advanced age also showed remarkable preservation of reti

57 To evaluate how advanced age alters the host immune response to cutaneou

58 operative pulmonary complications, including advanced age, American Society of Anesthesiologists clas

59 frequent but more prevalent in patients with advanced age and a PS of >/= 2, underscoring the need to

60 Patient characteristics, including advanced age and comorbidity, and tumor anatomy are bein

61 or invasive treatments and in the setting of advanced age and complex health status.

62 Advanced age and complex mitral valve pathologies increa

63 In conclusion, advanced age and different clinical presentations of the

64 ality of autologous CD34+ cells decline with advanced age and diminished cardiovascular health.

65 n 3 years, reflecting a population with more advanced age and disease than seen in trial populations

66 In contrast, Tg2576 form plaques at a more advanced age and do not show cell death.

67 Although advanced age and elevated metabolic syndrome risk were a

68 gher torsion, though the association between advanced age and greater torsion was more pronounced in

69 These responses may increase with advanced age and have been linked to an "immune risk pro

70 While advanced age and increased glioma grade reduced SI chang

71 s increased in number and became larger with advanced age and increasing CGG repeat length, supportin

72 ounding tissues, and is associated with both advanced age and joint injury.

73 Increase in polyp size, advanced age and location in the distal colon were assoc

74 hough risk factors for pulmonary NTM such as advanced age and low BMI are known, the mechanisms under

75 al in patients considered "too ill/old" were advanced age and low functional status.

76 nt predictors for excess DCS mortality, with advanced age and male sex being associated with higher e

77 Mutant cases were associated with advanced age and monosomy 7/deletion 7q (-7/del(7q)) con

78 ne in clinical status that often accompanies advanced age and multimorbidity.

79 ay be a good option among patients with very advanced age and multiple comorbidities.

80 en in brain samples from humans with autism, advanced age and neurodegeneration (Alzheimer's disease

81 should be kept in mind that in patients with advanced age and pain in the left quadrant of the abdome

82 His risk factors for cholecystitis included advanced age and previous abdominal surgeries.

83 AF-TR is not rare and is associated with advanced age and right atrial enlargement.

84 Advanced age and severe fibrosis at HCV diagnosis are pr

85 Advanced age and severe fibrosis were significant risk f

86 Advanced age and splenectomy are risk factors for PAH in

87 The relation between muscle mass in advanced age and telomere length, however, has rarely be

88 s of the world provide care to patients with advanced age and terminal illness at different rates and

89 an elevated risk of CDI simply due to their advanced age and the fact that they are receiving care i

90 Due to the general health condition, advanced age and the large size of the aneurysm we decid

91 In addition to advanced age and the presence of comorbidities, there ar

92 Advanced age and tumor grade do not have a combined effe

93 d endothelial dysfunction can prevail during advanced age and we questioned how calcium signalling ma

94 acroglobulinemia (WM), most of which were of advanced age and with adverse prognostic factors.

95 or potentially curative treatment because of advanced age and/or clinically relevant comorbidities an

96 e study period: 73 for acute disease, 18 for advanced age and/or comorbidities, and 17 to avoid the r

97 ch that the beneficial effects are lost with advanced age and/or with extended hormone deprivation.

98 risk stratification protocol for patients of advanced age and/or with preexisting cardiac disease.

99 104 significantly improves motor function at advanced ages and also mildly extends lifespan.

100 an anatomical breakdown of the MZ occurs in advanced age, and a reduction in frequency of MZM may af

101 Left ventricular size, renal dysfunction, advanced age, and atrial fibrillation/flutter were signi

102 wer lung function, current smoking, obesity, advanced age, and having nonatopic asthma.

103 s age-associated diseases, improve health at advanced age, and increase life span.

104 r mortality were low total lymphocyte count, advanced age, and male sex.

105 In contrast, female gender, advanced age, and nonwhite race, all risk factors for in

106 ctors for stillbirth, including nulliparity, advanced age, and obesity.

107 iring the perirhinal cortex are disrupted in advanced age, and suggest that at least some of these im

108 we uncover in CRPS does not break down with advanced age, and surprisingly, remains stable across su

109 (DRIs) are not specific for women living to advanced ages, and little research has been conducted sp

110 xposure, such as in early development and at advanced age; and, second, the potential of stress-induc

111 Advanced age appeared to be of advantage for both bindin

112 k factors of family history, black race, and advanced age are associated with increased risk for POAG

113 who have substantial comorbidities or are of advanced age are at high risk of both relapse and nonrel

114 as cholangiocarcinoma (n = 594); patients of advanced age at diagnosis had an increased incidence com

115 ia and its presence has been associated with advanced age at diagnosis, higher hemoglobin and leukocy

116 etween young and old mice via alphaARs; with advanced age, attenuated dilatation of upstream branches

117 iated with higher readmission rates included advanced age, body mass index, cardiovascular/pulmonary

118 Outcomes using advanced age brain-dead or cardiac-dead donor kidneys ar

119 for atrial fibrillation were associated with advanced age but were fairly infrequent.

120 elief, prolongation of ovarian function into advanced age by Bax deficiency did not lead to an increa

121 Thus, microvascular endothelium can adapt to advanced age by reducing Ca(2+) influx during elevated o

122 Hindlimb ischemia was surgically induced in advanced-age C57/BL6 mice.

123 These patients were more likely to have advanced age, cardiac disease, chronic obstructive pulmo

124 predictors of DNR status at enrollment were advanced age, chronic obstructive pulmonary disease, pre

125 In multivariable analyses, advanced age, comorbidities, and disease severity were s

126 However, advanced age, comorbidities, and myocardial injury in pa

127 lack race (odds ratio [OR], 0.76; P < .001), advanced age, comorbidity, and Medicare insurance.

128 In advanced age, decreased CD8(+) cytotoxic T-lymphocyte (C

129 duals with a variety of conditions including advanced age, dementia, and cancer.

130 ity score adjustment for surgery showed that advanced age, diabetes mellitus, health care-associated

131 redictors of ranolazine intolerance, such as advanced age, diabetes, poor exercise tolerance, or hist

132 the hypothesis that "exceptional agers" with advanced ages do not have significant ADP because they h

133 Advanced age does not impair bone marrow engraftment, th

134 independent baseline predictors (female sex, advanced age, elevated serum creatinine and white blood

135 Cognitive decline is commonly observed in advanced aging even in the absence of disease.

136 x gene, which sustains ovarian lifespan into advanced age, extends fertile potential and minimizes ma

137 Advanced age, features of the metabolic syndrome, and ch

138 ndependent predictors of major bleeding were advanced age, female gender, diabetes, hypertension, ren

139 Clinical features of AF-TR included advanced age, female sex, greater right atrial than left

140 Screening patients with advanced age for HIV is economically attractive in many

141 feature of insulin-resistant states such as advanced age, genetic diabetes, and diet-induced obesity

142 of more hypomethylated DNA sequences in the advanced age group.

143 For CVG, multivariate analysis identified advanced age (> 70 years), concomitant coronary artery s

144 Participants were stratified by advanced age (>/=70 years), sex, and diagnosed hypertens

145 death, severe comorbidity, refusal of care, advanced age (>/=80 years), or prior malignancy.

146 In our cohort, advanced age (>67) was the strongest predictor of overal

147 Patients with advanced age (>74 years) had a higher risk of extraction

148 fluenced by limited education (<8 years) and advanced age (>80 years, P < 0.001).

149 Patients with ischaemic stroke who were of advanced age, had increased neurological impairment, or

150 Whether patients of more advanced age harbor similar risks is unresolved, often c

151 Advanced age has repeatedly been identified as an indepe

152 ly associated with 1-year mortality included advanced age (hazard ratio [HR] for >/=95 vs <75 years,

153 Because of his advanced age, he is not considered a candidate for lung

154 antation risk score, based on combination of advanced age, high HCT-CI, very poor-risk cytogenetic an

155 Thus, advanced age, high-fat diet, and decreased CFH induce su

156 nt cardiovascular disease, heart failure, or advanced age (higher risk).

157 to worsen over time and was associated with advanced age, higher baseline insulin level, and hemodyn

158 Among those with more advanced age, higher pulse pressure was also associated

159 Multivariate analysis demonstrated that advanced age, history of coronary artery disease, prolon

160 sk factors for BI/NAP1/027 infection include advanced age, hospitalization, and exposure to specific

161 mal lipid synthesis in humans and in mice of advanced age (i.e., >75 years in human or >18-24 months

162 combination of a poor performance status and advanced age identified a group of patients with a very

163 w here that CMA activity is maintained until advanced ages if the decrease in the receptor abundance

164 eterminants of poor outcome are factors such advanced age; impaired premorbid health status, especial

165 h in 2 individuals compared with survival to advanced age in 6 individuals).

166 dial infarction was increased in patients of advanced age in both CEA and CAS (OR, 1.64; 95% CI, 1.57

167 ffect the gammadelta T cell compartment with advanced age in humans.

168 lts indicate a decline in whole body EE with advanced age in mice, independent of changes in body wei

169 ll proliferation is severely restricted with advanced age in mice, whether stimulated by partial panc

170 ly associated with increased creatinine, and advanced age in PMF (P < .001) and hemoglobin less than

171 e prophylactic defibrillator implantation at advanced ages in HCM.

172 , and it was driven by positive selection at advanced ages in the presence of microenvironmental decl

173 s, characteristics that are observed only at advanced ages in WT flies.

174 ease in Alpl (-/-) mice prevents analysis at advanced ages, including studies to target rescue of den

175 ty of patients with heart failure presenting advanced age, infirmity, and impaired regenerative capac

176 Advanced age is a predictor of death and ventricular dil

177 Advanced age is a risk factor for development of and dea

178 Advanced age is an important risk factor for discharge t

179 Advanced age is associated with a breakdown of the epith

180 Advanced age is associated with alterations in innate an

181 Advanced age is associated with an increased risk of vas

182 Advanced age is associated with immune system deficits t

183 Surprisingly, even though selection at advanced age is expected to be weak, a CD33 allele prote

184 ome progressively impaired with age and that advanced age is itself a significant risk factor for car

185 Advanced age is known to impair neovascularization.

186 he hypothesis that attenuation of ROV during advanced age is most effective in proximal branches of m

187 resistance networks, attenuation of ROV with advanced age is most effective in proximal branches via

188 Outcome of treatment for patients of advanced age is often compromised by comorbid conditions

189 Advanced age is related to left ventricular (LV) remodel

190 Advanced age is the greatest risk factor for neurodegene

191 Advanced age is the main risk factor for most chronic di

192 Advanced age is the most important risk factor for atria

193 ether this function is impaired in humans of advanced age is unknown.

194 be predicted by clinical factors, including advanced age, ischemic cardiomyopathy, more severe heart

195 ia donor, high Kidney Donor Profile Index or advanced age kidneys are poorer than those with standard

196 ew of outcomes of expanded criteria donor or advanced age kidneys, we assessed the value of the Kidne

197 tically significant recurrence risk factors: advanced age, largest basal diameter, and the use of adj

198 ith a higher revascularization rate, whereas advanced age, left main disease, and smoking were associ

199 Advanced age, length of stay, and duration of life suppo

200 With advanced age, loss of dilatory signalling mediated throu

201 tients with atrial fibrillation and isolated advanced age, low body weight, or renal dysfunction have

202 Among baseline factors, advanced age, lower body mass index, poorer performance

203 d in symptomatic heart failure patients with advanced age, male gender, baseline hyperkalemia, renal

204 Among patients with SVR, advanced age, male gender, cirrhosis, decreased platelet

205 Studies have established that advanced age, male sex, and European ancestry are promin

206 In prognostic analyses, advanced age, male sex, poorer PS, increasing ratio of p

207 fusal in patients considered "too well" were advanced age, male sex, university hospital admission, c

208 sk factors for complications of GERD include advanced age, male sex, white race, abdominal obesity, a

209 ophagus include chronic GERD, hiatal hernia, advanced age, male sex, white race, cigarette smoking, a

210 Advanced age may act as a partial surrogate for conditio

211 Microvascular adaptation to advanced age may protect endothelial cells during elevat

212 ified 248 patients with Bcc BSI, who were of advanced age (mean, 68 years), chronically ill, and had

213 Patients with class 2 tumors had more advanced age (mean: 64 years vs 57 years; P = .001), had

214 , a similar relationship was present only at advanced ages (men aged > or = 80 years and women aged >

215 ons not meeting enrollment criteria included advanced age, noncardiovascular comorbidities, discharge

216 ring to interval appointments were having an advanced age (odds ratio, 1.02; 95% CI, 1.01-1.04) and k

217 rimordial follicle stage to ensure SCC up to advanced age of mice.

218 To assess the role of advanced age on survival and dialysis dependency after i

219 the major regionally distributed effects of advanced age on the brain involve reductions in prefront

220 Uncertainty exists about the influence of advanced age on the outcomes of carotid revascularizatio

221 nd is precluded for many patients because of advanced age or comorbidities.

222 or invasive treatments and in the setting of advanced age or complex health status.

223 rse diastolic and longitudinal function with advanced age or elevated load in both sexes, a significa

224 Each of these groups had advanced age or increased injury severity.

225 tients are poor surgical candidates owing to advanced age or medical comorbidities.

226 ith a limited life expectancy as a result of advanced age or severe comorbidity for whom dialysis wil

227 whether to perform colonoscopy in persons of advanced age or those with comorbid conditions.

228 logy and Chronic Health Evaluation II score, advanced age, or presence of nonrenal organ failures.

229 ndividuals--eg, those with comorbidities, of advanced age, or receiving immunosuppressive treatment--

230 ere demonstrated between SRSF2 mutations and advanced age (P < .01), IDH mutations (P < .01), and hig

231 On multivariate analysis, advanced age (P = 0.0021), extended resection (P = 0.000

232 Patients with advanced age (p = 0.01) and descending aorta grafting (p

233 Advanced age (P = 0.012), extended resection (P = 0.012)

234 tatistically significant decline of CCT with advanced age (P = 0.02).

235 follow-up was poor, which may be related to advanced age, poor initial VA, and the high incidence of

236 e the ADT Alzheimer's disease association in advanced age populations given the greater potential cli

237 s shared common clinical features, including advanced age, predominantly motor involvement, aggressiv

238 d propensity toward morbidity and mortality (advanced age, presence of cardiovascular risk factors, m

239 matologists frequently encounter patients of advanced age presenting with chronic eczematous eruption

240 ctive therapies is hampered by the fact that advanced age, primary age-related tauopathy or comorbidi

241 We tested the hypothesis that advanced age protects microvascular endothelium by atten

242 to date where hearing loss begins at such an advanced age, providing an opportunity to study both pro

243 ross the genome increased significantly with advanced age (r = 0.224, P =8 x 10(-30)).

244 Advanced age, radiographic pneumonia, requirement for ve

245 upheld in other human tissues and reveals an advanced aging rate in tumor tissue.

246 With advanced age, rats show deficits on PER-dependent behavi

247 patients with ARVC spans from adolescence to advanced age, reaching its peak between ages 21 and 40 y

248 Nineteen subjects, 12 with intermediate or advanced age-related macular degeneration (AMD) (AREDS c

249 betes (T2D), myocardial infarction (MI), and advanced age-related macular degeneration (AMD) as examp

250 inc supplementation decreases progression to advanced age-related macular degeneration (AMD) in patie

251 vitamins and minerals on the development of advanced age-related macular degeneration (AMD) in perso

252 Advanced age-related macular degeneration (AMD) is the l

253 Advanced age-related macular degeneration (AMD) is the l

254 To define the role of rare variants in advanced age-related macular degeneration (AMD) risk, we

255 mentation in reducing the risk of developing advanced age-related macular degeneration (AMD).

256 n shown to reduce the risk of progression to advanced age-related macular degeneration (AMD).

257 ciated with progression from intermediate to advanced age-related macular degeneration (AMD).

258 ntermediate and large drusen usually precede advanced age-related macular degeneration (AMD).

259 found to be associated with reduced risk of advanced age-related macular degeneration (AMD).

260 rmediate age-related macular degeneration or advanced age-related macular degeneration (neovascular o

261 successful in preventing the development of advanced age-related macular degeneration by 25%.

262 s and zinc can reduce the risk of developing advanced age-related macular degeneration by about a qua

263 c and antioxidants slowed the progression of advanced age-related macular degeneration in high-risk p

264 etina as well as reducing the progression to advanced age-related macular degeneration in higher risk

265 risk of age-related macular degeneration or advanced age-related macular degeneration in one eye are

266 d 50 to 85 years, at risk for progression to advanced age-related macular degeneration.

267 cts on the primary outcome of progression to advanced age-related macular degeneration.

268 axanthin are associated with a lower risk of advanced age-related macular degeneration.

269 are also associated with a decreased risk of advanced age-related macular degeneration.

270 ay vary in conferred risk for progression to advanced age-related macular disease.

271 hether they induce chronic inflammation with advanced age remains unclear.

272 Males of advanced age represent a rapidly growing population at r

273 Patients with advanced age represent a substantial subgroup of patient

274 Because advanced age represents a risk factor for complications

275 obic exercise training, initiated even at an advanced age, restores muscle blood flow distribution pa

276 Exercise training, initiated at an advanced age, reverses age-related diastolic and microva

277 Advanced age should not be used as an independent contra

278 to the patient (ie, poor performance status, advanced age, significant weight loss, severe comorbid d

279 inked to coronary artery disease and include advanced age, smoking, diabetes mellitus, hyperlipidemia

280 Independent risk factors include advanced age, smoking, peripheral arterial disease, high

281 neurodegeneration were not observed even at advanced ages, supporting the hypothesis that RNA foci a

282 Advanced age, systolic blood pressure, and diabetes were

283 e exhibit a higher fat to lean mass ratio at advanced ages than age-matched wild type mice.

284 IAV-specific CD8(+) T-cell populations with advanced age that parallel age-associated changes in the

285 est that these brain regions are affected by advanced age, the extent to which aging alters appetitiv

286 With advanced age, the loss of sensory nerve function and dim

287 Together these data suggest that with advanced age there may be reduced afferent drive from ex

288 Despite their advanced age, these clones are euglycaemic, insulin sens

289 Among risk factors for CDI, the advanced age threshold was younger for Chinese patients

290 ROV) in skeletal muscle is attenuated during advanced age via alpha-adrenoreceptor (alphaAR) activati

291 Advanced age was a major risk factor for all adverse out

292 Advanced age was associated with a significantly greater

293 Advanced age was associated with greater LV concentricit

294 Advanced age was significantly associated with increased

295 Advanced age was the strongest risk factor for uterine c

296 As Alzheimer's disease is a disease of advanced age, we hypothesize that older individuals on A

297 addition, multivariable analysis identified advanced age, weight loss, anemia, thrombocytopenia, hyp

298 York Heart Association class IV status, and advanced age were powerful adjusted predictors of poor o

299 l degeneration relative to wild-type mice at advanced ages, when bred on the light-sensitive BALB/c b

300 th concomitant coronary artery disease, with advanced age, with chronic kidney disease, or with valvu