ライフサイエンスコーパス: adventitia

1 with inflammatory cell infiltration into the adventitia.

2 erative changes in the pulmonary artery (PA) adventitia.

3 odeled pulmonary, but not systemic, arterial adventitia.

4 d levels of collagen in the aortic media and adventitia.

5 compared with the collagen-dominant arterial adventitia.

6 by severe neointima formation with thickened adventitia.

7 brils and smooth muscle cells from intima to adventitia.

8 tory responses in porcine coronary media and adventitia.

9 hat the effects of SOD were localized to the adventitia.

10 mogenously throughout the intima, media, and adventitia.

11 eration and neovascularization in the aortic adventitia.

12 ed with 8, 12, 16, and 24 Gy targeted to the adventitia.

13 beled cells were detected exclusively in the adventitia.

14 in total vessel diameter or in the media or adventitia.

15 om an osteoprogenitor cell population in the adventitia.

16 ies contain a network of vasa vasorum in the adventitia.

17 nd IGF-I receptor in both the intima and the adventitia.

18 ble electroporation, purposely targeting the adventitia.

19 ed in medial smooth muscle as well as in the adventitia.

20 layers representing the intima/media and the adventitia.

21 ciated with the development of the thickened adventitia.

22 a strong preference for localization in the adventitia.

23 e, collagen-rich scar was evident within the adventitia.

24 ection localized this shift to the media and adventitia.

25 made up the majority of H chain mRNAs in the adventitia.

26 bserved in the positive sites, mainly in the adventitia.

27 to stem cell antigen-1-positive cells in the adventitia.

28 jacent to the lumen in the near and far wall adventitia.

29 er bundles under in situ loading of coronary adventitia.

30 2 different sites on the anterior esophageal adventitia.

31 zygotes compared to TT homozygotes in aortic adventitia.

32 e and the junction between the media and the adventitia.

33 0 was sufficient to recruit monocytes to the adventitia.

34 found in fibrotic areas of the neointima and adventitia.

35 nous dendritic cells (DCs) positioned in the adventitia.

36 d artery, it bound specifically to DS in the adventitia.

37 Shh protein deposited between the media and adventitia.

38 adventitial fat) and, to a lesser extent the adventitia.

39 the underlying media (3.14 +/- 0.74) or the adventitia (3.01 +/- 0.74).

40 The vascular adventitia acts as a biological processing center for th

41 the current evidence demonstrating that the adventitia acts as a key regulator of vascular wall func

42 ging experiments on unstained fresh coronary adventitia allowed morphometric measurements of collagen

43 factors occurred predominantly in the tunica adventitia, along with macrophage recruitment, adventiti

44 We conclude that eNOS gene transfer to the adventitia alters vascular reactivity, as demonstrated b

45 In this review of the contributions of the adventitia and adventitial lymphocytes to the developmen

46 nfiltrate of proliferating leukocytes in the adventitia and an increased circulating C-reactive prote

47 IL-17A(+) T cells resided in both adventitia and aortas of aged Apoe(-/-) mice fed a chow

48 y expressed by fibroblasts of the remodeling adventitia and by smooth muscle cells of the neointima.

49 ssion of genes involved in the remodeling of adventitia and collagen degradation potentially particip

50 GF-betaR:Fc) localized preferentially to the adventitia and developing neointima in the injured carot

51 pertoires and a B cell recirculation between adventitia and draining lymph nodes.

52 3D tissue regions (such as the collagen-rich adventitia and elastin-rich lamellae in intact rat arter

53 of recombinant eNOS protein in the vascular adventitia and endothelium, associated with significantl

54 simulations, dose volume histograms for the adventitia and intima were calculated.

55 In CTOs >1 year old, the adventitia and IP NC numbers were similar and exceeded N

56 IRS1 and miR-487b were present mainly in the adventitia and less or not at all in the intima and tuni

57 f Shh signaling is localized to the arterial adventitia and may play important roles in maintenance o

58 d viral antigen in skip areas, mostly in the adventitia and media and least in the intima.

59 was uniformly and strongly expressed in the adventitia and media of patent human vein grafts, with m

60 n and leads to leukocyte accumulation in the adventitia and media of the aorta.

61 on was significantly reduced on day 3 in the adventitia and media of the irradiated vessels compared

62 ointima, but was strongly upregulated in the adventitia and media, corroborating immunostaining data

63 in a profound inflammatory infiltrate in the adventitia and necrotic core region of atherosclerotic l

64 mRNA-containing cells were localized in the adventitia and neointima at the arterial injury site.

65 ata indicate that cells proliferating in the adventitia and neointima express NMMHC-B; however, its e

66 -1 (Cthrc1) as a novel gene expressed in the adventitia and neointima on arterial injury and found th

67 ulation of type I collagen is evident in the adventitia and neointima, whereas elastin accumulates ma

68 -9 in 4 and 8 weeks, most prominently in the adventitia and outer media.

69 enzyme responsible for O2- production in the adventitia and show that this enzyme is a constitutively

70 rol lungs (P<0.05) that was localized to the adventitia and smooth muscle cells of hypertensive vesse

71 corporation, were detectable at day 1 in the adventitia and subsequently throughout the wall.

72 es in the media, whereas microvessels in the adventitia and the intima were spared.

73 lls and surrounding fibrocytes of the tunica adventitia and the lamina propria and an inner epithelia

74 c vessel walls occurred predominantly in the adventitia and was composed of primarily T cells and occ

75 Neovascularization was observed in the adventitia and was more extensive in WT arteries, relati

76 n is produced endogenously in the rat aortic adventitia and whether sufficient superoxide anion is pr

77 -gp91ds-eGFP or controls to the left carotid adventitia, and 2 days later we implanted minipumps deli

78 intima, 38+/-12 percent of such cells in the adventitia, and 30+/-7 percent of such cells in the inte

79 tery that is surrounded by a large remodeled adventitia, and a medial break with pronounced dilation

80 ost of the sites (93%) received >4 Gy at the adventitia, and all of the sites received >4 Gy at the i

81 en narrowing, thickening of intima-media and adventitia, and increased circumference that were inhibi

82 creased DNA and protein content similarly in adventitia, and increased only protein content in intima

83 T) resulted in blue formazan staining of the adventitia, and lucigenin chemiluminescence was signific

84 analysis showed apoptosis within the media, adventitia, and neointima peaked at 18 hours, 6 hours, a

85 on to macrophage progeny particularly in the adventitia, and to a lesser extent the atheroma, of athe

86 The intima and adventitia are commonly involved by the disease process,

87 w that Gli1(+) cells located in the arterial adventitia are progenitors of vascular smooth muscle cel

88 rease in the ratio of neointima area/media + adventitia area (P < 0.05).

89 f the artery's wall layers or cluster in the adventitia as a perivasculitis.

90 proliferative activity in the media and the adventitia as compared with the intima of autogenous vei

91 Desmin expression was patchy in the adventitia, as opposed to its homogeneous distribution i

92 nostaining, reached the maximum level in the adventitia at 3 days, whereas at 14 and 28 days, the num

93 at 1 week and in the neointimal lesions and adventitia at 4 weeks.

94 ed in the intima compared with the media and adventitia at day 7 after injury.

95 smooth muscle cell layers that appear in the adventitia at or just before birth.

96 EL-labeled cells were found primarily in the adventitia at the medial tear, but no differences were d

97 ormation was augmented in coronary media and adventitia because of increased NAD(P)H oxidase activity

98 Pathologic changes observed at the media-adventitia border in temporal arteries of CeAD patients

99 ecapitulating their positioning at the media-adventitia border of normal arteries.

100 n immature DCs that are located at the media-adventitia border.

101 scular wall cell eradication with subsequent adventitia but minimal media repopulation.

102 d proliferative foci were not limited to the adventitia but rather extended many millimeters away fro

103 CD45(+) cells accumulated in adventitia but were minimal in media.

104 rteries, vasa vasorum were restricted to the adventitia, but in inflamed arteries, capillaries emerge

105 Histological disruption of coronary adventitia, but not media or intima, was noted in 44% of

106 crophages, were reduced significantly in the adventitia by glycine.

107 d progressively destroying the wall into the adventitia causing saccular aneurysms, which can thrombo

108 tion of angiogenic vessels within the aortic adventitia, coincident with prominent, neointimal prolif

109 phox) localized exclusively in rabbit aortic adventitia, coincident with the site of staining for O2-

110 At 2 to 3 days after severe injury, the adventitia contained numerous BrdU-labeled cells (37 +/-

111 Our data establish that the vascular adventitia contains phenotypically distinct subpopulatio

112 , the degree of inflammatory reaction in the adventitia did not correlate with the size of the neoint

113 An extraordinary expansion of the adventitia due to inflammation also distinguishes inflam

114 The proliferating activity in the adventitia exceeded that seen in the media at all times

115 as illustrated further by a lesser degree of adventitia expansion, reduced elastin degradation, fewer

116 Fibroblasts in normal adventitia expressed vimentin but no alpha-SM actin or d

117 the adventitia facing outward, (2) with the adventitia facing inward after inverting, or (3) with th

118 cing inward after inverting, or (3) with the adventitia facing outward after inverting twice (to cont

119 um nitroprusside, was less in rings with the adventitia facing outward compared with those in which i

120 sh this, the rings were mounted (1) with the adventitia facing outward, (2) with the adventitia facin

121 id artery, but it became concentrated in the adventitia following endothelial injury.

122 ow that elastin and collagen fibers in inner adventitia form concentric densely packed fiber sheets,

123 about 58-70-fold lower than that within the adventitia from 1 to 30 days.

124 In particular, the tunica adventitia has emerged as a progenitor-rich compartment

125 uring vascular repair, changes involving the adventitia have been largely neglected in previous studi

126 otypic markers revealed different plaque and adventitia Ig repertoires and a B cell recirculation bet

127 easing amount of interest in the role of the adventitia in coordinating the immune response in athero

128 sduced fibroblasts and was restricted to the adventitia in seeded vessels that were not injured.

129 is study demonstrates the involvement of the adventitia in the vascular repair process after medial i

130 helium, neointima, medial smooth muscle, and adventitia, in the hypertensive lungs.

131 resulted in the inflammatory response in the adventitia (increased expression of interleukin-6, tumor

132 IP NC growth derived from the adventitia increases with age and is strongly associated

133 ar remodeling in CXCR3-deficient recipients, adventitia-infiltrating macrophages of Gr1(low) resident

134 s to migrate from the arterial lumen and the adventitia into atherosclerotic lesions.

135 collagen spreads from an external location (adventitia) into the vascular media, while type IV colla

136 The vascular adventitia is a complex layer of the vessel wall consist

137 RATIONALE: The vascular adventitia is a complex layer of the vessel wall consist

138 ropose that in situ maturation of DCs in the adventitia is an early event in the pathogenesis of GCA.

139 states, adding weight to the notion that the adventitia is integral to vascular wall pathogenesis, an

140 Their preferential accumulation in the adventitia is most compatible with the model that they c

141 tic infiltrate appears to be confined to the adventitia, is responsible for medial remodeling, and re

142 ayer identified dendritic cells at the media-adventitia junction as the dominant pathogen sensors.

143 d slightly towards the outer boundary of the adventitia layer.

144 ima layer to the interface between media and adventitia layers (from 80 to 160 kPa), dropped abruptl

145 al interface and within the tunica media and adventitia may play a role in plaque instability.

146 , leukocyte infiltration was observed in the adventitia, media, and developing neointima.

147 expression of cyclooxygenase-2 and PGI(2) in adventitia, media, and endothelium.

148 essed an indigenous population of DCs at the adventitia-media border.

149 ed changes involving hypercellularity of the adventitia, myofibroblast formation, and fibrosis were a

150 d in the endocardium and arterial intima and adventitia near draining lymphatics.

151 In the adventitia next to mature atherosclerotic lesions, terti

152 ural crest origin, we found that neither the adventitia nor AdvSca1 cells were labeled in arteries co

153 Subtle thickening of proximal media/adventitia not typically seen in mice was also detected.

154 (+) T cells are selectively activated in the adventitia of affected arteries.

155 artery tertiary lymphoid organs in the aorta adventitia of aged apolipoprotein E-deficient mice.

156 omoted inflammatory cell accumulation in the adventitia of aortic allografts of wild-type and CCR1-de

157 VE-1(+)) macrophages decreased in the aortic adventitia of apoE(-/-) mice with atherosclerosis (P < 0

158 (Sca-1(+)) progenitors exist in the vascular adventitia of apolipoprotein E-deficient (apoE(-/-)) mic

159 formation of tertiary lymphoid tissue in the adventitia of atherosclerotic aortas.

160 proliferative response of the media and the adventitia of autogenous vein grafts transplanted into t

161 TF is found in adventitia of blood vessels and the lipid core of athero

162 ncrease in TSP-1 expression was found in the adventitia of blood vessels from diabetic rats.

163 crophages/monocytes, myofibroblasts, and the adventitia of blood vessels in lung tissue.

164 antigen was more likely to be present in the adventitia of both GCA-negative TAs (RR = 2.43; 95% CI,

165 phils infiltrated the lumen, epithelium, and adventitia of bronchioles and bronchi in lungs of calves

166 (eNOS) gene can be delivered in vivo to the adventitia of cerebral arteries and functionally express

167 ense inflammatory infiltrate occurred in the adventitia of cuffed arteries, which was associated with

168 f fibrin(ogen), nidogen, and perlecan in the adventitia of descending aortas.

169 at 5-LO-positive macrophages localize to the adventitia of diseased mouse and human arteries in areas

170 ated enhanced tryptase staining in media and adventitia of human and mouse AAA lesions.

171 in vitro in fibroblasts within the pulmonary adventitia of humans with idiopathic pulmonary arterial

172 bserved throughout the neointima, media, and adventitia of injured arteries.

173 TIMP-4 protein was present in the adventitia of injured carotid arteries from 24 hours aft

174 nd that O2- is produced predominantly in the adventitia of isolated rabbit aorta and acts as a barrie

175 in lymphoid tissue, resistance vessels, and adventitia of large vessels.

176 uscle, while NTPDase2 is associated with the adventitia of muscularized vessels, microvascular pericy

177 reactivities were present in endothelium and adventitia of neocortical arterioles.

178 B cells are abundant in the adventitia of normal and diseased vessels.

179 cells (DCs) and lymphocytes are found in the adventitia of normal arteries, their number is greatly e

180 d dendritic cells are already present in the adventitia of normal/noninflamed mouse aortas.

181 ke patent SVG, TN-C was not expressed in the adventitia of occluded grafts, except for a low level of

182 At the time of stenosis, the adventitia of one of the arteries was coated with 1 mmol

183 The neuronal NOS was located in the adventitia of P and NP arteries.

184 vasorum neovascularization occurring in the adventitia of pulmonary arteries in response to chronic

185 a vasorum endothelial cells (VVECs) from the adventitia of pulmonary arteries, we report that hypoxia

186 s indicate that NADPH oxidase located in the adventitia of rat thoracic aorta generates sufficient ex

187 colocalizing with proliferating ECs and the adventitia of remodeled vessels but not in the vascular

188 galactosidase (LacZ) and introduced into the adventitia of right carotid arteries of rats immediately

189 deposition of beta-amyloid in the media and adventitia of small arteries and capillaries of the lept

190 by applying the carbocyanine dye DiI to the adventitia of the aortic arch of anesthetized rats.

191 e marrow, spleen, liver, fat tissues and the adventitia of the arterial wall.

192 as pseudoenhancement occurs in the far wall adventitia of the carotid artery and should not be mista

193 ic oxide synthase (NOS) could be seen in the adventitia of the cat cerebral vessels.

194 ays after AMI, we delivered MultiStem to the adventitia of the infarct-related vessel in patients wit

195 proline/arginine-rich peptide (PR39) to the adventitia of the injured artery induced a marked increa

196 r alpha-actin-positive myofibroblasts in the adventitia of the irradiated vessels than in nonirradiat

197 ltration of macrophages in the neointima and adventitia of the ligated left carotid arteries compared

198 server were compared, no distinction between adventitia of the native aorta and allograft was possibl

199 5 x 10(5) MSCs, which were injected into the adventitia of the outflow vein at the time of AVF creati

200 7phox, and p67phox almost exclusively in the adventitia of the rat aorta with no substantial staining

201 and IV muscle afferent fibres located in the adventitia of the small vessels appear to respond to the

202 mber of lipid-laden macrophages presented in adventitia of the vessels; these cells were absent from

203 was localized to the luminal endothelium and adventitia of vein segments transduced with Ad.CMVLacZ.

204 ated gp91(phox) localized in endothelium and adventitia of WT mice.

205 re no macroscopically visible lesions on the adventitia or epithelium.

206 s substantial cell migration either from the adventitia or from an extravascular, but nonhematopoieti

207 ells of the adult mouse aorta but not in the adventitia or in several other tissues.

208 lammatory reaction or fibrosis in the media, adventitia, or perivascular space of vessels treated wit

209 ular inflammation exceeded that found in the adventitia (p < 0.001) or media (p = 0.0001) across all

210 III and TGF-beta1 protein expression in the adventitia (P < 0.05), related to an increase in smooth

211 l and experimental evidence suggest that the adventitia participates in the response to endoluminal v

212 dventitial, transduction was observed in the adventitia, particularly within microvessels (vasa vasor

213 the first two weeks onward, starting in the adventitia/perivascular tissue and variably inflaming/da

214 kocyte-fibroblast interactions in the aortic adventitia potentiate IL-6 production, inducing local mo

215 resent within the intima, the media, and the adventitia, respectively.

216 dia with intact and denuded endothelium, and adventitia, respectively.

217 anglia and spreads transaxonally to arterial adventitia, resulting in persistent inflammation and pat

218 of crosstalk between the intima, media, and adventitia, specific contributions of B lymphocytes and

219 ucing cells, particularly in the col(V)-rich adventitia subjacent to the atheromas.

220 Neutrophils accumulated in the adventitia surrounding the injury site from 2 hours to 3

221 AR blockade (except increased DNA content in adventitia that was also inhibited by alpha2-AR blockade

222 In the adventitia, the proliferation was most intense in the en

223 -media thickness; 0.21-0.41 for intima-media-adventitia thickness; and 0.23 for CAWS; all models P<0.

224 ess [intima-media thickness and intima-media-adventitia thickness], and carotid artery wall stress [C

225 estigation was to assess the response of the adventitia to coronary arterial injury.

226 e failure by the microfibrillar array of the adventitia to sustain physiological haemodynamic stress,

227 The adventitia undergoes remodeling changes after a deep med

228 ly homed to the aorta and resided within the adventitia up to 7 d after transfer.

229 umen narrowing in some of the vessels of the adventitia was also observed.

230 In CTOs < 1 year old, the adventitia was associated with a larger number and size

231 Transgene expression in the adventitia was confirmed by histochemistry for beta-gala

232 Prolonged retention of MSCs at the adventitia was evidenced by serial PET images of (89)Zr-

233 velopment of a hypercellular response in the adventitia was evident 3 days after balloon-induced medi

234 NMMHC-B expression in the adventitia was markedly increased 3 days after balloon a

235 Intima-media and adventitia were separated and DNA content, protein synth

236 The fibrotic reaction in the adventitia, which does not involve cell migration, did n

237 portant role may be attributed to the tunica adventitia, which harbors regulatory cells and probably

238 mulates the formation of a dense collagenous adventitia, which prevents constrictive remodeling by ac

239 r of proliferating cells were located in the adventitia, with significantly fewer positive cells foun

240 type I procollagen protein increased in the adventitia within 2 days after injury.

241 othelial nitric oxide synthase (eNOS) to the adventitia would alter vascular reactivity.